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| 1 | Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the common lethal types of tumor all over the world.The lethality of HCC accounts for many reasons.One of them,the lack of reliable diagnostic markers at the early stage,in this context,serum miRNAs became promising diagnostic biomarkers.Herein,we aimed to identify the predictive value of two miRNAs(miR-122 and miR-224)in plasma of patients with HCC preceded by chronic HCV infection.Taqman miRNA assays specific for hsa-miR-122 and hsa-miR-224 were used to assess the expression levels of the chosen miRNAs in plasma samples collected from three groups;40 patients with HCC related to HCV,40 with CHC patients and 20 healthy volunteers.This study revealed that the mean plasma values of miRNA-122 were significantly lower among HCC group when compared to CHC and control groups(P<0.001).Whereas,miR-224 mean plasma values were significantly higher among HCC group when compared to both CHC group and control group.Moreover,it was found that miR-122 can predict development of HCC at cut-off value<0.67(RQ)and(AUC Z 0.98,P<0.001).As regards miR-224,it can predict development of HCC at cut-off value>1.2(RQ)and(AUC Z 0.93,P<0.001),while the accuracy of AFP to diagnose HCC was(AUC:0.619;P Z 0.06).In conclusion,the expression plasma of miR-122 and miR-224 could be used as noninvasive biomarkers for the early prediction of developing HCC at the early stage. | Khalda S.Amr Hanan Abd Elmawgoud Atia Rehab Abd Elazeem Elbnhawy Wafaa M.Ezzat | 2017 | Genes & Diseases2017，4，4： | 17 |
| 2 | 高产色素低产桔霉素红曲霉菌株的筛选、鉴定和抑菌性分析显示文摘从各地收集的样品中分离纯化获得235株红曲霉菌株。采用分光光度法测定菌丝红曲色素的色价,高效液相色谱法(HPLC)测定发酵液中桔霉素含量,筛选获得1株高产色素低产桔霉素的红曲霉M-92菌株,经鉴定为紫色红曲霉(Monascus purpureus)。用红曲霉M-92菌株作菌种制备红曲米,按GB 4926—2008方法测定红曲米色价,可达2 138 U/g。用牛津杯法测定红曲米粉对4种单细胞微生物的抑制效果,抑菌强弱顺序依次为:金黄色葡萄球菌>枯草芽孢杆菌>白色念球菌>大肠杆菌;用生长速率法测定红曲米粉对5种植物病原真菌的抑制效果,根据半最大效应浓度EC50的大小,抑菌强弱顺序依次为:番茄早疫病菌>白绢病菌>黄瓜枯萎病菌>赤霉菌>苦瓜枯萎病菌。 | Marey Rehab 谷佳欢 许楚旋 蒋冬花 | 2018 | 湖南农业科学2018，，1： | 6 |
| 3 | The oncofetal protein IMP3 is an indicator of early recurrence and poor outcome in mucoepidermoid carcinoma of salivary glands显示文摘Objective: Mucoepidermoid carcinoma(MEC) is the most common primary malignancy of the salivary glands. Insulin-like growth factor-II m RNA-binding protein-3(IMP3) is an important prognostic factor in some cancers and a tool that differentiates between benign and malignant pancreatic lesions. This study aimed to identify a relationship between the expression of IMP3 and the outcome of salivary gland MEC, as well as to differentiate MEC from pleomorphic adenoma(PA).Methods: Tissue specimens from 70 cases of salivary gland MEC, 40 cases of PA, and 10 cases with normal salivary gland were examined immunohistochemically for IMP3. The association among the expression of IMP3, clinicopathological characteristics and patient's survival was assessed.Results: IMP3 was present in 51.4% of MEC but absent in PA and normal salivary gland tissues. IMP3 expression was associated with age > 60 years, submandibular gland tumors, tumor size > 4 cm, high-grade tumors, lymph node metastasis, involvement of surgical margins, perineural invasion, distant metastasis, advanced TNM stage, tumor relapse, and death(P<0.05). Increased expression of IMP3, tumors of the submandibular gland, and lymph node metastasis were independent prognostic factors of disease-free survival(DFS). In addition, IMP3 was a strong predictor of overall survival(OS) together with distant metastasis and intermediate and high-grade tumors.Conclusions: IMP3 expression is highly important in evaluating the outcome of MEC. IMP3 can be used to differentiate MEC from PA of salivary glands. | Mohamed R.Elshafey Rehab A.Ahmed Mohamed I Mourad Essam T.Gaballah | 2016 | Cancer Biology & Medicine2016，13，2： | 5 |
| 4 | Expression levels ofβcatenin and galectin-3 in meningioma and their effect on brain invasion and recurrence:a tissue microarray study显示文摘Objective:Meningiomas are neoplasms that arise from the meninges of the central nervous system(CNS).They constitute about25.6%of CNS tumors diagnosed in Egypt.Some morphological variants of meningiomas display aggressive behavior,leading to brain-invasive growth pattern.Although meningiomas are usually treated by complete surgical excision,the risk of postoperative recurrence remains.Hence,additional biomarkers for predicting aggressive behavior must be discovered.This study aims to explore the clinical and biological relevance of the protein expression levels ofβ-catenin and galectine-3 in meningioma and to understand the pathobiology of this neoplasm.Methods:This retrospective study was carried out on 153 cases of meningioma by using tissue microarrays and immunohistochemistry forβ-catenin and galectine-3.Results:Highβ-catenin expression was significantly associated with transitional and meningiotheliomatous meningiomas,low tumor grade,low recurrence rate,and low incidence of brain invasion.Meanwhile,high galectin-3 expression was associated with brain invasion,recurrence,high tumor grade,and tumor type.Logistic regression analysis indicated that among all variables included in the model,β-catenin and galactin-3 expression levels were significant predictors of tumor recurrence(P<0.001).Conclusions:Galectin-3 andβ-catenin are involved in meningioma recurrence but not in brain invasion.These molecules could be important potential therapeutic targets and predictors for meningiomas. | Rehab Allah Ahmed Abdelhadi M Shebl Hany Onsy Habashy | 2017 | Cancer Biology & Medicine2017，14，3： | 4 |
| 5 | Difference between papillary and follicular thyroid carcinoma outcomes:an experience from Egyptian institution显示文摘Objective: Differentiated thyroid carcinomas(DTCs) are classified into papillary thyroid carcinoma(PTC) and follicular thyroid carcinoma(FTC). DTCs are analyzed as a single group in clinical studies that investigated the prognostic factors and prognosis of these malignancies. However, the biological behaviors of these carcinomas significantly differ. In the present study, we aimed to detect differences in the outcomes between PTC and FTC in Mansoura University Hospital in Egypt. Methods: A total of 558 patients with histologically proven thyroid carcinomas from January 2003 to December 2012 were retrospectively enrolled. The clinical and pathological data of patients were reviewed. Results: Large primary tumor size, lymph node involvement, extrathyroid extension, and distant metastasis were significant poor prognostic factors for overall survival(OS) in old PTC patients. Cox hazard analysis showed that the patient's age, extra thyroid extension, and distant metastasis were the only independent prognostic factors. In FTC patients, only the distant metastasis and degree of tumor invasion were significant poor prognostic factors in OS univariate analysis. However, these factors were nonsignificant in multivariate analysis. The 10-year OS rates were 97% and 89% for PTC and FTC, respectively(P=0.003). The 10-year disease-free survival(DFS) rates were 77.2% in PTC vs. 65% in FTC(P=0.179). Conclusion: The significant prognostic factors vary between the two types of DTCs. Therefore, PTC and FTC patients need to be analyzed and reported independently. PTC survival is widely and significantly affected by age, extrathyroid extension, and distant metastasis. By contrast, these factors were nonsignificant in FTC, which showed poorer survival than PTC. | Engy M.Aboelnaga Rehab Allah Ahmed | 2015 | Cancer Biology & Medicine2015，12，1： | 4 |
| 6 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 7 | Effect of Sirtuin 1 inhibition on matrix metalloproteinase 2 and Forkhead box O3a expression in breast cancer cells显示文摘Breast cancer is the most common invasive cancer in women worldwide.Sirtuin 1(SIRT1)has recently been shown to have implications in regulating cancer cell growth and apoptosis.SIRT1 regulates Forkhead box O3a(FOXO3a)by both inhibiting FOXO3-induced apoptosis and potentiating the ability of FOXO3a to resist oxidative stress.Matrix metalloproteinase 2(MMP2)participates in tumor invasion and metastasis by degrading extracellular matrix.SIRT1 up regulates MMP2 expression by its deacetylation activity.This study aimed to investigate the expression of SIRT1,FOXO3a and MMP2 in breast tissues of women with breast cancer.In addition,the effect of SIRT1 inhibition on both FOXO3a and MMP2 expression in breast cancer(MCF-7)cells was assessed.The expression levels of SIRT1,FOXO3a and MMP2 in the breast tissues were determined by real-time PCR in 60 patients with malignant tumor and in 24 patients with benign tumors.After SIRT1 inhibition,protein levels of SIRT1 and FOXO3a were assessed by Western Blot and levels of MMP2 by ELISA in MCF-7 cells.The expression levels of SIRT1,FOXO3a and MMP2 were significantly higher in breast cancer tissues compared to in benign breast tumor and adjacent normal tissues.SIRT1,MMP2 and FOXO3a expression were associated directly with each other.SIRT1 inhibition suppresses MMP2 and FOXO3a expression compared to control MCF7.Sirtinol(SIRT1 inhibitor)effectively induced inhibition of MMP2 and FOXO3a expression in MCF-7 cells,indicating the promising therapeutic strategy of targeting SIRT1 for breast cancer. | Hanan Abdelmawgoud Rehab Refaat El Awady | 2017 | Genes & Diseases2017，4，4： | 3 |
| 8 | Non-alcoholic fatty liver disease:Epidemiology,pathophysiology and an update on the therapeutic approaches显示文摘Non-alcoholic fatty liver disease(NAFLD)denotes a spectrum of fatty liver disease in individuals without significant alcohol consumption.NAFLD is set to be the most common etiology of serious liver diseases in numerous nations when accompanied by obesity and type 2 diabetes.It is further histologically categorized into the non-alcoholic fatty liver(NAFL;steatosis without hepatocellular injury)and non-alcoholic steatohepatitis(NASH)which is characterized by the coexistence of hepatic steatosis and inflammation and is accompanied by hepatocyte injury(ballooning),either with or without fibrosis.NAFL is considered the benign and reversible stage arising from the excessive accumulation of triglycerides in hepatocytes.However,NASH is a more progressive stage of NAFLD,due to the increased risks of evolving more serious diseases such as cirrhosis,hepatocellular carcinoma.This concept,however,has been lately challenged by a hypothesis of multiple parallel hits of NAFLD,in which steatosis and NASH are separate entities rather than two points of the NAFLD spectrum,not only from a set of histological patterns but also from a pathophysiological perspective.The current review highlights the epidemiology and pathophysiology of NAFLD,and its progression towards steatohepatitis,with special focus on the novel imminent therapeutic approaches targeting the molecular aspects and the pathogenic pathways involved in the development,and progression of NAFLD. | Rehab F.Abdel-Rahman | 2022 | Asian Pacific Journal of Tropical Biomedicine2022，12，3： | 2 |
| 9 | Solitary wave solutions for the variable-coefficient coupled nonlinear Schrödinger equations and Davey-Stewartson system using modified sine-Gordon equation method显示文摘In this study,the sine-Gordon equation method is modified to deal with variable-coefficient systems containing imaginary parts,such as nonlinear Schrödinger systems.These are of considerable importance in many fields of research,including ocean engineering and optics.As an example,we apply the modified method to variable-coefficient coupled nonlinear Schrödinger equations and Davey-Stewartson system with variable coefficients,treating them as one-dimensional and two-dimensional systems,respectively.As a result of this application,novel solitary wave solutions are obtained for both cases.Moreover,some figures are provided to illustrate how the solitary wave propagation is determined by the different values of the variable group velocity dispersion terms,which can be used to model various phenomena. | Rehab M.El-Shiekh Mahmoud Gaballah | 2020 | Journal of Ocean Engineering and Science2020，5，2： | 2 |
| 10 | Performance of American Society for Gastrointestinal Endoscopy guidelines for dyspepsia in Saudi population: Prospective observational study显示文摘AIM: To evaluate adherence of primary care physicians(PCPs) to international guidelines when referring patients for upper-gastrointestinal endoscopy(UGE), evaluate the importance of alarm symptoms and the performance of the American Society for Gastrointestinal Endoscopy(ASGE) guidelines in a Saudi population.METHODS: A prospective, observational cross-sectional study on dyspeptic patients undergoing UGE who were referred by PCPs over a 4 mo period. Refer-rals were classified as appropriate or inappropriate according to adherence to ASGE guidelines.RESULTS: Total of 221 dyspeptic patients was enrolled; 161 patients met our inclusion criteria. Mean age was 40.3 years(SD ± 18.1). Females comprised 70.1%. Alarm symptoms included low hemoglobin level(39%), weight loss(18%), vomiting(16%), loss of appetite(16%), difficulty swallowing(3%), and gastrointestinal bleeding(3%). Abnormal endoscopy findings included gastritis(52%), duodenitis(10%), hiatus hernia(7.8%), features suggestive of celiac disease(6.5%), ulcers(3.9%), malignancy(2.6%) and gastroesophageal reflux disease(GERD: 17%). Among patients who underwent UGE, 63% met ASGE guidelines, and 50% had abnormal endoscopic findings. Endoscopy was not indicated in remaining 37% of patients. Among the latter group, endoscopy was normal in 54% of patients. There was no difference in proportion of abnormal endoscopic findings between two groups(P = 0.639).CONCLUSION: Dyspeptic patients had a low prevalence of important endoscopic lesions, and none of the alarm symptoms could significantly predict abnormalendoscopic findings. | Nahla A Azzam Majid A Almadi Hessah Hamad Alamar Lamis Atyah Almalki Rehab Nawaf Alrashedi Rawabi Saleh Alghamdi Waleed Al-hamoudi | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 11 | Cureuming biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes 显示文摘 | Rehab EA Sureshi S | 2006 | Ann NY Acad Sci2006，1067，： | 1 |
| 12 | The role of CK7, Ki‐67, CD34 and vimentin in the differentiation between biliary atresia and idiopathic neonatal hepatitis in Egyptian cholestatic neonates显示文摘 | HAYAM ABDEL SAMIE AIAD MONA ABDEL HALIM KANDIL REHAB MONIR SAMAKA MERVAT MAHMOUD SULTAN MOHAMED TAWFIK BADR GAMMAL ELDIN MAHMOUD NADA | 2012 | APMIS2012，，7： | 1 |
| 13 | Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involve- ment显示文摘 | Maba Yousif Rehab Habib Heba Esaely | 2015 | Egyptian Journal of Chest Diseases and Tuberculosis2015，64，1： | 1 |
| 14 | Protective and therapeutic potentials of Dunaliella salina on aging-associated cardiac dysfunction in rats显示文摘Objective: To investigate the possible protective and/or therapeutic potentials of Dunaliella salina(D. salina) biomass, its carotenoid and polar fractions on cardiac dysfunction associated with D-galactose(D-GAL) induced aging in rats. Methods: Aging associated cardiac dysfunction was induced in rats by injection of D-GAL(200 mg/kg; i.p) for 8 weeks. D-GAL injected rats were treated with two regimens; protective regimen where D. salina biomass(250 mg/kg), its carotenoid(250 μg/kg) and polar(250 μg/kg) fractions were given orally for two weeks concurrently with D-GAL injection as well as treatment regimen where the three treatments were given orally for 28 consecutive days after D-GAL injection. Results: D-GAL injection for 8 weeks was accompanied with dramatic electrocardiographic changes as well as profound elevation in serum levels of homocysteine, creatinine kinase isoenzyme and lactate dehydrogenase in addition to the reduction of the cardiac content of glucose trasporter 4. D-GAL also induced reduction in cardiac superoxide dismutase activity and elevation of inducible nitric oxide synthetase and interleukin-6. On the other hand, oral administration of D. salina carotenoid fraction as well as the total biomass significantly attenuated the D-GAL-induced disturbances in the above mentioned parameters where the protective regimen appeared more successful in controlling the manifestations of cardiac dysfunction. The histopathological examination further emphasized the promising results. Besides, the HPLC analysis of the carotenoid fraction of D. salina revealed the presence of 2.31%. salina carotenoid fraction as well as the total biomass amelior β-carotene. Conclusions: Date D-GAL-induced aging associated cardiac dysfunction which is attributed to the potent antioxidant activity of β-carotene. | Farouk K.El-Baz Gehad A.Abdel Jaleel Dalia O.Saleh Rehab A.Hussein | 2018 | Asian Pacific Journal of Tropical Biomedicine2018，8，8： | 1 |
| 15 | Nanocomposite materials based on polyurethane intercalated into montmorillonite clay显示文摘 | Rehab A Salahuddin N | 2005 | Materials Science and Engineering:A2005，399，1： | 1 |
| 16 | Catalytic activity of polymer-montmorillonite composites in chemical reactions显示文摘 | Akelah A Rehab A Kenawy E R | 2006 | Journal of Applied Polymer Science2006，101，： | 1 |
| 17 | Genetically improved PSO algorithm for efficient data clustering显示文摘 | ABDEL K REHAB | | 0，，： | 1 |
| 18 | Ischemic heart diseases in Egypt: role of xanthine oxidase system and ischemia-modified albumin显示文摘 | Ola Sayed Ali Hanan Muhammad Abdelgawad Makram Sayed Mohammed Rehab Refaat El-Awady | 2014 | Heart and Vessels2014，，： | 1 |
| 19 | Photocrosslinked Polymers Based on Pendant Extended Chalcone as Photoreactive Moieties显示文摘 | Rehab A Salahuddin N | 1999 | Polymer1999，40，9： | 1 |
| 20 | Polymer-organoclay hybrids by polymerization intomontmorillonite-vinyl monomer interlayers 显示文摘 | REHAB A AKELAH A AGAG T | 2007 | Journalof Applied Polymer Science2007，106，5： | 1 |
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