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| 1 | Molecular targeting agents associated with transarterial chemoembolization or radiofrequency ablation in hepatocarcinoma treatment显示文摘Hepatocellular carcinoma(HCC)is the fifth most common cause of cancer in the world.According to Barcelona Clinic Liver Cancer modified criteria,patients with early stage disease are candidate to radiofrequency ablation(RFA),while patients with intermediate stage HCC are usually treated by transarterial chemoembolization(TACE).TACE and RFA induce a transient devascularisation effect followed by strong neoangiogenic stimulus.In fact,after these procedures,it has been demonstrated an up-regulation of pro-angiogenic and growth factors such as vascular endothelial growth factor-A,which might contribute to accelerated progression in patients with incomplete response.Several studies have demonstrated that MAP-kinase and AKT pathways,in addition to neo-angiogenesis,have an important role in the development of HCC.In advanced HCC,anti-angiogenic therapy and tyrosine kinases inhibitors showed potential clinical benefit.Actually,a number of clinical studies are ongoing testing these agents in combination with TACE or RFA.In this paper,we have reviewed the most recent preclinical and clinical results of such trials. | Girolamo Ranieri Ilaria Marech Vito Lorusso Veronica Goffredo Angelo Paradiso Domenico Ribatti Cosmo Damiano Gadaleta | 2014 | World Journal of Gastroenterology2014，20，2： | 14 |
| 2 | Treatment for isolated loco-regional recurrence of gastric adenocarcinoma: Does surgery play a role?显示文摘AIM: To evaluate the role of surgical treatment for isolated loco-regional recurrences of operated gastric adenocarcinoma. METHODS: Among the 837 patients operated for gastric adenocarcinoma between December 1979 and April 2004, 713 (85%) underwent resection with curative intent. A retrospective review of a prospectively collected gastric cancer database was carried out. Overall recurrence rate was 44% (315 cases), with 75% occurring within the first 2 years from the operation. Isolated L-R recurrences were observed in 38 (12%) patients. Symptomatic lesions were observed in 27 (71%). RESULTS: Six (16%) patients were macroscopically resected with curative intent. The recurrence was located in the gastric stump after a STG in three patients, in the esophagojejunal anastomosis after a TG in two patients and in the gastric bed after a TG in one patient. Surgical procedures consisted of three secondary TG, two esophagojejunal resection and one excision of an extraluminal recurrence. Postoperative complications occurred in two patients (33%), including one anastomotic leakage and one hemorrhage. The latter patient died of sepsis 35 d after the surgery (mortality rate 17%). All patients died of recurrent gastric cancer: 2 within 1 year from surgery (8 and 11 mo, respectively), 2 after 16 and 17 mo respectively and 1 after 28 mo from the second operation. CONCLUSION: Surgery plays a very limited role in the treatment for isolated loco-regional recurrence of gastric adenocarcinoma. | Fabio Carboni Pasquale Lepiane Roberto Santoro Riccardo Lorusso Pietro Mancini Massimo Carlini Eugenio Santoro | 2005 | World Journal of Gastroenterology2005，11，44： | 5 |
| 3 | Total and not bevacizumab-bound vascular endothelial growth factor as potential predictive factors to bevacizumab-based chemotherapy in colorectal cancer显示文摘AIM: To identify suitable biomarkers of response to bevacizumab(BV)- it remains an open question. The measurement of serum vascular endothelial growth factor(VEGF) has been proposed as a predictive factor for this drug, even if literature data are contradictory. METHODS: We prospectively evaluated the role of BV, total and not BV-bound VEGF and angiopoietin-2(Ang-2) serum levels as potential predictive factors of response for BV in combination with an oxaliplatinbased chemotherapy. BV, Ang-2, total and not BVbound VEGF levels were measured at baseline, before 2^(nd) and 5^(th) cycle of oxaliplatin-based chemotherapy in 20 consecutive metastatic colorectal cancer patients. RESULTS: Results were correlated to response to treatment. Variability in BV levels have been found, with decreased level in less responding patients. In particular, the concentration of BV increased of 3.96 ± 0.69 folds in serum of responsive patients after 3 more cycles of therapy compared to those with stable or progressive disease with a 0.72 ± 0.25 and 2.10 ± 0.13 fold increase, respectively. The determination of free and total VEGF demonstrated that the ratio between the two values, evaluated immediately before the 2^(nd) and the 5^(th) cycle of therapy, decreased from 26.65% ± 1.33% to 15.50% ± 3.47% in responsive patients and from 53.41% ± 4.75 to 34.95% ± 2.88% in those with stable disease. Conversely, in those with progression of disease, the ratio showed the opposite behavior coming up from 25.99% ± 5.23% to 51.71% ± 5.28%. The Ang-2 levels did not show any relationship. CONCLUSION: Our data show that the ratio of not BV-bound VEGF to total VEGF serum and BV plasma concentrations for predicting the response to BV plus oxaliplatin-based chemotherapy could be a promising biomarker of response to BV. | Amalia Azzariti Letizia Porcelli Oronzo Brunetti Marzia Del Re Vito Longo Patrizia Nardulli Michele Signorile Jian-Ming Xu Angela Calabrese Anna Elisa Quatrale Evaristo Maiello Vito Lorusso Nicola Silvestris | 2016 | World Journal of Gastroenterology2016，22，27： | 4 |
| 4 | Sustained attention in psychosis:Neuroimaging findings显示文摘To provide a systematic review of scientific literatureon functional magnetic resonance imaging(fMRI) stud-ies on sustained attention in psychosis. We searchedPubMed to identify fMRI studies pertaining sustainedattention in both affective and non-affective psycho-sis. Only studies conducted on adult patients using asustained attention task during fMRI scanning wereincluded in the final review. The search was conductedon September 10 th, 2013. 15 fMRI studies met our in-clusion criteria: 12 studies were focused on Schizophre-nia and 3 on Bipolar Disorder Type Ⅰ(BDI). Only halfof the Schizophrenia studies and two of the BDI stud-ies reported behavioral abnormalities, but all of themevidenced significant functional differences in brain re-gions related to the sustained attention system. Alteredfunctioning of the insula was found in both Schizophre-nia and BDI, and therefore proposed as a candidate trait marker for psychosis in general. On the other hand, other brain regions were differently impaired in affective and non-affective psychosis: alterations of cingulate cortex and thalamus seemed to be more common in Schizophrenia and amygdala dysfunctions in BDI. Neural correlates of sustained attention seem to be of great interest in the study of psychosis, highlight-ing differences and similarities between Schizophrenia and BDI. | Gianna Sepede Maria Chiara Spano Marco Lorusso Domenico De Berardis Rosa Maria Salerno Massimo Di Giannantonio Francesco Gambi | 2014 | World Journal of Radiology2014，6，6： | 2 |
| 5 | Target Therapies in Pancreatic Carcinoma显示文摘 | Nicola Silvestris Antonio Gnoni Anna Elisabetta Brunetti Leonardo Vincenti Daniele Santini Giuseppe Tonini Francesca Merchionne Evaristo Maiello Vito Lorusso Patrizia Nardulli Amalia Azzariti Michele Reni | 2014 | Current Medicinal Chemistry2014，，8： | 2 |
| 6 | Similar long-term results of mitral valve repair for anterior compared with posterior leaflet prolapse显示文摘 | Michele De Bonis Roberto Lorusso Elisabetta Lapenna Samer Kassem Giuseppe De Cicco Lucia Torracca Francesco Maisano Giovanni La Canna Ottavio Alfieri | 2006 | The Journal of Thoracic and Cardiovascular Surgery2006，，2： | 2 |
| 7 | The tumor microenvironment and its contribution to tumor evolution toward metastasis显示文摘 | Girieca Lorusso Curzio Rüegg | 2008 | Histochemistry and Cell Biology2008，，6： | 2 |
| 8 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 9 | Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer显示文摘 | Frasci G Lorusso V Panza N | 2000 | J Clin On- col2000，18，13： | 1 |
| 10 | How should we prescribe lapatinib to our patients: once daily or twice daily, and at what dose显示文摘 | Ciccarese M Lorusso V | 2009 | J Clin Oncol2009，27，2： | 1 |
| 11 | Results of a pancreatectomy with a limited venous resection for pancreatic cancer显示文摘 | Giulio Illuminati Fabio Carboni Riccardo Lorusso Antonio D’Urso Gianluca Ceccanei Vassilios Papaspyropoulos Maria Antonietta Pacile Eugenio Santoro | 2008 | Surgery Today2008，，6： | 1 |
| 12 | The spatial distribution of visual attention in developmental dyslexia显示文摘 | Facoetti A Lorusso ML Paganoni P | | 0，，： | 1 |
| 13 | Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors显示文摘 | Edward Sausville Patricia LoRusso Michael Carducci Judith Carter Mary F. Quinn Lisa Malburg Nilofer Azad David Cosgrove Richard Knight Peter Barker Sonya Zabludoff Felix Agbo Patricia Oakes Adrian Senderowicz | 2014 | Cancer Chemotherapy and Pharmacology2014，，3： | 1 |
| 14 | Improvements in Quality of Life and Disease-related Symptoms in Phase I Trials of the Selective Oral Epidermal Growth Factor Receptor Tyrosin Kinase Inhibitor ZD1839 in Non-Small Cell Lung Cancer and Other Solid Tumors显示文摘 | LoRusso PM Herbst RS Rischin D | 2003 | Clin Cancer Res2003，9，6： | 1 |
| 15 | Role of liposomal anthracyclines in breast cancer 显示文摘 | LORUSSO V MANZIONE L SILVESTRIS N | 2007 | Ann Onco12007，18，6： | 1 |
| 16 | Targeting the Hedgehog path- way in cancer 显示文摘 | Gupta S Takebe N Lorusso P | 2010 | Ther Adv Med Oncol2010，2，4： | 1 |
| 17 | Gem('itabine plus cispl- atin for advanced transitional ('ell carcinoma of the urinary tract : a phase1 multicenter trial显示文摘 | Lorusso V Manzione 1 De Vita F | 2000 | J Urol2000，164，1： | 1 |
| 18 | Parabolic trend in endometrial thickness at embryo transfer in in vitro fertilization/intracytoplasmic sperm injection cases with clinical pregnancy evidence 显示文摘 | Lamanna G Scioscia M Lorusso F | 2008 | Fertil Steril2008，90，： | 1 |
| 19 | Neurocognitive profiles in Duchenne muscular dystrophy and gene mutation site 显示文摘 | D'Angelo MG Lorusso ML Civati F | 2011 | Pediatr Neurol2011，45，5： | 1 |
| 20 | Evaluation ofpemetrexed (alimta,ly231514) as second-linechemotherapy in persistent or recurrent carcinoma of thecervix: the cervix 1 study of the mito (multicentre italiantrials in ovarian cancer and gynecologic malignancies)group 显示文摘 | Lorusso D Ferrandina G Pignata S | 2010 | Ann Oncol2010，21，1： | 1 |
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