|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy显示文摘Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer(CRC) were proposed recently based on genetic profiles that show four types of molecular alterations: BRAF gene mutations, KRAS gene mutations, microsatellite instability, and hypermethylation of Cp G islands. This review summarizes what is known about the serrated pathway of CRC, including CRC molecular and clinical features, prognosis, and response to chemotherapy. | Oscar Murcia Miriam Juárez Eva Hernández-Illán Cecilia Egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo Jover | 2016 | World Journal of Gastroenterology2016，22，13： | 18 |
| 2 | Serrated polyposis syndrome:Molecular,pathological and clinical aspects显示文摘Hyperplastic polyps have traditionally been considered not to have malignant potential.New pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this area.Until recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found thatthis pathway accounts for only approximately 70%-80% of colorectal cancer(CRC)cases.The majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite instability.The mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF oncogene.Serrated polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon.Clinical characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified yet.Patients with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been described.Clinical criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal cancer.In this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome. | Carla Guarinos Cristina Sánchez-Fortún María Rodríguez-Soler Cristina Alenda Artemio Payá Rodrigo Jover | 2012 | World Journal of Gastroenterology2012，18，20： | 8 |
| 3 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Cesare Hassan Enrique Quintero Jean-Marc Dumonceau Jaroslaw Regula Catarina Brand?o Stanislas Chaussade Evelien Dekker Mario Dinis-Ribeiro Monika Ferlitsch Antonio Gimeno-García Yark Hazewinkel Rodrigo Jover Mette Kalager Magnus Loberg Christian Pox Bjorn | 2013 | Endoscopy2013，，10： | 3 |
| 4 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 5 | Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency显示文摘 | Ajay Goel Rosa M. Xicola Thuy–Phuong Nguyen Brian J. Doyle Vanessa R. Sohn Prathap Bandipalliam Laura S. Rozek Josep Reyes Carmen Cordero Francesc Balaguer Antoni Castells Rodrigo Jover Montserrat Andreu Sapna Syngal C. Richard Boland Xavier Llor | 2010 | Gastroenterology2010，，5： | 1 |
| 6 | Resul tados prelim-inares de cangrejos(Procambarus clarkii)alimentados con pien-sos de differente contenido en proteína y carbohidratos显示文摘 | Jover M Rodrigo E Fernandze-Carmona J | 1990 | ActasIII Congerso Nacional Acuicultura1990，，： | 1 |
| 7 | The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status显示文摘 | Rodrigo Jover Pedro Zapater Antoni Castells Xavier Llor Montserrat Andreu Joaquín Cubiella Francesc Balaguer Laura Sempere Rosa M. Xicola Luis Bujanda Josep M. Re?é Juan Clofent Xavier Bessa Juan D. Morillas David Nicolás-Pérez Elisenda Pons Artemio Payá | 2008 | European Journal of Cancer2008，，3： | 1 |
| 8 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
| 9 | Phosphate-activated glutaminase activity is enhanced in brain, intestine and kidneys of rats following portacaval anastomosis显示文摘瞄准:估计在老鼠的门腔静脉吻合(PCA ) 是否在肾影响蛋白质表示或谷酰胺酶的活动,肠并且在外皮的三个大脑区域,基础轧了神经胶质和小脑并且解释在肝的脑病发现的神经病学的改变(他) 。方法:称 250-350 g 的十六只男 Wistar 老鼠被组织进假冒操作的控制(n=8 ) 或 portacaval (n=8 ) 。在过程以后的 28 天,动物被牺牲。十二指肠,肾和大脑被移开, homogenised 和线粒体被孤立。氨在大脑和血被测量。激活磷酸盐的谷酰胺酶(PAG ) 活动被与 O-phthalaldehyde (OPA ) 和每蛋白质(蛋白质的 mukat/g ) 的克以单位表示的特殊活动在 37 摄氏度测量氨生产追随者孵化一个小时决定。蛋白质表示被弄污的免疫测量。结果:十二指肠并且和蛋白质内容的肾 PAG 活动比在 PCA 组是显著地更高的在控制或假冒操作老鼠(十二指肠 PAG 活动是在 PCA 老鼠对在假冒操作老鼠的蛋白质的 429.19+/-126.92mukat/g 的蛋白质的 976.95+/-268.87 mukat/g;肾 PAG 活动是在 PCA 老鼠对在控制的蛋白质的 669.67+/-400.8 mukat/g 的 1259.18+/-228.79 mukat/g 蛋白质, P<0.05;十二指肠的蛋白质内容:173% 在 PCA 对假冒操作老鼠;在肾,蛋白质的内容在 PCA 对假冒操作老鼠是 152%) 。在 PCA 老鼠的 PAG 活动和蛋白质表示在外皮是更高的并且基础在假冒操作老鼠比那些轧了神经胶质(外皮:蛋白质的 6646.6+/-1870.4 mukat/g 对在控制老鼠的蛋白质的 3573.8+/-2037.4 mukat/g, P<0.01;基础轧了神经胶质, PAG 活动是在 PCA 老鼠对在假冒的操作老鼠的蛋白质的 2271.2+/-384 mukat/g 的蛋白质的 3657.3+/-1469.6 mukat/g, P<0.05;在小脑,分别地, PAG 活动是蛋白质的 2471.6+/-701.4 mukat/g 对在 PCA 和假冒的老鼠的蛋白质的 1452.9+/-567.8 mukat/g P<0.05;蛋白质的内容:大脑皮质:162%+/-40% 对 100%+/-26% , P<0.009;并且基础轧了神经胶质:140%+/-39% 对 100%+/-14% , P<0.05;然而并非在里面小脑:100%+/-25% 对 100%+/-16% , P=ns ) 。结论:在肾和十二指肠的增加的 PAG 活动能在 PCA 老鼠显著地作出贡献到 hyperammonaemia,脑病的动物模型。PAG 从外皮在 non-synaptic 线粒体被增加并且基础轧了神经胶质并且能在肝的脑病的致病被含有。因此, PAG 能是为处理的一个可能的目标他或肝机能障碍。 | Manuel Romero-Gómez María Jover Daniel Díaz-Gómez Laura Collantes de Terán Regina Rodrigo Inés Camacho Miriam Echevarría Vicente Felipo Juan D Bautista | 2006 | World Journal of Gastroenterology2006，12，15： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员