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| 1 | 胰腺导管腺癌放射学报告模板:腹部放射协会和美国胰腺协会的共识声明显示文摘胰腺导管腺癌(PDA)是一种具有侵袭性、死亡率高的恶性肿瘤。在肿瘤分期时,通过影像学分析,合理判定肿瘤的范围,是患者治疗措施中最重要的步骤之一。考虑到不同医生在专业知识水平和疾病严重程度的判定有所差异,以及在放射学检查时经常缺乏相关影像学表现的完整报道,有必要采用标准化的影像学报告模板以及大家一致接受和认可的胰腺实性肿瘤术语。在腹部放射协会和美国胰腺协会的共同资助下,胰腺导管腺癌(PDA)多机构专家组(包括放射学专家、胃肠病学和肝胆胰外科学专家)共同发起了一份描述标准化报告模板的共识声明。采用这种标准化的影像学报告模板将能改进PDA患者的治疗决策过程,并可通过提供一份完整、相关、精准的疾病分期报告以优化治疗方案。通过对可行手术切除的患者恰当、一致的分期,标准化报告模板有助于促进临床和科研实验设计,从而实现在不同机构之间的实验结果的比较。 | Mahmoud M.Al-Hawary Isaac R.Francis Suresh T.Chari Elliot K.Fishman David M.Hough David S.Lu Michael Macari Alec J.Megibow Frank H.Miller Dushyant V.Sahani Diane M.Simeone 黄翔 孙灿辉 | 2014 | 影像诊断与介入放射学2014，23，4： | 52 |
| 2 | Real-Time Distributed Fiber Optic Sensor for Security Systems: Performance, Event Classification and Nuisance Mitigation显示文摘任何周界侵入察觉系统的成功取决于三个重要性能参数:察觉(邮政部门) 的概率,讨厌的东西警报率(NAR ) ,和虚惊评价(远) 。最基本的参数,邮政部门,通常与象利息,传感器的敏感,系统的安装质量,和察觉到的设备的可靠性的事件那样的很多个因素有关。没有在纤维的降级的敏感的讨厌的东西闹钟的抑制眼的侵入察觉系统对维持可接受的性能关键。维持邮政部门并且消除讨厌的东西闹钟的信号处理算法为完成这是关键的。在这份报纸,使用的一个柔韧的事件分类系统和十字路口(LC ) 基于的水平监督了神经网络特征抽取算法在一个基于篱笆的光纤的侵入察觉系统为侵入和不闯入事件的察觉和识别被介绍。A 水平十字路口算法也与动态阀值被使用在一个篱笆系统压制奔流的导致雨的讨厌的东西闹钟。结果证明导致雨的讨厌的东西闹钟能与侵入事件的同时的察觉超过 100 mm/hr 为降雨率被压制。穿过基于的察觉和新奇分类算法的水平的使用也为埋葬的管道纤维被介绍为讨厌的东西事件的抑制和侵入事件的辨别的眼的侵入察觉系统。为系统的两种类型采用的传感器是分布式的双向光纤的 Mach-Zehnder (MZ ) 干涉仪。 | Seedahmed S. MAHMOUD Yuvaraja VISAGATHILAGAR Jim KATSIFOLIS | 2012 | Photonic Sensors2012，2，3： | 36 |
| 3 | Nano-microbubble flotation of fine and ultrafine chalcopyrite particles显示文摘As is well known to mineral processing scientists and engineers, fine and ultrafine particles are difficult to float mainly due to the low bubble-particle collision efficiencies. Though many efforts have been made to improve flotation performance of fine and ultrafine particles, there is still much more to be done. In this paper, the effects of nano-microbubbles(nanobubbles and microbubbles) on the flotation of fine( 38 + 14.36 lm) and ultrafine( 14.36 + 5 lm) chalcopyrite particles were investigated in a laboratory scale Denver flotation cell. Nano-microbubbles were generated using a specially-designed nanomicrobubble generator based on the cavitation phenomenon in Venturi tubes. In order to better understand the mechanisms of nano-microbubble enhanced froth flotation of fine and ultrafine chalcopyrite particles, the nano-microbubble size distribution, stability and the effect of frother concentration on nanobubble size were also studied by a laser diffraction method. Comparative flotation tests were performed in the presence and absence of nano-microbubbles to evaluate their impact on the fine and ultrafine chalcopyrite particle flotation recovery. According to the results, the mean size of nano-microbubbles increased over time, and decreased with increase of frother concentration. The laboratory-scale flotation test results indicated that flotation recovery of chalcopyrite fine and ultrafine particles increased by approximately 16–21% in the presence of nano-microbubbles, depending on operating conditions of the process. The presence of nano-microbubbles increased the recovery of ultrafine particles( 14.36 + 5 lm) more than that of fine particles( 38 + 14.36 lm). Another major advantage is that the use of nano-microbubbles reduced the collector and frother consumptions by up to 75% and 50%,respectively. | Ahmadi Rahman Khodadadi Darban Ahmad Abdollahy Mahmoud Fan Maoming | 2014 | International Journal of Mining Science and Technology2014，24，4： | 28 |
| 4 | Regulation of spermatogenesis by paracrine/autocrine testicular factors显示文摘Spermatogenesis is a complex process regulated by endocrine and testicular paracrine/autocrine factors.Gonadotropins are involved in the regulation of several testicular paracrine factors, mainly of the IL-1 family and testicular hormones. Testicular cytokines and growth factors (such as IL-1, IL-6, TNF, IFN-T, LIF and SCF) were shown to affect both the germ cell proliferation and the Leydig and Sertoli cells functions and secretion. Cytokines and growth factors are produced by immune cells and in the interstitial and seminiferous tubular compartments by various testicular cells, including Sertoli, Leydig, peritubular cells, spermatogonia, differentiated spermatogonia and even spermatozoa. Corresponding cytokine and growth factor receptors were demonstrated on some of the testicular cells. These cytokines also control the secretion of the gonadotropins and testosterone in the testis. Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis. Thus,the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility. (Asian J Androl 2004 Sep; 6: 259-268) | Mahmoud Huleihel Eitan Lunenfeld | 2004 | Asian Journal of Andrology2004，6，3： | 22 |
| 5 | Molecular identification of hepatitis B virus genotypes/subgenotypes:Revised classification hurdles and updated resolutions显示文摘The clinical course of infections with the hepatitis B virus(HBV)substantially varies between individuals,as a consequence of a complex interplay between viral,host,environmental and other factors.Due to the high genetic variability of HBV,the virus can be categorized into different HBV genotypes and subgenotypes,which considerably differ with respect to geographical distribution,transmission routes,disease progression,responses to antiviral therapy or vaccination,and clinical outcome measures such as cirrhosis or hepatocellular carcinoma.However,HBV(sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods.Thus,an accurate,holistic and dynamic classification system is essential.In this review article,we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification.Analyzing fulllength genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system.Careful attention must be paid to all aspects of phylogenetic analysis,such as bootstrapping values and meeting the necessary thresholds for(sub)genotyping.Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel.As many of these strains were misclassified due to genetic differences resulting from recombination,we propose the term'recombino-subgenotype'.Moreover,immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV(sub)genotypes.We therefore suggest the term'immigro-subgenotype'to distinguish exotic(sub)genotypes from native ones.We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis,diagnosis and treatment. | Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Fuat Kurbanov Marc Van Ranst Frank Tacke | 2014 | World Journal of Gastroenterology2014，20，23： | 20 |
| 6 | Cryopreservation of mammalian oocytes and embryos: current problems and future perspectives显示文摘Cryopreservation techniques for mammalian oocytes and embryos have rapidly progressed during the past two decades,emphasizing their importance in various assisted reproductive technologies.Pregnancies and live births resulting from cryopreserved oocytes and embryos of several species including humans have provided proof of principle and led to the adoption of cryopreservation as an integral part of clinical in vitro fertilization.Considerable progress has been achieved in the development and application of the cryopreservation of mammalian oocytes and embryos,including preservation of the reproductive potential of patients who may become infertile,establishment of cryopreserved oocyte banks,and transport of oocytes and embryos internationally.However,the success rates are still far lower than those obtained with fresh oocytes and embryos,and there are still obstacles that need to be overcome.In this review,we address the major obstacles in the development of effective cryopreservation techniques.Such knowledge may help to eliminate these hurdles by revealing which aspects need improvement.Furthermore,this information may encourage further research by cryobiologists and increase the practical use of cryopreservation as a major part of assisted reproductive technologies for both humans and animal species. | MOUSSA Mahmoud SHU Juan ZHANG XueHong ZENG FanYi | 2014 | Science China(Life Sciences)2014，57，9： | 18 |
| 7 | 湿润烧伤膏治疗慢性糖尿病足溃疡的多中心对照研究显示文摘目的 通过多中心的对照研究,观察、评估湿润烧伤膏(MEBO) 治疗慢性糖尿病足溃疡的疗效及安全性.方法 对2005年1月至2010年1月间,中国和科威特的5个中心治疗的并符合入选标准的128例慢性糖尿病患者(160处溃疡),随机分为MEBO组(实验组,66例,共82处溃疡) 和生理盐水湿润敷料组(对照组,62例患者,共78处溃疡).前瞻性收集患者的人口统计学数据、患者特征以及溃疡创面特点等数据.研究的前12周,每隔2周计算、对比一次患者的溃疡表面积和愈合指数,24周时记录截肢和溃疡发展的情况.结果 两组患者的人口学特征,临床及溃疡特点相似.MEBO组患者在第2周和第3周时分别呈现出愈合指数的明显升高和溃疡表面积的明显下降,这种趋势连续保持了12周(P<0 01).在治疗12周时MEBO组一半以上的溃疡(53 7%)实现了完全愈合(愈合指数=1),与对照组在治疗12周时的25 66%的愈合率相比有非常显著性差异(P=0 0006);治疗12周时,对照组28 2%的患者愈合指数<0 5,而MEBO组无1例患者发生此状况(P=0 0001).治疗24周后,13例患者(10 2%) 因组织坏死行足前段截肢术,其中只有2例患者来自MEBO组(χ2=4 44,P=0 035).此外,每组各有2例患者在治疗24周后出现了新溃疡(P>0 05).实验过程中未见局部用药引发的任何副作用或过敏反应.结论 1)除了具备安全性以外,MEBO在开始治疗2周后就显著提高了各种溃疡的愈合指数,治疗4周后溃疡表面积开始明显缩小,12周时超过50%的溃疡完全愈合,大大缩短了慢性糖尿病足溃疡的愈合过程;2)MEBO组患者治疗24周后的截肢率明显下降. | Mahmoud F.Sakr Hossam M.Hamed 陈永翀 李桂茹 张勇 | 2012 | 中国烧伤创疡杂志2012，24，2： | 16 |
| 8 | Semi-hot Stamping as an Improved Process of Hot Stamping显示文摘Reducing the forming load,deletion of springback,increasing the formability of sheets as well as producing high strength parts are the main reasons to apply hot stamping process.Hot stamping process and 22MnB5 steels are the state of the art process and grades,respectively;however novel processes and steel grades are under considerations.In the current research,behavior of the steel grade MSW1200 blanks under semi and fully hot stamping processes was characterized.During semi-hot stamping process,the blank was firstly heated to a temperature of about 650℃ and then formed and quenched in the die assembly,simultaneously.Microstructure and mechanical properties of semi and fully hot stamped blanks were studied and the results were compared with those of normally water/air quenched blanks.The hot stamped blanks attained the strength values as high as water quenched blanks.The highest ductility and consequently,the best formability were achieved for the blank which had been semi-hot stamped.It was concluded that for the mentioned steel,semi-hot stamping process could be considered as an improved thermo-mechanical process which not only guaranteed a high formability,but also led to ultra high strength values. | Malek Naderi Mostafa Ketabchi Mahmoud Abbasi Wolfgang Bleck | 2011 | Journal of Materials Science & Technology2011，27，4： | 15 |
| 9 | 分层装药爆破间隔填塞长度优化研究显示文摘分层装药爆破在工程中应用广泛,其具有良好的爆破减振和提高孔口堵塞段破碎等效果。但是在实践中,合理的中间填塞长度选择一直缺乏依据。通过有限元软件LSDYNA对90 mm孔径6 m深的炮孔分别建立中间填塞段长度为25~105 cm的五个模型,上、下药包装药量固定,耦合装药,以爆破损伤以及单元所受最大拉应力两个指标来分析填塞段长度对分层爆破效果的影响。结果表明:中间填塞长度过短,能量集中作用于中间段,会导致岩石过于粉碎;中间填塞长度的增加,孔口堵塞段岩体破碎效果也随之改善,填塞长度105 cm和25 cm相比,地表处单元所受最大拉应力增加了约1倍,但中间段破碎效果弱化;当中间填塞段长度为85 cm时,中间填塞段岩体和上部岩体均有较好的破碎效果;通过振动分析,中间填塞长度变化对离炮孔较远区域爆破振动的影响较小。基于数值模拟结果的工程试验表明,最佳中间填塞段长度为85~95 cm,较数值模拟结果稍大。 | 叶海旺 汪柳俊 冉成 宁卫星 雷涛 房泽法 TAWUM Juvert Mabh SIDI Mohamed Mahmoud 龙梅 | 2017 | 爆破2017，34，2： | 15 |
| 10 | Differentiation of murine male germ cells to spermatozoa n a soft agar culture system显示文摘建立一在里面允许阴囊的细菌房间的发展到精子的 vitro 系统将为男不孕为精子发生和未来治疗的研究是珍贵的。在现在的学习,我们用三维的琼脂文化系统(囊) 处于 vitro 文化条件发展了,它有能力导致阴囊的细菌房间到达精子发生的最后的阶段,包括精子产生。从 7-day-old 老鼠的睾丸的生精的小管酶地被分裂,并且 intratubular 房间在在与胎儿的小牛浆液(FCS ) 补充的 RPMI 媒介的 SACS 的上面的层是有教养的。SACS 的更低的层包含了与 FCS 补充的仅仅 RPMI 媒介。在上面的层的殖民地在文化的 14 和 28 天以后被孤立并且根据他们的尺寸被分类。Immunofluorescence 和即时 PCR 被用来分析在无差别、区分的 spermatogonia 表示的特定的标记(Vasa, Dazl, OCT-4, C 工具包, GFR-α -1, CD9 和 α -6-integrin), meiotic 房间(LDH, Crem-1 和议会) 和 post-meiotic 房间(Protamine-1,精子酵素和 SP-10 ) 。我们的结果表明导致老鼠是可能的阴囊的 pre-meiotic 细菌房间扩大并且在囊导致他们的区别到精子。精子显示出正常形态学并且包含了 acrosomes。因此,我们的结果证明囊能为 pre-meiotic 鼠标细菌房间的成熟在 vitro 系统被用作一篇小说到 post-meiotic 阶段和词法上正常的精子。 | Mahmoud Abu Elhija Eitan Lunenfeld Stefan Schlatt Mahmoud Huleihel | 2012 | Asian Journal of Andrology2012，14，2： | 14 |
| 11 | Multi-modality imaging review of congenital abnormalities of kidney and upper urinary tract显示文摘Congenital abnormalities of the kidney and urinary tract(CAKUT) include a wide range of abnormalities ranging from asymptomatic ectopic kidneys to life threatening renal agenesis(bilateral). Many of them are detected in the antenatal or immediate postnatal with a significant proportion identified in the adult population with varying degree of severity. CAKUT can be classified on embryological basis in to abnormalities in the renal parenchymal development, aberrant embryonic migration and abnormalities of the collecting system. Renal parenchymal abnormalities include multi cystic dysplastic kidneys, renal hypoplasia, number(agenesis or supernumerary), shape and cystic renal diseases. Aberrant embryonic migration encompasses abnormal location and fusion anomalies. Collecting system abnormalities include duplex kidneys and Pelvi ureteric junction obstruction. Ultrasonography(US) is typically the first imaging performed as it is easily available, noninvasive and radiation free used both antenatally and postnatally. Computed tomography(CT) and magnetic resonance imaging(MRI) are useful to confirm the ultrasound detected abnormality, detection of complex malformations, demonstration of collecting system and vascular anatomy and more importantly for early detection of complications like renal calculi, infection and malignancies. As CAKUT are one of the leading causes of end stage renal disease, it is important for the radiologists to be familiar with the varying imaging appearances of CAKUT on US, CT and MRI, thereby helping in prompt diagnosis and optimal management. | Subramaniyan Ramanathan Devendra Kumar Maneesh Khanna Mahmoud Al Heidous Adnan Sheikh Vivek Virmani Yegu Palaniappan | 2016 | World Journal of Radiology2016，8，2： | 13 |
| 12 | Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases. | Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 13 | Clinicopathological features and surgical outcome of patients with fibrolamellar hepatocellular carcinoma(experience with 22 patients over a 15-year period)显示文摘AIM To evaluate the clinicopathological features and the surgical outcomes of patients with fibrolamellar hepato-cellular carcinoma(FL-HCC)over a 15-year period. METHODS This is a retrospective study including 22 patients with a pathologic diagnosis of FL-HCC who underwent hepatectomy over a 15-year period. Tumor characteristics,survival and recurrence were evaluated. RESULTS There were 11 male and 11 female with a median age of 29 years(range from 21 to 58 years). Two(9%)patients had hepatitis C viral infection and only 2(9%)patients had alpha-fetoprotein level > 200 ng/m L. The median size of the tumors was 12 cm(range from 5-20 cm). Vascular invasion was detected in 5(23%)patients. Four(18%)patients had lymph node metastases. The median follow up period was 42 mo and the 5-year survival was 65%. Five(23%)patients had a recurrent disease,4 of them had a second surgery with 36 mo median time interval. Vascular invasion is the only significant negative prognostic factor CONCLUSION FL-HCC has a favorable prognosis than common HCC and should be suspected in young patients with non cirrhotic liver. Aggressive surgical resection should be done for all patients. Repeated hepatectomy should be considered for these patients as it has a relatively indolent course. | Mohamed Abdel Wahab Ehab El Hanafy Ayman El Nakeeb Mahmoud Abdelwahab Ali | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 12 |
| 14 | Recombinase polymerase amplification as a promising tool in hepatitis C virus diagnosis显示文摘Hepatitis C virus(HCV)infection represents a significant health problem and represents a heavy load on some countries like Egypt in which about 20%of the total population are infected.Initial infection is usually asymptomatic and result in chronic hepatitis that give rise to complications including cirrhosis and hepatocellular carcinoma.The management of HCV infection should not only be focus on therapy,but also to screen carrier individuals in order to prevent transmission.In the present,molecular detection and quantification of HCV genome by real time polymerase chain reaction(PCR)represent the gold standard in HCV diagnosis and plays a crucial role in the management of therapeutic regimens.However,real time PCR is a complicated approach and of limited distribution.On the other hand,isothermal DNA amplification techniques have been developed and offer molecular diagnosis of infectious dieses at point-of-care.In this review we discuss recombinase polymerase amplification technique and illustrate its diagnostic value over both PCR and other isothermal amplification techniques. | Hosam Zaghloul Mahmoud El-shahat | 2014 | World Journal of Hepatology2014，6，12： | 12 |
| 15 | 哺乳动物卵母细胞和胚胎冷冻保存研究进展:现存问题与未来展望显示文摘在过去的几十年中,哺乳动物卵母细胞和胚胎冷冻保存技术因在辅助生殖技术及实际生产中应用广泛,其研究发展尤为迅速.多个物种(包括人)的卵母细胞和胚胎冷冻保存研究获得了受孕和活产的成功佐证,为冷冻保存技术的临床应用提供了理论依据,并成为体外受精不可缺少的环节.尽管哺乳动物卵母细胞和胚胎的冷冻保存技术的研发和应用取得了巨大进展,例如为可能不育的患者贮藏生殖潜能、卵子冻存库的建立以及卵母细胞和胚胎的跨国运输,但成功率仍达不到使用新鲜卵母细胞和胚胎的水平,还存在许多难题有待解决.本文针对低温保存技术中制约冷冻效率和成功率的主要问题进行了综述,旨在解决技术研发中遇到的瓶颈,为改进技术提供借鉴和参考,鼓励低温生物学研究者继续开展深入研究,加快推进冷冻保存技术在人类和动物辅助生殖技术中的实际应用. | MOUSSA Mahmoud 舒娟 张雪洪 曾凡一 | 2014 | 中国科学:生命科学2014，44，7： | 12 |
| 16 | Development of an intelligent system based on ANFIS for predicting wheat grain yield on the basis of energy inputs显示文摘Energy is regarded as one of the most important elements in agricultural sector.During the last decades energy consumption in agriculture has increased,so finding the relationship between energy consumption and crop yields in agricultural production can help to achieve sustainable agriculture.In this study several adaptive neuro-fuzzy inference system(ANFIS)models were evaluated to predict wheat grain yield on the basis of energy inputs.Moreover,artificial neural networks(ANNs)were developed and the obtained results were compared with ANFIS models.For the best ANFIS structure gained in this study,R,RMSE and MAPE were calculated as 0.976,0.046 and 0.4,respectively.The developed ANN was a multilayer perceptron(MLP)with eleven neurons in the input layer,two hidden layers with 32 and 10 neurons and one neuron(wheat grain yield)in the output layer.For the best ANN model,R,RMSE and MAPE were computed as 0.92,0.9 and 0.1,respectively.The results illustrated that ANFIS model can predict the yield more precisely than ANN. | Benyamin Khoshnevisan Shahin Rafiee Mahmoud Omid Hossein Mousazadeh | 2014 | Information Processing in Agriculture2014，1，1： | 12 |
| 17 | CDX2 as a marker for intestinal differentiation: Its utility and limitations显示文摘CDX2 is a nuclear homeobox transcription factor that belongs to the caudalrelated family of CDX homeobox genes. The gene encoding CDX2 is a nonclustered hexapeptide located on chromosome 13q12-13. Homeobox genes play an essential role in the control of normal embryonic development. CDX2 is crucial for axial patterning of the alimentary tract during embryonic development and is involved in the processes of intestinal cell proliferation, differentiation, adhesion, and apoptosis. It is considered specif ic for enterocytes and has been used for the diagnosis of primary and metastatic colorectal adenocarcinoma. CDX2 expression has been reported to be organ specif ic and is normally expressed throughout embryonic and postnatal life within the nuclei of epithelial cells of the alimentary tract from the proximal duodenum to the distal rectum. In this review, the authors elaborate on the diagnostic utility of CDX2 in gastrointestinal tumors and other neoplasms with intestinal differentiation. Limitations with its use as the sole predictor of a gastrointestinal origin of metastatic carcinomas are also discussed. | Reda S Saad Zeina Ghorab Mahmoud A Khalifa | 2011 | World Journal of Gastrointestinal Surgery2011，3，11： | 11 |
| 18 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 19 | Review of tumoral calcinosis: A rare clinico-pathological entity显示文摘Tumoral calcinosis(TC) has long been a controversial clinico-pathological entity. Its pathogenesis and genetic background have been gradually unravelled since its first description in 1943. According to the presence or absence of an underlying calcifying disease process, TC has been divided into primary and secondary varieties. Two subtypes of the primary variety exist; a hyperphosphatemic type with familial basis represented by mutations in Gal NAc transferase 3 gene(GALNT3), KLOTHO or Fibroblast growth factor 23(FGF23) genes, and a normo-phosphatemic type with growing evidence of underlying familial base represented by mutation in SAMD9 gene. The secondary variety is mainly associated with chronic renal failure and the resulting secondary or tertiary hyperparathyroidism. Diagnosis of TC relies on typical radiographic features(on plain radiographs and computed tomography) and the biochemical profile. Magnetic resonance imaging can be done in difficult cases, and scintigraphy reflects the disease activity. Treatment is mainly surgical for the primary variety; however, a stage-oriented conservative approach using phosphate binders, phosphate restricted dietsand acetazolamide should be considered before the surgical approach is pursued due to the high rate of recurrences and complications after surgical intervention. Medical treatment is the mainstay for treatment of the secondary variety, with failure warranting subtotal or total parathyroidectomy. Surgical intervention in these patients should be kept as a last resort. | Ibrahim Fathi Mahmoud Sakr | 2014 | World Journal of Clinical Cases2014，2，9： | 11 |
| 20 | Predictors of long term survival after hepatic resection for hilar cholangiocarcinoma:A retrospective study of 5-year survivors显示文摘AIM:To determine predictors of long term survival after resection of hilar cholangiocarcinoma(HC) by comparing patients surviving > 5 years with those who survived < 5 years.METHODS:This is a retrospective study of patients with pathologically proven HC who underwent surgical resection at the Gastroenterology Surgical Center,Mansoura University,Egypt between January 2002 and April 2013.All data of the patients were collected from the medical records.patients were divided into two groups according to their survival:patients surviving less than 5 years and those who survived > 5 years.RESULTS:There were 34(14%) long term survivors(5 year survivors) among the 243 patients.Fiveyear survivors were younger at diagnosis than those surviving less than 5 years(mean age,50.47 ± 4.45 vs 54.59 ± 4.98,p = 0.001).Gender,clinical presentation,preoperative drainage,preoperative serum bilirubin,albumin and serum glutamic-pyruvic transaminase were similar between the two groups.The level of CA 19-9 was significantly higher in patients surviving < 5 years(395.71 ± 31.43 vs 254.06 ± 42.19,p = 0.0001).Univariate analysis demonstrated nine variables to be significantly associated with survival > 5 year,includingyoung age(p = 0.001),serum CA19-9(p = 0.0001),non-cirrhotic liver(p = 0.02),major hepatic resection(p = 0.001),caudate lobe resection(p = 0.006),well differentiated tumour(p = 0.03),lymph node status(0.008),R0 resection margin(p = 0.0001) and early postoperative liver cell failure(p = 0.02).CONCLUSION:Liver status,resection of caudate lobe,lymph node status,R0 resection and CA19-9 were demonstrated to be independent risk factors for long term survival. | Mohamed Abd El Wahab Ayman El Nakeeb Ehab El Hanafy Ahmad M Sultan Ahmed Elghawalby Waleed Askr Mahmoud Ali Mohamed Abd El Gawad Tarek Salah | 2016 | World Journal of Gastrointestinal Surgery2016，8，6： | 10 |
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