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| 1 | Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran显示文摘AIM: To study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS: Paraffin-embedded tissue samples of 25 patients (18 males and 7 females) with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method (avidin-biotin-peroxidase) for detection of p53, cyclinD1, RB1, c-fos and N-ras proteins. RESULTS: Six (24%), 5 (20%), 12 (48%) and 2 samples (8%) were positive for p53, cyclinD1, C-fos and N-ras expression, respectively. Twenty-two (88%) samples had alterations in the G1 cell-cycle checkpoint protein expression (RB1 or cyclinD1). P53 positive samples showed a higher (9 times) risk of being positive for RB1 protein than p53 negative samples. Loss of expression of RB1 in association with p53 over-expression was observed in 4 (66.7%) of 6 samples. Loss of expression of RB1 was seen in all cyclinD1 positive, 20 (90.9%) N-ras negative, and 11 (50%) C-fos positive samples, respectively. CyclinD1 positive samples showed a higher (2.85 and 4.75 times) risk of being positive for c-fos and N-ras expression than cyclinD1 negative samples. CONCLUSION: The expression of p53, RB1 and c-fos genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma. | SJ Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali | 2007 | World Journal of Gastroenterology2007，13，4： | 73 |
| 2 | Cross-cultural research in advertising:Assessment methodologies显示文摘 | Samiee S Jeong I | | 0，，22： | 1 |
| 3 | Advancing the Country Image Construct-a Commentary Essay 显示文摘 | Samiee S | 2010 | Journal of Business Research2010，63，： | 1 |
| 4 | Influence of Solution Treatment on Precipitation Behavior of a Ni-Co Alloy 显示文摘 | Samiee M Asgari S | 2007 | Scripta Materialia2007，57，2： | 1 |
| 5 | Retailing and Channel Considerations in Developing Countries : A Review and Research Propositions 显示文摘 | Samiee S | 1993 | Journal of Business Research1993，27，12： | 1 |
| 6 | The Influence of Global Marketing Standardization on Performance显示文摘 | Samiee S Roth K | 1992 | Journal of Marketing1992，56，2： | 1 |
| 7 | r/alysis of p53 ,cyclinDl, RBI ,c-los and N-ras gene expression in hepa- tocellular carcinoma in Iran 显示文摘 | Moghaddam SJ Haghighi EN Samiee S | 2012 | World ''J Gastroenterol2012，13，58： | 1 |
| 8 | Genetic risk identifies multiple myeloma patients who do not benefit from autologous stem cell transplantation显示文摘 | Chang H Qi XY Samiee S | | 0，，： | 1 |
| 9 | Strategy Fit and Performance Consequences of International Marketing Stan- dardization 显示文摘 | Katsikeas C S Samiee S Theodosiou M | 2006 | Strategic Management Journal2006，27，9： | 1 |
| 10 | Influence of solution treatment on precipitation behavior of a Ni-Co alloy显示文摘 | SAMIEE M ASGARI S | 2007 | Scripta Materialia2007，57，2： | 1 |
| 11 | The influ- ence of organic organizational cultures,market re- sponsiveness, and product strategy on firm显示文摘 | Wei Y H(Susan) Samiee S Ruby P L | 2013 | Management Journal2013，19，2： | 1 |
| 12 | Advancing the country image construct -- A commentary essay显示文摘 | Samiee S | 2010 | Journal of Business Research2010，63，4： | 1 |
| 13 | Knowledge structure in international marketing: a multi-method bibliometric analysis 显示文摘 | Samiee S Chabowski B R | 2012 | Journal of the Academy Of Marketing Science2012，40，2： | 1 |
| 14 | Prognostic relevance of CD56 expres-sion in multiple myeloma : a study including 107 cases treated withhigh-dose melphalan- based chemotherapy and autologous stem celltransplant显示文摘 | Chang H Samiee S Yi Q L | 2006 | Leuk Lymphoma2006，47，1： | 1 |
| 15 | Total ionizing dose effects on flashed-based field programmable gate array显示文摘 | Wang J J Samiee S Chen H S | 2004 | IEEE Trans on Nuclear Science2004，51，6： | 1 |
| 16 | Currency choice in industrial pricing: A cross-national evaluation显示文摘 | Samiee S Patrik A | 1998 | Journal of Marketing1998，62，3： | 1 |
| 17 | Retailing and Channel Considerations in Developing Countries: A Review and Research Propositions显示文摘 | Samiee S | 1993 | Journal of Business Research1993，27，2： | 1 |
| 18 | The influence of global marketing standardization on performance显示文摘 | Samiee S Roth K | 1992 | Journal of Marketing1992，56，2： | 1 |
| 19 | Currency choice in industrial pricing:A cross-national evaluation显示文摘 | Samiee S Anckar P | 1998 | Journal of Marketing1998，62，3： | 1 |
| 20 | Adult precursor T-lymphoblastic leukemia/lymphoma with myeloid- associated antigen expression is associated with a lower complete remission rate following induction chemotherapy显示文摘 | A1 khabori M Samiee S Fung S | 2008 | Acta haematol2008，120，1： | 1 |
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