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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Ligation-assisted endoscopic mucosal resection of gastric heterotopic pancreas显示文摘Heterotopic pancreas is a congenital anomaly characterized by ectopic pancreatic tissue.Treatment of heterotopic pancreas may include expectant observation,endoscopic resection or surgery.The aim of this report was to describe the technique of ligation-assisted endoscopic mucosal resection(EMR) for resection of heterotopic pancreas of the stomach.Two patients(both female,mean age 32 years) were referred for management of gastric subepithelial tumors.Endoscopic ultrasound in both disclosed small hypoechoic masses in the mucosa and submucosa.Band ligation-assisted EMR was performed in both cases without complications.Pathology from the resected tumors revealed heterotopic pancreas arising from the submucosa.Margins were free of pancreatic tissue.Ligation-assisted EMR is technically feasible and may be considered for the endoscopic management of heterotopic pancreas. | Mouen A Khashab Oscar W Cummings John M DeWitt | 2009 | World Journal of Gastroenterology2009，15，22： | 25 |
| 3 | 随班就读教师融合教育教学效能感研究显示文摘采用Sharma等人编制的《教师融合教育教学效能感量表》和Saloviita编制的《教师融合教育态度量表》对南京市592名随班就读教师进行调查,发现:(1)南京市随班就读教师融合教育教学效能感处于中等偏上水平,其中行为管理的效能感水平最高;(2)教师的融合教育教学效能感在学历、职称、教龄和学段上均存在显著差异;(3)随班就读教师的融合教育教学效能感对融合教育态度具有正向预测作用,其中开展合作效能感的预测作用最为显著。因此,应当提高随班就读教师的入职要求,提升随班就读教师合作效率,促进随班就读教师教学效能感的发展,进而提高随班就读教育质量。 | 熊琪 Terry Cumming 李泽慧 | 2019 | 中国特殊教育2019，0，2： | 19 |
| 4 | 北京市髋部骨折发生率流行病学研究显示文摘为了解北京市髋部骨折发生率,调查了北京市所有能收治骨折的76所医院1988~1992年髋部骨折的出院病例。为避免遗漏非住院治疗的髋部骨折,在北京城区随机抽样2113名50岁以上妇女进行入户调查以了解过去骨折史。应答率97%。所有资料均经多方面、系统的有效性核实。基于1990年人口普查资料,计算出北京市年龄标化后的髓都骨折发生率女性为88/10万,男性为97/10万。用同样方法和人群标化的其它国家和地区比较,北京市的髋部骨折发生率仍属最低。 | 刘爱民 徐苓 赵熙和 陈孝曙 Steven R Cummings | 1996 | 中华流行病学杂志1996，17，1： | 16 |
| 5 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 6 | New era of colorectal cancer screening显示文摘Colorectal cancer(CRC) is the 2^(nd) most common cancer in women and 3^(rd) most common cancer in men worldwide. Most CRCs develop from adenomatous polyps arising from glandular epithelium. Tumor growth is initiated by mutation of the tumor suppressor gene APC and involves other genetic mutations in a stepwise process over years. Both hereditary and environmental factors contribute to the development of CRC. Screening has been proven to reduce the incidence of CRC. Screening has also contributed to the decrease in CRC mortality in the United States. However,CRC incidence and/or mortality remain on the rise in some parts of the world(Eastern Europe,Asia,and South America),likely due to factors including westernized diet,lifestyle,and lack of healthcare infrastructure. Multiple screening options are available,ranging from direct radiologic or endoscopic visualization tests that primarily detect premalignant or malignant lesions such as flexible sigmoidoscopy,optical colonoscopy,colon capsule endoscopy,computed tomographic colonography,and double contrast barium enema- to stool based tests which primarily detect cancers,including fecal DNA,fecal immunochemical test,and fecal occult blood test. The availability of some of these tests is limited to areas with high economic resources. This article will discuss CRC epidemiology,pathogenesis,risk factors,and screening modalities with a particular focus on new technologies. | Maysaa El Zoghbi Linda C Cummings | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，5： | 7 |
| 7 | Millikan改良网塞疝修复术显示文摘自1890年Bassini发表腹股沟疝修补术以来,在术式方面有过了多改进.过去20年中,网片修补技术因具减张的优点而被广泛接受.20世纪70年代,Lichtenstein和Shore首先创用网塞治疗股疝和复发性疝[1]:Gilbert随之在80年代用之于治疗斜疝[2]:Rutkow和Robbins在90年代倡用预制的网塞加补片治疗各种腹股沟疝[3,4]. | Keith W.Millikan Brice Cummings Alexander Doolas 王晔鸣 | 2005 | 外科理论与实践2005，10，6： | 6 |
| 8 | Diet,ageing and genetic factors in the pathogenesis of diverticular disease显示文摘Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in western nations.The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum.Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality.In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber.In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development.We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal.We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease. | Daniel Martin Commane Ramesh Pulendran Arasaradnam Sarah Mills John Cummings Mathers Mike Bradburn | 2009 | World Journal of Gastroenterology2009，15，20： | 5 |
| 9 | Neuropsychiatric profiles in patients with Alzheimer's disease and vascular dementia显示文摘 | J-L Fuh S-J Wang J L Cummings | 2005 | 中国生物学文摘2005，19，11： | 5 |
| 10 | 安徽何郢遗址植物残体切割形态与脱粒农具的关系显示文摘石器和植物残体的相关研究证明,脱粒板曾大规模应用于近东地区。为探索古代中国或远东是否也曾使用过这种工具或类似工具,本研究对何郢遗址植物残体形态进行了研究,结果表明中国商周遗址存在切割形态植物残体的证据,以此推测类似脱粒板的农具在商周时期曾被使用。无疑,这一发现对我国古代农作物的脱粒加工方式具有重要的启示,可望深化我国农业考古的探索。 | 吴妍 王昌燧 Linda Scott Cummings Patricia C.Anderson | 2012 | 文物保护与考古科学2012，24，1： | 5 |
| 11 | No Significant Effects of Ethyl-eicosapentanoic Acid on Histologic Features of Nonalcoholic Steatohepatitis in a Phase 2 Trial显示文摘 | Arun J. Sanyal Manal Abdelmalek Ayako Suzuki William Cummings Mario Chojkier | 2014 | Gastroenterology2014，，： | 4 |
| 12 | 产出导向法研究设计与方向(英文)显示文摘The development of the Production-Oriented Approach(POA,Wen,2016)has impressed me as an exemplary application of design-based research.The unique ways in which research has shaped this innovative approach to language teaching are worth my elaborating on here because the principles and applications of design-based research are not | Alister Cumming | 2017 | Chinese Journal of Applied Linguistics2017，40，4： | 3 |
| 13 | 膳食纤维显示文摘 | Cummings JH 张钦元 | 1983 | 国外医学:卫生学分册1983，1，1： | 3 |
| 14 | Transferring R&D knowledge: the key factors affecting knowledge transfer success显示文摘 | Jeffrey L Cummings Bing-Sheng Teng | 2003 | Journal of Engineering and Technology Management2003，，1： | 3 |
| 15 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 16 | Presence and significance of microvesicular steatosis in nonalcoholic fatty liver disease显示文摘 | Sweta Tandra Matthew M. Yeh Elizabeth M. Brunt Raj Vuppalanchi Oscar W. Cummings Aynur ünalp-Arida Laura A. Wilson Naga Chalasani | 2011 | Journal of Hepatology2011，，3： | 3 |
| 17 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 18 | Particulate fouling of surface microfilters with slotted and circular pore geometry显示文摘 | A.J Bromley R.G Holdich I.W Cumming | 2002 | Journal of Membrane Science2002，，1： | 2 |
| 19 | Disease modification and Neuroprotection in neurodegenerative disorders显示文摘Background:Disease modifying therapies(DMTs)are urgently needed for neurodegenerative diseases(NDD)such as Alzheimer’s disease(AD)and many other disorders characterized by protein aggregation and neurodegeneration.Despite advances in understanding the neurobiology of NDD,there are no approved DMTs.Discussion:Defining disease-modification is critical to drug-development programs.A DMT is an intervention that produces an enduring change in the trajectory of clinical decline of an NDD by impacting the disease processes leading to nerve cell death.A DMT is neuroprotective,and neuroprotection will result in disease modification.Disease modification can be demonstrated in clinical trials by a drug-placebo difference in clinical outcomes supported by a drug-placebo difference on biomarkers reflective of the fundamental pathophysiology of the NDD.Alternatively,disease modification can be supported by findings on a staggered start or delayed withdrawal clinical trial design.Collecting multiple biomarkers is necessary to support a comprehensive view of disease modification.Conclusion:Disease modification is established by demonstrating an enduring change in the clinical trajectory of an NDD based on intervention in the fundamental pathophysiology of the disease leading to nerve cell death.Supporting data are collected in clinical trials.Effectively defining a DMT will assist in NDD drug development programs. | Jeffrey Cummings | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 20 | Epidemiology and outcomes of osteoporotic fractures显示文摘 | Steven R Cummings L Joseph Melton | 2002 | The Lancet2002，，9319： | 2 |
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