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| 1 | 2007年美国肝硬化胃食管静脉曲张及出血的防治指南显示文摘该文章已于我刊2007年第六期纲要发表,应读者要求于本期将较详细的内容再次发表,以飧读者。 | Garcia-Tsao G Sanyal AJ Grace ND 李建生(摘译) 张明礼(摘译) | 2008 | 胃肠病学和肝病学杂志2008，17，2： | 47 |
| 2 | Laboratory simulated dissipation of metsulfuron methyl and chlorimuron ethyl in soils and their residual fate in rice, wheat and soybean at harvest显示文摘Two sulfonylurea herbicides, metsulfuron methyl (Ally 20 WP) and chlorimuron ethyl (Classic 25 WP) were evalu-ated for their dissipation behaviour in alluvial, coastal saline and laterite soils under laboratory incubated condition at 60% water holding capacity of soils and 30 °C temperature was maintained. In field study herbicides were applied twice for the control of grasses, annual and perennials broad leaves weeds and sedges in rice, wheat and soybean to find out the residual fate of both the herbicides on different matrices of respective crops after harvest. Extraction and clean up methodologies for the herbicides were standardized and subsequently analyzed by HPLC. The study revealed that the half-lives of metsulfuron methyl and chlorimuron ethyl ranged from 10.75 to 13.94 d irrespective of soils and doses applied. Field trials with rice, wheat and soybean also revealed that these two herbicides could safely be recommended for application as no residues were detected in the harvest samples. | SANYAL Nilanjan PRAMANIK Sukhendu Kumar PAL Raktim CHOWDHURY Ashim | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，3： | 11 |
| 3 | Sensitive and rapid determination of amantadine without derivatization in human plasma by LC–MS/MS for a bioequivalence study显示文摘A highly sensitive, rapid and rugged liquid chromatography-tandem mass spectrometry(LC-ESI-MS/MS)method was developed for reliable estimation of amantadine(AMD), an antiviral drug in human plasma.The analyte and internal standard(IS), amantadine-d6(AMD-d6), were extracted from 200 m L plasma by solid phase extraction on Phenomenex Strata-X-C 33 m cartridges. Chromatography was performed on Synergi? Hydro-RP C18(150 mm ? 4.6 mm, 4 mm) analytical column using a mixture of acetonitrile and10 m M ammonium formate, p H 3.0(80:20, v/v) as the mobile phase. Detection and quantitation was done by multiple reaction monitoring in the positive ionization mode for AMD(m/z 152.1-135.1) and IS(m/z 158.0-141.1) on a triple quadrupole mass spectrometer. The assay was linear in the concentration range of 0.50–500 ng/m L with correlation coefficient(r2) Z 0.9969. The limit of detection of the method was 0.18 ng/m L. The intra-batch and inter-batch precisions were r 5.42% and the accuracy varied from98.47% to 105.72%. The extraction recovery of amantadine was precise and quantitative in the range of97.89%–100.28%. IS-normalized matrix factors for amantadine varied from 0.981 to 1.012. The stability of AMD in whole blood and plasma was evaluated under different conditions. The developed method was successfully applied for a bioequivalence study with 100 mg of AMD in 32 healthy volunteers. The reproducibility of the assay was determined by reanalysis of 134 subject samples. | Abhaysingh Bhadoriya Shivprakash Rathnam Bhavesh DasANDi Dharmesh Parmar Mallika Sanyal Pranav S.Shrivastav | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 9 |
| 4 | Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease显示文摘 | Sunder Mudaliar Robert R. Henry Arun J. Sanyal Linda Morrow Hanns-Ulrich Marschall Mark Kipnes Luciano Adorini Cathi I. Sciacca Paul Clopton Erin Castelloe Paul Dillon Mark Pruzanski David Shapiro | 2013 | Gastroenterology2013，，： | 7 |
| 5 | Optimisation of Adventitious Shoot Regeneration and Agrobacterium-mediated Transformation in Canna × generalis(Canna Lily)显示文摘Canna being ornamental plants has a significant role in agriculture, medical, economy and food industry. Canna has a limited vase life due to the rapid loss of moisture from its perianth. For improving its market value, cuticularisation of the perianth can be achieved by the expression of a heterologous cutin producing gene, using the tissue culture and transformation protocol developed in this study. Efficient, rapid and direct adventitious shoot regeneration was successfully established in Canna × generalis using recalcitrant rhizome explants. The explants were cultured on MS medium supplemented with 6-benzylaminopurine(6-BA), thidiazuron(TDZ), and kinetin. Among the four genotypes taken for tissue culture, the ‘Trinacria variegata' was the best responding cultivar. And 2 mg · L^(-1)6-BA or 1.5 mg · L^(-1) TDZ along with 0.1 mg · L^(-1) IAA was optimum for their regeneration. The highest regeneration was achieved in ‘Trinacria variegata'(36%) on 6-BA, 33% on TDZ while kinetin failed to evoke any regenerative responses. Regeneration was enhanced by supplementation of 100 mg · L^(-1) ascorbic acid(AsA), while, 100 mg · L^(-1) of l-cysteine or 100 mg · L^(-1) dithiothreitol(DTT), inhibited regeneration. Shoots were observed to develop 3–5 fibrous roots on MS medium supplemented with 0.5 mg · L^(-1) indole-3-butyric acid(IBA). The plantlets were transplanted into pots and acclimatised in glasshouse with 100%survival. For transformation of Canna, rhizome explants were co-cultivated for 60 min in Agrobacterium suspension. The explants were washed with 500 mg · L^(-1) cefotaxime solution, subjected to 100 mg · L^(-1) kanamycin selection followed by excision of the shoots and culturing them on IBA-supplemented media for root development. Transgene integration in the putative transformants was confirmed by PCR assay and copy number by Southern blot hybridisation analysis. | Rani Singh Arvind Kumar Dubey Indraneel Sanyal | 2019 | Horticultural Plant Journal2019，5，1： | 6 |
| 6 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 7 | The diagnosis and management of non‐alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association显示文摘 | Naga Chalasani Zobair Younossi Joel E. Lavine Anna Mae Diehl Elizabeth M. Brunt Kenneth Cusi Michael Charlton Arun J. Sanyal | 2012 | Hepatology2012，，6： | 5 |
| 8 | Fast and sensitive LC–MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma显示文摘A sensitive and rapid liquid chromatography-tandem mass spectrometry(LC–MS/MS) method has been developed for the simultaneous determination of lisinopril(LIS) and hydrochlorothiazide(HCTZ) in human plasma using their labeled internal standards(ISs). Sample pre-treatment involved solid phase extraction on Waters Oasis HLB cartridges using 100 μL of plasma, followed by liquid chromatography on Hypersil Gold C_(18)(50 mm×3.0 mm, 5 μm) column. The analytes were eluted within 2.0 min using acetonitrile-5.0 m M ammonium formate, p H 4.5(85:15, v/v) as the mobile phase. The analytes and ISs were analyzed in the negative ionization mode and quantified using multiple reaction monitoring. The method showed excellent linearity over the concentration range of 0.50–250.0 ng/m L for both the analytes. The intra-batch and inter-batch precision(% CV) was ≤5.26% and their extraction recoveries were in the range of 96.6%–103.1%. Matrix effect evaluated in terms of IS-normalized matrix factors ranged from 0.97 to 1.03 for both the analytes. The validated method was successfully applied to determine the plasma concentration of the drugs using 10 mg lisinopril and 12.5 mg hydrochlorothiazide fixed dose formulation in 18 healthy Indian volunteers. | Jaivik V.Shah Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 5 |
| 9 | No Significant Effects of Ethyl-eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial显示文摘 | Arun J. Sanyal Manal Abdelmalek Ayako Suzuki William Cummings Mario Chojkier | 2014 | Gastroenterology2014，，： | 4 |
| 10 | Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation显示文摘 | R. Todd Stravitz Mitchell L. Shiffman Melissa Kimmel Puneet Puri Velimir A. Luketic Richard K. Sterling Arun J. Sanyal Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2012 | Liver Int2012，，7： | 3 |
| 11 | AGA technical review on nonalcoholic fatty liver disease显示文摘 | Arun J. Sanyal | 2002 | Gastroenterology2002，，5： | 3 |
| 12 | Surveillance for Hepatocellular Carcinoma in Patients with Cirrhosis Improves Outcome显示文摘 | Richard Todd Stravitz Douglas M. Heuman Nisha Chand Richard K. Sterling Mitchell L. Shiffman Velimir A. Luketic Arun J. Sanyal Adil Habib Anastasios A. Mihas Ho-Chong S. Giles Daniel G. Maluf Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2008 | The American Journal of Medicine2008，，2： | 3 |
| 13 | Fabrication of Noble metal-semiconductor hybrid nanostructures using phase transfer显示文摘 | Tanushree Bala Ajay Singh Ambarish Sanyal Catriona O'Sullivan Fathima Laffir Claudia Coughlan Kevin M. Ryan | 2013 | Nano Research2013，6，2： | 3 |
| 14 | Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Amy G. Shah Alison Lydecker Karen Murray Brent N. Tetri Melissa J. Contos Arun J. Sanyal | 2009 | Clinical Gastroenterology and Hepatology2009，，10： | 3 |
| 15 | Simultaneous quantification of prodrug oseltamivir and its metabolite oseltamivir carboxylate in human plasma by LC-MS/MS to support a bioequivalence study显示文摘A simple,precise and rapid liquid chromatography-tandem mass spectrometry(LC-MS/MS) method has been developed and validated for the simultaneous determination of oseltamivir and oseltamivir carboxylate,a neuraminidase inhibitor,using their deuterated analogs as internal standards(ISs).The method involved solid phase extraction of the analytes and ISs from 200 μL human plasma with no reconstitution and drying steps.The chromatographic separation was achieved on a Symmetry C18(100 mm 4.6 mm,5 μm) column using 10 mM ammonium formate and acetonitrile(30:70,v/v) as the mobile phase in a run time of 2.0 min.Quantitation of analytes and ISs were done by multiple reaction monitoring on a triple quadrupole mass spectrometer in the positive ionization mode.The linearity of the method was established in the concentration range of 0.5-200 ng/mL and 2.0-800 ng/mL for oseltamivir and oseltamivir carboxylate respectively.The mean extraction recovery for oseltamivir(94.4%) and oseltamivir carboxylate(92.7%) from spiked plasma samples was consistent and reproducible.The application of this method was demonstratedby a bioequivalence study in 42 healthy Indian subjects with 75 mg oseltamivir phosphate capsules.The assay reproducibility was established by reanalysis of 151 incurred subject samples. | Ajay Gupta Swati Guttikar Pranav S. Shrivastav Mallika Sanyal | 2013 | Journal of Pharmaceutical Analysis2013，3，3： | 3 |
| 16 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome显示文摘 | Arun J. Sanyal Thomas Boyer Guadalupe Garcia–Tsao Frederick Regenstein Lorenzo Rossaro Beate Appenrodt Andres Blei Veit Gülberg Samuel Sigal Peter Teuber | 2008 | Gastroenterology2008，，5： | 3 |
| 17 | Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease显示文摘 | Kris V. Kowdley Patricia Belt Laura A. Wilson Matthew M. Yeh Brent A. Neuschwander‐Tetri Naga Chalasani Arun J. Sanyal James E. Nelson | 2011 | Hepatology2011，，： | 3 |
| 18 | Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities显示文摘 | Arun J. Sanyal Carol Campbell-Sargent Faridoddin Mirshahi William B. Rizzo Melissa J. Contos Richard K. Sterling Velimir A. Luketic Mitchell L. Shiffman John N. Clore | 2001 | Gastroenterology2001，，5： | 3 |
| 19 | Mechanisms of Obesity-induced Gastrointestinal Neoplasia显示文摘 | José O. Alemán Leonardo H. Eusebi Luigi Ricciardiello Kavish Patidar Arun J. Sanyal Peter R. Holt | 2013 | Gastroenterology2013，，： | 3 |
| 20 | Effect of pioglitazone on nerve conduction velocity of the median nerve in the carpal tunnel in type 2 diabetes patients显示文摘AIM To evaluate the impact of pioglitazone pharmacotherapy in median nerve electrophysiology in the carpal tunnel among type 2 diabetes patients.METHODS The study was executed in patients with type 2 diabetes, treated with oral drugs, categorized under pioglitazone or non-pioglitazone group(14 in each group), and who received electrophysiological evaluation by nerve conduction velocity at baseline and 3 mo.RESULTS At 3 mo, pioglitazone-category had inferior amplitude in sensory median nerve [8.5 interquartile range(IQR) = 6.5 to 11.5) vs non-pioglitazone 14.5(IQR 10.5 to 18.75)](P = 0.002). Non-pioglitazone category displayed amelioration in amplitude in the sensory median nerve [baseline 13(IQR = 9 to 16.25) vs 3 mo 8.5(IQR = 6.5 to 11.5)](P = 0.01) and amplitude in motor median nerve [baseline 9(IQR = 4.75 to 11) vs 3 mo 6.75(IQR = 4.75 to 10.25)](P = 0.049); and deterioration of terminal latency of in motor ulnar nerve [baseline 2.07(IQR = 1.92 to 2.25) vs 3 mo 2.16(IQR = 1.97 to 2.325)](P = 0.043). There was amelioration of terminal latency in sensory ulnar nerve [baseline 2.45(IQR = 2.315 to 2.88) vs 3 mo 2.37(IQR = 2.275 to 2.445) for pioglitazone group(P = 0.038).CONCLUSION Treatment with pioglitazone accentuates probability of compressive neuropathy. In spite of comparable glycemic control over 3 mo, patients treated with pioglitazone showed superior electrophysiological parameters for the ulnar nerve. Pioglitazone has favourable outcome in nerve electrophysiology which was repealed when the nerve was subjected to compressive neuropathy. | Sudip Chatterjee Debmalya Sanyal Sourav Das Choudhury Mili Bandyopadhyay Suraj Chakraborty Arabinda Mukherjee | 2016 | World Journal of Diabetes2016，7，19： | 3 |
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