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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study显示文摘A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry(LC-ESI-MS/MS)method was developed for reliable estimation of amantadine(AMD), an antiviral drug in human plasma.The analyte and internal standard(IS), amantadine-d6(AMD-d6), were extracted from 200 m L plasma by solid phase extraction on Phenomenex Strata-X-C 33 m cartridges. Chromatography was performed on Synergi? Hydro-RP C18(150 mm ? 4.6 mm, 4 mm) analytical column using a mixture of acetonitrile and10 m M ammonium formate, p H 3.0(80:20, v/v) as the mobile phase. Detection and quantitation was done by multiple reaction monitoring in the positive ionization mode for AMD(m/z 152.1-135.1) and IS(m/z 158.0-141.1) on a triple quadrupole mass spectrometer. The assay was linear in the concentration range of 0.50–500 ng/m L with correlation coefficient(r2) Z 0.9969. The limit of detection of the method was 0.18 ng/m L. The intra-batch and inter-batch precisions were r 5.42% and the accuracy varied from98.47% to 105.72%. The extraction recovery of amantadine was precise and quantitative in the range of97.89%–100.28%. IS-normalized matrix factors for amantadine varied from 0.981 to 1.012. The stability of AMD in whole blood and plasma was evaluated under different conditions. The developed method was successfully applied for a bioequivalence study with 100 mg of AMD in 32 healthy volunteers. The reproducibility of the assay was determined by reanalysis of 134 subject samples. | Abhaysingh Bhadoriya Shivprakash Rathnam Bhavesh DasANDi Dharmesh Parmar Mallika Sanyal Pranav S.Shrivastav | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 9 |
| 3 | The Sulfate Transporter Family in Wheat: Tissue-Specific Gene Expression in Relation to Nutrition显示文摘发展地,在植物的硫酸盐举起和分发被 transporters 的一个家庭的微分表示空间地管理,并且响应硫营养。包含的发信号的小径的说明要求部件部分和他们的相互作用的知识。这里,在小麦的硫酸盐 transporters 的完整的补充的表示模式由开发和硫营养影响了被描述。这里描绘的 10 小麦硫酸盐 transporters 与为米饭和 Brachypodium,完整的染色体信息是谁可得到的基因家庭相比。表达式在与硫酸盐剥夺的关系从滋养的答案和微分表示在举起与角色的一个焦点在年轻幼苗被报导。另外,在在充满舞台的谷物的所有机关的表示的模式在特定的纸巾和把硫送到发展中的谷物的举起,存储,和动员的全面协作被报导并且显示微分回答到单个 transporters 的营养的信号。 | Peter Buchner Saroj Parmar Anne Kriegel Magali Carpentier Malcolm J. Hawkesford | 2010 | Molecular Plant2010，3，2： | 6 |
| 4 | Therapeutic potential of snake venom in cancer therapy:current perspectives显示文摘Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer.Snake venom toxins coutributed significantly to the treatment of many medical conditions.There are many published studies describing and elucidating the anti-cancer potential of snake venom.Cancer therapy is one of the main areas for the use of protein peptides and enzymes originating from animals of different species.Some of these proteins or peptides and enzymes from snake venom when isolated and evaluated may bind specifically to cancer cell membranes,affecting the migration and proliferation of these cells.Some of substances found in the snake venom present a great potential as anti-tumor agent.In this review,we presented the main results of recent years of research involving the active compounds of snake venom that have anticancer activity. | Vivek Kumar Vyas Keyur Brahmbhatt Hardik Bhatt Utsav Parmar | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 5 |
| 5 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 5 |
| 6 | Quantitation of tadalafil in human plasma using a sensitive and rapid LC-MS/MS method for a bioequivalence study显示文摘A highly sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) method was developed for the determination of tadalafil(TAD) in human plasma. TAD and its deuterated internal standard(IS), tadalafil-d3, were extracted from 200 mL plasma using Phenomenex Strata-X-C 33 m extraction cartridges. Chromatographic analysis was carried out on Synergi? Hydro-RP C18(100 mm ? 4.6 mm, 4 mm)column with a mobile phase consisting of methanol and 10 m M ammonium formate, p H 4.0(90:10, v/v),delivered at a flow rate of 0.9 m L/min. Quantitation of the protonated analyte was done on a triple quadrupole mass spectrometer using multiple reaction monitoring via electrospray ionization. The precursor to product ions transitions monitored for TAD and TAD-d3 were m/z 390.3-268.2 and m/z393.1-271.2, respectively. The calibration curve was linear over the concentration range of 0.50–500 ng/m L with correlation coefficient, r2 Z 0.9994. Acceptable intra-batch and inter-batch precision(r3.7%) and accuracy(97.8% to 104.1%) were obtained at five concentration levels. The recovery of TAD from spiked plasma was highly precise and quantitative(98.95% to 100.61%). Further, the effect of endogenous matrix components was minimal. TAD was found to be stable under different storage conditions in human plasma and also in whole blood samples. The validated method was successfully used to determine TAD plasma concentration in a bioequivalence study with 20 mg TAD tablets in 24 healthy volunteers. Method performance was evaluated by reanalyzing 115 study samples. | Abhaysingh Bhadoriya Bhavesh Dasandi Dharmesh Parmar Priyanka A. Shah Pranav S. Shrivastav | 2018 | Journal of Pharmaceutical Analysis2018，8，4： | 4 |
| 7 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet2009，，9666： | 3 |
| 8 | Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial显示文摘 | David Sebag-Montefiore Richard J Stephens Robert Steele John Monson Robert Grieve Subhash Khanna Phil Quirke Jean Couture Catherine de Metz Arthur Sun Myint Eric Bessell Gareth Griffiths Lindsay C Thompson Mahesh Parmar | 2009 | The Lancet . 2009 (9666)2009，，9666： | 3 |
| 9 | Nitrogen efficiency of wheat: Genotypic and environmental variation and prospects for improvement显示文摘 | Peter B. Barraclough Jonathan R. Howarth Janina Jones Rafael Lopez-Bellido Saroj Parmar Caroline E. Shepherd Malcolm J. Hawkesford | 2010 | European Journal of Agronomy2010，，1： | 2 |
| 10 | Diagnosis, incidence, and outcomes of suspected typhlitis in oncology patients—experience in a tertiary pediatric surgical center in the United Kingdom显示文摘 | Dhanya Mullassery Abdulgader Bader Anna J. Battersby Zeenat Mohammad Emma Louise L. Jones Chetan Parmar Roger Scott Barry L. Pizer Colin T. Baillie | 2009 | Journal of Pediatric Surgery2009，，： | 2 |
| 11 | Phylogeny and taxonomy of Afrocayratia,a new genus of Vitaceae from continental Africa and Madagascar显示文摘The genus Cayratia Juss.in the traditional sense(i.e.,Cayratia s.l.)of the grape family has been shown to be non-monophyletic.Previous studies supported the splitting of Cayratia s.l.into three genera,that is,Cayratia s.s.,Causonis Raf.,and a new genus representing the African Cayratia clade.However,the morphology of the African Cayratia clade has not been studied carefully and its phylogenetic position within Vitaceae remains unclear.Our study integrates molecular,distributional,and morphological data and supports the recognition of the new genus Afrocayratia from continental Africa and Madagascar.Phylogenetic analyses strongly support the monophyly of Afrocayratia and resolve it as a sister of Cayratia s.s.based on the chloroplast data,but it is placed sister to Cyphostemma based on the internal transcribed spacer dataset.Molecular dating suggests that Afrocayratia split with Cayratia s.s.during the Paleocene,but that the extant species of Afrocayratia did not diversify until the early Miocene.Afrocayratia differs from its allied genera in having short stigmas and seeds with subcircular ventral infold cavities in cross-section.Three clades are detected within Afrocayratia,with A.debilis(Baker)J.Wen&L.M.Lu as the first diverged lineage.The second diverged lineage includes A.delicatula(Willems)J.Wen&Z.D.Chen and A.gracilis(Guill.&Perr.)J.Wen&Z.D.Chen.The third diverged lineage includes A.imerinensis(Baker)J.Wen&L.M.Lu,A.longiflora(Desc.)J.Wen&Rabarijaona,and A.triternata(Baker)J.Wen&Rabarijaona from Madagascar,which form a monophyletic group that diverged from the second lineage in the middle Miocene.Combining the morphological and molecular evidence,we formally describe the new genus Afrocayratia,make seven new combinations,and provide a key to species of the genus. | Romer Narindra Rabarijaona Viet-Cuong Dang Gaurav Parmar Bing Liu Jun Wen Zhi-Duan Chen Li-Min Lu | 2020 | Journal of Systematics and Evolution2020，58，6： | 2 |
| 12 | G-protein coupled receptors and synaptic plasticity in sleep deprivation显示文摘Insufficient sleep has been correlated to many physiological and psychoneurological disorders.Over the years,our understanding of the state of sleep has transcended from an inactive period of rest to a more active state involving important cellular and molecular processes.In addition,during sleep,electrophysiological changes also occur in pathways in specific regions of the mammalian central nervous system(CNS).Activity mediated synaptic plasticity in the CNS can lead to long-term and sometimes permanent strengthening and/or weakening synaptic strength affecting neuronal network behaviour.Memory consolidation and learning that take place during sleep cycles,can be affected by changes in synaptic plasticity during sleep disturbances.G-protein coupled receptors(GPCRs),with their versatile structural and functional attributes,can regulate synaptic plasticity in CNS and hence,may be potentially affected in sleep deprived conditions.In this review,we aim to discuss important functional changes that can take place in the CNS during sleep and sleep deprivation and how changes in GPCRs can lead to potential problems with therapeutics with pharmacological interventions. | Shweta Parmar Ramakrishna Tadavarty Bhagavatula R Sastry | 2021 | World Journal of Psychiatry2021，11，11： | 2 |
| 13 | Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies显示文摘CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ingredient.Box-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug release.Optimised liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into tablet.In vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the drug.FT-IR data revealed no physicochemical interaction between drug and excipients.Solid state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution studies.TEM analysis exhibited spherical globules.Further,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical properties.Thus,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin. | Komal Parmar Jayvadan Patel Navin Sheth | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，5： | 2 |
| 14 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 15 | MR imaging features of pigmented villonodular synovitis of the cervical spine显示文摘 | Parmar HA Sitoh YY Tan KK | 2004 | AJNR Am J Neuroradiol2004，25，1： | 1 |
| 16 | The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder eancer:a further report with 7 years of follow up 显示文摘 | Tolley DA Parmar MK Grigor KM | 1996 | J Urol1996，155，4： | 1 |
| 17 | The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer:a further report with7years of follow up显示文摘 | Tolley D A Parmar M K Grigor K M | 1996 | J Uro11996，155，4： | 1 |
| 18 | Subretinal fluid analysis in the diagnosis of choroidal tuberculosis显示文摘 | Salman A Parmar P Rajamohan M | 2003 | Retina2003，23，6： | 1 |
| 19 | An Experimental and Theoritical Study of Pressure and Thermal Distortions in a Mechanical Seal 显示文摘 | Doust T G Parmar A I | 1985 | ASLE Trans1985，29，2： | 1 |
| 20 | Chromosomal location of Hor -3, a new locus governing storage proteins in barley 显示文摘 | Shewry P R Finch R A Parmar S | 1983 | Heredity1983，50，： | 1 |
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