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| 1 | Ehealth:Low FODMAP diet vs Lactobacillus rhamnosus GG in irritable bowel syndrome显示文摘AIM:To investigate the effects of a low fermentable,oligosaccharides,disaccharides,monosaccharides and polyols diet(LFD)and the probiotic Lactobacillus rhamnosus GG(LGG)in irritable bowel syndrome(IBS).METHODS:Randomised,unblinded controlled trial on the effect of 6-wk treatment with LFD,LGG or a normal Danish/Western diet(ND)in patients with IBS fulfilling Rome III diagnostic criteria,recruited betweenNovember 2009 and April 2013.Patients were required to complete on a weekly basis the IBS severity score system(IBS-SSS)and IBS quality of life(IBS-QOL)questionnaires in a specially developed IBS web selfmonitoring application.We investigated whether LFD or LGG could reduce IBS-SSS and improve QOL in IBS patients.RESULTS:One hundred twenty-three(median age 37years,range:18-74 years),90(73%)females were randomised:42 to LFD,41 to LGG and 40 to ND.A significant reduction in mean±SD of IBS-SSS from baseline to week 6 between LFD vs LGG vs ND was revealed:133±122 vs 68±107,133±122 vs 34±95,P<0.01.Adjusted changes of IBS-SSS for baseline covariates showed statistically significant reduction of IBS-SSS in LFD group compared to ND(IBS-SSS score75;95%CI:24-126,P<0.01),but not in LGG compared to ND(IBS-SSS score 32;95%CI:18-80,P=0.20).IBS-QOL was not altered significantly in any of the three groups:mean±SD in LFD 8±18 vs LGG 7±17,LFD 8±18 vs ND 0.1±15,P=0.13.CONCLUSION:LFD is efficacious for patients with IBS. | Natalia Pedersen Nynne Nyboe Andersen Zsuzsanna Végh Lisbeth Jensen Dorit Vedel Ankersen Maria Felding Mette Hestetun Simonsen Johan Burisch Pia Munkholm | 2014 | World Journal of Gastroenterology2014，20，43： | 16 |
| 2 | Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology显示文摘AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis. METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment. RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score. CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis. | Mikkel Malham SΦren Peter JΦrgensen Peter Ott JΦrgen Agnholt Hendrik Vilstrup Mette Borre Jens F Dahlerup | 2011 | World Journal of Gastroenterology2011，17，7： | 15 |
| 3 | Gender gap in acute coronary heart disease:Myth or reality?显示文摘AIM: To investigate potential gender differences in the prevalence of cardiovascular risk factors, cardiovascular disease (CVD) management, and prognosis in acute coronary syndrome (ACS). METHODS: A systematic literature search was performed through Medline using pre-specified key words . An additional search was performed, focusing specifically on randomized controlled clinical trials in relation to therapeutic intervention and prognosis. In total, 92 relevant articles were found. RESULTS: Women with CVD tended to have more hypertension and diabetes at the time of presentation, whereas men were more likely to smoke. Coronary angiography and revascularization by percutaneous coronary intervention were performed more often in men. Women were at a greater risk of short-term mortality and complications after revascularization. Interestingly, women under 40 years presenting with ACS were athighest risk of cardiovascular death compared with men of the same age, irrespective of risk factors. This disadvantage disappeared in older age. The long-term mortality risk of ACS was similar in men and women, and even in favor of women. CONCLUSION: Mortality rates are higher among young women with ACS, but this difference tends to disappear with age, and long-term prognosis is even better among older women. | Mette Claassen Kirsten C Sybrandy Yolande E Appelman Folkert W Asselbergs | 2012 | World Journal of Cardiology2012，4，2： | 9 |
| 4 | Human-driven topographic effects on the distribution of forest in a flat, lowland agricultural region显示文摘复杂地形学在多山的区域对采伐森林缓冲森林。然而,如果地面也在人的影响是可能的是地面抑制的更少的低地塑造森林分发,它是未知的。在如此的区域,如果重要根本,地志的效果将取决于文化历史的因素并且因此人驱动(人为) 而非自然,除了在一般气候或极端玷污的区域,限制森林的出现。我们使用了空间回归当模特儿估计地志的因素向解释森林分发的程度(存在缺席在一 48 ? | Mette V. ODGAARD Peder K. BOCHER Tommy DALGAARD Jesper E. MOESLUND Jens-Christian SVENNING | 2014 | Journal of Geographical Sciences2014，24，1： | 6 |
| 5 | Localization of the Arabidopsis Senescence- and Cell Death-Associated BFN1 Nuclease: From the ER to Fragmented Nuclei显示文摘植物联系老朽或联系 PCD 的核酸酶从不同有机体与核酸酶分享重要相同。然而,他们的功能的知识是有限的。Arabidopsis 联系老朽、联系 PCD 的核酸酶 BFN1 的细胞内部的本地化被调查。在短暂地转变的烟草原物的 BFN1GFP 本地化的分析表明在细丝状的结构的起始的本地化在整个细胞质传播了,它然后在原物开始衰老的原子核附近聚类。这些细丝状的结构作为具有被识别嗯起源。在 BFN1GFP 转基因的 Arabidopsis 植物, BFN1GFP 的类似的本地化在年轻叶子被观察,也就是说,在细丝状的结构,那仅仅在开始衰老在原子核附近重新组织房间。在迟了的老朽, BFN1GFP 与在包膜的泡的碎裂的原子核是局部性的。BFN1 的要求的功能作为 nucleic,在老朽和 PCD 的酸降级的酶被它的本地化模式支持。我们的结果建议在老朽和 PCD 的 nucleic 酸降级处理的调停的奉献分隔空间的存在。 | Sarit Farage-Barhom Shaul Burd Lilian Sonego Ana Mett Eduard Belausov David Gidoni Amnon Lers | 2011 | Molecular Plant2011，4，6： | 5 |
| 6 | Nutrition in chronic pancreatitis显示文摘The pancreas is a major player in nutrient digestion.In chronic pancreatitis both exocrine and endocrine insufficiency may develop leading to malnutrition over time.Maldigestion is often a late complication of chronic pancreatic and depends on the severity of the underlying disease.The severity of malnutrition is correlated with two major factors:(1)malabsorption and depletion of nutrients(e.g.,alcoholism and pain)causes impaired nutritional status;and(2)increased metabolic activity due to the severity of the disease.Nutritional deficiencies negatively affect outcome if they are not treated.Nutritional assessment and the clinical severity of the disease are important for planning any nutritional intervention.Good nutritional practice includes screening to identify patients at risk,followed by a thoroughly nutritional assessment and nutrition plan for risk patients.Treatment should be multidisciplinary and the mainstay of treatment is abstinence from alcohol,pain treatment,dietary modifications and pancreatic enzyme supplementation.To achieve energy-end protein requirements,oral supplementation might be beneficial.Enteral nutrition may be used when patients do not have sufficient calorie intake as in pylero-duodenalstenosis,inflammation or prior to surgery and can be necessary if weight loss continues.Parenteral nutrition is very seldom used in patients with chronic pancreatitis and should only be used in case of GI-tract obstruction or as a supplement to enteral nutrition. | Henrik Hφjgaard Rasmussen φivind Irtun Sφren Schou Olesen Asbjφrn Mohr Drewes Mette Holst | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 7 | A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor显示文摘Glucagon-like peptides(GLP-1 and GLP-2)are two proglucagon-derived intestinal hormones that mediate distinct physiological functions through two related receptors(GLP-1R and GLP-2R)which are important drug targets for metabolic disorders and Crohn's disease,respectively.Despite great progress in GLP-1 R structure determination,our understanding on the differences of peptide binding and signal transduction between these two receptors remains elusive.Here we report the electron microscopy structure of the human GLP-2R in complex with GLP-2 and a Gs heterotrimer.To accommodate GLP-2 rather than GLP-1,GLP-2R fine-tunes the conformations of the extracellular parts of transmembrane helices(TMs)1,5,7 and extracellular loop 1(ECL1).In contrast to GLP-1,the N-terminal histidine of GLP-2 penetrates into the receptor core with a unique orientation.The middle region of GLP-2 engages with TM1 and TM7 more extensively than with ECL2,and the GLP-2 C-terminus closely attaches to ECL1,which is the most protruded among 9 class B G protein-coupled receptors(GPCRs).Functional studies revealed that the above three segments of GLP-2 are essential for GLP-2 recognition and receptor activation,especially the middle region.These results provide new insights into the molecular basis of ligand specificity in class B GPCRs and may facilitate the development of more specific therapeutics. | Wen Sun Li-Nan Chen Qingtong Zhou Li-Hua Zhao Dehua Yang Huibing Zhang Zhaotong Cong Dan-Dan Shen Fenghui Zhao Fulai Zhou Xiaoqing Cai Yan Chen Yan Zhou Sarina Gadgaard Wijnand JCvan der Velden Suwen Zhao Yi Jiang Mette MRosenkilde HEric Xu Yan Zhang Ming-Wei Wang | 2020 | Cell Research2020，30，12： | 4 |
| 8 | User Driven Innovation in the Building Process显示文摘During the late years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due to introduction of advanced information and communication technology (ICT). The paper focuses on creative changes of the building process powered by user driven innovation activities. An overview of existing user driven innovation methodologies is given as well experiences from the ongoing Virtual Innovation in Construction (VIC) project. One important driving force for change is the opportunity for users to develop and articulate real needs concerning for example different functionalities of a building and its parts, but also on artifacts supporting the actual needs capture and requirements formulation during building design. A general methodological framework and meta ontology for Virtual Innovation in Construction is presented as well as findings from implementation of the method. | Per Christiansson Kistian Birch Sφrensen Mette Rφdtness Mette Abrahamsen Lars Ostenfeld Riemnann Morten Alsdorf | 2008 | Tsinghua Science and Technology2008，13，S1： | 4 |
| 9 | 警惕仔猪缺铁性贫血显示文摘由于仔猪在出生后第1周可给予铁剂,因缺铁导致的仔猪贫血症已被视为过去式。然而,在现代养猪生产中,仔猪贫血又卷土重来,影响了仔猪的福利和猪场的利润。是时候重新公开本案例了。 | 陶莉 罗静如 Anne Mette Scrunz Hanl | 2014 | 国外畜牧学(猪与禽)2014，0，12： | 4 |
| 10 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Cesare Hassan Enrique Quintero Jean-Marc Dumonceau Jaroslaw Regula Catarina Brand?o Stanislas Chaussade Evelien Dekker Mario Dinis-Ribeiro Monika Ferlitsch Antonio Gimeno-García Yark Hazewinkel Rodrigo Jover Mette Kalager Magnus Loberg Christian Pox Bjorn | 2013 | Endoscopy2013，，10： | 3 |
| 11 | 麦秆水解液发酵生产燃料乙醇的研究显示文摘对腐生真菌Mucorindicus在湿氧化预处理的小麦秸秆水解液培养基中的生长及发酵产生酒精的性能进行了研究。结果表明,在厌氧条件下,乙醇对总糖的转化率和菌体生物量分别达到了0.37g/g和0.12g/g;好氧条件下,乙醇对总糖的转化率和菌体生物量分别达到0.33g/g和0.24g/g;该菌株对水解液中发酵抑制剂甲酸、乙酸等有较强的耐受能力。 | 金花 陆军 李涛 侯霖 朴敬惠 刘一清 Mette H.T. 张强 | 2007 | 酿酒科技2007，，12： | 3 |
| 12 | Comparison of Osteoprotegerin to Traditional Atherosclerotic Risk Factors and High-Sensitivity C-Reactive Protein for Diagnosis of Atherosclerosis显示文摘 | Rasmus Mogelvang Sune H. Pedersen Allan Flyvbjerg Mette Bjerre Allan Z. Iversen Soren Galatius Jan Frystyk Jan S. Jensen | 2012 | The American Journal of Cardiology2012，，4： | 3 |
| 13 | Individualized home-monitoring of disease activity in adult patients with inflammatory bowel disease can be recommended in clinical practice: A randomized-clinical trial显示文摘BACKGROUND The optimal way to home-monitor patients with inflammatory bowel disease(IBD)for disease progression or relapse remains to be found.AIM To determine whether an electronic health(eHealth)screening procedure for disease activity in IBD should be implemented in clinical practice,scheduled every third month(3M)or according to patient own decision,on demand(OD).METHODS Adult IBD patients were consecutively randomized to 1-year open-label eHealth interventions(3M vs OD).Both intervention arms were screening for disease activity,quality of life and fatigue and were measuring medical compliance with the constant care web-application according to the screening interventions OD or 3M.Disease activity was assessed using home measured fecal calprotectin(FC)and a disease activity score.RESULTS In total,102 patients were randomized(n=52/503M/OD)at baseline,and 88 patients completed the 1-year study(n=433M;n=45 OD).No difference in the two screening procedures could be found regarding medical compliance(P=0.58),fatigue(P=0.86),quality of life(P=0.17),mean time spent in remission(P>0.32),overall FC relapse rates(P=0.49),FC disease courses(P=0.61),FC time to a severe relapse(P=0.69)and remission(P=0.88)during 1 year.Median(interquartile range)numbers of FC home-monitoring test-kits used per patient were significantly different,3M:6.0(5.0-8.0)and OD:4.0(2.0-9.0),P=0.04.CONCLUSION The two eHealth screening procedures are equally good in capturing a relapse and bringing about remission.However,the OD group used fewer FC home testkits per patient.Individualized screening procedures can be recommended for adult IBD patients in clinical web-practice. | Dorit Vedel Ankersen Petra Weimers Dorte Marker Mette Bennedsen Sanaz Saboori Kristine Paridaens Johan Burisch Pia Munkholm | 2019 | World Journal of Gastroenterology2019，25，40： | 2 |
| 14 | 欧洲华人社会新动态——《国际移民》两辑“欧洲华人研究特刊”之比较显示文摘论文以英文学术期刊《国际移民》于2003年和2020年出版的两辑特刊为样本,进行了比较与分析,梳理了21世纪以来欧洲华人社会在人口流动、经济活动和政治参与三个方面发展变化的新动态,探讨了欧洲华人研究的新动向,并就当前发达国家将公民权商品化、移民社会发展中偶然与必然的辩证统一关系以及生命历程理论视野下的追踪研究等问题进行理论思辨。 | 李明欢 Mette Thunø | 2022 | 华侨华人历史研究2022，，2： | 2 |
| 15 | Shot-noise limited, supercontinuum-based optical coherence tomography显示文摘We present the first demonstration of shot-noise limited supercontinuum-based spectral domain optical coherence tomography(SD-OCT)with an axial resolution of 5.9μm at a center wavelength of 1370 nm.Current supercontinuumbased SD-OCT systems cannot be operated in the shot-noise limited detection regime because of severe pulse-topulse relative intensity noise of the supercontinuum source.To overcome this disadvantage,we have developed a low-noise supercontinuum source based on an all-normal dispersion(ANDi)fiber,pumped by a femtosecond laser.The noise performance of our 90 MHz ANDi fiber-based supercontinuum source is compared to that of two commercial sources operating at 80 and 320 MHz repetition rate.We show that the low-noise of the ANDi fiber-based supercontinuum source improves the OCT images significantly in terms of both higher contrast,better sensitivity,and improved penetration.From SD-OCT imaging of skin,retina,and multilayer stacks we conclude that supercontinuumbased SD-OCT can enter the domain of shot-noise limited detection. | Shreesha Rao D.S. Mikkel Jensen Lars Grüner-Nielsen Jesper Toft Olsen Peter Heiduschka Björn Kemper Jürgen Schnekenburger Martin Glud Mette Mogensen Niels Møller Israelsen Ole Bang | 2021 | Light(Science & Applications)2021，10，7： | 2 |
| 16 | Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors显示文摘 | Christina B. Rasmussen Mette T. Faber Allan Jensen Estrid H?gdall Claus H?gdall Jan Blaak?r Susanne K. Kjaer | 2013 | Cancer Causes & Control2013，，7： | 2 |
| 17 | Oximes: Unrecognized Chameleons in Genera and Specialized Plant Metabolism显示文摘 | Mette S rensen Elizabeth H.J. Neilson Birger Lindberg Moiler | 2018 | Molecular Plant2018，11，1： | 2 |
| 18 | Romantic Belief: Their Influence on Relationships and Patterns of Change Over Time 显示文摘 | Sprecher S Metts S | 1999 | Journal of Social and Personal Relationships1999，16，： | 1 |
| 19 | Transcriptional gene silencing and promoter methylation triggered by double stranded RNA 显示文摘 | Aufsatz W van der Winden J Matzke M A Matzke A J M | 2000 | EMBO J2000，19，： | 1 |
| 20 | Human-derived, plant-produced monoclonal antibody for the treatment of anthrax显示文摘 | Hulla A K Carolyn J Mett V | 2005 | Vaccine2005，23，1718： | 1 |
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