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| 1 | Management of tear trough deformity with and without tear trough-orbicularis retaining ligament complex release in transconjunctival blepharoplasty: a comparative study显示文摘AIM: To evaluate the effect of releasing the orbicularis retaining ligament(ORL) complex of the tear trough combined with the transconjunctival blepharoplasty in the surgical management of tear trough deformity compared with the effect of blepharoplasty alone. METHODS: A prospective, randomized(by closed envelope technique), controlled surgical trial which included 50 patients(100 eyes) with bilateral visible tear trough deformity and lower eyelid fat bulging, was divided into two groups where 25 patients(50 eyes) had tear trough-ORL release with blepharoplasty and 25 patients(50 eyes) didn't. Qualitative and quantitative assessments of tear trough deformity were done at 6 mo postoperatively, achieving grade 0 or 1 of Barton's classification was considered a success. Standardized photographic documentation of each patient was done pre and postoperatively, also assessment of the patients' satisfaction postoperatively was done and ranked as excellent, very good, good or fair. RESULTS: There was statistically significant difference between the two groups in the overall aesthetic results postoperatively regarding the qualitative and quantitative analysis of the tear trough deformity, where patients who had tear trough-ORL complex release had more successful outcomes than those of the second group. CONCLUSION: ORL release should be done in patients with tear trough deformity in order to release the tethering effect of this ligament which causes the prominence of the naso jugal groove. | Tamer Ismail Gawdat Engy Abd Eltawab Elsherif Yomna Amr Alahmadawy Yehia Salah Eldin Mostafa | 2019 | International Journal of Ophthalmology(English edition)2019，12，1： | 12 |
| 2 | Safety and efficacy of photodynamic therapy using BCECF-AM compared to mitomycin C in controlling post-operative fibrosis in a rabbit model of subscleral trabeculectomy显示文摘AIM:To evaluate the safety and efficacy of cellular photoablation using BCECF-AM[2',7'-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester mixed isomers]as a method to control postoperative fibrosis in subscleral trabeculectomy(SST) compared to mitomycin C(MMC) in a rabbit model.· METHODS:A comparative prospective case-control animal study was conducted.Fourteen rabbits were subjected to SST with intraoperative use of wound modulating agents(MMC or BCECF-AM) of the right eye(study groups Ⅰ and Ⅱ respectively) and SST without use of intraoperative wound modulating agents for the left eye(control group Ⅱ).Two rabbits 4 eyes were considered as control group Ⅰ with no surgical intervention.BCECF-AM was injected subconjunctivally30 min before surgery followed by intraoperative illumination with diffuse blue light for 10 min.Antifibrotic efficacy was established by clinical response and histological examination.Clinical response was assessed by measuring intraocular pressure(IOP) at day 1,3,5,7,14,21 postoperatively.Success was defined by >20.0%reduction in IOP from the preoperative values without anti-glaucoma medications.· RESULTS:The mean percentage of reduction was35.0%in the study group Ⅰ with only one eye(14.3%) had12.5%reduction.The mean percentage of reduction was28.0%in the study group Ⅱ with two eyes(28.6%) in study group Ⅱ had 14.2%reduction each.Regarding the control group Ⅱ,the mean percentage of reduction was14.3%with 64.3%eyes had <20.0%reduction.There was a highly statistically significant difference between each of the study groups(right eyes) and the corresponding control group Ⅱ(left eyes) as regards the mean postoperative IOP values started from day 5 in both study groups and this highly significant difference remained so till the end of the follow up period.Histologically,MMC treated blebs showed thinning of conjunctival epithelium with marked reduction of the goblet cells relative to control.Marked sub-epithelial edema was seen along with variable collagen dispersion.Mild cellularity was noted in sub-epithelial tissue.BCECF-AM treated blebs showed normal conjunctival epithelial thickness with abundant goblet cells.Mild subepithelial edema was noted along with moderate collagen dispersion.No histological abnormality was noted in the ciliary body or the cornea in any of the studied groups.· CONCLUSION:Cellular photoablation using BCECF-AM is a safe and effective wound modulating agent to control postoperative fibrosis in trabeculectomy.However MMC considered as a more potent adjuvant to trabeculectomy than BCECF-AM in promoting IOP reduction. | Azza Mohamed Ahmed Said Rania Gamal Eldin Zaki Thanaa Helmy Mohamed Manal Ibraheem Salman | 2016 | International Journal of Ophthalmology(English edition)2016，9，3： | 5 |
| 3 | The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments显示文摘Objective:To determine the prevalence and antimicrobial resistance rates of nosocomial pathogens isolated from cancer patients and hospital environments.Methods:A descriptive cross-sectional study was conducted between December 2010 to May 2013 at Radiation and Isotopes Centre of Khartoum,Sudan.A total of 1 503 samples(505 clinical and 998 environmental)were examined.Isolates were identified,and their antimicrobial susceptibility was determined using standard laboratory procedures.Results:Out of 505 clinical samples,nosocomial pathogens were found as 48.1%.Among hospital environment samples,bacterial contaminants were detected in 29.7%of samples.The main microorganisms recovered from cancer patients were Proteus spp.(23.5%),Escherichia coli(22.2%),Pseudomonas aeruginosa(P.aeruginosa)(21.0%)and Staphylococcus aureus(20.2%).The most frequent isolates from hospital environments were Bacillus spp.(50.0%),Staphylococcus aureus(14.2%)and P.aeruginosa(11.5%).The proportions of resistance among Gram-negative pathogens from cancer patients were high for ampicillin,cefotaxime,ceftazidime and ceftriaxone.Moderate resistance rates were recorded to ciprofloxacin,such as 51.0%for P.aeruginosa,21.7%for Klebsiella pneumoniae and 55.5%for Escherichia coli.Except Klebsiella,there were no significant differences(P0.05)of resistance rates between Gram-negative isolates from cancer patients to those from the hospital environments.The proportions of extended-spectrum b-lactamase producing isolates from cancer patients were not differ significantly(P=0.763)from those collected from the hospital environments(49.2%;91/185 vs.47%;32/68).Conclusions:The prevalence of nosocomial infection among cancer patients was high(48.1%)with the increasing of antimicrobial resistance rates.Hospital environments are potential reservoirs for nosocomial infections,which calls for intervention program to reduce environmental transmission of pathogens. | Aymen Mudawe Nurain Naser Eldin Bilal Mutasim Elhadi Ibrahim | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，12： | 4 |
| 4 | Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?显示文摘Hepatitis C virus(HCV) affects about 3% of the world'spopulation, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution(highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential. | Anna Maria Spera Tarek Kamal Eldin Grazia Tosone Raffaele Orlando | 2016 | World Journal of Hepatology2016，8，12： | 4 |
| 5 | Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats显示文摘Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic rats.Methods: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological changes.Results: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ndings.Conclusions: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus. | Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 3 |
| 6 | Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL)显示文摘 | Gamal Shiha Shiv Kumar Sarin Alaa Eldin Ibrahim Masao Omata Ashish Kumar Laurentius A. Lesmana Nancy Leung Nurdan Tozun Saeed Hamid Wasim Jafri Hitoshi Maruyama Pierre Bedossa Massimo Pinzani Yogesh Chawla Gamal Esmat Wahed Doss Taher Elzanaty Puja Sakhuj | 2009 | Hepatology International2009，，2： | 2 |
| 7 | Experimental investigations of granular shape effects on the generation of electrostatic charge显示文摘In solid processing systems,electrostatic problems are commonly observed for granules of various shapes.However,a complete understanding of the basic dependence of electrostatic charge generation on particle shape has yet to be established.This observation motivated the present study on examining the effect of granular shape on electrostatics.In this study,polyvinyl chloride(PVC) granules(diameter 1.1-4.1 mm,in the shape of a triangle or trapezium) were first discharged to remove any residual charges and subsequently their electrostatic charging characteristics were studied by allowing a granule to slide along a pipe wall.Several factors such as granular front-facing angle,length-ratio,sliding area,sliding orientation,sliding times,and relative humidity were considered when studying their effects on the electrostatic charging of granules.It was found that triangular granules with smaller front-facing angles tended to generate more electrostatic charge.The amount of electrostatic charge increased with granular lengthratio and sliding area but decreased with humidity.In addition,granular sliding in the orientation of the front-facing angle(for triangular granules) or the short side(for trapezoidal granules) generated more electrostatic charge than that in the orientation of the long side.For both granule shapes,the electrostatic charge increased with granular sliding times and reached a saturated state after around 8-9 sliding movements.The saturated electrostatic charge increased with either granular length ratio or sliding area. | Jun Yao Jiejie Wu Yanlin Zhao Eldin Wee Chuan Lim Peigen Cao Fang Zhou Chi-Hwa Wang Ning Li | 2014 | Particuology2014，12，4： | 2 |
| 8 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 9 | Experimental and computational studies of multiphase hydrodynamics in a hydrocyclone separator system显示文摘 | Eldin Wee Chuan Lim Yi-Ren Chen Chi-Hwa Wang Rome-Ming Wu | 2010 | Chemical Engineering Science2010，，24： | 2 |
| 10 | The Load Sharing Classification of Spine Fractures显示文摘 | Thomas McCormack Eldin Karaikovic Robert W. Gaines | 1994 | Spine1994，，15： | 2 |
| 11 | Successful Short-Segment Instrumentation and Fusion for Thoracolumbar Spine Fractures: A Consecutive 4?-Year Series显示文摘 | Jeffrey W. Parker Joel R. Lane Eldin E. Karaikovic Robert W. Gaines | 2000 | Spine2000，，9： | 2 |
| 12 | The Impact of Optimizing Trim on Reducing Fuel Consumption显示文摘 | Ahmed Helmy Abouelfadl Essam Eldin YoussefAbdelraouf | 2016 | Journal of Shipping and Ocean Engineering2016，6，3： | 2 |
| 13 | Do FDI patterns differ between manufacturing and service sector in CEE countries显示文摘 | Vesna Babic-Hodovic Eldin Mehic Emir Agic | 2010 | Journal of US-China Public Administration2010，7，3： | 2 |
| 14 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 15 | TRIM22 E3 ubiquitin ligase activity is required to mediate antiviral activity against encephalomyocarditis virus显示文摘 | ELDIN P PAPON L OTEIZA A | 2009 | J Gen Virol2009，90，3： | 1 |
| 16 | Undrained triaxial tests on satu- rated sands and their significance in the general theory of shear Strength 显示文摘 | Bishop A W Eldin G | 1950 | G6oteehnique1950，2，1： | 1 |
| 17 | Highperformance liquid chromatographic analysis of secoisolariciresinol diglucoside and hydroxycinnamic acid glucosides in flaxseed by alkaline extraction显示文摘 | Eliasson C Kamal Eldin A Andersson R | 2003 | Journal of Chromatography A2003，1012，： | 1 |
| 18 | An inventory model for deteriorating item显示文摘 | Raafat F Wolfe P M Eldin H K | 1991 | Computers and Industrial Engineering1991，20，1： | 1 |
| 19 | Lower pole midsize (1-2 cm) calyeeal stones: outcome analysis of 56 cases显示文摘 | Aboutaleh H E1-Shazly M Badr Eldin M | 2012 | Urollnt2012，89，3： | 1 |
| 20 | Characterisation of aldehydicacids in used and unused fryir^ oils显示文摘 | AFAF KATNAL ELDIN’ GLORIA MARQUEZ-RUIZ CARMEN DOBARGANES | 1997 | Journal of ChromatographyA1997，776，3： | 1 |
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