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| 1 | A totally mini-invasive approach for colorectal laparoscopic surgery显示文摘AIM:To study the short-term outcome of patients treated with laparoscopic right colectomy and how intracorporeal anastomosis has improved the outcome.METHODS:We retrospectively examined all patients affected by colorectal cancer who underwent a laparoscopic right colectomy between January 2006 and December 2010 in our department.Our evaluation criteria were:diagnosis of colorectal carcinoma at presurgical biopsy,elective surgery,and the same surgeon.We excluded:emergency surgery,conversions from laparotomic colectomy,and other surgeons.The endpoints we examined were:surgical time,number of lymph nodes removed,length of stay(removal of nasogastric tube,bowel movements,gas evacuation,solid and liquid feeding,hospitalization),and major complications.Seventy-two patients were divided into two groups:intracorporeal anastomosis(39 patients)and extracorporeal anastomosis(33 patients).RESULTS:Significant differences were observed between intracorporeal vs extracorporeal anastomosis,respectively,for surgical times(186.8 min vs 184.1 min,P < 0.001),time to resumption of gas evacuation(3 d vs 3.5 d,P < 0.001),days until resumption of bowel movements(3.8 d vs 4.9 d,P < 0.001),days until resumption of liquid diet(3.5 d vs 4.5 d,P < 0.001),days until resuming a solid diet(4.6 d vs 5.7 d,P < 0.001),and total hospitalization duration(7.4 d vs 8.5 d,P < 0.001).In the intracorporeal group,on average,19 positive lymph nodes were removed;in the extracorporeal group,on average,14 were removed P < 0.001).Thus,intracorporeal anastomosis for right laparoscopic colectomy improved patient outcome by providing faster recovery of nutrition,faster recovery of intestinal function,and shorter hospitalization than extracorporeal anastomosis.CONCLUSION:Short-term outcomes favor intracorporeal anastomosis,confirming that a less traumatic surgical approach improves patient outcome. | Gabriele Anania Mirco Santini Lucia Scagliarini Alice Marzetti Laura Vedana Serafino Marino Claudio Gregorio Giuseppe Resta Giorgio Cavallesco | 2012 | World Journal of Gastroenterology2012，18，29： | 8 |
| 2 | A prospective study on radiofrequency ablation locally advanced pancreatic cancer显示文摘BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced cancer.This study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic head.METHODS:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and gastrojejunal-anastomosis.Intra-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were evaluated.RESULTS:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for treatment.The RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the neoplasm.In all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after RFA.All patients died respectively,at 3,4,and 5 months after the treatment.CONCLUSIONS:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative complications.Moreover,pain control,life quality and survival rate are poor.The few data suggest no impact on survival. | Riccardo Casadei Claudio Ricci Raffaele Pezzilli Carla Serra Lucia Calculli Antonio Maria Morselli-Labate Donatella Santini Francesco Minni | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 6 |
| 3 | Effects of KRAS, BRAF, NRAS , and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis显示文摘 | Wendy De Roock Bart Claes David Bernasconi Jef De Schutter Bart Biesmans George Fountzilas Konstantine T Kalogeras Vassiliki Kotoula Demetris Papamichael Pierre Laurent-Puig Frédérique Penault-Llorca Philippe Rougier Bruno Vincenzi Daniele Santini Giusepp | 2010 | Lancet Oncology2010，，8： | 6 |
| 4 | A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA显示文摘 | Marcella Cesana Davide Cacchiarelli Ivano Legnini Tiziana Santini Olga Sthandier Mauro Chinappi Anna Tramontano Irene Bozzoni | 2011 | Cell2011，，4： | 4 |
| 5 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 6 | Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome显示文摘 | Giovanni Barbara Vincenzo Stanghellini Roberto De Giorgio Cesare Cremon Graeme S. Cottrell Donatella Santini Gianandrea Pasquinelli Antonio M. Morselli-Labate Eileen F. Grady Nigel W. Bunnett Stephen M. Collins Roberto Corinaldesi | 2004 | Gastroenterology2004，，3： | 3 |
| 7 | State of the art biological therapies in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib(a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is the only schedule with a biological agent approved for advanced pancreatic cancer, but it has resulted in a very modest survival benefit in unselected patients. In our work, we report a summary of the main clinical trials(closed and ongoing) that refer to biological therapy evaluation in pancreatic cancer treatment. | mariacristina di marco elisa grassi sandra durante silvia vecchiarelli andrea palloni marina macchini riccardo casadei claudio ricci riccardo panzacchi donatella santini guido biasco | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 8 | Trans-Septal Catheterization in the Electrophysiology Laboratory显示文摘 | Roberto De Ponti Riccardo Cappato Antonio Curnis Paolo Della Bella Luigi Padeletti Antonio Raviele Massimo Santini Jorge A. Salerno-Uriarte | 2006 | Journal of the American College of Cardiology2006，，5： | 2 |
| 9 | Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis显示文摘 | Piergiovanni Buonamici Rossella Marcucci Angela Migliorini Gian Franco Gensini Alberto Santini Rita Paniccia Guia Moschi Anna Maria Gori Rosanna Abbate David Antoniucci | 2007 | Journal of the American College of Cardiology2007，，： | 2 |
| 10 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 11 | Target Therapies in Pancreatic Carcinoma显示文摘 | Nicola Silvestris Antonio Gnoni Anna Elisabetta Brunetti Leonardo Vincenti Daniele Santini Giuseppe Tonini Francesca Merchionne Evaristo Maiello Vito Lorusso Patrizia Nardulli Amalia Azzariti Michele Reni | 2014 | Current Medicinal Chemistry2014，，8： | 2 |
| 12 | Experimental analysis of the gas-particle flow in a circulating fluidized bed using a phase doppler particle analyzer显示文摘 | MOORTEL T V AZARIO E SANTINI R | 1998 | Chemical Engineering Science1998，53，10： | 2 |
| 13 | Maize Morphophysiological Responses to Intense Crowding and Low Nitrogen Availability: An Analysis and Review显示文摘 | Boomsma Christopher R Santini Judith B Tollenaar Matthijs Vyn Tony J | 2009 | Agronomy Journal2009，，6： | 2 |
| 14 | Elastography: New Developments in Ultrasound for Predicting Malignancy in Thyroid Nodules显示文摘 | T Rago F Santini M Scutari A Pinchera P Vitti | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，8： | 2 |
| 15 | Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: A systematic review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Ugo De Giorgi Roberto Iacovelli Francesco Pantano Luciano Burattini Giovanni Muzzonigro Rossana Berardi Daniele Santini Stefano Cascinu | 2014 | Int. J. Cancer2014，，： | 2 |
| 16 | A new type I IFN-mediated pathway for the rapid differentiation of monocytes into highly active dendritic cells显示文摘 | Di Pucchio T Lapenta C | 2003 | Stem Cells2003，21，3： | 1 |
| 17 | Solid-papillary tumors of the pancreas:histopathology JOP显示文摘 | Santini D Poli F Lega S | 2006 | J Pancreas2006，7，1： | 1 |
| 18 | Pamidronate induces modifications of circulating angiogenetic factors in cancer patients显示文摘 | D·Santini B·Vincenzi G·Avvisati | 2002 | Clinical Cancer Research2002，8，5： | 1 |
| 19 | 686 A 50 HZ sinusoidal magnetic field affects principally cell adhesion molecules (CAM's)in MG-63 and SAOS-2 osteosarcoma cell lines 显示文摘 | Santini MT Rainaldi G Ferrante A | 2003 | Toxicol Lett2003，144，1： | 1 |
| 20 | survivin as a marker of cervical intraepithelial neoplasia and high-risk human papilloma virus and a predictor of virus clearance and prognosis in cervical cancer显示文摘 | Branca M Giorgi C Santini D | 2005 | Clin Pathol2005，124，1： | 1 |
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