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| 1 | 近40年艾比湖湿地自然保护区生态干扰度时空动态及景观格局变化显示文摘以新疆艾比湖湿地为研究区,利用1972、1998、2007年及2013年4个时期的Landsat遥感影像作为数据源,并结合湿地的土地覆被状况,参考《全国土地利用分类》建立艾比湖湿地生态干扰类型分类系统。借助生态干扰度指数、景观格局指数以及GIS空间分析方法,探讨艾比湖湿地的生态干扰度的时空动态及景观响应机制。结果表明:(1)1972—2013年,研究区的生态干扰度总体呈现较为稳定的趋势,但其空间分布发生变化。生态干扰度类型之间的转化速率有加快的趋势。(2)1972—2013年,边缘密度指数(ED),平均形状指数(MSI),面积加权的平均斑块分形指数(AWMPFD)及景观分离度(DIVISION)4项景观格局指数大体呈上升的趋势,2013年区域的景观指数较为稳定。(3)景观格局指数与生态干扰程度有密切的一致性。生态干扰度与景观格局指数空间分布相关性大小依次为:边缘密度指数(ED)<景观丰度密度(PRD)<香农多样性指数(SHDI)<平均形状指数(MSI)<面积加权的平均斑块分形指数(AWMPFD)<景观分离度(DIVISION)。客观系统的认识和评价艾比湖湿地的生态系统及环境,可为干旱区实现自然环境的保护,协调土地利用及环境保护之间的关系提供较为实用的参考。 | 张月 张飞 王娟 任岩 Abduwasit Ghulam Hsiang-te KUNG 陈芸 | 2017 | 生态学报2017，37，21： | 50 |
| 2 | Differential response of root morphology to potassium deficient stress among rice genotypes varying in potassium efficiency显示文摘Disparity in the root morphology of six rice(Oryza sativa L.) genotypes varying in potassium(K) efficiency was studied with three K levels:5 mg/L(low),10 mg/L(moderate) and 40 mg/L(adequate) in hydroponic culture. Morphological parameters included root length,surface area,volume and count of lateral roots,as well as fine(diameter<0.2 mm) and thick(diameter>0.2 mm) roots. The results indicate that the root growth of all genotypes was reduced under low K,but moderate K deficiency increased the root length of the efficient genotypes. At deficient and moderate K levels,all the efficient rice genotypes developed more fine roots(diameter<0.2 mm) than the inefficient ones. Both fine root count and root surface area were found to be the best parameters to portray K stress in rice. In accordance with the root morphology,higher K concentrations were noted in shoots of the efficient genotypes when grown at moderate and deficient K levels,indicating that root morphology parameters are involved in root uptake for K and in the translocation of K up to shoots. K deficiency affected not only the root morphology,but also the root ultra-structure. The roots of high-efficient genotypes had stronger tolerance to K deficient stress for root membrane damage,and could maintain the developed root architecture to adapt to the low K growth medium. | Yan-bo JIA Xiao-e YANG Ying FENG Ghulam JILANI | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，5： | 36 |
| 3 | 基于LUCC的艾比湖区域生态风险评价及预测研究显示文摘以新疆内陆艾比湖流域典型区域为研究区,基于RS和GIS技术分析1998、2013年土地利用变化,尝试用CA-Markov模型预测2028年土地利用/覆盖变化.借助Fragstats3.4软件,基于土地利用/覆盖变化构建景观生态风险评价模型,分析1998~2028年景观生态风险的时空分异特征.结果表明:(1)1998~2013年,研究区土地类型面积变化明显.耕地面积增加量最大,增加的面积为152139hm^2,而未利用地面积减少量最大,减少的面积为67605hm^2.2013~2028年,耕地和裸露的河床及盐渍地的面积增加明显,增加的面积分别为30730hm^2,12427hm^2,而未利用地和水体的面积分别从954376hm^2和44889hm^2,减至921079hm^2和37157hm^2.(2)1998~2028年,研究区生态风险等级空间分布差异明显.高生态风险区面积变化较为显著,其面积分别约占总面积的36.6%,7.3%,23.7%.1998~2028年,全局Moran’s I值分别为0.436962,0.442202,0.506622,表现为一定程度的正相关.(3)1998~2028年,耕地分布在低,较低生态风险的比重上升,所占百分比分别为58.46%,78.58%,79.9%.林、草地类型的各生态风险等级的所占的比重的波动较大. | 张月 张飞 王娟 任岩 Abduwasit Ghulam Hsiang-te KUNG | 2016 | 中国环境科学2016，36，11： | 31 |
| 4 | Toxic tau: structural origins of tau aggregation in Alzheimer’s disease显示文摘Alzheimer’s disease is characterized by the extracellular accumulation of the amyloidβin the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary tangles.Most of the Alzheimer’s drugs targeting amyloidβhave been failed in clinical trials.Particularly,tau pathology connects greatly in the pathogenesis of Alzheimer’s disease.Tau protein enhances the stabilization of microtubules that leads to the appropriate function of the neuron.Changes in the quantity or the conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is involved.The molecular mechanisms leading to the accumulation of tau are principally signified by numerous posttranslational modifications that change its conformation and structural state.Therefore,aberrant phosphorylation,as well as truncation of tau protein,has come into focus as significant mechanisms that make tau protein in a pathological entity.Furthermore,the shape-shifting nature of tau advocates to comprehend the progression of Alzheimer’s disease precisely.In this review,we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of Alzheimer’s disease. | Abdullah Al Mamun Md.Sahab Uddin Bijo Mathew Ghulam Md Ashraf | 2020 | Neural Regeneration Research2020，15，8： | 21 |
| 5 | 一次引发南亚大暴雨的季风低压结构、涡度与水汽收支分析显示文摘对2003年夏季风期间,7月24~28日印度季风槽内季风低压发展西移与阿拉伯海中尺度低压合并引发南亚的一次大暴雨过程进行了诊断分析,探讨了印度季风槽、季风低压的三维结构以及低压区域的涡度、水汽收支.揭示和确认了一些事实:1)印度季风槽区对流层中下层存在明显的风场切变,槽区高温高湿,为单一性质的热带气团,低层为对流不稳定,槽区对应正涡度区;2)季风低压是一较深厚系统.动力结构为低层正涡度,高层负涡度,低层辐合,高层辐散.其西移速度约500 km·d.季风低压北侧整层为深厚的东风,南侧在对流层中低层为西风,在高层为东风.热力结构在低层(700~800 hPa)间存在弱冷区,而中高层几乎为暖心结构.低压对应高湿区,低压中心西侧整层为相对湿度大值区;3)季风低压的发展过程中,低层的辐合场制造正涡度,促进低压的发展;4)低压区水汽强烈辐合,西边界输入量最大.在此研究工作的基础上,作者还比较了夏季风期间南亚印度季风槽和东亚梅雨锋系统的异同. | 孔期 Ghulam Rasul 赵思雄 | 2005 | 气候与环境研究2005，10，3： | 19 |
| 6 | 艾比湖流域地表水水质指标与水体指数关系研究显示文摘传统的水域水质监测手段不仅成本高,而且空间信息有限,难以对相关水域进行全面的监测与评价.利用遥感技术进行水域水质监测可克服这些局限.本文以新疆艾比湖流域为研究对象,结合2015年5月实测水质数据和从准同步Landsat OLI数据上提取的水体指数值,利用空间分析和多元统计方法进行分析.结果发现,水体指数EWI、AWEIsh、Vegetation index(VI)、NDWI、NWI、NEW与水质指标之间的相关性显著(0.55≤r≤0.88).因此,选用以上6种水体指数与水质指标进行回归分析并建立数学关系估算模型,发现模型均方根误差均较低.利用同期实测数据对估算模型进行精度验证,发现验证判定系数高,验证点的相对平均误差偏低,均方根误差偏小.与此同时,利用2015年10月的40个采样点对模型进行二次验证,发现验证的判定系数满足0.22 | 王小平 张飞 Abduwasit Ghulam 于海洋 任岩 王娟 张月 | 2017 | 环境科学学报2017，37，3： | 16 |
| 7 | 光谱指数的植被叶片含水量反演显示文摘利用光谱技术监测植被水分状况是了解植被生理状况及生长趋势的重要手段之一。选择艾比湖湿地自然保护区作为靶区。采用聚类分析、变量投影重要性分析(VIP)以及敏感性分析等方法,对植被不同含水量进行分级,并针对不同等级的植被含水量进行估算及验证。结果表明:(1)基于聚类分析中的欧氏距离的方法将植被叶片相对含水量划分为高等、中等、低等三个等级,其范围分别为70.76%~80.69%,53.27%~70.76%,31.00%~53.27%。在中红外与远红外(1 350~2 500nm)之间,反射率越低植被含水量越高;波长380~1 350nm范围,无此现象。(2)应用VIP方法可知,所选的8种植被水分指数VIP值均超过了0.8,说明植被水分指数预测能力均较强且差别不显著。其中MSI,GVMI与植被叶片相对含水量的非线性三次拟合函数效果最佳,MSI决定系数R2为0.6575和GVMI决定系数R2为0.674 2。植被叶片相对含水量在30%~45%范围,MSI指数的NE值最低,在45%~90%范围时,GVMI指数的NE值最低。NDWI1240指数的NE值在70%左右起伏较大,说明NDWI1240指数在植被含水量为70%左右,预测能力较差。(3)通过误差分析可知GVMI指数反演的结果误差最小,不同的植被指数对不同含水量的植被估算结果相差较为明显,因此分段估算植被含水量是有必要的。综上所述,利用高光谱遥感技术对监测艾比湖保护区植被生长及干旱环境提供基础研究。 | 张海威 张飞 张贤龙 李哲 Abduwasit Ghulam 宋佳 | 2018 | 光谱学与光谱分析2018，38，5： | 16 |
| 8 | A method for canopy water content estimation for highly vegetated surfaces-shortwave infrared perpendicular water stress index显示文摘In this paper, a new method for canopy water content (FMC) estimation for highly vegetated surfaces- shortwave infrared perpendicular water stress index (SPSI) is developed using NIR, SWIR wavelengths of Enhanced Thematic Mapper Plus (ETM+) on the basis of spectral features and distribution of surface targets with different water conditions in NIR-SWIR spectral space. The developed method is further explored with radiative transfer simulations using PROSPECT, Lillesaeter, SailH and 6S. It is evident from the results of validation derived from satellite synchronous field measurements that SPSI is highly correlated with FMC, coefficient of determination (R squared) and root mean square error are 0.79 and 26.41%. The paper concludes that SPSI has a potential in vegetation water content estimation in terms of FMC. | GHULAM Abduwasit KASIMU Alimujiang | 2007 | Science China Earth Sciences2007，50，9： | 15 |
| 9 | 新疆艾比湖流域地表水丰水期和枯水期水质分异特征及污染源解析显示文摘采用2015年艾比湖流域54个采样点的10个地表水水质指标数据,首先利用水质指数模型(WQI)和地统计学方法对流域水质污染情况进行全局评价,然后利用层次聚类法、判别分析法和因子分析法分析艾比湖流域地表水丰水期和枯水期水质分异特征.在水质时空分异特征研究的基础上,利用主成分回归分析法对艾比湖流域水质进行污染源解析.结果表明:艾比湖流域丰水期WQI值介于38~70之间,枯水期WQI值介于31~71之间,艾比湖流域丰水期的地表水水质污染情况比枯水期严重,而艾比湖、博尔塔拉河和精河靠近艾比湖湖区的河道污染程度均比其他河道严重.由聚类分析和判别分析得出艾比湖流域丰水期和枯水期的水质采样点在空间上均被分成A、B两组,A组包括艾比湖湖区西部、奎屯河、古尔图河和四棵树河,B组包括艾比湖湖区东部、精河和博尔塔拉河.艾比湖流域丰水期和枯水期的水体主要受到化学需氧量、溶解氧、氨氮和悬浮物浓度等指标的影响,B组水质污染指标的值相比于A组的值偏高,B组区域内存在高污染企业,艾比湖流域水环境治理工作需主要集中在B组所包括的艾比湖湖区、博尔塔拉河和精河.(4)艾比湖湖区、精河和博尔塔拉河地表水体的污染主要来自于有机物污染和营养物质污染,其次为工矿业污染;而奎屯河、古尔图河、四棵树河地表水体的污染主要来自于有机物污染,其次为营养物质污染,生物污染的影响较为微弱.该研究结果可为艾比湖流域地表水水环境改善和治理提供一定参考. | 任岩 张飞 王娟 张月 杨胜天 Abduwasit Ghulam Kung Hsiangte | 2017 | 湖泊科学2017，29，5： | 15 |
| 10 | Ag/Ag_3PO_4/g-C_3N_4三元复合光催化剂的制备及其可见光驱动下的光催化活性增强(英文)显示文摘报道了一种新型Ag/Ag3PO4/g-C3N4三元复合光催化剂的制备及其半导体界面处的快速载流子分离所引起的光催化活性的显著增强效应.通过X射线衍射,扫描电子显微镜,紫外-可见吸收光谱以及光致发光光谱等就其晶体结构、形貌、组分、光学吸收以及载流子的快速分离行为进行了表征与分析.以罗丹明B作为模型化合物分子,研究发现,所制备的Ag/Ag3PO4/g-C3N4三元复合光催化剂在可见光照射下表现出比Ag3PO4以及Ag3PO4/g-C3N4二元催化剂更为优异的光催化活性.研究认为,Ag3PO4表面尺寸约为40 nm的Ag纳米粒子在可见光下受激所产生的等离子表面共振效应以及Ag3PO4与g-C3N4界面处所形成的类似异质结结构对所制备的Ag/Ag3PO4/g-C3N4三元复合光催化剂光催化活性的显著增强起到重要作用. | 沈凯 Mohammed Ashraf Gondal Rashid Ghulam Siddique 施珊 王斯琦 孙江波 徐庆宇 | 2014 | 催化学报2014，35，1： | 14 |
| 11 | 新疆艾比湖主要入湖河流精河与博尔塔拉河三维荧光光谱特性及其与水质的关系显示文摘以艾比湖主要入湖河流——精河与博尔塔拉河为研究对象,分别分析了精河与博尔塔拉河的水体溶解性有机质(DOM)的组成结构及水质参数与荧光指数的关系.利用平行因子分析法对三维荧光光谱(EEM)分析发现,精河与博尔塔拉河均含有C1(260/420 nm)腐殖酸等有机质、C2(240,240/490 nm)UVC类腐殖质、C3(220/280,300/450 nm)蛋白质类有机质和C4(260,270/530 nm)类腐殖质,且不同荧光组分结构具有一定差异性.为了进一步了解DOM组分特征,采用三维荧光区域积分法分析各区域标准体积百分比,结果表明精河与博尔塔拉河EEM的区域Ⅰ与区域Ⅱ蛋白质有机质含量最高,区域Ⅲ富里酸含量最低.相关性分析表明,主要入湖河流的水质参数与荧光指数中,自生源指数(BIX)与总氮(TN)浓度以及腐殖化指数(HIX)与铵态氮(NH_4^+-N)浓度的相关性较强,相关系数分别为0.831和0.684,且具有显著性;HIX与TN浓度的相关系数为0.604,达到显著性水平.进而对相关性较强的水质参数与荧光指数进行3次拟合,其中HIX与NH_4^+-N浓度的拟合效果最好,相关性系数为0.908,其次是BIX与TN浓度,相关性系数为0.844.总之,通过分析精河与博尔塔拉河三维荧光特征,以及探讨荧光指数与水质参数的关系,可为治理干旱区水环境问题提供理论依据和参考. | 张海威 张飞 李哲 Abduwasit Ghulam Kung Hsiangte 任岩 陈芸 | 2017 | 湖泊科学2017，29，5： | 13 |
| 12 | Biochar for Sustainable Soil Health:A Review of Prospects and Concerns显示文摘Biochar as a soil amendment is confronted with the challenge that it must benefit soil health as it can be by no means separated from soils once it is added. The available literature even though sparse and mostly based on short-term studies has been encouraging and the trend obtained so far has raised many hopes. Biochar has been reported to positively impact an array of soil processes ranging from benefiting soil biology, controlling soil-borne pathogens, enhancing nitrogen fixation, improving soil physical and chemical properties,decreasing nitrate(NO-3) leaching and nitrous oxide(N2O) emission to remediation of contaminated soils. However, very little biochar is still utilized as soil amendment mainly because these benefits are yet to be quantified, and also the mechanisms by which the soil health is improved are poorly understood. Due to the infancy of research regarding this subject, there are still more questions than answers. The future research efforts must focus on carrying out long-term experiments and uncover the mechanisms underlying these processes so that key concerns surrounding the use of biochar are addressed before its large scale application is recommended. | Aabid H.LONE Ghulam R.NAJAR Mumtaz A.GANIE Javid A.SOFI Tahir ALI | 2015 | Pedosphere2015，25，5： | 12 |
| 13 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 14 | 玫烟色棒束孢对多种刺吸式口器害虫防治潜力的室内评测显示文摘刺吸式口器昆虫常发生严重且抗药性强。本文室内测定了玫烟色棒束孢Isaria fumosorosea Ifu13a对梨冠网蝽、小绿叶蝉和温室白粉虱等多种刺吸式口器害虫的控制潜力。在1.0×10~8、1.0×10~7和1.0×10~6孢子/mL接种浓度下,在处理后初始2 d保持RH(95±5)%,随后8 d保持RH(78±5)%的条件下,小绿叶蝉和温室白粉虱成虫的累积死亡率均达到100%,其致死中时LT50分别为4.12、4.11、5.43和4.77、5.55、5.32 d,而梨冠网蝽的致死中时为7.32、8.22、9.79 d。在1.0×10~8和1.0×10~7孢子/mL浓度下,小绿叶蝉和温室白粉虱累计死亡率均在5 d内即达到100%,2种害虫的致死中浓度LC_(50)分别为3.90×10~3和3.03×10~4孢子/mL;而梨冠网蝽第10 d在2种浓度下的累计死亡率分别达到了81.25%、77.5%,其LC_(50)为6.88×10~5孢子/mL。菌株Ifu13a显示出一定的寄主专化性,菌株Ifu13a显现了对多种刺吸式口器害虫的高控制潜力。 | 王滨 曹娜 GHULAM Ali Bugti | 2018 | 中国生物防治学报2018，34，1： | 8 |
| 15 | Addition of simvastatin to carvedilol non responders: A new pharmacological therapy for treatment of portal hypertension显示文摘AIM To determine whether addition of simvastatin could be an important pharmacological rescue therapy for carvedilol non-responders. METHODS One hundred and two consecutive patients of cirrhosis of liver with significant portal hypertension were included. Hepatic venous pressure gradient(HVPG) was measured at the base line and after proper optimization of dose; chronic response was assessed at 3 mo. Carvedilol non-responders were given simvastatin 20 mg per day(increased to 40 mg per day at day 15). Carvedilol plus simvastatin was continued for 1 mo and hemodynamic response was again measured at 1 mo.RESULTS A total of 102 patients with mean age of 58.3 ± 6.6 years were included. Mean baseline HVPG was 16.75 ± 2.12 mmH g and after optimization of dose and reassessment of HVPG at 3 mo, mean reduction of HVPG from baseline was 5.5 ± 1.7 mm Hg and 2.8 ± 1.6 mm Hg among responders and non-responders respectively(P < 0.001). Addition of simvastatin to carvedilol non-responders resulted in significant response in 16 patients(42.1%) and thus overall response with carvedilol and carvedilol plus simvastatin was seen in 78 patients(80%). Two patients were removed in chronic protocol study with carvedilol and three patients were removed in carvedilol plus simvastatin study due to side effects.CONCLUSION Addition of simvastatin to carvedilol non-responders may prove to be an excellent rescue therapy in patients with portal hypertension. | Zeeshan Ahmad Wani Sonmoon Mohapatra Afaq Ahmad Khan Ashutosh Mohapatra Ghulam Nabi Yatoo | 2017 | World Journal of Hepatology2017，9，5： | 8 |
| 16 | A Diagnostic Study of Heavy Rainfall in Karachi Due to Merging of a Mesoscale Low and a Diffused Tropical Depression during South Asian Summer Monsoon显示文摘This paper presents the results of a diagnostic study of a typical case of very heavy rainfall during the South Asian summer monsoon when a mesoscale low in a desert climate merged with a diffused tropical depression. The former low was located over Pakistan's desert region and the latter depression originated over the Bay of Bengal. Surface and NCEP reanalysis data supported by satellite and radar images were incorporated in the diagnosis. The relationship between the heavy precipitation process and large-scale circulations such as monsoon trough, subtropical high, westerly jet, low level jet and water vapor transport were investigated to further understand the mechanism of this peculiar interaction. It was found that: (1)the mesoscale low developed as a result of cold air advection aloft from northern latitudes and strong convection over the region of humidity convergence on 24 July 2003 over the Indian Rajistan area. (2) On the same day, a low that formed over the Bay of Bengal was transformed into a monsoon depression and moved westward to the mesoscale low which existed over southwest India and the adjoining southeastern parts of Pakistan. (3) Initially, the mesoscale low received moisture supply from both the Bay of Bengal as well as the Arabian Sea, whereas the Bay of Bengal maintained the continuous supply of moisture to the monsoon depression. (4) After the depression crossed central India, the Bay's moisture supply was cut off and the Arabian Sea became the only source of moisture to both the closely located systems. On 27July, both of the systems merged together and the merger resulted in a heavy downpour in the Karachi metropolitan and in its surroundings. (5) With the intensification as well as the southeastward extension of the subtropical high and the shift of the monsoon trough axis from southwest-west to northeast-east,the monsoon depression moved southwestward. In this situation, there existed a very favourable condition for a merger of the two systems in the presence of cross-latitude influence. (6) A number of convective cloud clusters were developed and organized in the mesoscale low. Probably, interactions existed among the multi-scale systems. | Ghulam RASUL Qamar-uz-Zaman CHAUDHRY 赵思雄 曾庆存 齐琳琳 张高英 | 2005 | Advances in Atmospheric Sciences2005，22，3： | 8 |
| 17 | Genome-wide analysis of BES1 genes in Gossypium revealed their evolutionary conserved roles in brassinosteroid signaling显示文摘Brassinosteroids(BRs), which are essential phytohormones for plant growth and development, are important for cotton fiber development. Additionally, BES1 transcription factors are critical for BR signal transduction. However, cotton BES1 family genes have not been comprehensively characterized. In this study, we identified 11 BES1 genes in G. arboreum, 11 in G.raimondii, 16 in G. barbadense, and 22 in G. hirsutum. The BES1 sequences were significantly conserved in the Arabidopsis thaliana, rice, and upland cotton genomes. A total of 94 BES1 genes from 10 different plant species were divided into three clades according to the neighbor-joining and minimum-evolution methods. Moreover, the exon/intron patterns and motif distributions were highly conserved among the A. thaliana and cotton BES1 genes. The collinearity among the orthologs from the At and Dt subgenomes was estimated. Segmental duplications in the At and Dt subgenomes were primarily responsible for the expansion of the cotton BES1 gene family. Of the GhBES1 genes, GhBES1.4_At/Dt exhibited BL-induced expression and was predominantly expressed in fibers. Furthermore, Col-0/mGhBES1.4_At plants produced curled leaves with long and bent petioles. These transgenic plants also exhibited decreased hypocotyl sensitivity to brassinazole and constitutive BR induced/repressed gene expression patterns. The constitutive BR responses of the plants overexpressing mGhBES1.4_At were similar to those of the bes1-D mutant. | Zhao Liu Ghulam Qanmber Lili Lu Wenqiang Qin Ji Liu Jie Li Shuya Ma Zhaoen Yang Zuoren Yang | 2018 | Science China(Life Sciences)2018，61，12： | 7 |
| 18 | NS1 antigen: A new beam of light in the early diagnosis of dengue infection显示文摘Objective: To evaluate NS1 antigen detection ELISA for the early laboratory diagnosis of dengue virus infection. Methods: The present study was conducted to evaluate the overall positivity of NS1 antigen detection ELISA and its comparison with viral RNA detection via real time PCR and Ig M antibodies detection by ELISA. Results: A total of 1 270 serum samples were tested 86%(1 097/1 270) were detected positive by one or more than one diagnostic test. Out of 1 270, 64%(807/1 270) were positive by NS1 ELISA and 52%(662/1 270), 51%(646/1 270) were positive by real-time RT-PCR and Ig M ELISA respectively.Conclusions: NS1 antigen detection ELISA is highly suitable diagnostic tools and it also has great value for use in outbreak and epidemic situation. | Muhammad Suleman Rani Faryal Muhammad Masroor Alam Salmaan Sharif Shahzad Shaukat Uzma Bashir Aamir Adnan Khurshid Mehar Angez Massab Umair Mian Muhammad Sufian Yasir Arshad Ghulam Mujtaba Syed Sohail Zahoor Zaidi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 6 |
| 19 | MicroRNA and mRNA profiling of cerebral cortex in a transgenic mouse model of Alzheimer’s disease by RNA sequencing显示文摘In a previous study,we found that long non-coding genes in Alzheimer’s disease(AD)are a result of endogenous gene disorders caused by the recruitment of microRNA(miRNA)and mRNA,and that miR-200a-3p and other representative miRNAs can mediate cognitive impairment and thus serve as new biomarkers for AD.In this study,we investigated the abnormal expression of miRNA and mRNA and the pathogenesis of AD at the epigenetic level.To this aim,we performed RNA sequencing and an integrative analysis of the cerebral cortex of the widely used amyloid precursor protein and presenilin-1 double transgenic mouse model of AD.Overall,129 mRNAs and 68 miRNAs were aberrantly expressed.Among these,eight down-regulated miRNAs and seven up-regulated miRNAs appeared as promising noninvasive biomarkers and therapeutic targets.The main enriched signaling pathways involved mitogen-activated kinase protein,phosphatidylinositol 3-kinase-protein kinase B,mechanistic target of rapamycin kinase,forkhead box O,and autophagy.An miRNA-mRNA network between dysregulated miRNAs and corresponding target genes connected with AD progression was also constructed.These miRNAs and mRNAs are potential biomarkers and therapeutic targets for new treatment strategies,early diagnosis,and prevention of AD.The present results provide a novel perspective on the role of miRNAs and mRNAs in AD.This study was approved by the Experimental Animal Care and Use Committee of Institute of Medicinal Biotechnology of Beijing,China(approval No.IMB-201909-D6)on September 6,2019. | Li Zeng Hai-Lun Jiang Ghulam Md Ashraf Zhuo-Rong Li Rui Liu | 2021 | Neural Regeneration Research2021，16，10： | 6 |
| 20 | Ginsenoside Rg1 ameliorates bloodebrain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release显示文摘During the traumatic brain injury(TBI),improved expression of circulatory miR-21 serves as a diagnostic feature.Low levels of exosome-miR-21 in the brain can effectively improve neuroinflammation and bloodebrain barrier(BBB)permeability,reduce nerve apoptosis,restore neural function and ameliorate TBI.We evaluated the role of macrophage derived exosomes-miR-21(M-Exos-miR-21)in disrupting BBB,deteriorating TBI,and Rg1 interventions.IL-1β-induced macrophages(ⅡA)-Exos-miR-21 can activate NF-kB signaling pathway and induce the expressions of MMP-1,-3 and-9 and downregulate the levels of tight junction proteins(TJPs)deteriorating the BBB.Rg1 reduced miR-21-5 p content in ⅡA-Exos(RⅡA-Exos).The interaction of NMIIAe HSP90 controlled the release of Exos-miR-21,this interaction was restricted by Rg1.Rg1 could inhibit the Exos-miR-21 release in peripheral blood flow to brain,enhancing TIMP3 protein expression,MMPs proteolysis,and restricting TJPs degradation thus protected the BBB integrity.Conclusively,Rg1 can improve the cerebrovascular endothelial injury and hold the therapeutic potential against TBI disease. | Kefeng Zhai Hong Duan Wei Wang Siyu Zhao Ghulam Jilany Khan Mengting Wang Yuhan Zhang Kiran Thakur Xuemei Fang Chao Wu Jianbo Xiao Zhaojun Wei | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 6 |
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