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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis显示文摘瞄准:在有人半胱氨酸(HCY ) 和 haemostatic 系统的各种各样的部件的 PBC 和它的关系估计 hypercoagulability。方法:我们调查了 51 个 PBC 病人(43F/8M;意味着年龄:63+/-13.9 年) 并且 102 个健康题目(86 个 women/16 人;63+/-13 年) ,并且由 PFA-100 由 Sonoclot 分析和血小板功能在全血评估了 haemostatic 过程设备。我们然后测量了 HCY (禁食并且在蛋氨酸装载以后) ,织物因素(TF ) , thrombin-antithrombin 建筑群(梭织) , D 暗淡(D-D ) , thrombomodulin (TM ) , folic,维生素 B6 和 B12 血浆铺平。C677T 5,10-methylenetetrahydrofolate 还原酶(MTHFR ) 多型性被分析。结果:病人的 Sonoclot 率值是显著地(P<0.001 ) 比那些高控制。山峰价值的 Sonoclot 时间和 PFA-100 闭合时间在病人和控制是可比较的。梭织, TF 和 HCY 层次,两个在禁食并且蛋氨酸以后的装载,显著地(P<0.001 ) 在病人更高与比在控制。维生素缺乏在 45/51 病人(88.2%) 被检测。同型结合的 TT677 MTHFR 遗传型的流行比在控制(17.5%)(P<0.05 ) 在病人(31.4%) 是显著地更高的。Sonoclot 率价值与 HCY 层次和 TF 显著地相关。结论:在 PBC, hyper-HCY 与维生素缺少和基因预先安排因素有关。内皮激活的增加的 TF 和 HCY 层次和符号与 hypercoagulability 被联系并且可以在血凝固激活有一个重要角色。 | Maria Rosa Biagini Alessandro Tozzi Rossella Marcucci Rita Paniccia Sandra Fedi Stefano Milani Andrea Galli Elisabetta Ceni Marco Capanni Raffaele Manta Rosanna Abbate Calogero Surrenti | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 3 | Consensus and Future Directions on the Definition of High On-Treatment Platelet Reactivity to Adenosine Diphosphate显示文摘 | Laurent Bonello Udaya S. Tantry Rossella Marcucci Ruediger Blindt Dominick J. Angiolillo Richard Becker Deepak L. Bhatt Marco Cattaneo Jean Philippe Collet Thomas Cuisset Christian Gachet Gilles Montalescot Lisa K. Jennings Dean Kereiakes Dirk Sibbing Die | 2010 | Journal of the American College of Cardiology2010，，12： | 3 |
| 4 | Photonic extreme learning machine by free-space optical propagation显示文摘Photonic brain-inspired platforms are emerging as novel analog computing devices,enabling fast and energyefficient operations for machine learning.These artificial neural networks generally require tailored optical elements,such as integrated photonic circuits,engineered diffractive layers,nanophotonic materials,or time-delay schemes,which are challenging to train or stabilize.Here,we present a neuromorphic photonic scheme,i.e.,the photonic extreme learning machine,which can be implemented simply by using an optical encoder and coherent wave propagation in free space.We realize the concept through spatial light modulation of a laser beam,with the far field acting as a feature mapping space.We experimentally demonstrate learning from data on various classification and regression tasks,achieving accuracies comparable with digital kernel machines and deep photonic networks.Our findings point out an optical machine learning device that is easy to train,energetically efficient,scalable,and fabrication-constraint free.The scheme can be generalized to a plethora of photonic systems,opening the route to real-time neuromorphic processing of optical data. | DAVIDE PIERANGELI GIULIA MARCUCCI CLAUDIO CONTI | 2021 | Photonics Research2021，9，8： | 2 |
| 5 | Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis显示文摘 | Piergiovanni Buonamici Rossella Marcucci Angela Migliorini Gian Franco Gensini Alberto Santini Rita Paniccia Guia Moschi Anna Maria Gori Rosanna Abbate David Antoniucci | 2007 | Journal of the American College of Cardiology2007，，： | 2 |
| 6 | Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development显示文摘Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its root.This study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast cancer.Methods: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin V/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo assay.Results: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated animals.Conclusion: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy. | Carlos R.Oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-Santos Soraya S.Smaili Gustavo J.S.Pereira André Hinsberger Ezequiel P.Viriato Maria Cristina Marcucci Alexandra C.H.F.Sawaya Samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto | 2019 | Journal of Integrative Medicine2019，17，2： | 2 |
| 7 | Resectable Pancreatic Cancer: Who Really Benefits From Resection?显示文摘 | Giuliano Barugola MD Stefano Partelli MD Stefano Marcucci MD Nora Sartori MD Paola Capelli MD Claudio Bassi MD Paolo Pederzoli MD Massimo Falconi MD | 2009 | Annals of Surgical Oncology2009，，12： | 2 |
| 8 | Exprimental campaigns on textile wastewater for reuse by means of different membrane processes显示文摘 | MARCUCCI M CIARDELLI G MATTEUCCI A | 2002 | Desalination2002，149，123： | 1 |
| 9 | Phase 1 and pharmaco- dynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed a- cute leukemia显示文摘 | Marcucci G Byrd J C Dai G | 2003 | Blood2003，101，2： | 1 |
| 10 | hnpact of p latelet reactivity after clopidogrel administration on drug-eluting stent thrombosis 显示文摘 | Buonamici P Marcucci R Migliorini A | 2007 | Am Coll Cardiol2007，49，24： | 1 |
| 11 | Determination of ambroxol in bionlogical Material by gas chromatography with electron-capture Detection显示文摘 | Colombl L Marcucci F Marini MG | 1990 | Chromatogr1990，530，1： | 1 |
| 12 | Consensus andfuture directions on the definition of high on-treatmentplatelet reactivity to adenosine diphosphate 显示文摘 | Bonello L Tantry US Marcucci R | 2010 | J Am CollCardiol2010，56，12： | 1 |
| 13 | Consensus and future di- rections on the definition of high on - treatment platelet reactivity to a- denosine diphosphate 显示文摘 | Bonello L Tantry US Marcucci R | 2010 | J Am Coil Cardiol2010，56，12： | 1 |
| 14 | Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptortargeted liposomes显示文摘 | Chiu SJ Marcucci G lee RJ | 2006 | Anticancer Res2006，26，2： | 1 |
| 15 | PhaseIstudy of oblim- ersen sodium, an antisense to Bcl -2, in untreated older pa- tients with acute myeloid leukemia: pharmacokinetics, phar- macodynemics, and clinical activity显示文摘 | Marcucci G Stock W Dai G | 2005 | J Clin Oncol2005，23，15： | 1 |
| 16 | The prognostic and functional role of microRNAs in acute myeloid leukemia 显示文摘 | Marcucci G Mrozek K Radmacher MD | 2011 | Blood2011，117，4： | 1 |
| 17 | Uridine diph- osphate glucuronosyl transferase 1A1 promoter polymor- phism predicts the risk of gastrointestinal toxicity and fa- tigue induced by irinotecan-based chemotherapy 显示文摘 | Massacesi C Terrazzino S Marcucci F | 2006 | Can- cer2006，106，5： | 1 |
| 18 | High expression levels of the ETS-related gene,ERG,predict adverse outcome and improve molecular risk-based classification of cytogenetically normal acute myeloid leukemia:a Cancer and Leukemia Group B Study显示文摘 | Marcucci G Maharry K Whitman SP | 2007 | J Clin Oncol2007，25，22： | 1 |
| 19 | Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity显示文摘 | Laurent D Marcucci M | 1999 | J Clin Invest1999，103，： | 1 |
| 20 | Impact of platelet reactivity after clopidogrel administration on drug-eluting stem thrombosis显示文摘 | Buonemici P Marcucci R Migliorini A | 2007 | J Am Coll Cardiol2007，49，24： | 1 |
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