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| 1 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 2 | Clinical impact of surveillance for head and neck cancer in patients with esophageal squamous cell carcinoma显示文摘AIM To evaluate the clinical impact of surveillance for head and neck(HN) region with narrow band imaging(NBI) in patients with esophageal squamous cell carcinoma(ESCC).METHODS Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC beforetreatment, and each follow-up. The patients with newly diagnosed stage Ⅰ to Ⅲ ESCC were enrolled and classified into two groups as follows: Group A(no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008). We comparatively evaluated the detection rate of superficial head and neck squamous cell carcinoma (HNSCC), and the serious events due to metachronous advanced HNSCC during the follow-up.RESULTS A total 561 patients(group A: 254, group B: 307) were enrolled. Synchronous superficial HNSCC was detected in 1 patient (0.3%) in group A, and in 12 (3.9%) in group B (P=0.008). During the follow up period, metachronous HNSCC were detected in 10 patients(3.9%) in group A and in 30 patients(9.8%) in group B(P = 0.008). All metachronous lesions in group B were early stage, and 26 patients underwent local resection, however, 6 of 10 patients (60%) in group A lost their laryngeal function and died with metachronous HNSCC.CONCLUSION Surveillance for the HN region by using NBI endoscopy increase the detection rate of early HNSCC in patients with ESCC, and led to decrease serious events related to advanced metachronous HNSCC. | Hiroyuki Morimoto Tomonori Yano Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Ryuichi Hayashi Atsushi Ohtsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，6： | 12 |
| 3 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 4 | 芽孢杆菌JPC-2的营养竞争测定及其对小麦根部病害的防治效果显示文摘对营养竞争拮抗测定方法进行了改进,对接法将芽孢杆菌JPC-2与小麦纹枯病菌接种于大豆麦麸(SWB)培养基上,JPC-2可在SWB培养基上迅速扩展并完全抑制小麦纹枯病菌的菌丝生长。田间试验表明,芽孢杆菌JPC-2液体菌剂(107cfu/mL,1∶100)处理种子对小麦纹枯病的冬前期防效高于扬花期防效,防治效果为61.9%,高于3%苯醚甲环唑包衣处理(用量为种子质量的0.3%);对小麦根腐病的防治效果可达46.8%,与空白对照差异显著(p<0.05);并使小麦增产73.5%,高于3%苯醚甲环唑种衣剂。芽孢杆菌JPC-2固体菌剂(106cfu/mL,225kg/hm2)沟施于土壤,再播种液体菌剂包衣(107cfu/mL,药种比1∶30)的小麦种子,对小麦纹枯病菌的冬前期防效为68.9%,扬花期防效为59.7%,小麦增产38.9%,与0.2%戊唑醇种衣剂(1∶50)增产效果相当。 | 郭荣君 李世东 李国强 刘书义 李长松 Yoshihiro Ohtsu | 2007 | 植物保护2007，33，5： | 6 |
| 5 | Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study显示文摘 | Narikazu Boku Seiichiro Yamamoto Haruhiko Fukuda Kuniaki Shirao Toshihiko Doi Akira Sawaki Wasaburo Koizumi Hiroshi Saito Kensei Yamaguchi Hiroya Takiuchi Junichiro Nasu Atsushi Ohtsu | 2009 | Lancet Oncology2009，，11： | 5 |
| 6 | Comparison of HER2 gene amplification assessed by fluorescence in situhybridization and HER2 protein expression assessed by immunohistochemistry ingastric cancer显示文摘 | Tomonori Yano Toshihiko Doi Atsushi Ohtsu Narikazu Boku Kaoru Hashizume Mamoru Nakanishi Atsushi Ochiai | 2006 | Oncology Reports2006，，1： | 4 |
| 7 | A new technique for endoscopic mucosal resection with an insulated-tip electrosurgical knife improves the completeness of resection of intramucosal gastric neoplasms显示文摘 | Shin’ichi Miyamoto Manabu Muto Yasuo Hamamoto Narikazu Boku Atsushi Ohtsu Satoshi Baba Motoki Yoshida Masana Ohkuwa Kouichi Hosokawa Hisao Tajiri Shigeaki Yoshida | 2002 | Gastrointestinal Endoscopy2002，，4： | 3 |
| 8 | 基于互联网的船舶动态实时监视显示文摘介绍了一种船舶动态实时监视的新概念。这个系统由几个传感器和微机软件组成。所测的数据是通过海事宽频系统(MBS)传送的。MBS由互联网基站服务器和通讯卫星及2个地面站组成。它分别安装在船上和陆地上,使用通讯卫星JCSAT-1B(日本通讯卫星),它能提供比INMARSAT Fleet77更快的信号传输服务。实时监视系统软件是新开发的原创软件。程序代码是用Mcrosoft Visaul C++语言编写的,采用了DirectPlay动态函数库和客户服务器通讯模块。为了验证系统性能指标,在东京海洋科学技术大学的T.SShioji-Maru试验船上进行了可行性试验。下面就这个新的商船航运管理工具的优点和开发中所暴露出来的问题加以讨论和报告。 | Toshio Iseki Joe Aoki Kohei Ohtsu 杨英(译) 邹元晶(校) | 2006 | 舰船电子对抗2006，29，5： | 3 |
| 9 | Bevacizumab in Combination With Chemotherapy As First-Line Therapy in Advanced Gastric Cancer: A Biomarker Evaluation From the AVAGAST Randomized Phase III Trial显示文摘 | Eric Van Cutsem Sanne de Haas Yoon-Koo Kang Atsushi Ohtsu Niall C. Tebbutt Jian Ming Xu Wei Peng Yong Bernd Langer Paul Delmar Stefan J. Scherer Manish A. Shah | 2012 | Journal of Clinical Oncology2012，，17： | 3 |
| 10 | A laterally-spreading tumor in a colonic interposition treated by endoscopic submucosal dissection显示文摘Herein we describe an early colonic carcinoma which developed in a colonic interposition 14 years after surgery for esophageal cancer, which was successfully treated by endoscopic submucosal dissection (ESD). An 80-year-old man underwent colonic interposition between the upper esophagus and stomach after surgery for an early esophageal squamous cell carcinoma in 1994. He received a surveillance endoscopy, and a laterally-spreading tumor of granular type, approximately 20 mm in size, was identified in the colonic interposition. An endoscopic biopsy revealed moderately differentiated adenocarcinoma histologically, however, we diagnosed the lesion as an intramucosal carcinoma based on the endoscopic findings. The lesion was safely and completely removed en bloc by ESD using a bipolar knife. Histologically, the lesion was an intramucosal moderately differentiated adenocarcinoma in a tubular adenoma. | Hideaki Bando Hiroaki Ikematsu Kuang-I Fu Yasuhiro Oono Takashi Kojima Keiko Minashi Tomonori Yano Takahisa Matsuda Yutaka Saito Kazuhiro Kaneko Atsushi Ohtsu | 2010 | World Journal of Gastroenterology2010，16，3： | 3 |
| 11 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 2 |
| 12 | History,current developments,and future directions of near‐field optical science显示文摘This paper reviews the science of the optical near-field(ONF),which is created and localized in a nanometer-sized material(NM)or on its surface.It is pointed out that work on near-field optics was started in order to break through the diffraction limit in optical microscopy and had already come to an end without giving answers to the essential questions on the origin of the near-field optical interaction.However,recent studies have reincarnated these studies and identified the ONF as an off-shell quantum field.Based on this identification,a novel science called off-shell science has started on the basis that the dispersion relation between energy and momentum is invalid for the ONF.This quantum field is called the dressed photon because it is created as a result of the interaction between photons and electrons(or excitons)in a NM and,thus,it accompanies the energies of electrons or excitons.In reviewing current developments,this paper presents fifteen novel phenomena that are contrary to the common views in conventional optical science.Novel technologies developed by applying these phenomena are also reviewed.These include:nanometer-sized optical devices,nano-fabrication technology,and energy conversion technology.High-power Si light emitting diodes,Si lasers,and SiC polarization rotators are reviewed as examples of electrical to optical energy conversion.For future directions,this paper also reviews novel theoretical studies that have commenced recently by relying on physical and mathematical bases. | Motoichi Ohtsu | 2020 | Opto-Electronic Advances2020，3，3： | 2 |
| 13 | Phase 1 study of efatutazone, a novel oral peroxisome proliferator-activated receptor gamma agonist, in combination with FOLFIRI as second-line therapy in patients with metastatic colorectal cancer显示文摘 | Yoshito Komatsu Takayuki Yoshino Kentaro Yamazaki Satoshi Yuki Nozomu Machida Takahide Sasaki Ichinosuke Hyodo Yutaka Yachi Hiroshi Onuma Atsushi Ohtsu | 2014 | Investigational New Drugs2014，，3： | 2 |
| 14 | Tests for Serum Levels of Trefoil Factor Family Proteins Can Improve Gastric Cancer Screening显示文摘 | Susumu Aikou Yasukazu Ohmoto Toshiaki Gunji Nobuyuki Matsuhashi Hiroshi Ohtsu Hirona Miura Kensuke Kubota Yukinori Yamagata Yasuyuki Seto Atsushi Nakajima James R. Goldenring Michio Kaminishi Sachiyo Nomura | 2011 | Gastroenterology2011，，3： | 2 |
| 15 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | 2010 (9742)2010，，9742： | 2 |
| 16 | Activation of hepatitis B virus infection by chemotherapy containing glucocorticoid in hepatitis B virus carriers with hematologic malignancies显示文摘 | Sai T Oka M | 1991 | Jpn J Clin Oncol1991，21，5： | 1 |
| 17 | Discussion of onset of skimming flow on stepped spillways显示文摘 | Ohtsu I Yasuda Y Takahashi M | 2001 | J Hydr Eng ASCE2001，127，6： | 1 |
| 18 | Loss of RNA-dependent RNA polymerase 2 (RDR2) function causes widespread and unexpected changes in the expression of transposons, genes, and 24 nt small RNAs显示文摘 | Jia Y Lisch D R Ohtsu K | 2009 | PLoS Genet2009，5，10： | 1 |
| 19 | Disparities in gastric cancer chemotherapy between the East and West显示文摘 | Ohtsu A Yoshida S Saijo N | 2006 | Clini Oneol2006，24，： | 1 |
| 20 | Long-term toxicity after definitive chemoradiotherapy for squamous cell carcinoma of the thoracic esophagus显示文摘 | Ishikura S Nihei K Ohtsu A | 2003 | J Clin Oncol2003，21，： | 1 |
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