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| 1 | 长期配戴角膜接触镜对角膜厚度、屈率及表面规则性的影响显示文摘目的 :了解长期配戴角膜接触镜对角膜厚度、屈率及表面规则性的影响。方法 :应用Orbscan角膜地形图系统检测 3 5例 (64只眼 )配戴角膜接触镜 5年以上患者的全角膜厚度、前表面角膜屈率及角膜前、后表面高度地形图。 2 0例 (4 0只眼 )正常人为正常对照。采用TMS 1角膜地形图系统的参数评价角膜表面规则性。比较正常人和配戴角膜接触镜 5年以上患者的全角膜厚度、角膜屈率、表面规则指数 (SRI)、表面不对称指数 (SAI)、预测视力(PVA)及角膜地形图图形的差异。结果 :戴镜组病例其配戴角膜接触镜的平均时间为 (13 45± 6 42 )年。与正常对照组相比 ,长期配戴角膜接触镜患者其角膜中央及周边 8个测量区的平均角膜厚度减少 3 0~ 5 0 μm (P <0 0 0 1) ,角膜屈率、最大角膜屈率 (MaxK )及最小角膜屈率 (MinK)明显增加 (P <0 0 1)。两组间角膜散光度无显著性差异。长期配戴角膜接触镜的患者其TSM 1系统参数中的SRI和SAI值较正常人明显增加 (P <0 0 1) ,PVA值无明显改变 (P =0 15 )。应用两种角膜地形图仪检查所得的角膜屈率地形图及角膜高度地形图的彩色编码图形类型 ,两组间无显著性差异。结论 :长期配戴角膜接触镜将导致全角膜厚度减小。 | 刘祖国 张梅 Stephen C Pflugfelder | 2002 | 中国实用眼科杂志2002，20，5： | 18 |
| 2 | Localized bursting of mesocarp cells triggers catastrophic fruit cracking显示文摘The so-called rain-cracking of sweet cherry fruit severely threatens commercial production.Simple observation tells us that cuticular microcracking(invisible)always precedes skin macrocracking(visible).The objective here was to investigate how a macrocrack develops.Incubating detached sweet cherry fruit in deionized water induces microcracking.Incubating fruit in D2O and concurrent magnetic resonance imaging demonstrates that water penetration occurs only(principally)through the microcracks,with nondetectable amounts penetrating the intact cuticle.Optical coherence tomography of detached,whole fruit incubated in deionized water,allowed generation of virtual cross-sections through the zone of a developing macrocrack.Outer mesocarp cell volume increased before macrocracks developed but increased at a markedly higher rate thereafter.Little change in mesocarp cell volume occurred in a control zone distant from the crack.As water incubation continued,the cell volume in the crack zone decreased,indicating leaking/bursting of individual mesocarp cells.As incubation continued still longer,the crack propagated between cells both to form a long,deep macrocrack.Outer mesocarp cell turgor did not differ significantly before and after incubation between fruit with or without macrocracks;nor between cells within the crack zone and those in a control zone distant from the macrocrack.The cumulative frequency distribution of the logtransformed turgor pressure of a population of outer mesocarp cells reveals all cell turgor data followed a normal distribution.The results demonstrate that microcracks develop into macrocracks following the volume increase of a few outer mesocarp cells and is soon accompanied by cell bursting. | Eckhard Grimm Jan Hahn Daniel Pflugfelder Moritz Jonathan Schmidt Dagmar van Dusschoten Moritz Knoche | 2019 | Horticulture Research2019，6，1： | 5 |
| 3 | Dry eye and delayed tear clearance: ''a call to arms''显示文摘 | Pflugfelder SC Solomon A Dursun D | 2002 | Adv Exp Med Biol2002，506，： | 2 |
| 4 | The Pathology of Dry Eye: The Interaction Between the Ocular Surface and Lacrimal Glands显示文摘 | Michael E. Stern Roger W. Beuerman Robert I. Fox Jianping Gao Austin K. Mircheff Stephen C. Pflugfelder | 1998 | Cornea1998，，6： | 1 |
| 5 | Evaluation of corneal thickness and topography in normal eyes using the Orbsean corneal topography system显示文摘 | Liu Z Huang A J Pflugfelder SC | 1999 | Br J Ophthalmol1999，83，： | 1 |
| 6 | Cloning and sequencing of eDNA encoding human DNA topoisomerase Ⅱ and localization of the gene to chromosome region 17q21 -22 显示文摘 | Tsai - pflugfelder M Liu LF Liu AA | 1988 | Prec Natl Acad Sci1988，85，： | 1 |
| 7 | Topical nonpreserved methylprednisolone therapy for keratoconjunetivitis sicca in Sjogren syndrome 显示文摘 | Marsh P Pflugfelder SC | 1999 | Ophthalmology1999，106，4： | 1 |
| 8 | Inflammation in Dry Eye显示文摘 | Michael E. Stern Stephen C. Pflugfelder | 2004 | The Ocular Surface2004，，2： | 1 |
| 9 | Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid显示文摘 | Pflugfelder SC Liu ZG Monoroy M Li DQ Caruijal ME Price-Schiavi SA | 2000 | Invest Ophthalmol Vis Sci2000，41，6： | 1 |
| 10 | Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion显示文摘 | Turner K Pflugfelder SC Ji Z Feuer WJ Stem M Reis BL | 2000 | Cornea2000，19，4： | 1 |
| 11 | The pathology of dry eye:the interaction betw een the ocular surface and lacrimal glands显示文摘 | Stern ME Beuerman RW Fox RI Mircheff AK Pflugfelder SC | 1998 | Cornea1998，17，6： | 1 |
| 12 | Aqueous tear production in patients with neurotrophic keratitis显示文摘 | Heigle TJ Pflugfelder SC | 1996 | Cornea1996，15，2： | 1 |
| 13 | Quantification of cardiac function by conventional and cine magnetic resonance imaging显示文摘 | Udo Sechtem Peter Pflugfelder Charles B. Higgins | 1987 | Cardiovascular and Interventional Radiology1987，，6： | 1 |
| 14 | The role of radiother- apy in the overall treatment of melanoma显示文摘 | Forschner A Hein_rich V Pflugfelder A | 2013 | Clin Dermatol2013，31，3： | 1 |
| 15 | Prevalence,burden,and pharmacoeconomics of dry eye disease显示文摘 | Pflugfelder SC | 2008 | Am J Manag Care2008，14，3： | 1 |
| 16 | Interleukin-5 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion 显示文摘 | Turner K Pflugfelder SC Ji Z Fewer WJ Stem M Reis BL | 2000 | Cornea2000，19，4： | 1 |
| 17 | The diagnosis and management of dry eye显示文摘 | Pflugfelder SC Solomo A Stem ME | 2000 | Cornea2000，19，： | 1 |
| 18 | Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation 显示文摘 | Pflugfelder SC Tseng SC Sanabria O | 1998 | Cornea1998，17，： | 1 |
| 19 | Anti inflammatory therapy for dry eye 显示文摘 | Pflugfelder SC | 2004 | Am J Oph- thalmol2004，137，2： | 1 |
| 20 | Evidence for convergent nucleotide evolution and high allelic turnover rates at the complementary sex determiner gene of Western and Asian honeybees 显示文摘 | Hasselmann M Vekemans X Pflugfelder J | 2008 | Molecular Biology Evolution2008，25，4： | 1 |
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