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| 1 | Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia显示文摘BACKGROUND In recent years,increasing evidence of second neoplasms associated with gastrointestinal stromal tumors(GIST)has been found.Numerous case reports,mostly retrospective studies and a few reviews,have been published.To our knowledge,however,no systematic review or meta-analysis of the existing data has been performed so far.AIM To prepare a compilation,as complete as possible,of all reported second tumor entities that have been described in association with GIST and to systematically analyze the published studies with regard to frequency,localization,and types of GIST-associated neoplasms.METHODS The MEDLINE and EBSCO databases were searched for a combination of the keywords GIST/secondary,synchronous,coincident/tumor,neoplasm,and relevant publications were selected by two independent authors.RESULTS Initially,3042 publications were found.After deletion of duplicates,1631 remained,and 130 papers were selected;22 of these were original studies with a minimum of 20 patients,and 108 were case reports.In the 22 selected studies,comprising a total number of 12050 patients,an overall rate of GIST-associated neoplasias of 20%could be calculated.Most second neoplasias were found in the gastrointestinal tract(32%)and in the male and female urogenital tract(30%).The specific risk scores of GISTs associated with other tumors were significantly lower than those without associated neoplasias.CONCLUSION In this first systematic review,we could confirm previously reported findings of a more than coincidental association between GIST and other neoplasias.The question whether there is an underlying causal association will need further investigation.Our data suggest that even GIST with a very low risk of disease progression should prompt screening for second neoplasia and subsequent frequent controls or extended staging. | Johanna Waidhauser Anne Bornemann Martin Trepel Bruno Markl | 2019 | World Journal of Gastroenterology2019，25，30： | 10 |
| 2 | Percutaneous Left Atrial Appendage Transcatheter Occlusion to Prevent Stroke in High-Risk Patients With Atrial Fibrillation: Early Clinical Experience显示文摘 | Horst Sievert Michael D. Lesh Thomas Trepels Heyder Omran Antonio Bartorelli Paola Della Bella Toshiko Nakai Mark Reisman Carlo DiMario Peter Block Paul Kramer Dirk Fleschenberg Ulrike Krumsdorf Detlef Scherer | 2002 | Circulation: Journal of the American Heart Association2002，，16： | 2 |
| 3 | Quantifying nitrogen retention in surface flow wetlands for environmental planning at the landscapescale显示文摘 | TREPEL M PALMERI L | 2002 | Ecological Engineering2002，19，2： | 1 |
| 4 | The Neural Basis of Loss Aversion in Decision-Making Under Risk显示文摘 | Tom SM Fox CR Trepel C | 2007 | Science2007，315，： | 1 |
| 5 | Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in aduhs with refractory and relapsed acute leukemias 显示文摘 | Gojo I Jiemjit A Trepel JB | 2007 | Blood2007，109，7： | 1 |
| 6 | Quantifying nitrogen retention in surface flow wetlands for environmental planning at the landscape scale 显示文摘 | Trepel M Palmeri L | 2002 | Ecological Engineering2002，19，： | 1 |
| 7 | Chemosensitivity of human malignant glioma: modulation by p53 gene transfer显示文摘 | Martin Trepel Peter Groscurth Ursula Malipiero Erich Gulbins Johannes Dichgans Michael Weller | 1998 | Journal of Neuro - Oncology1998，，1： | 1 |
| 8 | Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation;early clinical experience显示文摘 | Lesh MD Trepels T | 2002 | Circulation2002，105，16： | 1 |
| 9 | Quantifying nitrogen retention in surface flow wetlands for environmental planning at the landseapewseale显示文摘 | Trepel M Palmeri L | 2002 | Eeologieal Engineering2002，19，： | 1 |
| 10 | Immunochemotherapy of malignant glioma synergistic activity of CD95 ligand and chemotherapeutics显示文摘 | Roth W Fontana A Trepel M | 1997 | Cancer Immunol Immunother1997，44，1： | 1 |
| 11 | Incidence and clinical course of thrombus formation on atrial septal defect and patient foramen ovale closure devices in 1,000 consecutive patients显示文摘 | Ulrike Krumsdorf Stefan Ostermayer Kai Billinger Thomas Trepels Elisabeth Zadan Kathrin Horvath Horst Sievert | 2004 | Journal of the American College of Cardiology2004，，2： | 1 |
| 12 | The neural basis of loss aversion in decision-making under risk显示文摘 | TOM S M FOX C R TREPEL C | 2007 | Science2007，315，5811： | 1 |
| 13 | In vivo phage display and vascular heterogeneity:implications for targeted medicine显示文摘 | Trepel M Arap W Pasqualini R | 2002 | Curt Opin Chem Biol2002，6，3： | 1 |
| 14 | E2F site in the Op18 promoter are required for high level of expression in the human prostate earcinoma cell line PC-3-m 显示文摘 | Polzin RG Benlhabib H Trepel J | 2004 | Gene2004，341，10： | 1 |
| 15 | Long-term de- pression and depotentiation in the sensorimotor cortex of the freely moving rat显示文摘 | FROC D J CHAPMAN C A TREPEL C et ol | 2000 | The Journal of Neuroscience2000，20，1： | 1 |
| 16 | Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience显示文摘 | Sievert H Lesh MD Trepels T | 2002 | Circulation2002，105，16： | 1 |
| 17 | Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation: early clinical experience显示文摘 | Sievert H Lesh MD Trepels T | 2002 | Circulation2002，105，16： | 1 |
| 18 | A hybrid vector for ligand-directed tumor targeting and molecular imaging显示文摘 | Hajitou A Trepel M Lilley CE | 2006 | Cell2006，125，2： | 1 |
| 19 | Percutaneous left atrial appendage tra n scatheter occlusion to prevent stroke in high-risk patients with atrial fibrill ation显示文摘 | Sivert H Lesh MD Trepels T | 2002 | Circulation2002，105，16： | 1 |
| 20 | Targeting the dynamic Hsp90 complex in cancer 显示文摘 | Trepel J Mollapour M Giaecone G | 2010 | Nat Rev Cancer2010，10，8： | 1 |
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