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| 1 | 牙列缺失患者种植体支持的固定和可摘义齿的回顾性研究显示文摘目的:研究十年观察期内种植体支持的固定和可摘义齿修复牙列缺失患者种植体的生存率和影响因素。方法:1995-2006年,227例患者(92例男性,135例女性)平均年龄63.7岁,在Charite’大学口腔颌面外科门诊接受种植和修复治疗。共1652颗种植体种植在牙列缺失上颌骨、下颌骨或双侧颌骨,支持76例(24.68%)固定义齿,232例(75.32%)可摘义齿。观察性别,种植体部位、修复方法对种植体生存率的影响。结果:其中有50例患者73颗种植体丧失,累计种植体生存率94.76%,本研究显示种植体生存率女性(93.93%)略低于男性(95.93%),但没有显著性差异。在上颌骨种植的种植体生存率(95.87%)略高于在下颌骨种植(94.53%),但统计学没有显著性意义。10年累计固定和可摘义齿的种植体生存率分别是98.02%和93.55%,两种修复方法差异有显著性。结论:确认了种植体支持牙列缺失患者修复中长期的成功率,并得出结论种植体生存率与性别,种植部位关系不大,与修复方法有关。种植体支持的固定义齿预后比可摘义齿好。 | 项立新 熊亚茸 Katja Nelson Susanne Heberer Semper Wiebke | 2010 | 口腔颌面修复学杂志2010，11，1： | 8 |
| 2 | Short-term effectiveness of golimumab for ulcerative colitis: Observational multicenter study显示文摘AIM To evaluate the real-world effectiveness of golimumab in ulcerative colitis(UC) and to identify predictors of response.METHODS We conducted an observational, prospective and multi-center study in UC patients treated with golimumab, from September 2014 to September 2015. Clinical activity was assessed at wk 0 and 14 with the physician's global clinical assessment(PGA) and the partial Mayo score. Colonoscopies and blood tests were performed, following daily-practice clinical criteria, and the results were recorded in an SPSS database.RESULTS Thirty-three consecutive patients with moderately to severely active UC were included. Among them, 54.5% were female and 42 years was the average age. Thirty percent had left-sided UC(E2) and 70% had extensive UC(E3). All patients had an endoscopic Mayo score of 2 or 3 at baseline. Twenty-seven point three percent were anti-tumor necrosis factor(TNF) treatment na?ve, whereas 72.7% had previously received infliximab and/or adalimumab. Sixty-nine point seven percent showed clinical response and were steroid-free at wk 14(a decrease from baseline in the partial Mayo score of at least 3 points). Based on PGA, the clinical remission and clinical response rates were 24% and 55% respectively. Withdrawal of corticosteroids was observed in 70.8% of steroid-dependent patients at the end of the study. Three out of 10 clinical non-responders needed a colectomy. Mean fecal calprotectin value at baseline was 300 μg/g, and 170.5 μg/g at wk 14. Being anti-TNF treatment na?ve was a protection factor, which was related to better chances of reaching clinical remission. Twenty-seven point three percent of the patients required treatment intensification at 14 wk of followup. Only three adverse effects(AEs) were observed during the study; all were mild and golimumab was not interrupted.CONCLUSION This real-life practice study endorses golimumab's promising results, demonstrating its short-term effectiveness and confirming it as a safe drug during the induction phase. | Marta Maia Bosca-Watts Xavier Cortes Marisa Iborra Jose Maria Huguet Laura Sempere Gloria Garcia Rafa Gil Mari Fe Garcia Marga Munoz Pedro Almela Nuria Maroto Jose Maria Paredes | 2016 | World Journal of Gastroenterology2016，22，47： | 5 |
| 3 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 4 | Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021显示文摘The detection of dysplasia in patients with inflammatory bowel disease(IBD)continues to be important given the increased risk of colorectal cancer in this population.Therefore,in 2017,we performed a review and update of the recommendations for the management and follow-up of patients with IBD based on the clinical practice guidelines of various scientific societies.The present manuscript focuses on new aspects of the detection,follow-up,and management of dysplasia according to the latest studies and recommendations.While chromoendoscopy with targeted biopsy continues to be the technique of choice for the screening and detection of dysplasia in IBD,the associated difficulties mean that it is now being compared with other techniques(virtual chromoendoscopy),which yield similar results with less technical difficulties.Furthermore,the emergence of new endoscopy techniques that are still being researched but seem promising(e.g.,confocal laser endomicroscopy and full-spectrum endoscopy),together with the development of devices that improve endoscopic visualization(e.g.,Endocuff Vision),lead us to believe that these approaches can revolutionize the screening and follow-up of dysplasia in patients with IBD.Nevertheless,further studies are warranted to define the optimal follow-up strategy in this patient population. | Jose Maria Huguet Luis Ferrer-Barceló Patrícia Suárez Eva Sanchez Jose David Prieto Victor Garcia Javier Sempere | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 5 | Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation显示文摘 | Sempere LF Freemantle S Pitha-Rowe I | 2004 | Genome Biol2004，5，： | 1 |
| 6 | Expression profiling of mammalian microRNAs uncovers a subset of brain- expressed microRNAs with possible roles in murine and human neuronal differentiation显示文摘 | Sempere LF Freemantle S Pitha-Rowe I | 2004 | Genome Biol2004，5，3： | 1 |
| 7 | Optimal licensing in a spatial model显示文摘 | Caballero S F Moner C R Sempere J J | 2002 | Annales d'' Economie et de Statistique2002，，66： | 1 |
| 8 | Expression profiling of mammalian miRNAs uncovers a subset of brain-expressed miRNAs with possible roles in murine and human neuronal differentiation显示文摘 | Sempere L F Freemantle S Pitha-Rowe I | 2004 | Genome Biology2004，5，3： | 1 |
| 9 | The post-endodontic periapical lesion: Histologic and etiopathogenic aspects显示文摘 | Garcia CC Sempere FV Diago MP | 2007 | Med Oral Patol Oral Cir Bucal2007，12，8： | 1 |
| 10 | The phylogenetie distribu- tion of metazoan mieroRNAs :insights into evolutionary complexi- ty and constraint显示文摘 | Sempere LF Cole CN Mcpeek MA | 2006 | J gxp Zool B Mol Dev Evol2006，306，6： | 1 |
| 11 | Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation显示文摘 | Sempere L F Freemantle S Pitha-Rowe I | 2004 | Genome Biol2004，5，3： | 1 |
| 12 | Intratumoral heterogeneity of DNA content in renal cell carcinoma and its prognostic significance显示文摘 | Hernandez M Sempere A | 1999 | Cancer1999，86，4： | 1 |
| 13 | Uncovering growth-suppres- sive MicroRNAs in lung cancer 显示文摘 | Liu X Sempere LF Galimberti F | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 14 | Uncovering growth- suppressive MicroRNAs in lung cancer 显示文摘 | Liu X Sempere LF Galimberti F | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 15 | T regulatory cells and HIV infection显示文摘 | Sempere JM Soriano V Benito JM | | 0，，01： | 1 |
| 16 | Influence of manufacturing tolerances on the electro- motive force in permanent-magnet motors 显示文摘 | SIMON - SEMPERE V BURGOS - PAYAN M CERQUIDES - BUENO J R | 2013 | IEEE Transactions on Magnetics2013，49，11： | 1 |
| 17 | Maximum Temperature Attainable by Runaway of Synthesis Reaction in Semibatch Processes显示文摘 | SERRA E NOMEN R SEMPERE J J | 1997 | Journal of Loss Prevention in the Process Industries1997，10，4： | 1 |
| 18 | Uncovering growth- suppressive MicroRNAs in lung cancer 显示文摘 | Liu X Sempere L F Galimberti F | 2009 | Clin Cancer Res2009，15，4： | 1 |
| 19 | T regulatory cells and HIV infection显示文摘 | Sempere J M Soriano V Benito J M | 2007 | AIDS Rev2007，9，： | 1 |
| 20 | Incidence of tran-sient ischemic attacks and minor ischemic strokes inSegovia,Spain显示文摘 | Sempere A P Duarte J Cabezas C | 1996 | Stroke1996，27，4： | 1 |
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