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| 1 | Early radiological assessment of locally advanced pancreatic cancer treated with electrochemotherapy显示文摘AIM To report early imaging assessment of ablated area post electrochemotherapy(ECT) in patients with locally advanced pancreatic cancer(LAPC). METHODS ECT was performed in 19 LAPC patients enrolled in an approved ongoing clinical phase Ⅰ/Ⅱ study. Before and after ECT, 18 patients underwent computed tomography(CT) scan, 11 patients underwent morphological and functional magnetic resonance(MR) scan(dynamic contrast enhanced-MRI) calculating wash-in slope(WIS) and wash-out slope(WOS); diffusion weighted imaging calculating pseudo-diffusivity(Dp), perfusion fraction(fp) and tissue diffusivity(Dt); 10 patients underwentpositron emission tomography(PET). Response evaluation criteria in solid tumour(RECIST) on MR and CT were used to assess tumour therapy response. Choi on CT, PET response criteria in solid tumors(PERCIST) on PET and functional parameters on MR were used to evaluate treatment response.RESULTS For each patient no significant reduction was measurable by CT and MR using RECIST. According Choi criteria a partial response was obtained in 18/18(100.0%) patients. According PERCIST criteria 6/10(60.0%) patients showed a partial response, 3/10(30.0%) stable disease and 1/10(10.0%) progression disease. Moreover, using functional MR parameters, a significant reduction of viable tumour after ECT can be observed. According ΔWIS and ΔWOS 9/11(81.8%) patients exhibited a partial response and 2/11(18.2%) stable disease; 8/11(72.7%) patients were considered in partial response by ΔDp evaluation and 3/11(27.3%) in stable disease; according ΔDt 7/11(63.6%) patients showed a partial response, 1/11(9.1%) showed progression of disease and 3/11(27.3%) were stable. Perfusion fraction fp showed a significant reduction after ECT only in four patients. No significant difference was observed after ECT in signal intensity of T1-weighted images and T2-weighted images, and in equilibrium-phase of contrast study, according to χ2 test was observed. A good correlation was reported between ΔHounsfield unit and Δmaximum standardized uptake value and between Δfp and ΔWOS, with a significant statistically difference(P < 0.05) using Spearman correlation coefficient.CONCLUSION Perfusion and diffusion MR derived parameters, Choi, PERCIST criteria are more performant than morphological MR and CT criteria to assess ECT treatment response. | Vincenza Granata Roberta Fusco Sergio Venanzio Setola Mauro Piccirillo Maddalena Leongito Raffaele Palaia Francesco Granata Secondo Lastoria Francesco Izzo Antonella Petrillo | 2017 | World Journal of Gastroenterology2017，23，26： | 3 |
| 2 | Different Patterns of Recurrence in Gastric Cancer Depending on Lauren’s Histological Type: Longitudinal Study显示文摘 | Daniele Marrelli Franco Roviello Giovanni de Manzoni Paolo Morgagni Alberto Di Leo Luca Saragoni Alfonso De Stefano Secondo Folli Claudio Cordiano Enrico Pinto | 2002 | World Journal of Surgery2002，，9： | 2 |
| 3 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，3： | 1 |
| 4 | Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase显示文摘 | Scorziello A Pellegrini C Secondo A | 2004 | J Neurosci Res2004，76，6： | 1 |
| 5 | Zinc inhibits calcium-mediated and nitric oxide-mediated ion secretion in human enterocytes显示文摘 | Roberto Berni Canani Agnese Secondo Annalisa Passariello Vittoria Buccigrossi Lorella Maria Teresa Canzoniero Serena Ruotolo Cuono Puzone Francesco Porcaro Manuela Pensa Antonio Braucci Monica Pedata Lucio Annunziato Alfredo Guarino | 2009 | European Journal of Pharmacology2009，，2： | 1 |
| 6 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 7 | Rate dependence of swelling in lithium-ion cells显示文摘 | Ki-Yong Oh Jason B. Siegel Lynn Secondo Sun Ung Kim Nassim A. Samad Jiawei Qin Dyche Anderson Krishna Garikipati Aaron Knobloch Bogdan I. Epureanu Charles W. Monroe Anna Stefanopoulou | 2014 | Journal of Power Sources2014，，： | 1 |
| 8 | BHK cells transfected with NCX3 are more resistant to hypoxia followed by reoxygenation than those transfected with NCXl and NCX2:Possible relationship with mitochondrial membrane potential显示文摘 | Secondo A Staiano RI Scorziello A | 2007 | Cell Calcium2007，42，6： | 1 |
| 9 | Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxy- genation phase显示文摘 | Scorziello A Pellegrini C Secondo A | 2004 | J Neurosci RES2004，76，6： | 1 |
| 10 | Risk factors for lymph node metastases and their prognostic significance in early gastric cancer(EGC)for the Italian Research Group for Gastric Cancer(IRGGC)显示文摘 | Secondo Folli Paolo Morgagni Franco Roviello | 2001 | Japanese Journal of Clinical Oncology2001，31，： | 1 |
| 11 | Neuronal NOS activation during oxygen and glucose deprivation triggers cerebellar granule cell death in the later reoxygenation phase 显示文摘 | Scorziello A Pellegrini C Secondo A | 2004 | J Neurosci Res2004，76，6： | 1 |
| 12 | The role of radiolabeled somatostatin analogs in adrenal imaging显示文摘 | Simone Maurea Secondo Lastoria Corradina Caracò Michele Klain Paola Varrella Wanda Acampa Pietro Muto Marco Salvatore | | Nuclear Medicine and Biology0，，： | 1 |
| 13 | The Diagnosis of Nonfunctioning Pheochromocytoma The Role of I-123 MIBG Imaging显示文摘 | SIMONE MAUREA SECONDO LASTORIA ALBERTO CUOCOLO LUIGI CELENTANO MARCO SALVATORE | | Clinical Nuclear Medicine0，，： | 1 |
| 14 | Are Incubators And Science Parks Effective For Research Spin-offs? Evidence from Italy显示文摘 | Elisa Salvador Rolfo Secondo | | 0，，03： | 1 |
| 15 | Technetium-99m-methylene diphosphonate scintimammography to image primary breast cancer显示文摘 | Sergio Piceoco Secondo Lastoria Ciro Mainolfi | 1995 | The journal of nudear medicine1995，36，5： | 1 |
| 16 | Nuclear factor-kappaB ac- tivation by reactive oxygen species mediates voltage-gated K ^+ current en- hancement by neurotoxic beta-amyloid peptides in nerve growth factor-dif- ferentiated PC12 cells and hippocampal neurones 显示文摘 | Pannaccione A Secondo A Seorziello A | 2005 | J Neurochem2005，94，3： | 1 |
| 17 | Thyroid lymphoma: a rare tumor requiring combined management显示文摘 | FOPPIANI L SECONDO V ARLANDINI A | 2009 | Hormones (Athens)2009，8，3： | 1 |
| 18 | Postpartum urinary symptoms: prevalence and risk factors显示文摘 | Roberto Pregazzi Andrea Sartore Luigi Troiano Eva Grimaldi Paolo Bortoli Salvatore Siracusano Secondo Guaschino | 2002 | European Journal of Obstetrics and Gynecology2002，，2： | 1 |
| 19 | Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl-induced cell death in SH-SY 5Y neuroblastoma cells 显示文摘 | Canzoniero L M Adornetto A Secondo A | 2006 | J Neurosci Res2006，84，3： | 1 |
| 20 | Quality of life in dependent older adults living at home显示文摘 | Secondo F Paolo L | 2002 | Archives of Gerontology and Geriatrics2002，35，： | 1 |
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