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| 1 | Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives显示文摘Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies.A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the development of novel,more powerful therapies.The traditional,so-called'stochastic model'of tumor development,which assumes that each cancer cell is tumorigenic,has been deeply challenged during the past decade by the identification of cancer stem cells(CSCs),a biologically distinct subset of cells within the bulk of tumor mass.This discovery led to the development of the hierarchical model of tumorigenesis which assumes that only CSCs have the ability to initiate tumor growth,both at primary and metastatic sites.This model implies that the elimination of all CSCs is fundamental to eradicate tumors and that failure to do so might be responsible for the occurrence of relapses and/or metastases frequently observed in the clinical management of colorectal cancer patients.Identification and isolation of CSCs is essential for a better understanding of their role in the tumorigenetic process and for the development of CSC-specific therapies.Several methods have been used for this purpose and many efforts have been focused on the identification of specific CSC-surface markers.This review provides an overview of the proposed roles of CSC in human colorectal tumorigenesis focusing on the most important molecules identified as CSC-specific markers in colorectal cancer and on the potential strategies for the development of CSC-targeted therapy. | Caterina Fanali Donatella Lucchetti Marisa Farina Maddalena Corbi Valerio Cufino Achille Cittadini Alessandro Sgambato | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 2 | Polyethylene glycol microspheres loaded with irinotecan for arterially directed embolic therapy of metastatic liver cancer显示文摘AIM To study tumor response, and tolerability of arterially directed embolic therapy(ADET) with polyethylene glycol embolics loaded with irinotecan for the treatment of colorectal cancer liver metastases(CRC-LM). Secondary objectives were to monitor quality of life, time to progression and survival of patients.METHODS Patients were included in the study if they were affected by CRC-LM, refractory to systemic chemotherapy, treated with ADET using polyethylene glycol embolics, and had liver involvement < 50%. Tumor response, performance status(PS), tumor marker antigens, and quality of life(QoL) were monitored at 1, 3 and 6 mo after ADET. QoL was assessed with the Palliative Performance Scale(PPS).RESULTS We treated 50 consecutive CRC-LM patients with ADET using polyethylene glycol embolics. Their tumor response one month after ADET was: 28% of complete response(CR), 48% of partial response(PR), 8% stable disease(SD), and 16% of progression. Tumor response 3 mo after ADET was CR 24%, PR 38%, SD 19% and progression disease(PD) 19%. Tumor response 6 mo after ADET was CR 18%, PR 44%, SD 21% and PD 18%. QoL was 90% PPS at each time point. Median time to progression for patients who progressed was 2.5 mo(range 0.8-6). Median follow-up was 14 mo(0.8-25 range). ADETs were performed with no complications. Observed side effects(mild or moderate intensity) were: Pain in 32% of patients, increase of transaminase levels in 20% and fever in 14%, whereas 30% of patients did not complain any adverse event. CONCLUSION The treatment of unresectable CRC-LM with ADET using polyethylene glycol microspheres loaded with irinotecan was effective in tumor response and resulted in mild toxicity, and good QoL. | Giammaria Fiorentini Riccardo Carandina Donatella Sarti Michele Nardella Odysseas Zoras Stefano Guadagni Riccardo Inchingolo Massimiliano Nestola Alessandro Felicioli Daniel Barnes Navarro Fernando Munoz Gomez Camillo Aliberti | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 6 |
| 3 | A prospective study on radiofrequency ablation locally advanced pancreatic cancer显示文摘BACKGROUND:Radiofrequency ablation(RFA)has been suggested as a new treatment option for patients with locally advanced cancer.This study aimed to prospectively evaluate the efficacy and safety of intraoperative RFA in patients with unresectable,locally advanced,non-metastatic carcinoma of the pancreatic head.METHODS:RFA was the first step of the surgical procedure and was carried out on the mobilized pancreatic head followed by biliary by-pass and gastrojejunal-anastomosis.Intra-and post-operative morbidity and mortality,performance status, pain control,quality of life,and survival at 24 months were evaluated.RESULTS:Seven patients(3 men and 4 women;median age 66 years,range 47-80 years)were studied and 4 were eligible for treatment.The RFA procedure was carried out in 3 of the 4 patients;in one patient it was not carried out because of the upstaging of the neoplasm.In all 3 patients RFA achieved complete necrosis of the lesion.A biliary fistula developed 7 days after the procedure in one patient;all 3 patients developed ascites 8.6 days(range 7-9 days)on average after RFA.All patients died respectively,at 3,4,and 5 months after the treatment.CONCLUSIONS:In our experience,RFA is a feasible procedure, but it presents a very high rate of postoperative complications.Moreover,pain control,life quality and survival rate are poor.The few data suggest no impact on survival. | Riccardo Casadei Claudio Ricci Raffaele Pezzilli Carla Serra Lucia Calculli Antonio Maria Morselli-Labate Donatella Santini Francesco Minni | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，3： | 6 |
| 4 | Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus显示文摘AIM:To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS:Thirty-five consecutive adult patients with SLE and 35 age-and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS:Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), withhemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE pos- sibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION:SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE. | Annalisa Berzigotti Marilena Frigato Elena Manfredini Lucia Pierpaoli Rita Mulè Carolina Tiani Paola Zappoli Donatella Magalotti Nazzarena Malavolta Marco Zoli | 2011 | World Journal of Gastroenterology2011，17，40： | 5 |
| 5 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 6 | Multidisciplinary approach of colorectal cancer liver metastases显示文摘Large bowel cancer is a worldwide public health challenge.More than one third of patients present an advanced stage of disease at diagnosis and the liver is the most common site of metastases.Selection criteria for early diagnosis,chemotherapy and surgery have been recently expanded.The definition of resectability remains unclear.The presence of metastases is the most significant prognostic factor.For this reason the surgical resection of hepatic metastases is the leading treatment.The most appropriate resection approach remains to be defined.The two step and simultaneous resection processes of both primary and metastases have comparable survival long-term outcomes.The advent of targeted biological chemotherapeutic agents and the development of loco-regional therapies(chemoembolization,thermal ablation,arterial infusion chemotherapy) contribute to extend favorable results.Standardized evidence-based protocols are missing,hence optimal management of hepatic metastases should be single patient tailored and decided by a multidisciplinary team.This article reviews the outcomes of resection,systemic and loco-regional therapies of liver metastases originating from large bowel cancer. | Giammaria Fiorentini Donatella Sarti Camillo Aliberti Riccardo Carandina Andrea Mambrini Stefano Guadagni | 2017 | World Journal of Clinical Oncology2017，8，3： | 4 |
| 7 | Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome显示文摘 | Giovanni Barbara Vincenzo Stanghellini Roberto De Giorgio Cesare Cremon Graeme S. Cottrell Donatella Santini Gianandrea Pasquinelli Antonio M. Morselli-Labate Eileen F. Grady Nigel W. Bunnett Stephen M. Collins Roberto Corinaldesi | 2004 | Gastroenterology2004，，3： | 3 |
| 8 | Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes显示文摘Background:The 2014 Ebola epidemic in West Africa has attracted public interest worldwide,leading to millions of Ebola-related Internet searches being performed during the period of the epidemic.This study aimed to evaluate and interpret Google search queries for terms related to the Ebola outbreak both at the global level and in all countries where primary cases of Ebola occurred.The study also endeavoured to look at the correlation between the number of overall and weekly web searches and the number of overall and weekly new cases of Ebola.Methods:Google Trends(GT)was used to explore Internet activity related to Ebola.The study period was from 29 December 2013 to 14 June 2015.Pearson’s correlation was performed to correlate Ebola-related relative search volumes(RSVs)with the number of weekly and overall Ebola cases.Multivariate regression was performed using Ebola-related RSV as a dependent variable,and the overall number of Ebola cases and the Human Development Index were used as predictor variables.Results:The greatest RSV was registered in the three West African countries mainly affected by the Ebola epidemic.The queries varied in the different countries.Both quantitative and qualitative differences between the affected African countries and other Western countries with primary cases were noted,in relation to the different flux volumes and different time courses.In the affected African countries,web query search volumes were mostly concentrated in the capital areas.However,in Western countries,web queries were uniformly distributed over the national territory.In terms of the three countries mainly affected by the Ebola epidemic,the correlation between the number of new weekly cases of Ebola and the weekly GT index varied from weak to moderate.The correlation between the number of Ebola cases registered in all countries during the study period and the GT index was very high.Conclusion:Google Trends showed a coarse-grained nature,strongly correlating with global epidemiological data,but was weaker at country level,as it was prone to distortions induced by unbalanced media coverage and the digital divide.Global and local health agencies could usefully exploit GT data to identify disease-related information needs and plan proper communication strategies,particularly in the case of health-threatening events. | Cristiano Alicino Nicola Luigi Bragazzi Valeria Faccio Daniela Amicizia Donatella Panatto Roberto Gasparini Giancarlo Icardi Andrea Orsi | 2015 | Infectious Diseases of Poverty2015，4，1： | 3 |
| 9 | Partially hydrolyzed guar gum in pediatric functional abdominal pain显示文摘AIM:To assess the effects of partially hydrolyzed guar gum(PHGG) diet supplement in pediatric chronic abdominal pain(CAP) and irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in sixty children(8-16 years) with functional bowel disorders,such as CAP or IBS,diagnosed according to Rome Ⅲ criteria.All patients underwent ultrasound,blood and stool examinations to rule out any organic disease.Patients were allocated to receive PHGG at dosage of 5 g/d(n = 30) or placebo(fruitjuice n = 30) for 4 wk.The evaluation of the efficacy of fiber supplement included IBS symptom severity score(Birmingham IBS Questionnaire),severity of abdominal pain(Wong-Baker Face Pain Rating Score) and bowel habit(Bristol Stool Scale).Symptom scores were completed at 2,4,and 8 wk.The change from baseline in the symptom severity scale at the end of treatment and at 4 wk follow-up after treatment was the primary endpoint.The secondary endpoint was to evaluate compliance to supplementation with the PHGG in the pediatric population.Differences within groups during the treatment period and follow-up were evaluated by the Wilcoxon signed-rank test.RESULTS:The results of the study were assessed considering some variables,such as frequency and intensity of symptoms with modifications of the bowel habit.Both groups were balanced for baseline characteristics and all patients completed the study.Group A(PHGG group) presented a higher level of efficacy compared to group B(control group),(43% vs 5%,P = 0.025) in reducing clinical symptoms with modification of Birmingham IBS score(median 0 ± 1 vs 4 ± 1,P = 0.025),in intensity of CAP assessed with the Wong-Baker Face Pain Rating Score and in normalization of bowel habit evaluated with the Bristol Stool Scale(40% vs 13.3%,P = 0.025).In IBS subgroups,statistical analysis shown a tendency toward normalization of bowel movements,but there was no difference in the prevalence of improvement in two bowel habit subsets.PHGG was therefore better tolerated without any adverse effects.CONCLUSION:Although the cause of pediatric functional gastrointestinal disorders is not known,the results show that complementary therapy with PHGG may have beneficial effects on symptom control. | Claudio Romano Donatella Comito Annalisa Famiani Sabrina Calamarà Italia Loddo | 2013 | World Journal of Gastroenterology2013，19，2： | 3 |
| 10 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 11 | State of the art biological therapies in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma(PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib(a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is the only schedule with a biological agent approved for advanced pancreatic cancer, but it has resulted in a very modest survival benefit in unselected patients. In our work, we report a summary of the main clinical trials(closed and ongoing) that refer to biological therapy evaluation in pancreatic cancer treatment. | mariacristina di marco elisa grassi sandra durante silvia vecchiarelli andrea palloni marina macchini riccardo casadei claudio ricci riccardo panzacchi donatella santini guido biasco | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 3 |
| 12 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 13 | 中国和印度的结构变化与经济发展显示文摘文章对1978年以来中国经济和1992年以来印度经济的快速增长做一比较,认为两国经济的发展模式和结构变化明显不同,但都利用了'经济相对落后'的优势和'福特增长模式'的一些因素。中国从20世纪80年代开始进行经济改革,国内市场发展迅猛,90年代中期以后工业产品迅速打入国际市场,因此推动了经济结构上预期的深入转变。然而,中国大部分中高科技产品的出口得益于合资企业。虽然近几年印度在软件、钢铁、汽车和药品等领域正在增加世界市场上的占有率,但是其经济结构的转变较为平稳,进入国际市场的速度较为缓慢。印度拥有众多的小型企业和规模庞大的非正规经济部门,因此相对于中国而言,从规模经济和'福特增长模式'的第三次浪潮中收益较小。不过由于近期经济增长过快,两国都出现一些负外部性,尤其在中国,表现为收入差距扩大、环境污染、城市拥挤。 | Vittorio Valli(著) Donatella Saccone(著) 于晓言(译) | 2011 | 经济资料译丛2011，，4： | 2 |
| 14 | Undernutrition, risk of malnutrition and obesity in gastroenterological patients: A multicenter study显示文摘AIM: To investigate the prevalence of undernutrition, risk of malnutrition and obesity in the Italian gastroenterological population. METHODS: The Italian Hospital Gastroenterology Association conducted an observational, cross-sectional multicenter study. Weight, weight loss, and body mass index were evaluated. Undernutrition was defined as unintentional weight loss > 10% in the last threesix months. Values of Malnutrition Universal Screening Tool(MUST) > 2, NRS-2002 > 3, and Mini Nutritional Assessment(MNA) from 17 to 25 identified risk of malnutrition in outpatients, inpatients and elderly patients, respectively. A body mass index ≥ 30 indicated obesity. Gastrointestinal pathologies were categorized into acute, chronic and neoplastic diseases. RESULTS: A total of 513 patients participated in the study. The prevalence of undernutrition was 4.6% in outpatients and 19.6% in inpatients. Moreover, undernutrition was present in 4.3% of the gastrointestinal patients with chronic disease, 11.0% of those with acute disease, and 17.6% of those with cancer. The risk of malnutrition increased progressively and significantly in chronic, acute and neoplastic gastrointestinal diseases in inpatients and the elderly population. Logistical regression analysis confirmed that cancer was a risk factor for undernutrition(OR = 2.7; 95%CI: 1.2-6.44, P = 0.02). Obesity and overweight were more frequent in outpatients. CONCLUSION: More than 63% of outpatients and 80% of inpatients in gastroenterological centers suffered from significant changes in body composition and required specific nutritional competence and treatment. | Massimiliano Rizzi Silvia Mazzuoli Nunzia Regano Rosa Inguaggiato Margherita Bianco Gioacchino Leandro Elisabetta Bugianesi Donatella Noè Nicoletta Orzes Paolo Pallini Maria Letizia Petroni Gianni Testino Francesco William Guglielmi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 2 |
| 15 | Management of chronic hepatitis B in children: An unresolved issue显示文摘 | Claudia Della Corte Valerio Nobili Donatella Comparcola Francesca Cainelli Sandro Vento | 2014 | J Gastroenterol Hepatol2014，，5： | 2 |
| 16 | 针刺和聚焦冲击波疗法对肩袖肌腱病的止痛作用:一项回顾性临床研究显示文摘Objective:The purpose of the study is to evaluate whether the clinical effects of focused extracorporeal shockwave therapy(f-ESWT)and acupuncture anticipate the clinical response in patients with rotator cuff tendinopathy in the short term.Design:An observational retrospective clinical study.Setting/Location:Physical Medicine and Rehabilitation Unit,Sant’Andrea University Hospital in Rome,Italy.Subjects/Interventions:We analyzed retrospectively thirty patients(22 females and 8 males)with rotator cuff tendinopathy.Fifteen patients underwent f-ESWT and acupuncture combined therapy(Group A)and fifteen patients underwent only f-ESWT therapy(Group B).Outcome measures:The outcome measures were the Visual Analogic Scale(VAS),Assessment Shoulder and Elbow Scale(ASES)and Roles and Maudsley Score(RMS).The follow-ups were T0(pre-treatment),T1(3 weeks after the start of the treatment),and T2(at 8 weeks).In order to compare groups,the ANOVA and Friedman tests were adopted.Group A patients had a more rapid and statistically significant improvement trend in VAS(P<0.001),ASES scale(P<0.001),and a higher level of satisfaction to treatment assessed by RMS(P<0.001)than group B in the short term.Conclusions:The study showed that combined treatment decreases the recovery time of the shoulder involved in terms of pain and motor function in the short term.However,these results shall be confirmed by controlled randomized studies. | Enrico Bruno Diana Lalli Riccardo Vallorani Enrica Armienti Maria Chiara Vulpiani Mario Vetrano Donatella Trischitt Sveva Maria Nusca Flavia Santoboni | 2020 | World Journal of Acupuncture-Moxibustion2020，30，3： | 2 |
| 17 | Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors显示文摘 | Daniela C. Kroy Donatella Ciuffreda Jennifer H. Cooperrider Michelle Tomlinson Garrett D. Hauck Jasneet Aneja Christoph Berger David Wolski Mary Carrington E. John Wherry Raymond T. Chung Kenneth K. Tanabe Nahel Elias Gordon J. Freeman Rosemarie H. de Kru | 2014 | Gastroenterology2014，，2： | 2 |
| 18 | Isolated limb infusion chemotherapy with or without hemofiltration for recurrent limb melanoma显示文摘AIM: To better define the efficacy and the safety of intra-arterial infusion performed with or without hemofiltration for recurrent limb melanoma. METHODS: Patients with the following characteristics were included in the study: recurrent limb melanoma not indicated for surgical resection, measurable disease in the extremity, > 18 years, performances status(Eastern Cooperative Oncology Group) was 0-1 and life expectancy of at least 6 mo. Twenty nine consecutive patients were enrolled in the study. Patients underwent fluoroscopic placement of angiographic arterial and venous catheters to infuse the drug in the artery [isolated limb infusion(ILI)], and to stop the out flow(venous). Melphalan was rapidly infused into the isolated limb via the arterial catheter after the inflation of venous balloon catheter. Then the circulation of the limb was completely blocked with a pneumatic cuff at the root of the limb. Haemofiltration(HF) was available only in the main center, and was performed with an extracorporeal perfusion system, in order to reduce high systemic toxic peaks of drug.RESULTS: Thirty seven ILI were done in 29 cases(31 ILI-HF and 6 ILI) between 2001 and 2014 at Ancona and Pesaro Hospitals, Italy. Clinical outcomes were monitored 30 d after treatment. Eleven patients(38%) received infusion of melphalan alone, 7(24%) melphalan associated to mitomicin C and 7(24%) melphalan associated to cisplatin, the remaining 4 were treated with cisplatin, melphalan and epirubicin or cisplatin and mitomicin C. The overall response rate was 66%, in particular, 3 patients(10%) were complete responders and 16(56%) were partial responders; whereas 7 patients(24%) had stable disease, and 3(10%) showed progressive disease. Limb toxicity was assessed adopting Wieberdink scale, with evidence of 90% of low grade(I and II) toxicity.CONCLUSION: ILI-HF and ILI are effective and safe treatments for recurrent non-resectable limb melanoma. They present evidence of favorable clinical benefit and is effective in delaying progression. | Sara Cecchini Donatella Sarti Stefano Ricci Ludovico Delle Vergini Manuela Sallei Stefano Serresi Giuseppe Ricotti Luca Mulazzani Fabrizia Lattanzio Giammaria Fiorentini | 2015 | World Journal of Clinical Oncology2015，6，4： | 2 |
| 19 | Narrow band imaging combined with water immersion technique in the diagnosis of celiac disease显示文摘 | Francesco Valitutti Salvatore Oliva Donatella Iorfida Marina Aloi Silvia Gatti Chiara Maria Trovato Monica Montuori Antonio Tiberti Salvatore Cucchiara Giovanni Di Nardo | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 20 | Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa显示文摘精力为精子要求当 glycolysis 似乎是为沿着鞭子的 ATP 传播的重要来源时,活动性被氧化 phosphorylation 生产,这被建议了。一些研究调查了酶 glyceraldehyde 3 磷酸盐脱氢酶的化学、运动的性质在 glycolysis 和精子活动性的规定识别任何变化。相反,有很少研究,分析 hypokinesis 的基因基础。为这个原因,我们在人的精子调查了 glyceraldehyde 3 磷酸盐脱氢酶基因评估 asthenozoospermia 是否在它的表示与任何变化被相关。精液检查和 glyceraldehyde 3 磷酸盐脱氢酶基因表示研究在划分成二个组的 116 件精液样品上被执行 - 组 A 由 58 件 normokinetic 样品和 58 件运动减退的样品的组 B 组成了。全部的 RNA 从精子被提取,并且 mRNA 的即时 PCR quantification 用特定的教材和探针被执行。为组 A 和 B 的表示侧面是很类似的。吝啬的三角洲 Ct 如下 - 组 A, 5. | Donatella Paoli Marianna Pelloni Mariagrazia Gallo Giulia Coltrinari Francesco Lombardo Andrea Lenzi Loredana Gandini | 2017 | Asian Journal of Andrology2017，19，4： | 2 |
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