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| 1 | Gut microbiota and metabolic syndrome显示文摘Gut microbiota exerts a significant role in the pathogenesis of the metabolic syndrome,as confirmed by studies conducted both on humans and animal models.Gut microbial composition and functions are strongly influenced by diet.This complex intestinal'superorganism'seems to affect host metabolic balance modulating energy absorption,gut motility,appetite,glucose and lipid metabolism,as well as hepatic fatty storage.An impairment of the fine balance between gut microbes and host’s immune system could culminate in the intestinal translocation of bacterial fragments and the development of'metabolic endotoxemia',leading to systemic inflammation and insulin resistance.Diet induced weight-loss and bariatric surgery promote significant changes of gut microbial composition,that seem to affect the success,or the inefficacy,of treatment strategies.Manipulation of gut microbiota through the administration of prebiotics or probiotics could reduce intestinal low grade inflammation and improve gut barrier integrity,thus,ameliorating metabolic balance and promoting weight loss.However,further evidence is needed to better understand their clinical impact and therapeutic use. | Davide Festi Ramona Schiumerini Leonardo Henry Eusebi Giovanni Marasco Martina Taddia Antonio Colecchia | 2014 | World Journal of Gastroenterology2014，20，43： | 23 |
| 2 | Gastric cancer, Helicobacter pylori infection and other risk factors显示文摘Gastric cancer incidence is declining. However, it is too early to consider this neoplastic disease as rare and the worldwide mortality rate still remains high. Several risk factors have been identif ied for non-cardia gastric cancer and primary prevention is feasible since most of the risk factors can be removed. Helicobacter pylori eradication treatment reduces but does not abolish gastric cancer risk. Indeed, gastric cancer is a multifactorial disease and removing one factor does not therefore prevent all cases. Endoscopic surveillance is still needed, especially in subjects at higher risk. The def inition of high-risk patients will be the future challenge as well as identifying the best surveillance strategy for such patients. | Lorenzo Fuccio Leonardo Henry Eusebi Franco Bazzoli | 2010 | World Journal of Gastrointestinal Oncology2010，2，9： | 17 |
| 3 | Non-invasive tests for the prediction of primary hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension.Even in the presence of a well-established follow-up protocol for cirrhotic patients,to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients(cACLD).The gold standard method to evaluate the prognosis of patients with cACLD,beyond liver fibrosis assessed with histology,is the measurement of the hepatic venous pressure gradient(HVPG).An HVPG≥10 mmHg has been related to an increased risk of HCC in cACLD patients.However,these methods are burdened by additional costs and risks for patients and are mostly available only in referral centers.In the last decade increasing research has focused on the evaluation of several,simple,non-invasive tests(NITs)as predictors of HCC development.We reviewed the currently available literature on biochemical and ultrasound-based scores developed for the noninvasive evaluation of liver fibrosis and portal hypertension in predicting primary HCC.We found that the most reliable methods to assess HCC risk were the liver stiffness measurement,the aspartate aminotransferase to platelet ratio index score and the fibrosis-4 index.Other promising NITs need further investigations and validation for different liver disease aetiologies. | Giovanni Marasco Antonio Colecchia Giovanni Silva Benedetta Rossini Leonardo Henry Eusebi Federico Ravaioli Elton Dajti Luigina Vanessa Alemanni Luigi Colecchia Matteo Renzulli Rita Golfieri Davide Festi | 2020 | World Journal of Gastroenterology2020，26，24： | 8 |
| 4 | Diagnosis and management of gastric antral vascular ectasia显示文摘Gastric antral vascular ectasia (GAVE) is an uncommon but often severe cause of upper gastrointestinal (GI) bleeding, responsible of about 4% of non-variceal upper GI haemorrhage. The diagnosis is mainly based on endoscopic pattern and, for uncertain cases, on histology. GAVE is characterized by a pathognomonic endoscopic pattern, mainly represented by red spots either organized in stripes radially departing from pylorus, defined as watermelon stomach, or arranged in a diffused-way, the so called honeycomb stomach. The histological pattern, although not pathognomonic, is characterized by four alterations:vascular ectasia of mucosal capillaries, focal thrombosis, spindle cell proliferation and fibrohyalinosis, which consist of homogeneous substance around the ectatic capillaries of the lamina propria. The main differential diagnosis is with Portal Hypertensive Gastropathy, that can frequently co-exists, since about 30% of patients with GAVE co-present a liver cirrhosis. Autoimmune disorders, mainly represented by Reynaud's phenomenon and sclerodactyly, are co-present in about 60% of patients with GAVE; other autoimmune and connective tissue disorders are occasionally reported such as Sjogren's syndrome, systemic lupus erythematosus, primary biliary cirrhosis and systemic sclerosis. In the remaining cases, GAVE syndrome has been described in patients with chronic renal failure, bone marrow transplantation and cardiac diseases. The pathogenesis of GAVE is still obscure and many hypotheses have been proposed such as mechanical stress, humoural and autoimmune factors and hemodynamic alterations. In the last two decades, many therapeutic options have been proposed including surgical, endoscopic and medical choices. Medical therapy has not clearly shown satisfactory results and surgery should only be considered for refractory severe cases, since this approach has significant mortality and morbidity risks, especially in the setting of portal hypertension and liver cirrhosis. Endoscopic therapy, particularly treatment with Argon Plasma Coagulation, has shown to be as effective and also safer than surgery, and should be considered the first-line treatment for patients with GAVE-related bleeding. | Lorenzo Fuccio Alessandro Mussetto Liboria Laterza Leonardo Henry Eusebi Franco Bazzoli | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 8 |
| 5 | Can early precut implementation reduce endoscopic retrograde cholangiopancreatography-related complication risk? Meta-analysis of randomized controlled trials显示文摘 | V. Cennamo L. Fuccio R. Zagari L. Eusebi L. Ceroni L. Laterza C. Fabbri F. Bazzoli | 2010 | Endoscopy2010，，05： | 3 |
| 6 | Mechanisms of Obesity-induced Gastrointestinal Neoplasia显示文摘 | José O. Alemán Leonardo H. Eusebi Luigi Ricciardiello Kavish Patidar Arun J. Sanyal Peter R. Holt | 2013 | Gastroenterology2013，，： | 3 |
| 7 | Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: report of 5 cases 显示文摘 | Eusebi V Damiani S Ellis IO | 2003 | Am J Surg pathol2003，27，8： | 1 |
| 8 | Epidemiology of Helicobacterpylori Infection显示文摘 | Eusebi LH Zagari RM Bazzoli F | 2014 | Helicobacter2014，191，： | 1 |
| 9 | Differential role of CSF alpha- synuclein species, tau, and Aβ42 in Parkinson's disease显示文摘 | Pametti L Farotti L Eusebi P | 2014 | Front Aging Neurosci2014，6，： | 1 |
| 10 | Epidemiology of Helicobacter pylori Infection显示文摘 | Leonardo H. Eusebi Rocco M. Zagari Franco Bazzoli | 2014 | Helicobacter2014，，： | 1 |
| 11 | Endocrine differentiation in mucoid carcinoma of the breast显示文摘 | Capella C Eusebi V Mann B | 1980 | Histopathology1980，4，： | 1 |
| 12 | Podoplanin and E- cadherin expression in preoperative incisional biopsies of oral squamous cell carcinoma is related to lymph node metastases 显示文摘 | Foschini MP Leonardi E Eusebi LH | 2013 | Int I Surg Patho12013，21，2： | 1 |
| 13 | Endocrine differentia-tion in mucous carcinoma of the breast显示文摘 | Capella C Eusebi V Mann B | 1980 | J Histopathol1980，4，6： | 1 |
| 14 | Classifications and prognosis of breast cancer:from morphology to molecular taxonomy 显示文摘 | Eusebi V | 2010 | Breast J2010，，： | 1 |
| 15 | Endocrine differentiation in mucoid carcinoma of the breast显示文摘 | Capella C Eusebi V Mann B | | 0，，： | 1 |
| 16 | Can early precut implementation reduce endoscopic retrograde cholangiopancreatography-related complication risk? Meta-analysis of randomized controlled trials显示文摘 | V. Cennamo L. Fuccio R. Zagari L. Eusebi L. Ceroni L. Laterza C. Fabbri F. Bazzoli | 2010 | Endoscopy2010，，05： | 1 |
| 17 | Predictive value of ad- mission blood glucose level on short-term mortality in acute cerebral ischemia显示文摘 | NARDI K MILIA P EUSEBI P | 2012 | Diabetes Complications2012，26，2： | 1 |
| 18 | Spindle cell lipoma- like tumor, solitary fibrous tumor and myofibroblastoma of the breast : a clinico-pathological analysis of 13 cases in favor of a uni- fying histogenetic concept 显示文摘 | Magro G Bisceglia M Michal M Eusebi V | 2002 | Virchows Arch2002，440，3： | 1 |
| 19 | Endocrine differentiation in mucous carcinoma of the breast显示文摘 | Capella C Eusebi V Mann B | | 0，，06： | 1 |
| 20 | Meta analysis: canHelicobacter pylori eradication treatment reduce the risk for gastric cancer显示文摘 | Fuccio L Zagari RM Eusebi LH | 2009 | Ann Intern Med2009，151，2： | 1 |
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