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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Microstructure and adherence of cobalt containing and cobalt free enamels to low carbon steel 显示文摘 | Samiee L Sarpoolaky H Mirhabibi A | 2006 | Materials Science and Engineering2006，10，12： | 1 |
| 3 | The role of CK7, Ki‐67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates显示文摘 | HAYAM ABDEL SAMIE AIAD MONA ABDEL HALIM KANDIL REHAB MONIR SAMAKA MERVAT MAHMOUD SULTAN MOHAMED TAWFIK BADR GAMMAL ELDIN MAHMOUD NADA | 2012 | APMIS2012，，7： | 1 |
| 4 | Laparoscopic transcystic bile duct exploration: the treatment of first choice for common bile duct stones显示文摘 | Faisal Hanif Zubir Ahmed M. Abdel Samie Ahmad H. M. Nassar | 2010 | Surgical Endoscopy2010，，7： | 1 |
| 5 | Transdermal delivery of anti- sense oligonucleotides with microprojection patch (Macroflux) technology显示文摘 | Lin W Cormier M Samiee A | 2001 | Pharm Res2001，18，12： | 1 |
| 6 | Akutes H?moperitoneum bei einer spontanen Tumorruptur als Erstmanifestation eines hepatozellul?ren Karzinoms显示文摘 | A Abdel Samie G Otto L Theilmann | 2007 | Z Gastroenterol2007，，07： | 1 |
| 7 | Cross-cultural research in advertising:Assessment methodologies显示文摘 | Samiee S Jeong I | | 0，，22： | 1 |
| 8 | Advancing the Country Image Construct-a Commentary Essay 显示文摘 | Samiee S | 2010 | Journal of Business Research2010，63，： | 1 |
| 9 | Transdermal delivery of antisense oligonucleotides with microprojection patch(Macroflux) technology显示文摘 | Lin WQ Cormier M Samiee A | 2001 | Pharm Res2001，18，12： | 1 |
| 10 | Endometrial ablation with the NovaSure system in Iran 显示文摘 | Asgari Z Moini A Samiee H | 2011 | Int J Gynaecol Obstet2011，114，1： | 1 |
| 11 | Influence of Solution Treatment on Precipitation Behavior of a Ni-Co Alloy 显示文摘 | Samiee M Asgari S | 2007 | Scripta Materialia2007，57，2： | 1 |
| 12 | The Internationalization of Services:Trends,Obstacles and Issues显示文摘 | Saeed Samiee | 1999 | Journal of services marketing1999，13，45： | 1 |
| 13 | Influence of source of fat and supplementation of the diet with vitamin E and C on performance and egg quality of laying hens from forty four to fifty six weeks of age显示文摘 | H. Irandoust A.H. Samie H.R. Rahmani M.A. Edriss G.G. Mateos | 2012 | Animal Feed Science and Technology . 2012 (1-2)2012，，1： | 1 |
| 14 | Retailing and Channel Considerations in Developing Countries : A Review and Research Propositions 显示文摘 | Samiee S | 1993 | Journal of Business Research1993，27，12： | 1 |
| 15 | Endometrial ablation with the Nova Sure system in Iran显示文摘 | Asgari Z Moini A Samiee H | 2011 | Int J Gynaecol Obstet2011，114，1： | 1 |
| 16 | Prognostic relevance of CD56 expression in multiple myeloma: A study including 107 cases treated with high-dose melphalan-based chemotherapy and autologous stem cell transplant显示文摘 | Hong Chang Sara Samiee Qi Long Yi | 2006 | Leukemia & Lymphoma2006，，1： | 1 |
| 17 | Endometrial ablation with theN ovasure system in Iran显示文摘 | Asgari Z Moini A Samiee H | 2011 | Int J Gynaecol Obstet2011，114，1： | 1 |
| 18 | Tranadermal delivery of antisense oligonucleotides with microprojection pateh(Macroflux) technology显示文摘 | Cormier M Samiee A | 2001 | Pharm Res2001，18，12： | 1 |
| 19 | Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux)tectmology显示文摘 | LIN W CORMIER M SAMIEE A | 2001 | Pharm Res2001，18，17： | 1 |
| 20 | The Influence of Global Marketing Standardization on Performance显示文摘 | Samiee S Roth K | 1992 | Journal of Marketing1992，56，2： | 1 |
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