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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | A commentary review on the use of normalized diff erence vegetation index(NDVI)in the era of popular remote sensing显示文摘The Normalized Diff erence Vegetation Index(NDVI),one of the earliest remote sensing analytical products used to simplify the complexities of multi-spectral imagery,is now the most popular index used for vegetation assessment.This popularity and widespread use relate to how an NDVI can be calculated with any multispectral sensor with a visible and a near-IR band.Increasingly low costs and weights of multispectral sensors mean they can be mounted on satellite,aerial,and increasingly—Unmanned Aerial Systems(UAS).While studies have found that the NDVI is effective for expressing vegetation status andquantified vegetation attributes,its widespread use and popularity,especially in UAS applications,carry inherent risks of misuse with end users who received little to no remote sensing education.This article summarizes the progress of NDVI acquisition,highlights the areas of NDVI application,and addresses the critical problems and considerations in using NDVI.Detailed discussion mainly covers three aspects:atmospheric eff ect,saturation phenomenon,and sensor factors.The use of NDVI can be highly eff ective as long as its limitations and capabilities are understood.This consideration is particularly important to the UAS user community. | Sha Huang Lina Tang Joseph P.Hupy Yang Wang Guofan Shao | 2021 | Journal of Forestry Research2021，32，1： | 12 |
| 3 | Recruitment of endogenous progenitor cells by erythropoietin loaded particles for in situ cartilage regeneration显示文摘Cartilage injury affects millions of people throughout the world,and at this time there is no cure.While transplantation of stem cells has shown some success in the treatment of injured cartilage,such treatment is limited by limited cell sources and safety concerns.To overcome these drawbacks,a microscaffolds system was developed capable of targeting,reducing the inflammatory response and recruiting endogenous progenitor cells to cartilage-defect.Erythropoietin(EPO)-loaded-hyaluronic acid(HA)microscaffolds(HA+EPO)were fabricated and characterized.HA-microscaffolds showed good cell-compatibility and could target chondrocytes via CD44 receptors.HA+EPO was designed to slowly release EPO while recruiting progenitor cells.Finally,the ability of HA+EPO to repair cartilage-defects was assessed using a rabbit model of full-thickness cartilagedefect.Our results showed that the intra-articular administration of EPO,HA,and EPO+HA reduced the number of inflammatory cells inside the synovial-fluid,while EPO+HA had the greatest anti-inflammatory effects.Furthermore,among all groups,EPO+HA achieved the greatest progenitor cell recruitment and subsequent chondrogenesis.The results of this work support that,by targeting and localizing the release of growthfactors,HA+EPO can reduce inflammatory responses and promote progenitor cells responses.This new platform represents an alternative treatment to stem-cell transplantation for the treatment of cartilage injury. | Amirhossein Hakamivala Shuxin li Kayti Robinson YiHui Huang Shuai Yu Baohong Yuan Joseph Borrelli Jr. Liping Tang | 2020 | Bioactive Materials2020，5，1： | 7 |
| 4 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 5 | Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling显示文摘Modulation of alloimmune responses is critical to improving transplant outcome and promoting long-term graft survival.To determine mechanisms by which a nonhematopoietic erythropoietin(EPO)derivative,carbamylated EPO(CEPO),regulates innate and adaptive immune cells and affects renal allograft survival,we utilized a rat model of fully MHC-mismatched kidney transplantation.CEPO administration markedly extended the survival time of kidney allografts compared with the transplant alone control group.This therapeutic effect was inhibited when the recipients were given LY294002,a selective inhibitor of the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway or anti-EPO receptor(EPOR)antibody,in addition to CEPO.In vitro,CEPO inhibited the differentiation and function of dendritic cells and modulated their production of proinflammatory and anti-inflammatory cytokines,along with activating the PI3K/AKT signaling pathway and increasing EPOR mRNA and protein expression by these innate immune cells.Moreover,after CD4^(+)T cells were exposed to CEPO the Th1/Th2 ratio decreased and the regulatory T cell(Treg)/Th17 ratio increased.These effects were abolished by LY294002 or anti-EPOR antibody,suggesting that CEPO regulates immune responses and promotes kidney allograft survival by activating the PI3K/AKT signaling pathway in an EPOR-dependent manner.The immunomodulatory and specific signaling pathway effects of CEPO identified in this study suggest a potential therapeutic approach to promoting kidney transplant survival. | Ning Na Daqiang Zhao Jinhua Zhang Jiaqing Wu Bin Miao Heng Li Yingxun Luo Zuofu Tang Wensheng Zhang Joseph A.Bellanti Song Guo Zheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 6 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 7 | Pathological correlations between traumatic brain injury and chronic neurodegenerative diseases显示文摘Traumatic brain injury is among the most common causes of death and disability in youth and young adults.In addition to the acute risk of morbidity with moderate to severe injuries,traumatic brain injury is associated with a number of chronic neurological and neuropsychiatric sequelae including neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.However,despite the high incidence of traumatic brain injuries and the established clinical correlation with neurodegeneration,the causative factors linking these processes have not yet been fully elucidated.Apart from removal from activity,few,if any prophylactic treatments against post-traumatic brain injury neurodegeneration exist.Therefore,it is imperative to understand the pathophysiological mechanisms of traumatic brain injury and neurodegeneration in order to identify potential factors that initiate neurodegenerative processes.Oxidative stress,neuroinflammation,and glutamatergic excitotoxicity have previously been implicated in both secondary brain injury and neurodegeneration.In particular,reactive oxygen species appear to be key in mediating molecular insult in neuroinflammation and excitotoxicity.As such,it is likely that post injury oxidative stress is a key mechanism which links traumatic brain injury to increased risk of neurodegeneration.Consequently,reactive oxygen species and their subsequent byproducts may serve as novel fluid markers for identification and monitoring of cellular damage.Furthermore,these reactive species may further serve as a suitable therapeutic target to reduce the risk of post-injury neurodegeneration and provide long term quality of life improvements for those suffering from traumatic brain injury. | Marcela Cruz-Haces Jonathan Tang Glen Acosta Joseph Fernandez Riyi Shi | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 8 | Preoperative Nutritional Status Is an Important Predictor of Survival in Patients Undergoing Surgery for Renal Cell Carcinoma显示文摘 | Todd M. Morgan Dominic Tang Kelly L. Stratton Daniel A. Barocas Christopher B. Anderson Justin R. Gregg Sam S. Chang Michael S. Cookson S. Duke Herrell Joseph A. Smith Peter E. Clark | 2011 | European Urology2011，，6： | 2 |
| 9 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 10 | Identification of a novel HIV-1 intra-circulating recombinant form 01_AE in China: a descendant of the previously identified CRF01_AE transmission clusters 1 and 6显示文摘Dear Editors,Here,we report a novel HIV-1 intra-circulating recombinant form 01_AE(intra-CRF01_AE:CRF01-1AE/CRF01-6AE)composed of CRF01_AE transmission clusters 1 and 6,which was identified in a heterosexual male from Fujian,with one breakpoint observed in the vif gene.The CRF01_AE region I(HXB2:868–5184)of the recombinant clustered with CRF01_AE transmission cluster 1,which | NING ChuanYi LI XingGuang TANG WeiMing ZHOU Bo CAI WeiPing TUCKER Joseph D. | 2015 | Science China(Life Sciences)2015，58，7： | 2 |
| 11 | Misleading funnel plot for detection of bias in meta-analysis显示文摘 | Jin-ling tang Joseph LY Live | 2000 | J Clin Epidemiology2000，53，： | 1 |
| 12 | Squamous-Cell Carcinoma of the Rectum: A Rare but Curable Tumor显示文摘 | Caio S. R. Nahas M.D. Jinru Shia M.D. Romane Joseph M.D. Deborah Schrag M.D. Bruce D. Minsky M.D. Martin R. Weiser M.D. Jose G. Guillem M.D. Phillip B. Paty M.D. David S. Klimstra M.D. Laura H. Tang M.D. W. Douglas Wong M.D. Larissa K. Temple M.D | 2007 | Diseases of the Colon & Rectum2007，，9： | 1 |
| 13 | Su1990 Integrative Identification of EBV-Associated Variations At Genomic, Epigenomic and Transcriptomic Levels in Gastric Cancer显示文摘 | Qiaoyi Liang Xiaotian Yao Senwei Tang Tung On Yau Junhong Zhao Joseph J.Y. Sung Jun Yu | 2013 | Gastroenterology2013，，5： | 1 |
| 14 | Platelet-Derived Growth Factor-AB Promotes the Generation of Adult Bone Marrow–Derived Cardiac Myocytes显示文摘 | Munira Xaymardan Lilong Tang Leze Zagreda Benedetta Pallante Jingang Zheng Joseph L. Chazen Andrew Chin Inga Duignan Patrick Nahirney Shahin Rafii Takashi Mikawa Jay M. Edelberg | 2004 | Circulation Research: Journal of The American Heart Association2004，，5： | 1 |
| 15 | Powers Antioxidant activity and quality of asparagus affected by microwave - circulated water combination and conventional sterilization 显示文摘 | Sun T Tang J Joseph R | 2007 | Food Chemistry2007，100，2： | 1 |
| 16 | Effect of Enzymatic Macerate Treatment on Rutin Content, Antioxidant Activity, Yield, and Physical Properties of Asparagus Juice显示文摘 | Ting Sun Joseph R Powers Juming Tang | 2007 | Journal of food science2007，72，4： | 1 |
| 17 | Feasibility of prospectively ECG-triggered high-pitch coronary CT angiography with 30 mL iodinated contrast agent at 70 kVp: initial experience显示文摘 | Long Jiang Zhang Li Qi Jing Wang Chun Xiang Tang Chang Sheng Zhou Xue Man Ji James V. Spearman Carlo Nicola Cecco Felix G. Meinel U. Joseph Schoepf Guang Ming Lu | 2014 | European Radiology2014，，： | 1 |
| 18 | Hydrogen sulfide in- duced relaxation of resistance mesenterie artery beds of rats 显示文摘 | Cheng YQ Joseph FN Tang GH | 2004 | Heart Circ Physiol2004，287，5： | 1 |
| 19 | Some results on the self-similarity property in communication networks显示文摘 | SONG S B JOSEPH K TANG B H | 2004 | IEEE Transactions on Communications2004，52，10： | 1 |
| 20 | Misleading funnel plot for detection of bias in meta-analysis显示文摘 | Jin-Ling Tang Joseph LY Liu | 2000 | Journal of Clinical Epidemiology2000，，5： | 1 |
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