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| 1 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 2 | Multifunctional SnO2/3D graphene hybrid materials for sodium-ion and lithium-ion batteries with excellent rate capability and long cycle life显示文摘 | Jung-ln Lee Junhua Song Younghwan Cha Shaofang Fu Chengzhou Zhu Xiaolin Li Yuehe Lin Min-Kyu Song | 2017 | Nano Research2017，10，12： | 2 |
| 3 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 4 | Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer显示文摘The synergistic therapy of chemotherapy and photothermal therapy(PTT)has been reported as a promising antitumor strategy.To achieve effective combination therapy,developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary.Herein,a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin(DOX)loading.We further designed PtPd-ethylene glycol(PEG)-folic acid(FA)-doxorubicin(DOX)nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting.Moreover,excellent photoacoustic(PA)imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’targeting effect.The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor. | Yanpeng Jia Yang Song Ying Qu Jinrong Peng Kun Shi Dan Du He Li Yuehe Lin Zhiyong Qian | 2020 | Nano Research2020，13，6： | 2 |
| 5 | Application of artificial intelligence-driven endoscopic screening and diagnosis of gastric cancer显示文摘The landscape of gastrointestinal endoscopy continues to evolve as new technologies and techniques become available.The advent of image-enhanced and magnifying endoscopies has highlighted the step toward perfecting endoscopic screening and diagnosis of gastric lesions.Simultaneously,with the development of convolutional neural network,artificial intelligence(AI)has made unprecedented breakthroughs in medical imaging,including the ongoing trials of computer-aided detection of colorectal polyps and gastrointestinal bleeding.In the past demi-decade,applications of AI systems in gastric cancer have also emerged.With AI’s efficient computational power and learning capacities,endoscopists can improve their diagnostic accuracies and avoid the missing or mischaracterization of gastric neoplastic changes.So far,several AI systems that incorporated both traditional and novel endoscopy technologies have been developed for various purposes,with most systems achieving an accuracy of more than 80%.However,their feasibility,effectiveness,and safety in clinical practice remain to be seen as there have been no clinical trials yet.Nonetheless,AI-assisted endoscopies shed light on more accurate and sensitive ways for early detection,treatment guidance and prognosis prediction of gastric lesions.This review summarizes the current status of various AI applications in gastric cancer and pinpoints directions for future research and clinical practice implementation from a clinical perspective. | Yu-Jer Hsiao Yuan-Chih Wen Wei-Yi Lai Yi-Ying Lin Yi-Ping Yang Yueh Chien Aliaksandr A Yarmishyn De-Kuang Hwang Tai-Chi Lin Yun-Chia Chang Ting-Yi Lin Kao-Jung Chang Shih-Hwa Chiou Ying-Chun Jheng | 2021 | World Journal of Gastroenterology2021，27，22： | 2 |
| 6 | Optimal controller for homing missiles显示文摘 | C F Lin W R Yueh | 1985 | Journal of Guidance Control and Dynamics1985，8，3： | 1 |
| 7 | Wild-type p53 reactivation by small-molecule Minnelide in human papillomavirus(HPV)-positive head and neck squamous cell carcinoma显示文摘 | Caicedo G E Lin R Fujisawa C Yueh B | 2014 | Oral Oncol2014，50，12： | 1 |
| 8 | A sol-gel-modified poly (methyl methacrylate) electrophoresis mieroehip with a hydrophilic channel wall显示文摘 | Chen Gang Xu Xuejian Lin Yuehe | 2007 | Chem Eur J2007，13，22： | 1 |
| 9 | Magnetic beads-based bioelectrochemical immunoassay of polycyclic aromatic hydrocarbons显示文摘 | Ying-Ying Lin Guodong Liu C.M. Wai Yuehe Lin | 2007 | Electrochemistry Communications2007，，7： | 1 |
| 10 | Functionalized carbon nanotubes and nanofibers for biosensing applications显示文摘 | WANG Jun LIN Yuehe | | 0，，07： | 1 |
| 11 | Genetic polymorphism of the angiotensin converting enzyme and L-dopa-induced adverse effects in Parkinson's disease显示文摘 | Lin J J Yueh K C Lin S Z | 2007 | J Neurol Sci2007，252，： | 1 |
| 12 | Template-directed synthesis of nitrogen- and sulfur- codoped carbon nanowire aerogels with enhanced electrocatalytic performance for oxygen reduction显示文摘做的 Heteroatom,精确作文控制,和合理形态学设计是为在燃料房间为氧减小反应(ORR ) 生产新奇 nanocatalysts 的有效策略。此处,综合的一条划算的途径用一个难 templating 方法的 nitrogen-codoped 和 sulfur-codoped 碳 nanowire aerogels 被建议。aerogels 在碱的答案为 ORR 用热水的处理和碳化展览的联合准备了好催化活动。在在氮和硫先锋之间的最佳的退火温度和集体比率,结果的 aerogels 表演可比较的 electrocatalytic 活动到为 ORR 的商业 Pt/C 催化剂的。重要地,优化催化剂为甲醇转线路效果显示出更好长期的稳定性和令人满意的忍耐。这些 codoped aerogels 被期望在燃料房间有潜在的应用。 | Shaofang Fu Chengzhou Zhu Junhua Song Mark H. Engelhard Xiaolin Li Peina Zhang Haibing Xia Dan Du Yuehe Lin | 2017 | Nano Research2017，10，6： | 1 |
| 13 | Supercritical fluid extraction and chromatography of metal chelates and organometallic compounds 显示文摘 | Lin Yuehe Smart Neil G Wai CM | 1995 | Trends in Analytical Chemistry1995，14，3： | 1 |
| 14 | Monitoring environ- mental pollutants by microchip capillary electrophoresis with electrochemical detection 显示文摘 | CHEN Gang LIN Yuehe WANG J | 2006 | Talanta2006，68，3： | 1 |
| 15 | Supercritical fluid fabrication of metal nanowires and nanorods templated by multiwalled carbon nanotubes 显示文摘 | Ye Xiangrong Lin Yuehe Wang Chongming Wai C M | 2003 | Adv Mater2003，15，3： | 1 |
| 16 | Polymer crystallization confined in one, two, or three dimensions显示文摘 | Yueh Lin Loo Reehard A Register Anthony J Ryan | 2001 | Maeromoteeules2001，34，： | 1 |
| 17 | Disposable carbon nanotube modified screen-printed biosensor for amperometric detection of organophosphorus pesticides and nerve agents 显示文摘 | Lin Yuehe Lu Fang Wang Joseph | 2004 | Electroanalysis2004，16，12： | 1 |
| 18 | Novel hybrid materials with high stability for electrically switched ion exchange ~ Carbon nanotube-polyaniline-nickel hexacyanoferrate nanoeomposites显示文摘 | LIN Yuehe CUI Xiaoli | 2005 | The Royal Society of Chemistry2005，10，： | 1 |
| 19 | Manipulating structure and enhancing conductivity of polymer acid doped polyaniline by exploiting redox chemistry 显示文摘 | JACOB TARVER YUEH LIN LOO | 2013 | Thin Solid Films2013，539，31： | 1 |
| 20 | Modes of crystallization in block copolymer microdomains: breakout, templated, and eonfined显示文摘 | Yueh Lin Loo Rechard A Register Anthony J Ryan | 2002 | Macromolecules2002，35，： | 1 |
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