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| 1 | Olive oil consumption and non-alcoholic fatty liver disease显示文摘The clinical implications of non-alcoholic fatty liver diseases(NAFLD)derive from their potential to progress to fibrosis and cirrhosis.Inappropriate dietary fat intake,excessive intake of soft drinks,insulin resistance and increased oxidative stress results in increased free fatty acid delivery to the liver and increased hepatic triglyceride(TG)accumulation.An olive oil-rich diet decreases accumulation of TGs in the liver,improves postprandial TGs,glucose and glucagonlike peptide-1 responses in insulin-resistant subjects, and upregulates glucose transporter-2 expression in the liver.The principal mechanisms include:decreased nuclear factor-kappaB activation,decreased lowdensity lipoprotein oxidation,and improved insulin resistance by reduced production of inflammatory cytokines(tumor necrosis factor,interleukin-6)and improvement of jun N-terminal kinase-mediated phosphorylation of insulin receptor substrate-1.The beneficial effect of the Mediterranean diet is derived from monounsaturated fatty acids,mainly from olive oil.In this review,we describe the dietary sources of the monounsaturated fatty acids,the composition of olive oil,dietary fats and their relationship to insulin resistance and postprandial lipid and glucose responses in non-alcoholic steatohepatitis,clinical and experimental studies that assess the relationship between olive oil and NAFLD,and the mechanism by which olive oil ameliorates fatty liver,and we discuss future perspectives. | Nimer Assy Faris Nassar Gattas Nasser Maria Grosovski | 2009 | World Journal of Gastroenterology2009，15，15： | 22 |
| 2 | Soft drinks consumption and nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common clinical condition which is associated with metabolic syndrome in 70% of cases.Inappropriate dietary fat intake,excessive intake of soft drinks,insulin resistance and increased oxidative stress combine to increase free fatty acid delivery to the liver,and increased hepatic triglyceride accumulation contributes to fatty liver.Regular soft drinks have high fructose corn syrup which contains basic sugar building blocks,fructose 55% and glucose 45%.Soft drinks are the leading source of added sugar worldwide,and have been linked to obesity,diabetes,and metabolic syndrome.The consumption of soft drinks can increase the prevalence of NAFLD independently of metabolic syndrome.During regular soft drinks consumption,fat accumulates in the liver by the primary effect of fructose which increases lipogenesis,and in the case of diet soft drinks,by the additional contribution of aspartame sweetener and caramel colorant which are rich in advanced glycation end products that potentially increase insulin resistance and inflammation.This review emphasizes some hard facts about soft drinks,reviews fructose metabolism,and explains how fructose contributes to the development of obesity,diabetes,metabolic syndrome,and NAFLD. | William Nseir Fares Nassar Nimer Assy | 2010 | World Journal of Gastroenterology2010，16，21： | 20 |
| 3 | Octreotide ameliorates gastric lesions in chronically mild stressed rats显示文摘AIM:To evaluate the effect of chronic mild stress(CMS) on the emergence of gastric ulcers and possible modulation by octreotide,a synthetic somatostatin analogue. METHODS:Adult male Wistar rats were subjected to nine different unpredictable random stress procedures for 21 d,a multifactorial interactional animal model for CMS.Octreotide was administered daily for 21 d at two dose levels(50 and 90μg/kg)before exposure to stress procedure.Macro-and microscopical assessments were made,in addition to quantification of plasma corticosterone and gastric mucosal inflammatory,oxidative stress, and apoptotic biomarkers. RESULTS:Exposure to CMS elevated plasma corticosterone(28.3±0.6μg/dL,P=0.002),an event that was accompanied by gastric lesions(6.4±0.16 mm,P=0.01) and confirmed histopathologically.Moreover,the insult elevated gastric mucosal lipid peroxides(13±0.5 nmol/g tissue,P=0.001),tumor necrosis factor-α(3008.6±78.18 pg/g tissue,P<0.001),prostaglandin E2(117.1 ±4.31 pg/g tissue,P=0.002),and caspase-3 activity (2.4±0.14 OD/mg protein,P=0.002).Conversely,CMS mitigated interleukin-10(627.9±12.82 pg/g tissue,P= 0.001).Furthermore,in animals exposed to CMS,octreotide restored plasma corticosterone(61%and 71%from CMS,P=0.002)at both dose levels.These beneficial effects were associated with a remarkable suppression of gastric lesions(38%and 9%from CMS,P=0.01)and reversal of derangements in gastric mucosa. CONCLUSION:The current investigation provides evidence that exposure to CMS induces gastric ulceration, which was alleviated by administration of octreotide possibly possessing antioxidant,anti-inflammatory,and anti-apoptotic actions. | Noha N Nassar Mona F Schaalan Hala F Zaki Dalaal M Abdallah | 2011 | World Journal of Gastroenterology2011，17，9： | 6 |
| 4 | Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia显示文摘Objective:Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans(M.fragrans)(nutmeg) and Morinda citrifolia(M.citrifolia)(mengkudu) oils. Methods:The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essenlial oils were delermined by beta-carotene/ linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.Results:The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil.The nutmeg oil effectively inhibited the oxidation of linoleic acid with(88.68±0.1)%while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is(69.44±0.4)%.The nutmeg oil and mengkudu oil showed reducing power with an EC50 value of 181.4μg/mL and 3 043.0μg/mL,respectively.The anliangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC50 of 77.64μg/mL comparing to mengkudu oil which exhibits IC50 of 109.30μg/mL.Conclusion:Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs. | Suthagar Pillai Piaru Roziahanim Mahmud Amin Malik Shah Abdul Majid Zeyad Daoud Mahmoud Nassar | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 3 |
| 5 | A FINITE DIFFERENCE SCHEME FOR THE GENERALIZED NONLINEAR SCHRDINGER EQUATION WITH VARIABLE COEFFICIENTS显示文摘A finite difference scheme for the generalized nonlinear Schr dinger equation with variable coefficients is developed. The scheme is shown to satisfy two conservation laws. Numerical results show that the scheme is accurate and efficient. | Wei-zhong Dai Raja Nassar (Mathematics and Statistics, College of Engineering and Science, Louisiana Tech University, Ruston, LA 71272, USA) | 2000 | Journal of Computational Mathematics2000，18，2： | 3 |
| 6 | Predictors of hypoglycemia in insulin-treated patients with type 2 diabetes mellitus in Basrah显示文摘AIM To measure the incidence and determinants(predictors) of hypoglycemia among patients with type 2 diabetes mellitus(T2DM) who were on insulin treatment for at least one year. METHODS The present study is an out-patients based inquiry about the risk and predictors of hypoglycemia among patients with T2DM seeking care at the Al-Faiha Specialized Diabetes, Endocrine, and Metabolism Center, in Basrah over a period of 7 mo(from 15^(th) of April, 2013 to 15^(th) of October, 2013). The data used in the study were based on all detailed interview and selected laboratory investigations. A total of 336 patients could be included in the study.RESULTS The incidence of overall hypoglycemia among the studied patients was 75.3% within the last 3 mo preceding the interview. The incidence of hypoglycemia subtypes were 10.2% for severe hypoglycemia requiring medical assistance in the hospital, 44.36% for severe hypoglycemia treated at home by family; this includes both confirmed severe hypoglycemia with an incidence rate of 14.6% and unconfirmed severe hypoglycemia for which incidence rate was 29.76%. Regarding mild self-treated hypoglycemia, the incidence of confirmed mild hypoglycemia was 21.42%, for unconfirmed mildhypoglycemia the incidence rate was 50.0% and for total mild hypoglycemia, the incidence rate was 71.42%. The most important predictors of hypoglycemia were a peripheral residence, increasing knowledge of hypoglycemia symptoms, in availability and increasing frequency of self-monitoring blood glucose, the presence of peripheral neuropathy, higher diastolic blood pressure, and lower Hemoglobin A1c.CONCLUSION Hypoglycemia is very common among insulin-treated patients with T2DM in Basrah. It was possible to identify some important predictors of hypoglycemia. | Dhuha Tarik Nassar Omran S Habib Abbas Ali Mansour | 2016 | World Journal of Diabetes2016，7，18： | 3 |
| 7 | Single-Nucleotide Polymorphisms of IL-10 and IL-28B as Predictors of the Response of IFN Therapy in HCV Genotype 4–infected Children显示文摘 | Olfat G. Shaker Yasser H. Nassar Zeinab A. Nour Mona El Raziky | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，2： | 3 |
| 8 | Diallyl sulfide protects against N-nitrosodiethylamine-induced liver tumorigenesis:Role of aldose reductase显示文摘AIM: To evaluate the protective effect of diallyl sulfide (DAS) against N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis.METHODS: Male Wistar rats received either NDEA or NDEA together with DAS as protection.Liver energy metabolism was assessed in terms of lactate,pyruvate,lactate/pyruvate,ATP levels,lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G6PD) activities.In addition,membrane disintegration of the liver cells was evaluated by measuring lipid-peroxidation products,measured as malondialdehyde (MDA); nitric oxide (NO) levels; glucose-6-phosphatase (G6Pase),catalase (CAT) and superoxide dismutase (SOD) activities.Liver DNA level,glutathione-S-transferase (GST) and cytochrome c oxidase activities were used as DNA fragmentation indices.Aldose reductase (AR) activity was measured as an index for cancer cells resistant to chemotherapy and histopathological examination was performed on liver sections from different groups.RESULTS: NDEA significantly disturbed liver functions and most of the aforementioned indices.Treatment with DAS significantly restored liver functions and hepatocellular integrity; improved parameters of energy metabolism and suppressed free-radical generation.CONCLUSION: We provide evidence that DAS exerts a protective role on liver functions and tissue integrity in face of enhanced tumorigenesis caused by NDEA,as well as improving cancer-cell sensitivity to chemotherapy.This is mediated through combating oxidative stress of free radicals,improving the energy metabolic state of the cell,and enhancing the activity of G6Pase,GST and AR enzymes. | Safinaz S Ibrahim Noha N Nassar | 2008 | World Journal of Gastroenterology2008，14，40： | 2 |
| 9 | Current systematic reviews and meta-analyses of COVID-19显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)has left a significant impact on the world's health,economic and political systems;as of November 20,2020,more than 57 million people have been infected worldwide,with over 1.3 million deaths.While the global spotlight is currently focused on combating this pandemic through means ranging from finding a treatment among existing therapeutic agents to inventing a vaccine that can aid in halting the further loss of life.AIM To collect all systematic reviews and meta-analyses published related to COVID-19 to better identify available evidence,highlight gaps in knowledge,and elucidate further meta-analyses and umbrella reviews that are yet to be performed.METHODS We explored studies based on systematic reviews and meta-analyses with the keyterms,including severe acute respiratory syndrome(SARS),SARS virus,coronavirus disease,COVID-19,and SARS coronavirus-2.The included studies were extracted from Embase,Medline,and Cochrane databases.The publication timeframe of included studies ranged between January 01,2020,to October 30,2020.Studies that were published in languages other than English were not considered for this systematic review.The finalized full-text articles are freely accessible in the public domain.RESULTS Searching Embase,Medline,and Cochrane databases resulted in 1906,669,and 19 results,respectively,that comprised 2594 studies.515 duplicates were subsequently removed,leaving 2079 studies.The inclusion criteria were systematic reviews or meta-analyses.860 results were excluded for being a review article,scope review,rapid review,panel review,or guideline that produced a total of 1219 studies.After screening articles were categorized,the included articles were put into main groups of clinical presentation,epi-demiology,screening and diagnosis,severity assessment,special populations,and treatment.Subsequently,there was a second subclassification into the following groups:gastrointestinal,cardiovascular,neurological,stroke,thrombosis,anosmia and dysgeusia,ocular manifestations,nephrology,cutaneous manifestations,D-dimer,lymphocyte,anticoagulation,antivirals,convalescent plasma,immunosuppressants,corticosteroids,hydroxychloroquine,renin-angiotensin-aldosterone system,technology,diabetes mellitus,obesity,pregnancy,children,mental health,smoking,cancer,and transplant.CONCLUSION Among the included articles,it is clear that further research is needed regarding treatment options and vaccines.With more studies,data will be less heterogeneous,and statistical analysis can be better applied to provide more robust clinical evidence.This study was not designed to give recommendations regarding the management of COVID-19. | Mahmoud Nassar Nso Nso Mostafa Alfishawy Anastasia Novikov Salim Yaghi Luis Medina Bahtiyar Toz Sofia Lakhdar Zarwa Idrees Yungmin Kim Dawa Ongyal Gurung Raheel S Siddiqui David Zheng Mariam Agladze Vikram Sumbly Jasmine Sandhu Francisco Cuevas Castillo Nadya Chowdhury Ravali Kondaveeti Sakil Bhuiyan Laura Guzman Perez Riki Ranat Carlos Gonzalez Harangad Bhangoo John Williams Alaa Eldin Osman Joyce Kong Jonathan Ariyaratnam Mahmoud Mohamed Ismail Omran Mariely Lopez Akwe Nyabera Ian Landry Saba Iqbal Anoosh Zafar Gondal Sameen Hassan Ahmed Daoud Bahaaeldin Baraka Theo Trandafirescu Vincent Rizzo | 2021 | World Journal of Virology2021，10，4： | 2 |
| 10 | ABO incompatibility in renal transplantation显示文摘ABO blood group incompatibility(ABO-I)was historically considered an absolute contraindication to kidney transplantation due to the significant risk of acute antibody-mediated rejection and early graft loss.Nevertheless,the urge to minimize the gap between the candidates’number on the waitlist for kidney transplants and the available kidney donors encourage investigation into finding ways to use organs from ABO-I kidney donors,especially in the era of using more potent immunosuppression therapies.This review aims to discuss a general overview of ABO-I kidney transplantation and the different protocols adopted by some transplant centers to meaningfully overcome this barrier. | Mahmoud Mohamed Tara Sweeney Duaa Alkhader Mahmoud Nassar Ahmed Alqassieh Sofia Lakhdar Nso Nso Tibor Fulop Ahmed Daoud Karim M Soliman | 2021 | World Journal of Transplantation2021，11，9： | 2 |
| 11 | 杂交木薯消灭饥荒显示文摘作为世界第三大热量来源,木薯有潜力成为产量更高、营养更丰富的作物,改善发展中国家人们营养不良的问题。 | 纳吉布·纳萨尔(Nagib Nassar) 罗多米奥·奥尔蒂斯(Rodomiro Oniz) 张鹏(翻译) | 2010 | 环球科学2010，，6： | 2 |
| 12 | 工业燃气涡轮发动机变工况性能直接预测(英文)显示文摘The modern gas turbine engine has been used in current power generation industry for almost half a century. Gas turbines are designed to operate with the best efficiency during normal operating conditions and at specific operating points. However, the real world is non-optimal and the engine may have to operate at off-design conditions due to load requirements, different ambient temperatures, fuel types, relative humidity and driven equipment speed.Also more and more base-load gas turbines have to work today on partial load too, which can affect the hot gas path condition and life expectancy. At these off-design conditions, gas turbine's efficiency and life deterioration rate might significantly deviate from the design specifications. During a gas turbine's life, power generation providers might need to perform several overhauls or upgrades for their engines. Thus, the off-design performance after the overhaul also might be changed. Prediction of gas turbine's off-design performance is essential to economical operation of power generation equipment. In this paper, an integrated system for complex design and off-design performance prediction(Ax STREAM? Platform) is presented. It allows to predict gas turbine engine's design and off-design performance almost automatically. Each component's performance such as turbine, compressor, combustor and entire secondary flow(cooling) system is directly and simultaneously calculated for every off-design performance request, making possible to build an off-design performance map including cooling system. The example of off-design performance estimation of industrial gas turbine engine is presented. The presented approach provides wide capabilities for optimization of operation modes of industrial gas turbine engines and other complex turbomachinery systems for every specific operation conditions(environment, grid demands and other factors). | Leonid Moroz Valentyn Barannik Maksym Burlaka Abdul Nassar | 2018 | 风机技术2018，60，6： | 2 |
| 13 | New synthesis strategies for effective functionalization of kaolinite and saponite with silylating agents显示文摘 | Lilian R. Avila Emerson H. de Faria Katia J. Ciuffi Eduardo J. Nassar Paulo S. Calefi Miguel A. Vicente Raquel Trujillano | 2009 | Journal of Colloid And Interface Science2009，，1： | 2 |
| 14 | An Invasive Succulent Plant (Kalanchoe daigremontiana) Influences Soil Carbon and Nitrogen Mineralization in a Neotropical Semiarid Zone显示文摘It has long been recognized that plant invasions may alter carbon(C) and nitrogen(N) cycles, but the direction and magnitude of such alterations have been rarely quantified. In this study, we quantified the effects caused by the invasion of a noxious exotic plant,Kalanchoe daigremontiana(Crassulaceae), on C and N mineralization and enzymatic and microbial activities in the soil of a semiarid locality in Venezuela. We compared soil parameters associated with these processes(C and N mineralization time and the cumulative values, fluorescein diacetate hydrolytic activity, and activities of dehydrogenase, β-glucosidase, glucosaminidase, and urease) between invaded and adjacent non-invaded sites. In addition, correlations among these parameters and the soil physical-chemical properties were also examined to determine if a positive feedback exists between nutrient availability and K. daigremontiana invasion. Overall,our results showed that C mineralization and transformation of organic compounds to NH_4^+ were favored at sites colonized by K.daigremontiana. With this species, we found the highest cumulative amounts of NH_4^+-N and C and the lowest mineralization time.These results could be explained by higher activities of urease and glucosaminidase in soils under the influence of K. daigremontiana.In addition, higher amounts of organic matter and moisture content in invaded soils might favor C and N mineralization. In conclusion,invasion of Neotropical semiarid zones by K. daigremontiana may influence the chemical and biological properties of the soils covered by this species, increasing nutrient bioavailability, which, in time, can facilitate the invasion process. | Ileana HERRERA Jose R. FERRER-PARIS Diana BENZO Saul FLORES Belkis GARCIA Jafet M. NASSAR | 2018 | Pedosphere2018，28，4： | 2 |
| 15 | Clinicopathologic analysis of in-vasive micropapillary differentiation in breast carcinoma显示文摘 | Nassar H Wallis T Andea A | 2001 | Mod Pathol2001，14，9： | 1 |
| 16 | Biological control of Sclerotinia minor using achitino|ytic bacteriumand actinomycetes显示文摘 | E1-Tarabily K Soliman M H Nassar A H | 2000 | Plant Pathology2000，49，： | 1 |
| 17 | Laparoscopic cholecystectomy and the umbilicus显示文摘 | Nassar AH Ashkar KA Rashed AA | 1997 | British Journal of Surgery1997，，05： | 1 |
| 18 | Unsaturated polyester resins based on rosin maleic anhydride adduct as corrosion protections of steel 显示文摘 | ATI'A A M NASSAR I F BEDAWY H M | 2007 | Reactive & Functional Polymers2007，67，7： | 1 |
| 19 | Treatment of diffuse pigmentated villonodular syaovitis of the knee with combined surgical and radiosynovectomy显示文摘 | Nassar WA Bassiony AA Elghazaly HA | 2009 | HSS J2009，5，1： | 1 |
| 20 | Pregnancy outcomes and the effect of metformin treatment in women with polyeystie ovary syndrome: an overview显示文摘 | Ghazeeri GS Nassar AH Younes Z | 2012 | Aeta Obstet Gynecol Seand2012，91，6： | 1 |
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