|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Fast and interpretable classification of small X-ray diffraction datasets using data augmentation and deep neural networks显示文摘X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming steps in the development cycle of novel thin-film materials.We propose a machine learning-enabled approach to predict crystallographic dimensionality and space group from a limited number of thin-film XRD patterns.We overcome the scarce data problem intrinsic to novel materials development by coupling a supervised machine learning approach with a model-agnostic,physics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and experimental data.As a test case,115 thin-film metalhalides spanning three dimensionalities and seven space groups are synthesized and classified.After testing various algorithms,we develop and implement an all convolutional neural network,with cross-validated accuracies for dimensionality and space group classification of 93 and 89%,respectively.We propose average class activation maps,computed from a global average pooling layer,to allow high model interpretability by human experimentalists,elucidating the root causes of misclassification.Finally,we systematically evaluate the maximum XRD pattern step size(data acquisition rate)before loss of predictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD pattern to be obtained and classified in 5.5 min or less. | Felipe Oviedo Zekun Ren Shijing Sun Charles Settens Zhe Liu Noor Titan Putri Hartono Savitha Ramasamy Brian L.DeCost Siyu I.P.Tian Giuseppe Romano Aaron Gilad Kusne Tonio Buonassisi | 2019 | npj Computational Materials2019，，1： | 15 |
| 2 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 3 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 4 | Conversion of Catalytically Inert 2D Bismuth Oxide Nanosheets for Effective Electrochemical Hydrogen Evolution Reaction Catalysis via Oxygen Vacancy Concentration Modulation显示文摘Oxygen vacancies(Vo)in electrocatalysts are closely correlated with the hydrogen evo-lution reaction(HER)activity.The role of vacancy defects and the effect of their concentration,how-ever,yet remains unclear.Herein,Bi2O3,an unfavorable electrocata-lyst for the HER due to a less than ideal hydrogen adsorption Gibbs free energy(ΔGH*),is utilized as a perfect model to explore the func-tion of Vo on HER performance.Through a facile plasma irradia-tion strategy,Bi2O3 nanosheets with different Vo concentrations are fabricated to evaluate the influence of defects on the HER process.Unexpectedly,while the generated oxygen vacancies contribute to the enhanced HER performance,higher Vo concentrations beyond a saturation value result in a significant drop in HER activity.By tunning the Vo concentration in the Bi_(2)O_(3)nanosheets via adjusting the treatment time,the Bi2O3 catalyst with an optimized oxygen vacancy concentration and detectable charge carrier concentration of 1.52×10^(24)cm^(−3)demonstrates enhanced HER performance with an overpotential of 174.2 mV to reach 10 mA cm^(−2),a Tafel slope of 80 mV dec−1,and an exchange current density of 316 mA cm−2 in an alkaline solution,which approaches the top-tier activity among Bi-based HER electrocatalysts.Density-functional theory calculations confirm the preferred adsorption of H*onto Bi2O3 as a function of oxygen chemical potential(ΔμO)and oxygen partial potential(PO2)and reveal that high Vo concentrations result in excessive stability of adsorbed hydrogen and hence the inferior HER activity.This study reveals the oxygen vacancy concentration-HER catalytic activity relationship and provides insights into activating catalytically inert materials into highly efficient electrocatalysts. | Ziyang Wu Ting Liao Sen Wang Janith Adikaram Mudiyanselage Aaron SMicallef Wei Li Anthony PO’Mullane Jianping Yang Wei Luo Kostya Ostrikov Yuantong Gu Ziqi Sun | 2022 | Nano-Micro Letters2022，14，6： | 2 |
| 5 | An Information Diffusion -Based Recommendation Frame- work for Micro - Blogging显示文摘 | Jiesi Cheng Sun Aaron Hu Daning Zeng Daniel | 2011 | Journal of the Associa- tion for Information Systems2011，12，7： | 1 |
| 6 | Probing Electrode Losses in All - Vanadium Redox Flow Batteries with Impedance Spectroscopy 显示文摘 | Sun C N Delnick F M Aaron D S | 2013 | ECS Electrochem Lett2013，2，5： | 1 |
| 7 | Resolving Losses at the Negative Electrode in All-Vanadium Redox Flow Batteries Using Electrochemical impedance Spectroscopy 显示文摘 | Sun C N Delnick F M Aaron D S | 2014 | J Eleetrochem Soc2014，161，6： | 1 |
| 8 | Rate dependence of swelling in lithium-ion cells显示文摘 | Ki-Yong Oh Jason B. Siegel Lynn Secondo Sun Ung Kim Nassim A. Samad Jiawei Qin Dyche Anderson Krishna Garikipati Aaron Knobloch Bogdan I. Epureanu Charles W. Monroe Anna Stefanopoulou | 2014 | Journal of Power Sources2014，，： | 1 |
| 9 | Decline in Tested and Self-Reported Cognitive Functioning After Prophylactic Cranial Irradiation for Lung Cancer: Pooled Secondary Analysis of Radiation Therapy Oncology Group Randomized Trials 0212 and 0214显示文摘 | Vinai Gondi Rebecca Paulus Deborah W. Bruner Christina A. Meyers Elizabeth M. Gore Aaron Wolfson Maria Werner-Wasik Alexander Y. Sun Hak Choy Benjamin Movsas | 2013 | International Journal of Radiation Oncology, Biology, Physics2013，，： | 1 |
| 10 | “Picture to Puncture”: A Novel Time Metric to Enhance Outcomes in Patients Transferred for Endovascular Reperfusion in Acute Ischemic Stroke显示文摘 | Chung-Huan J. Sun Raul G. Nogueira Brenda A. Glenn Kerrin Connelly Susan Zimmermann Kim Anda Deborah Camp Michael R. Frankel Samir R. Belagaje Aaron M. Anderson Alexander P. Isakov Rishi Gupta | 2013 | Circulation2013，，10： | 1 |
| 11 | CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12显示文摘 | Yan-Xi Sun Elisabeth A. Pedersen Yusuke Shiozawa Aaron M. Havens Younghun Jung Jingcheng Wang Kenneth J. Pienta Russell S. Taichman | 2008 | Clinical & Experimental Metastasis2008，，7： | 1 |
| 12 | Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma显示文摘The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma model in mice, which results in aberrant cell fate and heterotopic ossification(HO). First, a high spatial degree of neurovascular congruency was observed to exist within extremity injury associated heterotopic ossification. Vascular and perivascular cells demonstrate characteristic responses to injury,as assessed by single cell RNA sequencing. This vascular response to injury was blunted in neurectomized mice, including a decrease in endothelial proliferation and type H vessel formation, and a downregulation of key transcriptional networks associated with angiogenesis. Independent mechanisms to chemically or genetically inhibit axonal ingrowth led to similar deficits in HO site angiogenesis, a reduction in type H vessels, and heterotopic bone formation. Finally, a combination of single cell transcriptomic approaches within the dorsal root ganglia identified key neural-derived angiogenic paracrine factors that may mediate neuron-to-vascular signaling in HO. These data provide further understanding of nerve-to-vessel crosstalk in traumatized soft tissues, which may reflect a key determinant of mesenchymal progenitor cell fate after injury. | Qizhi Qin Mario Gomez-Salazar Masnsen Cherief Chase A.Pagani Seungyong Lee Charles Hwang Robert J.Tower Sharon Onggo Yuxiao Sun Abhinav Piplani Zhao Li Sowmya Ramesh Thomas L.Clemens Benjamin Levi Aaron W.James | 2022 | Bone Research2022，10，3： | 1 |
| 13 | VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway显示文摘Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups.Notwithstanding,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular diseases.It is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying mechanisms.Using comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed.Mechanistically,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor growth.Our work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 pathway.Given the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases. | Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 14 | Application of Hausdorff fractal derivative to the determination of the vertical sediment concentration distribution显示文摘The Rouse formula and its variants have been widely used to calculate the steady-state vertical concentration distribution for suspended sediment in steady sediment-laden flows,where the diffusive flux is assumed to be Fickian.Turbulent flow,however,exhibits fractal properties,leading to non-Fickian diffusive flux for sediment particles.To characterize non-Fickian dynamics of suspended sediment,the current study proposes a Hausdorff fractal derivative based advection-dispersion equation(HADE)model,where the Fickian diffusive flux in the Rouse model is replaced by a fractal derivative re-scaled using a constant diffusivity.The order of the Hausdorff fractal derivative is designed to characterize the influence of the multi-fractal turbulence structure on sediment diffusion.Applications show that the HADE model,with the analytical solution expressed using a stretched exponential function,can accurately describe the observed vertical concentration profiles for suspended sediment with different sizes.This improvement well captures the non-exponential decay of the vertical sediment concentration in turbulent flow.Further analyses of measured sediment concentration profiles reveal that the Hausdorff fractal order decreases with the Rouse parameter,which describes the stronger impact of turbulent flow and a more uniform sediment concentration profile for smaller particles.Model comparisons also show that the HADE model provides better performance in describing the sediment concentration profiles than the improved Rouse formula and the standard fractional derivative advection-dispersion equation(FADE),which either under-or over-estimates vertical displacement of sediment particles,likely due to coherent turbulent structures. | Hongguang Sun Shiqian Nie Aaron I.Packman Yong Zhang Dong Chen Chengpeng Lu Chunmiao Zheng | 2023 | International Journal of Sediment Research2023，38，1： | 0 |
| 15 | 拍卖行化身多元艺术空间——嘉德艺术中心显示文摘嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起. | Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals Michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji Philipp Kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang Quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang | 2018 | 设计家2018，，1： | 0 |
| 16 | 肉类制品安全和质量监测的智能包装技术概述显示文摘食品包装行业自成立以来经历了长足的发展.在过去几十年里,包装行业的创新使得智能包装(SP)系统的发展,在竞争激烈的食品行业中占据了一席之地.SP系统除了它们的基本作用一保护产品不受有害的生物、化学和物理损害,并保持其清洁之外,在提高食品保质期和安全性方面具有巨大的潜力.指标和传感器,SP组件被用于实时监控肉类质量,和随后告知零售商和消费者产品的新鲜度、微生物、温度和保质期状况.在肉类包装中使用条码和无线电频率识别标签,以实时了解产品在供应链中的真实性和可追溯性.近年来,SP技术的创新使得肉和肉制品的新鲜度、微生物和保质期能够得到快速、灵敏和有效的检测、传感和保存记录.SP系统显示了对肉类行业广泛应用的承诺,以满足消费者对安全、优质肉制品以及减少浪费的观念需求.本文给出了更新正在进行的科学研究的概述,和最近的技术进步,发展智能的观点提供肉类包装系统能够监测的物理、微生物、化学变化的包装内容从生产商到销售点甚至更多,并修正这些潜在的不良反应. | Ishfaq Ahmed Hong Lin Long Zou Zhenxing Li Aaron L.Brody Ihsan Mabood Qazi Liangtao Lv Tushar Ramesh Pavase Mati Ullah Khan Sohaib Khan Lirui Sun | 2018 | 绿色包装2018，0，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员