|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 动脉粥样硬化血栓形成门诊患者1年内心血管事件的发生率显示文摘背景:目前,有关社区中动脉粥样硬化血栓形成稳定患者心血管(cardiovascular,CV)事件发生率的资料比较少,既往也无国际性队列研究对冠状动脉病(coronary artery disease,CAD)、脑血管病(cerebrovascular disease,CVD)、外周动脉病(peripheral arterial disease,PAD)确诊患者以及此类疾病高危患者不同事件的发生率进行评估。
目的:在患有动脉疾病的门诊患者或存在多个动脉粥样硬化血栓形成危险因素的门诊患者中确定当今世界1年内CV事件的发生率。
设计、地点及参试者:“减少动脉粥样硬化血栓形成维系健康(Reduction of Artherotllrombosis for Continued Health,REACH)”注册研究是一项国际前瞻性队列研究。研究人员于2003—2004年从44个国家、5587名医生入选68236例已确诊的动脉粥样硬化性血管病患者(CAD、PAD、CVD;n=55814)以及至少存在3个动脉粥样硬化血栓形成危险因素的患者(n=12422)。
主要观测指标:CV死亡、心肌梗死(myocardial infarction,MI)及卒中的发生率。结果:截至2006年7月,共有95.22%的患者(n=64977)提供了1年内的结局。心血管死亡、MI及卒中的总体发生率为4.24%;动脉粥样硬化性血管病患者为4.69%,仅存在多个危险因素的患者为2.15%。CAD、CVD及PAD患者CV死亡、MI及卒中的总体发生率分别为4.52%、6.47%和5.35%。CAD、CVD及PAD患者发生终点事件(即CV死亡、MI、卒中)以及因动脉粥样硬化血栓形成事件入院的几率分别为15.20%、14.53%和21.14%。上述事件发生率随症状性动脉疾病病变部位数量的增加而增加,仅存在危险因素的患者为5.31%,有1处症状性动脉疾病的患者为12.58%,有2处症状性动脉疾病的患者为21.14%,有3处症状性动脉疾病的患者为26.27%(趋势P〈0.001)。
结论:在这项当代大型国际研究中,患有动脉粥样硬化性血管病的门诊患者以及有动脉粥样硬化血栓形成危险的门诊患者CV事件的年发生率相对较高。存在多部位病变者CV事件的1年发生率升高。 | Gabriel Steg Deepak L. Bhatt Peter W. F. Wilson Ralph D' Agostino E. Magnus Ohman Joachim Roether Chiau-Suong Liau Alan T. Hirsch Jean-Louis Mas Yasuo Ikeda Michael J. Pencina Shinya Goto 徐成斌(译) 李呈亿(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 20 |
| 2 | 自然保护区、恢复力和动态景观显示文摘在这个日益被人类活动所改变的世界里,保护生物多样性对于维持有恢复力的生态系统和确保生态系统产品的可持续流动以及对社会的服务是至关重要的。但是,现有的自然保护区和国家公园不大可能结合生态系统的长期和大尺度的动态。因此,保护策略必须包括大面积的人类利用经营的土地。为了能使生态系统在大规模的自然和人为干扰之后得以重组,以生态存储形式出现的空间恢复力是必备的前提。生态存储包括那些能使生态系统得以重组的物种、相互作用和结构,它的组成部分可能出现在干扰斑块中,也可能出现在周围的景观中。现有的静态自然保护区应该由动态自然保护区加以补充,例如生态休闲地和动态演替保护区,这些都是在景观尺度上模拟自然干扰状况,进行生态系统经营的组成部分。 | Janne Bengtsson Per Angelstam Thomas Elmqvist Urban Emanuelsson Carl Folke Margareta Ihse Fredrik Moberg Magnus Nystrm 王胜 | 2003 | AMBIO-人类环境杂志2003，32，6： | 11 |
| 3 | 新型农村合作医疗制度试点对农民卫生服务利用的影响研究显示文摘目的揭示中国新型农村合作医疗制度试点对农民卫生服务利用的影响效果。方法在控制重要混杂因素的情况下采用分组与空白对照的方法进行分析性研究,通过Propensity Score Match的方法进行两组间的匹配后研究效果指标。结果自愿参合人群有一定选择性;参合对促进门诊利用总量增加有限,但对改善应就诊而未就诊的影响较明显;对促进住院服务利用总量增加明显,由于需住院人数和未住院人数的同时增加,对降低未住院率的作用不明显。不同补偿模式发挥作用不同,以补住院和门诊统筹模式的作用更好。结论试点性的新农合制度对农民卫生服务利用有一定的促进作用,作用的发挥与补偿模式紧密相关,仍需加大筹资力度以更好发挥新农合的作用。 | 钱军程 高军 饶克勤 Adam Wagstaff Magnus Lindelow | 2008 | 中国卫生统计2008，25，5： | 11 |
| 4 | Systematic review:Laparoscopic fundoplication for gastroesophageal reflux disease in partial responders to proton pump inhibitors显示文摘AIM:To assess laparoscopic fundoplication(LF)in partial responders to proton pump inhibitors(PPIs)for gastroesophageal reflux disease(GERD).METHODS:We systematically searched PubMed and Embase(1966-Dec 2011)for articles reporting data on LF efficacy in partial responders.Due to a lack of randomized controlled trials,observational studies were included.Of 558 articles screened,17 were eligible for inclusion.Prevalence data for individual symptoms were collated across studies according to mutually compatible time points(before and/or after LF).Where suitable,prevalence data were presented as percentage of patients reporting symptoms of any frequency or severity.RESULTS:Due to a lack of standardized reporting of symptoms,the proportion of patients experiencing symptoms was recorded across studies where possible.After LF,the proportion of partial responders with heartburn was reduced from 93.1%(5 studies)to 3.8%(5 studies),with similar results observed for regurgitation[from 78.4%(4 studies)to 1.9%(4 studies)].However,10 years after LF,35.8%(2 studies)of partial responders reported heartburn and 29.1%(1 study)reported regurgitation.The proportion using acidsuppressive medication also increased,from 8.8%(4studies)in the year after LF to 18.2%(2 studies)at 10years.In the only study comparing partial responders to PPI therapy with complete responders,higher symptom scores and more frequent acid-suppressive medication use were seen in partial responders after LF.CONCLUSION:GERD symptoms improve after LF,but subsequently recur,and acid-suppressive medication use increases.LF may be less effective in partial responders than in complete responders. | Lars Lundell Martin Bell Magnus Ruth | 2014 | World Journal of Gastroenterology2014，20，3： | 10 |
| 5 | Functional findings in irritable bowel syndrome显示文摘IBS 的病理生理学复杂、仍然不完全地知道。中央、外部的因素,包括的精神分析聚会因素,反常官方补给的活动性和分泌物,和内脏的超敏性,被认为贡献 IBS 的症状。几研究在 IBS 病人表明了改变的官方补给的运动机能,模式基于占优势的肠模式在 IBS 亚群之间不同。很少研究到目前为止在 IBS 探讨了官方补给的分泌物,但是有一些证据,在 IBS 病人的小肠支持改变的分泌物。内脏的超敏性当前被认为也许是在 IBS 的最重要的 pathophysiological 因素。重要地,几个外部、内部的因素能调制内脏的敏感,以及官方补给的活动性,并且在官方补给的道以内提高应答的海角到例如,应力和营养素在 IBS 病人被表明了。今天 IBS 被看在之上,包含在伤寒的反常功能是所谓的大脑勇气轴的 dysregulation 的混乱,自治或中枢神经系统,与可能在一些病人并且在其它的从圆周的信号的扰乱的中央处理统治的外部改变。 | Iris Posserud Amanda Ersryd Magnus Simrén | 2006 | World Journal of Gastroenterology2006，12，18： | 9 |
| 6 | 国际糖尿病足工作组:促进糖尿病足溃疡创面愈合干预指南——《国际糖尿病足工作组:糖尿病足防治国际指南(2019)》的一部分显示文摘推荐1.考虑到疼痛或严重缺血等相对禁忌证,采用锐性清创术去除糖尿病足溃疡的腐肉、坏死组织和周围的胼胝优于其他方法。(GRADE推荐强度:强;证据质量:低)2.选择敷料主要是考虑渗出物控制、舒适性和成本。(强;低)3.不要使用含表面抗菌药物的敷料以加速溃疡的愈合。(强;低)4.针对曾用最佳标准治疗难以愈合的未感染的神经性缺血性糖尿病足溃疡,可以考虑使用蔗糖八硫酸盐敷料(脂质水胶寡糖敷料—校者注)。 | Gerry Rayman Prashant Vas Ketan Dhatariya Vicki Driver Agnes Hartemann Magnus Londahl Alberto Piaggesi Jan Apelqvist Chris Attinger Fran Game 无 杨彩哲(译) 许樟荣(审校) | 2019 | 感染.炎症.修复2019，20，4： | 8 |
| 7 | 非甾体抗炎药(包括环氧化酶-2抑制剂)在治疗膝关节骨关节炎所致疼痛中的作用:随机安慰剂对照临床试验的汇总分析显示文摘目的评价包括选择性环氧化酶2抑制剂(昔布类)在内的非甾体抗炎药(NSAIDs)在膝关节骨关节炎患者中的镇痛作用。试验设计对随机安慰剂对照的临床试验进行系统回顾和汇总分析。文献回顾本项研究共对23项研究中的10845例患者进行了回顾性分析,患者的平均年龄为62.5岁,其中7807例患者接受了适当剂量的NSAIDs治疗,3038例患者接受了安慰剂治疗。患者入选时,经100mm视觉模拟尺(VAS)测定的权重疼痛分数基线的平均值为64.2mm,症状存在的平均时间为8.2年。主要观察指标总体疼痛程度的变化。结果各项临床试验的方法学质量可以接受,但是其中13项试验在随机化之前排除了对NSAIDs治疗没有反应的患者。一项试验报告了长期疗效的数据,结果提示治疗1~4年期间,NSAIDs的疗效与安慰剂相当。汇总所有入选试验的数据显示,在治疗2~13周后疼痛程度的差值为VAS10.1mm(95%可信区间为7.4~12.8),优于安慰剂15.6%。来自不同试验所得到的结果之间差异很大,随机效应模型显示,疼痛改善的效应量为0.32(0.24~0.39)。10项没有排除对NSAIDs治疗没有反应患者的试验中,结果比较一致,疼痛改善的效应量为0.23(0.15~0.31)。结论NSAIDs能够在短期内减轻骨关节炎患者的膝关节疼痛,其疗效略优于安慰剂,但是现在的分析不支持对这种疾病长期应用NSAIDs。由于口服NSAIDs可以导致严重的不良反应,因此只推荐有限制的使用。 | Jan Magnus Bjordal Anne Elisabeth Ljunggren Atle Klovning Lars SlΦdal 张卓莉 | 2005 | 英国医学杂志中文版2005，8，3： | 6 |
| 8 | Strategies to obtain pattern fidelity in nanowire growth from large-area surfaces patterned using nanoimprint lithography显示文摘位置控制 nanowire 生长为依靠轻排放或轻吸收的基于 nanowire 的 optoelectronic 部件是重要的。为收获应用程序的太阳能, nanowires 的稠密的数组被需要;然而,到获得稠密的 nanowire 数组的一个主要障碍是种子粒子排水量并且在 nanowire 生长以前在退火的舞台期间联合。这里,我们探索三不同策略改进 nanoimprint 平版印刷术为 nanowire 生长定义的大区域的催化剂粒子数组的模式保藏。首先,我们看到在 nanoimprint 平版印刷术以前对待生长底层的热改进模式保藏。第二,我们探索由在由修改生长过程退火以前在地方修理种子粒子改进模式保藏的可能性。并且第三,我们证明一个罪恶 x 生长面具罐头充分阻止种子粒子排水量。我们显示出这些策略怎么允许我们极大地与对太阳能电池应用合适的尺寸改进成年 InP nanowire 数组的模式忠实,在取样的区域上的最终完成的 100% 模式保藏。这些策略的通用性质通过 GaAs 和差距 nanowires 的合成被支持。 | Gaute Otnes Magnus Heurlin Mariusz Graczyk Jesper Wallentin Daniel Jacobsson Alexander Berg Ivan Maximov Magnus T. Borgstrom | 2016 | Nano Research2016，9，10： | 6 |
| 9 | Epidemiology of civilian blast injuries inflicted by terrorist bombings from 1970-2016显示文摘An upsurge of terrorist activity has occurred in the past two decades. As part of this, explosive devices continue to be extensively deployed against civilians in wide-ranging environments. Bombings remain the leading worldwide cause of civilian fatalities due to terrorism. This demands an understanding of modern terrorist bombing trends to inform mitigation strategy. The objective of this study was to identify the occurrence and severity of bombings against civilian targets in diverse attack settings, and to establish corresponding blast injury profiles. Data was obtained from analysis of the Global Terrorism Database(GTD) and a meta-analysis of blast injury data derived from the PubMed database. Closed environment explosions were associated with significantly greater(p<0.05) mortality than in open spaces. The injury profiles were found to be influenced by attack setting, with higher rates of primary injury on trains and buses, and secondary injury in open space. | Danyal Magnus Mansoor A.Khan William G.Proud | 2018 | Defence Technology(防务技术)2018，14，5： | 6 |
| 10 | 两例食管癌肉瘤克隆来源的分子生物学分析显示文摘 | 孙孟红 朱雄增 Peter Moeller Christian Herfarth Magnus von Knebel Doeberitz Hans K Schackert Thomas Lehnert Johannes Gebert | 2001 | 中华病理学杂志2001，30，5： | 6 |
| 11 | Pharmacological interventions for improved colonic anastomotic healing:A meta-analysis显示文摘AIM:To identify pharmaceuticals for the prophylaxis of anastomotic leakage(AL),we systematically reviewed studies on anastomosis repair after colorectal surgery.METHODS:We searched PubMed and EMBASE for articles published between January 1975 and December 2012.We included studies in English with the primary purpose of promoting healing of anastomoses made in the colon or rectum under uncomplicated conditions.We excluded studies on adverse events from interventions,nutritional interventions or in situ physical supporting biomaterials.The primary outcome was biomechanical strength or AL.We performed meta-analyses on therapeutic agents investigated by three or more independent research groups using the same outcome.The DerSimonian-Laird method for random effects was applied with P < 0.05.RESULTS:Of the 56 different therapeutic agents assessed,7 met our inclusion criteria for the metaanalysis.The prostacyclin analog iloprost increased the weighted mean of the early bursting pressure of colonic anastomoses in male rats by 60 mmHg(95%CI:30-89) vs the controls,and the immunosuppressant tacrolimus increased this value by 29 mmHg(95%CI:4-53) vs the controls.Erythropoietin showed an enhancement of bursting pressure by 45 mmHg(95%CI:14-76).The anabolic compound growth hormone augmented the anastomotic strength by 21 mmHg(95%CI:7-35),possibly via the up-regulation of insulin-like growth factor-1,as this growth factor increased the bursting pressure by 61 mmHg(95%CI:43-79) via increased collagen deposition.Hyperbaric oxygen therapy increased the bursting pressure by 24 mmHg(95%CI:13-34).Broad-spectrum matrix metalloproteinase inhibitors increased the bursting pressure by 48 mmHg(95%CI:31-66) on postoperative days 3-4.In the only human study,the AL incidence was not significantly reduced in the 103 colorectal patients treated with aprotinin(11.7%) compared with the 113 placebo-treated patients(9.7%).CONCLUSION:This systematic review identified only one randomized clinical trial and seven therapeutic agents from pre-clinical models that could be explored further for the prophylaxis of AL after colorectal surgery. | Mari Nanna φines Peter-Martin Krarup Lars Nannestad Jorgensen Magnus Sven Agren | 2014 | World Journal of Gastroenterology2014，20，35： | 5 |
| 12 | 世界各地动脉粥样硬化血栓形成门诊患者心血管危险因素的流行及诊治情况显示文摘背景:动脉粥样硬化血栓形成是导致心血管疾病和死亡的主要原因。至今,尚无国际数据库阐述动脉粥样硬化血栓形成患者动脉硬化危险因素的特征和治疗强度。
目的:确定动脉粥样硬化危险因素的发生及治疗在世界许多国家是否具有可比性。设计、地点及参试者:“降低动脉粥样硬化血栓形成保持健康研究”(Reduction of Atherothrombosis for Continued Health,REACH)搜集了动脉粥样硬化危险因素及治疗情况的数据。从2003年到2004年,44个国家、5473位内科从业医师总共发现67888例年龄≥45岁的动脉病患者(冠心病[coronaryartery disease,CAD],n=40258;脑血管病,n=18843;周围动脉病,n=8273)或≥3个动脉粥样硬化血栓形成危险因素(n=12389)。主要观测指标:动脉粥样硬化危险因素的基线发生率、药物应用情况及危险因素控制程度。结果:全世界动脉粥样硬化血栓形成患者具有相似的危险因素,即高血压(81.8%)、高胆固醇血症(72.4%)以及糖尿病(44.3%)的比例高。超重(39.8%)、肥胖(26.6%)以及病态肥胖(3.6%)的发生率在大部分地区相似,但是以北美最高(超重:37.1%,肥胖:36.5%,病态肥胖:5.8%;与其他地区比较P〈0.001)。患者采用他汀(总共69.4%;范围:从脑血管病的56.4%到CAD的76.2%)、抗血小板治疗(总共78.6%;范围:从≥3个危险因素的53.9%到CAD的85.6%)及其他循证(降低危险)普遍不足。确诊有血管病的患者在吸烟者为数可观(14.4%)。高血压病治疗不足(基线50.0%血压升高)、高血糖诊断不足(4.9%)以及空腹血糖受损(其中36.5%不知已有糖尿病)均很常见。在有症状的动脉粥样硬化血栓形成患者中,15.9%是有症状的多血管疾病患者。
结论:这项当代大型国际数据库研究显示,在世界许多地区典型心血管危险因素的发生是一致且常见的,但是大多治疗不足、控制不得力。 | Deepak L. Bhatt, MD P. Gabriel Steg, MD E. Magnus Ohman, MD Alan T. Hirsch, MD Yasuo Ikeda, MD Jean-Louis Mas, MD Shinya Goto, MD Chlau-Suong Liau, MD, PhD Alain J. Richard, MD, PhD Joachim Roether, MD Peter W. F. Wilson, MD 徐成斌(译) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 5 |
| 13 | 全球动脉粥样硬化血栓形成门诊患者中心血管危险因素的患病率、认知和治疗显示文摘Context: Atherothrombosis is the leading cause of cardiovascular morbidity and mortality around the globe. To date, no single international database has characterized the atherosclerosis risk factor profile or treatment intensity of individuals with atherothrombosis. Objective: To determine whether atherosclerosis risk factor prevalence and treatment would demonstrate comparable patterns in many countries around the world. Design, Setting, and Participants: The Reduction of Atherothrombosis for Continued Health(REACH) Registry collected data on atherosclerosis risk factors and treatment. A total of 67 888 patients aged 45 years or older from 5473 physician practices in 44 countries had either established arterial disease(coronary artery disease[CAD], n=40 258; cerebrovascular disease, n=18843; peripheral arterial disease, n=8273) or 3 or more risk factors for atherothrombosis(n=12 389) between 2003 and 2004. Main Outcome Measures: Baseline prevalence of atherosclerosis risk factors, medication use, and degree of risk factor control. Results: Atherothrombotic patients throughout the world had similar risk factor profiles: a high proportion with hypertension(81.8% ), hypercholesterolemia(72.4% ), and diabetes(44.3% ). The prevalence of overweight(39.8% ), obesity(26.6% ), and morbid obesity(3.6% ) were similar in most geographic locales, but was highest in North America(overweight: 37.1% , obese: 36.5% , and morbidly obese: 5.8% ; P< .001 vs other regions). Patients were generally undertreated with statins(69.4% overall; range: 56.4% for cerebrovascular disease to 76.2% for CAD), antiplatelet agents(78.6% overall; range: 53.9% for ≥ 3 risk factors to 85.6% for CAD), and other evidence-based risk reduction therapies. Current tobacco use in patients with established vascular disease was substantial(14.4% ). Undertreated hypertension(50.0% with elevated blood pressure at baseline), undiagnosed hyperglycemia(4.9% ), and impaired fasting glucose(36.5% in those not known to be diabetic) were common. Among those with symptomatic atherothrombosis, 15.9% had symptomatic polyvascular disease. Conclusion: This large, international, contemporary database shows that classic cardiovascular risk factors are consistent and common but are largely undertreated and undercontrolled in many regions of the world. | Bhatt D.L Gabriel Steg P Magnus Ohman E. 黄浙勇 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 5 |
| 14 | 稀土资源既非稀有,也不那么重要显示文摘地球上的稀土元素并不罕见,但由于主要用于半导体、电子元器件、合金、特殊材料等,长期以来被认为是一种战略性矿产资源,各国对于稀土资源的供需变化和价格波动极为敏感。本文从中国稀土资源发现谈起,首先系统梳理了稀土元素的发现历史、名称由来等基本内容,接着从化学特性、主要用途、资源需求等方面对稀土资源进行了需求分析,又从资源储量、资源潜力、开采生产、主要企业和项目、替代品和回收利用等方面分析了稀土资源的供应情况,最后分析了稀土价格波动和地缘政治影响因素,并提出了未来稀土资源的发展展望。通过分析,本文认为人们对稀土供应的担忧被过分高估,从绝对量的角度看,稀土资源并不稀有,而且重要性有限,未来稀土的供应保障不存在问题。本文特别指出,人们对中国稀土政策导致供应短缺的忧虑,更多是对中国迅速扩大的地缘政治影响抱有疑虑,而非真的是稀土供应短缺所致,稀土为他们提供了一个指责中国的机会。 | Magnus Ericsson | 2016 | 国土资源情报2016，，11： | 5 |
| 15 | Laparoscopic revolution in bariatric surgery显示文摘The history of bariatric surgery is investigational.Dedicated surgeons have continuously sought for an ideal procedure to relieve morbidly obese patients from their burden of comorbid conditions,reduced life expectancy and low quality of life.The ideal procedure must have low complication risk,both in short- and long term,as well as minimal impact on daily life.The revolution of laparoscopic techniques in bariatric surgery is described in this summary.Advances in minimal invasive techniques have contributed to reduced operative time,length of stay,and complications.The development in bariatric surgery has been exceptional,resulting in a dramatic increase of the number of procedures performed world wide during the last decades.Although,a complex bariatric procedure can be performed with operative mortality no greater than cholecystectomy,specific procedure-related complications and other drawbacks must be taken into account.The evolution of laparoscopy will be the legacy of the 21 st century and at present,day-care surgery and further reduction of the operative trauma is in focus.The impressive effects on comorbid conditions have prompted the adoption of minimal invasive bariatric procedures into the field of metabolic surgery. | Magnus Sundbom | 2014 | World Journal of Gastroenterology2014，20，41： | 5 |
| 16 | 大堡礁和大峡谷世界遗产区的适应性管理显示文摘关于人类和环境相互关系的传统观念正在迅速改变。那种认为人类与自然是相互隔离的,自然资源是取之不尽用之不竭的,而且认为世界是稳定的、可以预测的并且是平衡的旧观点已经过时了。在动态的社会-生态景观中强调学习和灵活性管理为基础的适应性方法的新的理念框架已经迅速初现端倪。我们以两个典型的世界遗产地区(大堡礁和大峡谷)为案例来研究如何在自然资源管理中通过改善科学和社会两个方面的结合来指导多尺度管理系统的变革从而应对和处理人类越来越占据主导的世界中出现的不确定性、风险和变化。 | Terence P.Hughes Lance H.Gunderson Carl Folke Andrew H.Baird David Bellwood Fikret Berkes Beatrice Crona Ariella Helfgott Heather Leslie Jon Norberg Magnus Nystrm Per Olsson Henrik sterblom Marten Scheffer Heidi Schuttenberg Robert S.Steneck Maria Teng Max Troell Brian Walker James Wilson Boris Worm 丁莉 | 2007 | AMBIO-人类环境杂志2007，36，B11： | 4 |
| 17 | Identification of differentially expressed genes after partial rat liver ischemia/reperfusion by suppression subtractive hybridization显示文摘AIM: To identify potential diagnostic target genes in early reperfusion periods following warm liver ischemia before irreversible liver damage occurs.METHODS: We used two strategies (SSH suppression subtractive hybridization and hybridization of cDNA arrays)to determine early changes in gene expression profiles in a rat model of partial WI/R, comparing postischemic and adjacent nonischemic liver lobes. Differential gene expression was verified (WT/R; 1 h/2 h) and analyzed in more detail after warm ischemia (1 h) in a reperfusion time kinetics (0, 1, 2 and 6 h) and compared to untreated livers by Northern blot hybridizations. Protein expression was examined on Western blots and by immunohistochemistry for four differentially expressed target genes (Hsp70,Hsp27, Gadd45a and IL-1rl).RESULTS: Thirty-two individual WI/R target genes showing altered RNA levels after confirmation by Northern blot analyzes were identified. Among them, six functionally uncharacteristic expressed sequences and 26 known genes (12 induced in postischemic liver lobes, 14 with higher transcriptional expression in adjacent nonischemic liver lobes). Functional categories of the verified marker genes indicate on the one hand cellular stress and tissue damage but otherwise activation of protective cellular reactions (AP-1 transcription factors, apoptosis related genes, heat shock genes). In order to assign the transcriptional status to the biological relevant protein level we demonstrated that Hsp70, Hsp27, Gadd45a and IL-1rI were clearly up-regulated comparing postischemic and untreated rat livers, suggesting their involvement in the WI/R context.CONCLUSION: This study unveils a WI/R response gene set that will help to explore molecular pathways involved in the tissue damage after WI/R. In addition, these genes especially Hsp70and Gadd45a might represent promising new candidates indicating WI/R liver damage. | Christine Fallsehr Christina Zapletal Michael Kremer Resit Demir Magnus von Knebel Doeberitz Ernst Klar | 2005 | World Journal of Gastroenterology2005，11，9： | 4 |
| 18 | 瑞典南部相邻桦树和欧洲云杉林分的地表植被和土壤特征(英文)显示文摘对瑞典南部 2 3对相邻的桦树和欧洲云杉林分的地表植被和土壤特征进行了研究。桦树和欧洲云杉林分曲芒发草( Deschampsia flexuosa L.)和苔藓植物的频度几乎没有区别 ,但桦树林分越桔 ( Vaccinium myrtillus L.)和黑果越桔 ( Vac-cinium vitis-idaea L.)的频度远大于欧洲云杉林分的频度。欧洲云杉林分各层土壤 (腐殖质层、0~ 1 0 cm矿物质土壤层和1 1~ 30 cm矿物质土壤层 )的酸度稍大于桦树林分各层土壤的酸度。欧洲云杉林分土壤可交换性 K、Ca和 Mg离子的含量稍大于桦树林分土壤的含量 ,但差别不明显 ,只有可交换性 Na离子的含量在欧洲云杉林分土壤中明显偏高。由于现在硫沉降明显降低 。 | 史作民 Magnus Dahlgren Bengt Nihlgrd | 2001 | 生态学报2001，21，5： | 4 |
| 19 | In Situ Etching for Total Control Over Axial and Radial Nanowire Growth显示文摘We report a method using in situ etching to decouple the axial from the radial nanowire growth pathway,independent of other growth parameters.Thereby a wide range of growth parameters can be explored to improve the nanowire properties without concern of tapering or excess structural defects formed during radial growth.We demonstrate the method using etching by HCl during InP nanowire growth.The improved crystal quality of etched nanowires is indicated by strongly enhanced photoluminescence as compared to reference nanowires obtained without etching. | Magnus T.Borgström Jesper Wallentin Johanna Trägårdh Peter Ramvall Martin Ek LReine Wallenberg Lars Samuelson Knut Deppert | 2010 | Nano Research2010，3，4： | 4 |
| 20 | InP/GaInP nanowire tunnel diodes显示文摘 | Xulu Zeng Gaute Otnes Magnus Heurlin Renato T Mourao Magnus T Borgstrom | 2018 | Nano Research2018，11，5： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员