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| 1 | 基于经验模态分解和神经网络的微网混合储能容量优化配置显示文摘提出一种针对独立微网的超级电容/蓄电池混合储能系统(HESS)的容量优化方法。运用经验模态分解技术,将一段记录完全的非平稳风功率分解成为若干固有模态函数(IMF)。在各固有模态函数的瞬时频率—时间曲线的基础上,通过'分频频率'将原始风功率分解成高频与低频2部分,并分别采用HESS中的超级电容和蓄电池来平抑风功率的高频、低频波动分量。平抑后输入负荷侧的功率平滑度可通过平滑度指标量化。采用神经网络模型优化HESS的容量,通过成本和平滑度指标之间的折中实现HESS的容量优化配置。基于某风电场实测数据的仿真实验验证了所提方法的有效性。 | 孙承晨 袁越 San Shing CHOI 李梦婷 张新松 曹阳 | 2015 | 电力系统自动化2015，39，8： | 52 |
| 2 | Rapid quantification of semen hepatitis B virus DNA by real-time polymerase chain reaction显示文摘AIM: To examine the sensitivity and accuracy of real-time polymerase chain reaction (PCR) for the quantification of hepatitis B virus (HBV) DNA in semen.METHODS: Hepatitis B viral DNA was isolated from HBV carriers' semen and sera using phenol extraction method and QTAamp DNA blood mini kit (Qiagen, Germany). HBV DNA was detected by conventional PCR and quantified by TaqMan technology-based real-time PCR (quantitative polymerase chain reaction (qPCR)). The detection threshold was 200 copies of HBV DNA for conventional PCR and 10 copies of HBV DNA for real time PCR per reaction.RESULTS: Both methods of phenol extraction and QIAamp DNA blood mini kit were suitable for isolating HBV DNA from semen. The value of the detection thresholds was 500 copies of HBV DNA per mL in the semen. The viral loads were 7.5×107 and 1.67×107 copies of HBV DNA per mL in two HBV infected patients' sera, while 2.L4×105 and 3.02×105 copies of HBV DNA per mL in the semen.CONCLUSION: Real-time PCR is a more sensitive and accurate method to detect and quantify HBV DNA in the semen. | Wei-Ping Qian Yue-Qiu Tan Ying Chen Ying Peng Zhi Li Guang-Xiu Lu Made C. Liu Hsiang-Fu Kung Ming-Ling He Li-Ka Shing | 2005 | World Journal of Gastroenterology2005，11，34： | 25 |
| 3 | 用于能量调度的风–储混合系统运行策略及容量优化显示文摘随着风力发电渗透率的日益提高,风电波动给电网带来了大量的负面影响。采用超级电容–蓄电池混合储能系统平衡风功率和风电场计划出力之间的偏差。首先,采用经验模态分解技术(empirical mode decomposition,EMD)将电网中的计划出力与原始风功率之间的不平衡功率(unbalanced power,UP)分解成若干固有模态函数(intrinsic mode functions,IMFs)。其次,以各固有模态函数之间能量混叠最少为原则确定'划分频率',将不平衡功率分解成为高频分量和低频分量,并分别采用超级电容和蓄电池对其进行平抑。最后,以风电场实际出力数据为基础,设计了同时考虑投资成本与调度效果的混合储能系统(hybrid storage system,HSS),计算结果验证了所提方法的有效性。 | 孙承晨 袁越 CHOI San Shing 李梦婷 张新松 曹阳 | 2015 | 电网技术2015，39，8： | 16 |
| 4 | ACSL4 is a predictive biomarker of sorafenib sensitivity in hepatocellular carcinoma显示文摘Sorafenib is the first-line treatment of advanced hepatocellular carcinoma(HCC).However,there is a lack of validated biomarkers to predict sorafenib sensitivity.In this study we investigated the role of ACSL4,a positive-activating enzyme of ferroptosis,in sorafenib-induced cell death and HCC patient outcome.We showed that ACSL4 protein expression was negatively associated with IC50 values of sorafenib in a panel of HCC cell lines(R=−0.952,P<0.001).Knockdown of ACSL4 expression by specific siRNA/sgRNA significantly attenuated sorafenib-induced lipid peroxidation and ferroptosis in Huh7 cells,and also rescued sorafenib-induced inhibition of xenograft tumor growth in vivo.We selected 29 HCC patients with surgery as primary treatment and sorafenib as postoperative adjunct therapy from a hospital-based cohort.A high proportion(66.7%)of HCC patients who had complete or partial responses to sorafenib treatment(according to the revised RECIST guideline)had higher ACSL4 expression in the pretreated HCC tissues,compared with those who had stable or progressed tumor growth(23.5%,P=0.029).Since ACSL4 expression was independent of sorafenib treatment,it could serve as a useful predictive biomarker.Taken together,this study demonstrates that ACSL4 is essential for sorafenib-induced ferroptosis and useful for predicting sorafenib sensitivity in HCC.This study may have important translational impacts in precise treatment of HCC. | Ji Feng Pei-zhi Lu Guang-zhi Zhu Shing Chung Hooi Yong Wu Xiao-wei Huang Hui-qi Dai Pan-hong Chen Zhong-jie Li Wen-jing Su Chuang-ye Han Xin-ping Ye Tao Peng Jing Zhou Guo-dong Lu | 2021 | Acta Pharmacologica Sinica2021，42，1： | 11 |
| 5 | 独立电网供用电系统的电压质量控制器研究显示文摘独立电网供电广泛用于石油钻探、舰船、企业小型自备电站和野外作业等各种行业,这些系统由于发电容量的限制,对非线性负载的扰动抵抗能力比较差,电网电压的供电质量受到严重影响。本文提出一种采用主动控制方式实现电压质量控制的装置,它充分考虑了独立小电网系统中严重的谐波扰动、电压凹陷、瞬间失电及供电频率波动等各种电压质量问题,提出了以瞬时无功功率理论为基础的软锁相技术解决同步、相位锁定、电压幅值恒定等具体保障电压质量的控制技术,并对在频率变化时的谐波定义、计算方法进行了讨论。最后通过系统仿真和实际实验验证了作者的观点,取得了良好的电压质量控制效果。 | 卓放 Choi San Shing 王兆安 | 2004 | 电力电子技术2004，38，6： | 9 |
| 6 | Semiparametric Quantile Modelling of Hierarchical Data显示文摘 | Mao Zai TIAN Man Lai TANG Ping Shing CHAN | 2009 | Acta Mathematica Sinica,English Series2009，25，4： | 7 |
| 7 | 复发-缓解型多发性硬化边缘系统白质纤维束定量DTI改变显示文摘目的探讨复发一缓解型多发性硬化(relapsing remitting multiples clerosis,RRMS)患者边缘系统白质纤维束定量弥散张量的改变。方法RRMS患者24例,年龄和性别相匹配的健康志愿者24例为对照进行MRI扫描,获取常规MRI图像和弥散张量成像(DTI)图像,经GE工作站处理后进行测量分析,比较2组边缘系统主要纤维束(扣带束、穹窿束和终纹束)不同部分各向异性指数(FA)值和平均弥散系数(MD)值的变化。结果在考虑年龄和性别因素的影响后,RRMS组患者穹窿柬(F一15.605,P=0.000135)、右侧穹窿/终纹束(F=15.772,P=0.000127)、左侧穹窿/终纹束(F=8.53,P=0.004)的FA值较健康对照组明显降低;RRMS组患者穹窿束(F=13.28,P=0.0004)、右侧终纹束(F=10.943,p=0.002)、右侧穹窿/终纹束(F=7.326,P=0.008)的MD值较健康对照组明显增高;RRMS组患者左/右侧的前、后扣带束、右侧终纹束(F=0.986,P=0.326)、左侧终纹束的FA和对照组比较无明显差异,RRMS组患者左/右侧的前、后扣带束、左侧终纹束、左侧穹窿/终纹束的MD值较健康对照比较差异均无统计学意义。结论DTI可作为反映RRMS边缘系统纤维束病理性改变的较敏感的检测方法。 | 周福庆 Chi-- Shing Zee 龚洪翰 Mark Shiroishi | 2010 | 实用放射学杂志2010，26，3： | 7 |
| 8 | 让肾脏健康人人可享,处处可及——从预防到诊治显示文摘Around 850 million people currently are affected by different types of kidney disorders.Up to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly progressive.The global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney transplantation.Hence,CKD is a major cause of catastrophic health expenditure. | Philip Kam Tao Guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal Saadi Luisa Strani Ifeoma Ulasi Kamyar Kalantar Zadeh 无 | 2020 | 肾脏病与透析肾移植杂志2020，29，1： | 6 |
| 9 | Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles显示文摘Nanoparticles are considered to be a powerful approach for the delivery of poorly watersoluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable method, the flash nanoprecipitation(FNP) has been widely used to fabricate these drug nanoparticles, including pure drug nanocrystals, polymeric micelles,polymeric nanoparticles, solid lipid nanoparticles, and polyelectrolyte complexes. This review introduces the application of FNP to produce poorly water-soluble drug nanoparticles by controllable mixing devices, such as confined impinging jets mixer(CIJM), multi-inlet vortex mixer(MIVM) and many other microfluidic mixer systems. The formation mechanisms and processes of drug nanoparticles by FNP are described in detail. Then, the controlling of supersaturation level and mixing rate during the FNP process to tailor the ultrafine drug nanoparticles as well as the influence of drugs, solvent, anti-solvent, stabilizers and temperature on the fabrication are discussed. The ultrafine and uniform nanoparticles of poorly watersoluble drug nanoparticles prepared by CIJM, MIVM and microfluidic mixer systems are reviewed briefly. We believe that the application of microfluidic mixing devices in laboratory with continuous process control and good reproducibility will be benefit for industrial formulation scale-up. | Jinsong Tao Shing Fung Chow Ying Zheng | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 6 |
| 10 | Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene Regulates Water Transport via the C-Terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis显示文摘乙烯参予众多的细胞的事件和生物过程的规定,包括水损失,在枯萎的叶和花花瓣期间。多样的乙烯回答可以经由在蛋白质 phosphorylation/dephosphorylation 和 ubiquitin/26S 之间的动态相互影响被调整调停 proteasome 的蛋白质降级和朊酶劈开。探讨乙烯怎么通过叉形得多的发信号的小径改变蛋白质 phosphorylation,我们执行了 15 N 稳定的同位素对待空气、对待乙烯的乙烯感觉迟钝的 Arabidopsis 双 loss-of-function 异种 ein3-1/eil1-1 上的基于标签、微分、量的 phosphoproteomics 学习。识别的 Among535 非冗余的 phosphopeptides,二和四 phosphopeptides 起来 -- 并且由乙烯的 downregulated 分别地。aquaporin PIP2 的调整乙烯的 phosphorylation; 1 断然在叶与水流动率和水损失被相关。在有量的 proteomics 的联合的基因研究, immunoblot 分析,原物胀大/缩小实验,并且长叶表示两个的转基因的植物上的水损失试金野类型并且 S280A/S283A-mutated PIP2 ; 1 在里面 Col-0 和 ein3eil1 乙烯增加浇的基因 backgroundssuggest 在由在 PIP2 的 C 终点提高 S280/S283 phosphorylation 的 Arabidopsis 房间的运输率; 1 。未知 kinase 或磷酸酶活动可以参予 EIN3/EIL1 的细胞的功能的起始的起来规定独立人士。这发现贡献我们理解那通常在植物器官的收获以后的存储期间被观察调整乙烯的叶枯萎。 | Dongjin Qing Zhu Yang Mingzhe Li Wai Shing Wong Guangyu Guo Shichang Liu Hongwei Guo Ning Li | 2016 | Molecular Plant2016，9，1： | 6 |
| 11 | Catalytic conversion of lignocellulosic biomass into chemicals and fuels显示文摘In the search of alternative resources to make commodity chemicals and transportation fuels for a low carbon future,lignocellulosic biomass with over 180-billion-ton annual production rate has been identified as a promising feedstock.This review focuses on the state-of-the-art catalytic transformation of lignocellulosic biomass into value-added chemicals and fuels.Following a brief introduction on the structure,major resources and pretreatment methods of lignocellulosic biomass,the catalytic conversion of three main components,i.e.,cellulose,hemicellulose and lignin,into various compounds are comprehensively discussed.Either in separate steps or in one-pot,cellulose and hemicellulose are hydrolyzed into sugars and upgraded into oxygen-containing chemicals such as 5-HMF,furfural,polyols,and organic acids,or even nitrogen-containing chemicals such as amino acids.On the other hand,lignin is first depolymerized into phenols,catechols,guaiacols,aldehydes and ketones,and then further transformed into hydrocarbon fuels,bioplastic precursors and bioactive compounds.The review then introduces the transformations of whole biomass via catalytic gasification,catalytic pyrolysis,as well as emerging strategies.Finally,opportunities,challenges and prospective of woody biomass valorization are highlighted. | Weiping Deng Yunchao Feng Jie Fu Haiwei Guo Yong Guo Buxing Han Zhicheng Jiang Lingzhao Kong Changzhi Li Haichao Liu Phuc T.T.Nguyen Puning Ren Feng Wang Shuai Wang Yanqin Wang Ye Wang Sie Shing Wong Kai Yan Ning Yan Xiaofei Yang Yuanbao Zhang Zhanrong Zhang Xianhai Zeng Hui Zhou | 2023 | Green Energy & Environment2023，8，1： | 6 |
| 12 | Anticancer Activities and the Drug Targets of Botanical Saponins from a Medicinal Herb,Gynostemma Pentaphyllum显示文摘Triterpenoid saponins are metabolites produced in most plant species through complex biosynthetic pathways.They play important roles to humansowing to their diverse medicinal | W.L.Wendy HSIAO William Chi Shing TAI Ziyao MO Pui Kei WU | 2008 | Journal of Acupuncture and Tuina Science2008，6，5： | 6 |
| 13 | Command and Control Cities in Global Space-economy Before and after 2008 Geo-economic Transition显示文摘The global economic downturn caused primarily by the US sub-prime mortgage crisis in 2007 engendered revenue loss of the multinational corporations.Existing studies have yet to depict the detrimental impacts on city's command and control functions induced by the sub-prime mortgage crisis together with its residual wave of global economic recession on the global spatial economy.Recent and previous studies have produced an 'instant history' of the global spatial economy before the global economic downturn undermines the global economy in late 2008.However,the waxes and wanes of major cities' command and control functions on the global economic arena before and after the outbreak of financial crisis and its associated geo-economic transitions are still poorly understood.This paper attempts to contribute a new set of customized data to update and fill in the gap in the literature with the investigation of the command and control functions of cities around the world from 2005 to 2009.Particular attentions are paid to the time-space relationship of the geo-economic transition that can capture the recent historical images of the command and control situation of different cities in the world. | Ernest Ka Shing LEE Simon Xiaobin ZHAO Yang XIE | 2012 | Chinese Geographical Science2012，22，3： | 5 |
| 14 | Clinical outcomes of elderly South-East Asian patients in primary percutaneous coronary intervention for ST- elevation myocardial infarction显示文摘评估临床的特征和经历主要经皮的冠的干预(PPCI ) 的老东南亚洲病人的在里面医院结果 .MethodsFrom 2009 年 1 月到 2012 年 12 月, 1268 个病人(86.4% 男性, 58.4 楴 的吝啬的年龄? | Jieli Tong Wen Wei Xiang An Shing Ang Wen Jun Sim Kien Hong Quah David Foo Paul Jau Lueng Ong Hee Hwa Ho | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 15 | Overview of the Shenzhen Emergency Medical Service Call Pattern显示文摘BACKGROUND:In Shenzhen,the Emergency Medical Service(EMS) system has been in service since 1997.This study aims to examine the operation of Shenzhen 120 EMS center and to identify the reasons of calling EMS.METHODS:In this retrospective quantitative descriptive study,the data from the Shenzhen 120 EMS registry in 2011 were analyzed.RESULTS:Shenzhen 120 EMS center is a communication command center.When the number of 120 are dialed,it is forwarded to the closest appropriate hospital for ambulance dispatch.In2011,the Shenzhen 120 EMS center received 153 160 ambulance calls,with an average of 420 calls per day.Calling emergency services was mainly due to traffic accidents.Trauma and other acute diseases constituted a majority of ambulance transports.The adult patients aged 15-60 years are the principal users of EMS.There are no recognized 'paramedic' doctors and nurses.The pre-hospital emergency service is under the operation of emergency departments of hospitals.Shenzhen at present does not have specialized pre-hospital training for doctors and nurses in posttrauma management.Moreover,specialized pre-hospital training,financial support,and public health education on proper use of EMS should be emphasized.CONCLUSION:The Shenzhen 120 EMS center has its own epidemiology characteristics.Traumatic injury and traffic accident are the main reasons for calling ambulance service.In-depth study emphasizing the distribution and characteristics of trauma patients is crucial to the future development of EMS. | Shuk Man Lo Yi Min Yu Lap Yip Larry Lee Mi Ling Eliza Wong Sek Ying Chair Edward J Kalinowski Tak Shing Jimmy Chan | 2012 | World Journal of Emergency Medicine2012，3，4： | 4 |
| 16 | Endostatin:an endogenous inhibitor of angiogenesis and tumor growth显示文摘 | O'Reilly MS Boehm T Shing Y | | 0，，： | 4 |
| 17 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 18 | Frequency control ancillary service provided by a wind farm:dual-BESS scheme显示文摘Network frequency control function is incorporated into a grid-connected wind farm-dual battery energy storage system(BESS)scheme.The design of the scheme takes advantage of the rapid response characteristics of the BESS and the in-built short-term overloading capability of the associated power conversion devices.A control strategy to regulate the BESS output power is then proposed.It is shown that the frequency control action offered by the BESS complements amicably with that of conventional generators in enhancing the frequency regulation attribute of the grid system. | Dailin YAO San Shing CHOI King Jet TSENG Tek Tjing LIE | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，2： | 4 |
| 19 | Surgical outcomes for unilateral superior oblique palsy in Chinese population: a retrospective study显示文摘AIM: To evaluate the outcome after surgery for unilateral superior oblique(SO) palsy in Chinese.METHODS: The medical records of 39 patients that underwent surgery for unilateral SO palsy between January 2003 and December 2012 at Caritas Medical Centre, Hong Kong, were retrospectively reviewed. All surgeries were performed by a single surgeon. Pre-operative assessments for vertical deviation, cyclo-deviation, and Knapp's classification were obtained to determine the nature and degree of surgical correction.Vertical deviation was measured at 1wk; 1, 6mo and on last follow-up day post-operatively. Cyclo-deviation was measured on last follow-up day post-operatively.RESULTS: During the 10 y period, 39 subjects were recruited. The most common etiology was congenital(94.9%). Knapp's Type III(66.7%) and Type I(12.8%)classifications were the most common subtypes. To treat SO palsy, the most common surgical procedures were:isolated inferior oblique(IO) anteriorization(41.0%),isolated IO myectomy(10.3%), and isolated IO recession(10.3%). At 3.5 ±2.1y post-operatively, the vertical deviation was significantly reduced(15.1 ±6.2 PD versus0.5±1.4 PD, P <0.0001) without significant improvement in cyclo-deviation(P =0.5). Initial vertical deviation was correlated with cyclo-torsion(r =0.4, P =0.007). Those with over-correction had greater initial vertical deviation(19.4±7.2 PD versus 13.2±4.3 PD, P =0.003). After a single operation, 84.6% of subjects achieved a vertical deviation within ±3 PD.· CONCLUSION: The majority of subjects achieved corrected vertical deviation after a single surgery although there was no improvement in cyclo-deviation.Those with over-correction of primary position deviation had greater preoperative vertical deviation and it may be related to simultaneous multiple muscle surgery. | Gordon Shing Kin Yau Victor Tak Yau Tam Jacky Wai Yip Lee Theo Tak Kwong Chan Can Yin Fun Yuen | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 20 | Low effect‐site concentration of propofol target‐controlled infusion reduces the risk of hypotension during endoscopy in a T aiwanese population显示文摘 | Wen‐Hung Hsu Sophie SW Wang Hsiang‐Yao Shih Meng‐Chieh Wu Yi‐Yu Chen Fu‐Chen Kuo Hui‐Ying Yang Shun‐Li Chiu Koung‐Shing Chu Kuang‐I Cheng Deng‐Chyang Wu I‐Cheng Lu | 2013 | Journal of Digestive Diseases2013，，3： | 3 |
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