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| 1 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 2 | Sexual outcomes after partial penectomy for penile cancer: results from a multi-institutional study显示文摘阴茎癌症是不平常的恶意。外科的治疗不可避免地正在支解。就 patients’ 上的强壮的影响而言;我们想要在部分 penectomy 以后评估性功能和满足的性生活。在这的病人学习(n = 25 ) 代表了从 2011 年 10 月为阴茎癌症出席了我们的机构并且被诊断并且对待到 2013 年 11 月的所有那些。所有病人经历了部分 penectomy 并且跟随起来(平均数:14 个月;变化:12-25 ) 。性 presurgical 基线用可勃起的机能障碍 15 的国际索引(IIEF-15 ) 被估计。每个病人的性结果被估计考虑四标准化了并且验证问询表。我们包括可勃起的功能分析了 IIEF-15 的工具和范围(IIEF-1-5 和 -15), 高潮的功能(IIEF-9 和 -10), 性欲望(IIEF-11 和 -12), 交际满足(IIEF-6-8 ) ,和全面满足(IIEF-13 和 -14) 。然后,我们也使用了勃起问询表(QEQ ) 的质量,治疗满足的可勃起的机能障碍库存(编辑) 并且自尊和关系(灼烧) 评估我们的病人的性功能和满足。最后的结果证明阴茎癌症导致几性并且 psychosexual 机能障碍。不过,为阴茎癌症经历部分 penectomy 的病人能在对在外科前在经期存在的那些稍微更低的层次维持性结果。 | Salvatore Sansalone Mauro Silvani Rosario Leonardi Giuseppe Vespasiani Valerio Iacovelli | 2017 | Asian Journal of Andrology2017，19，1： | 6 |
| 3 | Risk of gastrointestinal events with sorafenib, sunitinib and pazopanib in patients with solid tumors: A systematic review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Ugo De Giorgi Roberto Iacovelli Francesco Pantano Luciano Burattini Giovanni Muzzonigro Rossana Berardi Daniele Santini Stefano Cascinu | 2014 | Int. J. Cancer2014，，： | 2 |
| 4 | Monochromatic excimer light 308 nm in the treatment of vitiligo: a pilot study 显示文摘 | Leone G Iacovelli P Paro Vidolin A | 2003 | J Eur Acad Dermatol Venereol2003，17，5： | 1 |
| 5 | Percutaneous Tibial Nerve Stimulation (PTNS) efficacy in the treatment of lower urinary tract dysfunctions: a systematic review显示文摘 | GAZIEV G1 TOPAZIO L IACOVELLI V | 2013 | BMC Urol2013，13，1： | 1 |
| 6 | Monochromatic excimer light 308 nm in the treatment of vitiligo: a pilot study显示文摘 | Iacovelli P Paro Vidolin A | 2003 | J Eur Acad Dermatol Venereol2003，17，5： | 1 |
| 7 | Iron homeostasis and toxicity in retinal degeneration显示文摘 | He X Hahn P Iacovelli J | 2007 | Prog Retin Eye Res2007，26，6： | 1 |
| 8 | Monochromaticexcimerlight 308 nm in the treatment of vitiligo: a pilot study 显示文摘 | Leone G Iacovelli P Paro Vidolin A | 2003 | J Eur Acad Dermatol Venereol2003，17，5： | 1 |
| 9 | Inhibition of the VEGF/VEGFR pathway improves survival in advanced kidney cancer:a systematic review and meta-analysis显示文摘 | Iacovelli R Sternberg CN Porta C | 2015 | Curr Drug Targets2015，16，2： | 1 |
| 10 | Veatilation with lower tidal volumes versus traditional tidal volumes in adults for acute lung injury and acute respiratory distress syndrome显示文摘 | Petrucci N Iacovelli W | 2004 | Cochrane Database syst Rev2004，，2： | 1 |
| 11 | Circulating tumor cells and 'suspicious objects' evaluated through CellSearch(R) in metastatic renal cell carcinoma显示文摘 | Gradilone A Iacovelli R Cortesi E | 2011 | Anticancer Res2011，31，12： | 1 |
| 12 | Regulation of lysophosphatidic acid receptor- stimulated response by O- protein-coupled receptor kinase- 2 and β - arrestinl in FRTL- 5 rat thyroid cells 显示文摘 | L Iacovelli L Capobianco G M D'Ancona | 2002 | Journal of Endocrinology2002，174，： | 1 |
| 13 | Reduced insulin-induced phosphate-ylinositol-3-kinase activation in peripheral blood mononu- clear leucocytes frompatients with Alzheimer's disease 显示文摘 | Castri P Iacovelli L De Blasi A | 2007 | Eur J Neu- rosci2007，26，： | 1 |
| 14 | Hormonal responses to whole-body vibration in men显示文摘 | BOSCO C IACOVELLI M TSARPELA O | 2000 | Eur J Appl Physiol2000，，81： | 1 |
| 15 | Percutaneous tibial nerve stimulation (PTNS) efficacy in the treatment of lower uri- nary tract dysfunctions: a systematic review 显示文摘 | Gaziev G Topazio L Iacovelli V | 2013 | BMC Urol2013，13，： | 1 |
| 16 | Prognostic factors for survival in patients with metastatic renal cell carcinoma treated with targeted therapies显示文摘 | Procopio G Verzoni E Iacovelli R | | 0，，8： | 1 |
| 17 | Clinical and pathological features of primary neuroectodermal tumor/Ewing sarcoma of the kidney显示文摘 | Risi E Iacovelli R Altavilla A | 2013 | Urology2013，82，2： | 1 |
| 18 | Ventilation with lower tidal volumes versus traditional tidal volumes in adults for acute lung injury and acute respiratory distress syndrome显示文摘 | Petrucci N Iacovelli W | 2003 | Cochrane Database Syst Rev2003，3，2： | 1 |
| 19 | Treatment‐related fatigue with sorafenib, sunitinib and pazopanib in patients with advanced solid tumors: An up‐to‐date review and meta‐analysis of clinical trials显示文摘 | Matteo Santoni Alessandro Conti Francesco Massari Giorgio Arnaldi Roberto Iacovelli Mimma Rizzo Ugo Giorgi Laura Trementino Giuseppe Procopio Giampaolo Tortora Stefano Cascinu | 2015 | Int. J. Cancer2015，，： | 1 |
| 20 | Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas显示文摘 | Iacovelli L Arcella A Battaglia G | 2006 | J Neurosci2006，26，： | 1 |
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