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| 1 | Endoscopic and histologic characteristics of serrated lesions显示文摘In recent years , a second pathway for colonic carcinogenesis , distinct from the adenomatous pathway, has been explored. This is referred to as serrated pathway and includes three types of polyp,characterised by a serrated appearance of the crypts:hyperplastic polyps(HP),sessile serrated adenomas(SSA)or lesions,and traditional serrated adenomas.Each lesion has its own genetic,as well as macroscopic and microscopic morphological features.Because of their flat aspect,their detection is easier with chromoendoscopy(carmin indigo or narrow-band imaging).However,as we show in this review,the distinction between SSA and HP is quite difficult.It is now recommended to resect in one piece as it is possible the serrated polyps with a control in a delay depending on the presence or not of dysplasia.These different types of lesion are described in detail in the present review in general population,in polyposis and in inflammatory bowel diseases patients.This review highlights the need to improve characterization and understanding of this way of colorectal cancerogenesis. | Driffa Moussata Gilles Boschetti Marion Chauvenet Karine Stroeymeyt Stéphane Nancey Franoise Berger Thierry Lecomte Bernard Flourié | 2015 | World Journal of Gastroenterology2015，21，10： | 14 |
| 2 | Sessile serrated adenoma/polyps: Where are we at in 2016?显示文摘It is currently known that colorectal cancers(CRC) arise from 3 different pathways: the adenoma to carcinoma chromosomal instability pathway(50%-70%); the mutator 'Lynch syndrome' route(3%-5%); and the serrated pathway(30%-35%). The World Health Organization has classified serrated polyps into three types of lesions: hyperplastic polyps(HP),sessile serrated adenomas/polyps(SSA/P) and traditional serrated adenomas(TSA),the latter two strongly associated with development of CRCs. HPs do not cause cancer and TSAs are rare. SSA/P appear to be the responsible precursor lesion for the development of cancers through the serrated pathway. Both HPs and SSA/Ps appear morphologically similar. SSA/P are difficult to detect. The margins are normally inconspicuous. En bloc resection of these polyps can hence be troublesome. A careful examination of borders,submucosal injection of a dye solution(for larger lesions) and resection of a rim of normal tissue around the lesion may ensure total eradication of these lesions. | Rajvinder Singh Leonardo Zorrón Cheng Tao Pu Doreen Koay Alastair Burt | 2016 | World Journal of Gastroenterology2016，22，34： | 13 |
| 3 | 结肠镜下息肉检出、治疗及质量控制显示文摘<正>结肠镜检查及治疗已广泛用于临床,镜下可仔细观察全结肠及末端回肠黏膜,发现息肉并镜下切除可降低结直肠癌的患病风险[1]。对于存在便血、腹泻、腹痛及排便习惯改变等症状或存在患癌风险的无症状人群,首选该检查。掌握结肠镜下息肉检出及治疗对于训练有素的医生并不困难,但如何对照指南进行质量控制提高水平非常重要。本文通过学习2014版美国消化内镜医师协会指南,回顾性分析笔者2009~2014年间相关资料,报告如下。 | 丁彤 胡爱翠 胡晓珊 张家敏 周莹 | 2015 | 中华结直肠疾病电子杂志2015，4，5： | 1 |
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