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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | 长期配戴角膜接触镜对角膜厚度、屈率及表面规则性的影响显示文摘目的 :了解长期配戴角膜接触镜对角膜厚度、屈率及表面规则性的影响。方法 :应用Orbscan角膜地形图系统检测 3 5例 (64只眼 )配戴角膜接触镜 5年以上患者的全角膜厚度、前表面角膜屈率及角膜前、后表面高度地形图。 2 0例 (4 0只眼 )正常人为正常对照。采用TMS 1角膜地形图系统的参数评价角膜表面规则性。比较正常人和配戴角膜接触镜 5年以上患者的全角膜厚度、角膜屈率、表面规则指数 (SRI)、表面不对称指数 (SAI)、预测视力(PVA)及角膜地形图图形的差异。结果 :戴镜组病例其配戴角膜接触镜的平均时间为 (13 45± 6 42 )年。与正常对照组相比 ,长期配戴角膜接触镜患者其角膜中央及周边 8个测量区的平均角膜厚度减少 3 0~ 5 0 μm (P <0 0 0 1) ,角膜屈率、最大角膜屈率 (MaxK )及最小角膜屈率 (MinK)明显增加 (P <0 0 1)。两组间角膜散光度无显著性差异。长期配戴角膜接触镜的患者其TSM 1系统参数中的SRI和SAI值较正常人明显增加 (P <0 0 1) ,PVA值无明显改变 (P =0 15 )。应用两种角膜地形图仪检查所得的角膜屈率地形图及角膜高度地形图的彩色编码图形类型 ,两组间无显著性差异。结论 :长期配戴角膜接触镜将导致全角膜厚度减小。 | 刘祖国 张梅 Stephen C Pflugfelder | 2002 | 中国实用眼科杂志2002，20，5： | 18 |
| 3 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 4 | 趋化因子受体CXCR4的结构与功能显示文摘目的 认识趋化因子受体CXCR4之结构与功能的关系。方法 分别建立野生型趋化因子受体CXCR4及CXCR2、5个CXCR4/CXCR2嵌合受体和 2个CXCR4突变受体的CHO稳定表达细胞株 ,以配体 -受体结合试验、细胞微生理监测术、体外细胞 -细胞融合实验为手段观察各变异受体与重组人SDF 1β的结合能力、在受刺激后的信号转导能力、以及作为HIV 1辅助受体的能力。结果 有 4个变异受体 (2 444a ,444 2 ,42 2 2 ,CXCR4 Tr)保持了程度不同的与SDF 1β的结合能力 ,其中 2个 (2 444a ,CXCR4 Tr)保留了程度不同的信号转导能力 ;除 1个变异受体 (42 2 2 )外 ,其它变异受体都程度不同的具有辅助受体功能。结论 CXCR4以多个结构区域参与与SDF 1β的相互作用。其N端胞外区足以具有与SDF 1β的高亲和性结合能力。第三环链对CXCR4的结合能力也有其特定的贡献。CXCR4的信号传导不仅需要保守结构DRY盒 ,而且还需要贯穿整个分子的 7个跨膜区域在受配体刺激后形成并维持一定的构象。CXCR4的辅助受体功能结构域与配体结合功能结构域间存在交叉重叠。 | 郑红 Stephen C Peiper 朱锡华 | 2001 | 第三军医大学学报2001，23，2： | 7 |
| 5 | Liver pathology of hepatitis C,beyond grading and stagingof the disease显示文摘Liver biopsy evaluation plays a critical role in management of patients with viral hepatitis C. In patients with acute viral hepatitis, a liver biopsy, though uncommonly performed, helps to rule out other nonviral causes of deranged liver function. In chronic viral hepatitis C, it is considered the gold standard in assessment of the degree of necroinflammation and the stage of fibrosis, to help guide treatment and determine prognosis. It also helps rule out any concomitant diseases such as steatohepatitis, hemochromatosis or others. In patients with chronic progressive liver disease with cirrhosis and dominant nodules, a targeted liver biopsy is helpful in differentiating a regenerative nodule from dysplastic nodule or hepatocellular carcinoma. In the setting of transplantation, the liver biopsy helps distinguish recurrent hepatitis C from acute rejection and also is invaluable in the diagnosis of fibrosing cholestatic hepatitis, a rare variant of recurrent hepatitis C. This comprehensive review discusses the entire spectrum of pathologic findings in the course of hepatitis C infection. | Sadhna Dhingra Stephen C Ward Swan N Thung | 2016 | World Journal of Gastroenterology2016，22，4： | 6 |
| 6 | 荧光多重实时PCR检测单纯疱疹病毒显示文摘目的建立单纯疱疹病毒的荧光多重实时PCR检测及分型技术,为生殖器疱疹的诊断及病毒分型提供快捷、敏感、特异的方法.方法以细胞培养法为对照,用Smart Cycler System作为实验平台,以DNA探针荧光标记技术建立荧光多重实时PCR,用于检测生殖器疱疹患者临床标本中的1型和2型单纯疱疹病毒(HSV1、HSV2)DNA.结果荧光多重实时PCR检测HSV1和HSV2 DNA的敏感性和特异性均为100%,可检测出低至1~5拷贝的HSV DNA,30 min左右即可完成整个检测过程,而细胞培养的敏感性和特异性分别为70.10%和100%.结论基于Smart Cycler System的荧光多重实时PCR是一种易于操作、扩增效率高、封闭式的核酸扩增技术,可用一次PCR反应就能快速、敏感、准确地对临床标本中的单纯疱疹病毒进行检测和分型. | 赖维 Cheng-Yen Chen 苏向阳 黄怀球 张玉清 Ron C Ballard Stephen A Morse | 2004 | 中华皮肤科杂志2004，37，5： | 6 |
| 7 | P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析显示文摘目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂(PPI)治疗对经皮冠状动脉介入(PCI)术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究,纳入2003至2014年因急性冠脉综合征人院行PCI术的患者,分为PPI组及非PPI组并随访1年,主要临床终点为全因死亡/再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类,将入组患者分为氯吡格雷组及替格瑞洛组,并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者,PPI组占54.8%,具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡/再发心肌梗死复合事件的发生差异无统计学意义(HR1.00,95%CI 0.86—1.18)。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组,不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异,联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险,尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。 | 冯斯婷 严妍 范婧尧 王晓 郑文 聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev | 2016 | 中华医学杂志2016，96，33： | 6 |
| 8 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 9 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 10 | Campylobacter concisus and inflammatory bowel disease显示文摘Investigation of the possible role of Campylobacter concisus(C. concisus) in inflammatory bowel disease(IBD) is an emerging research area. Despite the association found between C. concisus and IBD, it has been difficult to explain how C. concisus, a bacterium that is commonly present in the human oral cavity, may contribute to the development of enteric diseases. The evidence presented in this review shows that some C. concisus strains in the oral cavity acquired zonula occludens toxin(zot) gene from a virus(prophage) and that C. concisus Zot shares conserved motifs with both Vibrio cholerae Zot receptor binding domain and human zonulin receptor binding domain. Both Vibrio cholerae Zot and human zonulin are known to increase intestinal permeability by affecting the tight junctions. Increased intestinal permeability is a feature of IBD. Based on these data, we propose that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD. | Li Zhang Hoyul Lee Michael C Grimm Stephen M Riordan Andrew S Day Daniel A Lemberg | 2014 | World Journal of Gastroenterology2014，20，5： | 4 |
| 11 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 12 | Cancer-related inflammation and treatment effectiveness显示文摘 | Connie I Diakos Kellie A Charles Donald C McMillan Stephen J Clarke | 2014 | Lancet Oncology2014，，： | 3 |
| 13 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 14 | Adverse Effects of Low Dose Amiodarone: A Meta-Analysis显示文摘 | Vicken R Vorperian Thomas C Havighurst Stephen Miller Craig T January | 1997 | Journal of the American College of Cardiology1997，，3： | 2 |
| 15 | Community-level physiological profiles of bacteria and fungi: plate type and incubation temperature influences on contrasting soils显示文摘 | Aimée T Classen Sarah I Boyle Kristin E Haskins Steven T Overby Stephen C Hart | | FEMS Microbiology Ecology0，，： | 2 |
| 16 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hpqbww65xpn5q6kvc.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 17 | Global malaria mortality between 1980 and 2010: a systematic analysis显示文摘 | Christopher JL Murray Lisa C Rosenfeld Stephen S Lim Kathryn G Andrews Kyle J Foreman Diana Haring Nancy Fullman Mohsen Naghavi Rafael Lozano Alan D Lopez | 2012 | The Lancet2012，，9814： | 2 |
| 18 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 19 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 20 | 结缔组织病相关的间质性肺疾病的管理显示文摘肺是系统性结缔组织病(CTD)并发症的常见部位,肺部表现可以多种形式存在。间质性肺疾病(ILD)和肺高压(PH)是CTD中最常见的肺部表现。虽然普遍认为ILD发生在CTD之后,但它往往是CTD的最初表现(“肺主导”型CTD)。ILD可以存在于大多数类型的CTD中,包括类风湿关节炎、硬皮病、系统性红斑狼疮、多发性肌炎或皮肌炎、干燥综合征和混合性结缔组织病。尽管CTD相关的ILD(CTD-ILD)与其他形式的ILD有着相似的临床和病理表现,但CTD—ILD的预后和治疗却与其他的ILD(如特发性肺纤维化)有着极大的差异。PH可作为肺动脉高压的主要血管病变或与ILD相关(PH—ILD)。因此,需要详细的病史、体格检查、特定的血清学检测,偶尔还需肺活检,来诊断CTD-ILD。然而,PH的诊断需借助于非侵入性和(或)侵入性方法来评估肺血流动力学。尽管尚缺乏随机对照试验支持的ILD特异性治疗证据,但免疫抑制是ILD治疗的支柱。此外,治疗策略根据临床情况的不同而变化。例如,新诊断的CTD-ILD患者与急性加重的患者的治疗方案不同。免疫抑制剂仅在CTD-PH的特定病例中有所推荐,更常见的是使用选择性肺血管扩张剂。对于这两种疾病,应该评估和治疗诸如睡眠呼吸障碍、呼吸困难和咳嗽等并发症。疾病晚期的患者应考虑肺移植,但由于CTD和其他合并症,肺移植也并非总是可行的。故需要开展免疫抑制治疗等新型治疗方法的,临床试验,来提供最佳的治疗策略。 | Stephen C Mathai 罗萨 代华平 | 2017 | 英国医学杂志中文版2017，20，6： | 2 |
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