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| 1 | Biochemical changes in the injured brain显示文摘Brain metabolism is an energy intensive phenomenon involving a wide spectrum of chemical intermediaries. Various injury states have a detrimental effect on the biochemical processes involved in the homeostatic and electrophysiological properties of the brain. The biochemical markers of brain injury are a recent addition in the armamentarium of neuro-clinicians and are being increasingly used in the routine management of neuropathological entities such as traumatic brain injury, stroke, subarachnoid haemorrhage and intracranial space occupying lesions. These markers are increasingly being used in assessing severity as well as in predicting the prognostic course of neuro-pathological lesions. S-100 protein, neuron specific enolase, creatinine phosphokinase isoenzyme BB and myelin basic protein are some of the biochemical markers which have been proven to have prognostic and clinical value in the brain injury. While S-100, glial fibrillary acidic protein and ubiquitin C terminal hydrolase are early biomarkers of neuronal injury and have the potential to aid in clinical decisionmaking in the initial management of patients presenting with an acute neuronal crisis, the other biomarkers are of value in predicting long-term complications and prognosis in such patients. In recent times cerebral microdialysis has established itself as a novel way of monitoring brain tissue biochemical metabolites such as glucose, lactate, pyruvate, glutamate and glycerol while small non-coding RNAs have presented themselves as potential markers of brain injury for future. | Seelora Sahu Deb Sanjay Nag Amlan Swain Devi Prasad Samaddar | 2017 | World Journal of Biological Chemistry2017，8，1： | 22 |
| 2 | Adjuvants to local anesthetics: Current understanding and future trends显示文摘Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by itsduration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action. A large array of opioids ranging from morphine, fentanyl and sufentanyl to hydromorphone, buprenorphine and tramadol has been used with varying success. However, their use has been limited by their adverse effect like respiratory depression, nausea, vomiting and pruritus, especially with its neuraxial use. Epinephrine potentiates the local anesthetics by its antinociceptive properties mediated by alpha-2 adrenoreceptor activation along with its vasoconstrictive properties limiting the systemic absorption of local anesthetics. Alpha 2 adrenoreceptor antagonists like clonidine and dexmedetomidine are one of the most widely used class of local anesthetic adjuvants. Other drugs like steroids(dexamethasone), anti-inflammatory agents(parecoxib and lornoxicam), midazolam, ketamine, magnesium sulfate and neostigmine have also been used with mixed success. The concern regarding the safety profile of these adjuvants is due to its potential neurotoxicity and neurological complications which necessitate further research in this direction. Current research is directed towards a search for agents and techniques which would prolong local anaesthetic action without its deleterious effects. This includes novel approaches like use of charged molecules to produce local anaesthetic action(tonicaine and n butyl tetracaine), new age delivery mechanisms for prolonged bioavailability(liposomal, microspheres and cyclodextrin systems) and further studies with other drugs(adenosine, neuromuscular blockers, dextrans). | Amlan Swain Deb Sanjay Nag Seelora Sahu Devi Prasad Samaddar | 2017 | World Journal of Clinical Cases2017，5，8： | 18 |
| 3 | Intracranial pressure monitoring:Gold standard and recent innovations显示文摘Intracranial pressure monitoring (ICP) is based on the doctrine proposed by Monroe and Kellie centuries ago. With the advancement of technology and science, various invasive and non-invasive modalities of monitoring ICP continue to be developed. An ideal monitor to track ICP should be easy to use, accurate, reliable, reproducible, inexpensive and should not be associated with infection or haemorrhagic complications. Although the transducers connected to the extra ventricular drainage continue to be Gold Standard, its association with the likelihood of infection and haemorrhage have led to the search for alternate noninvasive methods of monitoring ICP. While Camino transducers, Strain gauge micro transducer based ICP monitoring devices and the Spiegelberg ICP monitor are the emerging technology in invasive ICP monitoring, optic nerve sheath diameter measurement, venous opthalmodynamometry, tympanic membrane displacement, tissue resonance analysis, tonometry, acoustoelasticity, distortionproduct oto-acoustic emissions, trans cranial doppler, electro encephalogram, near infra-red spectroscopy, pupillometry, anterior fontanelle pressure monitoring, skull elasticity, jugular bulb monitoring, visual evoked response and radiological based assessment of ICP are the non-invasive methods which are assessed against the gold standard. | Deb Sanjay Nag Seelora Sahu Amlan Swain Shashi Kant | 2019 | World Journal of Clinical Cases2019，7，13： | 16 |
| 4 | Vasopressors in obstetric anesthesia: A current perspective显示文摘Vasopressors are routinely used to counteract hypotension after neuraxial anesthesia in Obstetrics. The understanding of the mechanism of hypotension and the choice of vasopressor has evolved over the years to a point where phenylephrine has become the preferred vasopressor. Due to the absence of definitive evidence showing absolute clinical benefit of one over the other, especially in emergency and high-risk Cesarean sections, our choice of phenylephrine over the other vasopressors like mephentermine, metaraminol, and ephedrine is guided by indirect evidence on fetalacid-base status. This review article evaluates the present day evidence on the various vasopressors used in obstetric anesthesia today. | Deb Sanjay Nag Devi Prasad Samaddar Abhishek Chatterjee Himanshu Kumar Ankur Dembla | 2015 | World Journal of Clinical Cases2015，3，1： | 15 |
| 5 | The MDM2-p53 pathway revisited显示文摘The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important defense mechanism against cancer onset and progression, and is negatively regulated by interaction with the oncoprotein MDM2. In human cancers, the TP53 gene is frequently mutated or deleted, or the wild-type p53 function is inhibited by high levels of MDM2, leading to downregulation of tumor suppressive p53 pathways. Thus, the inhibition of MDM2-p53 interaction presents an appealing therapeutic strategy for the treatment of cancer. However, recent studies have revealed the MDM2-p53 interaction to be more complex involving multiple levels of regulation by numerous cellular proteins and epigenetic mechanisms, making it imperative to reexamine this intricate interplay from a holistic viewpoint. This review aims to highlight the multifaceted network of molecules regulating the MDM2-p53 axis to better understand the pathway and exploit it for anticancer therapy. | Subhasree Nag Jiangjiang Qin Kalkunte S.Srivenugopal Minghai Wang Ruiwen Zhang | 2013 | The Journal of Biomedical Research2013，27，4： | 13 |
| 6 | Frozen shoulder-A prospective randomized clinical trial显示文摘AIM To compare the results of arthroscopic capsular release with intra-articular steroid injections in patients of frozen shoulder.METHODS Fifty-six patients with frozen shoulder were randomised to one of two treatment groups: Group 1, complete 360 degree arthroscopic capsular release and group 2, intra-articular corticosteroid injection(40 mg methyl prednisolone acetate). Both groups were put on active and passive range of motion exercises following the intervention. The outcome parameters were visual analogue scale(VAS) score for pain, range of motion and Constant score which were measured at baseline, 4, 8, 12, 16 and 20 wk after intervention.RESULTS All the parameters improved in both the groups. The mean VAS score improved significantly more in the group 1 as compared to group 2 at 8 wk. This greater improvement was maintained at 20 wk with P value of 0.007 at 8 wk, 0.006 at 12 wk, 0.006 at 16 wk and 0.019 at 20 wk. The Constant score showed a more significant improvement in group 1 compared to group 2 at 4 wk, which was again maintained at 20 wk with P value of 0.01 at 4, 8, 12 and 16 wk. The gain in abduction movement was statistically significantly more in arthroscopy group with P value of 0.001 at 4, 8, 12, 16 wk and 0.005 at 20 wk. The gain in external rotation was statistically significantly more in arthroscopy group with P value of 0.007 at 4 wk, 0.001 at 8, 12, and 16 wk and 0.003 at 20 wk. There was no statistically significant difference in extension and internal rotation between the two groups at any time. CONCLUSION Arthroscopic capsular release provides subjective and objective improvement earlier than intra-articular steroid injection. | Rudra Narayan Mukherjee R M Pandey Hira Lal Nag Ravi Mittal | 2017 | World Journal of Orthopedics2017，8，5： | 11 |
| 7 | Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis显示文摘AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated cirrhosis.METHODS: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 mo.RESULTS: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show any significant difference(P =0.60) when compared to the control group. There was no improvement in aspartate transaminase, alanine transaminase, and bilirubin at any point in the study population. There was no mortality benefit in the study group. The procedure was safe with no procedural or treatment related complications.CONCLUSION: Autologous CD 34+ cell infusion is safe and effectively improves liver function in the short term and may serve as a bridge to liver transplantation. | Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata Reddy Kuncharam Chimpa Reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，23： | 9 |
| 8 | Management of hypersplenism in non-cirrhotic portal hypertension:a surgical series显示文摘BACKGROUND:Hypersplenism is commonly seen in patients with non-cirrhotic portal hypertension(NCPH).While a splenectomy alone can effectively relieve the hypersplenism,it does not address the underlying portal hypertension.The present study was undertaken to analyze the impact of shunt and non-shunt operations on the resolution of hypersplenism in patients with NCPH.The relationship of symptomatic hypersplenism,severe hypersplenism and number of peripheral cell line defects to the severity of portal hypertension and outcome was also assessed.METHODS:A retrospective analysis of NCPH patients with hypersplenism managed surgically between 1999 and 2009 at our center was done.Of 252 patients with NCPH,64(45 with extrahepatic portal vein obstruction and 19 with non-cirrhotic portal fibrosis) had hypersplenism and constituted the study group.Statistical analysis was done using GraphPad InStat.Categorical and continuous variables were compared using the chi-square test,ANOVA,and Student's t test.The MannWhitney U test and Kruskal-Wallis test were used to compare non-parametric variables.RESULTS:The mean age of patients in the study group was 21.81±6.1 years.Hypersplenism was symptomatic in 70.3% with an incidence of spontaneous bleeding at 26.5%,recurrent anemia at 34.4%,and recurrent infection at 29.7%.The mean duration of surgery was 4.16±1.9 hours,intraoperative blood loss was 457±126(50-2000) mL,and postoperative hospital stay 5.5±1.9 days.Following surgery,normalization of hypersplenism occurred in all patients.On long-term followup,none of the patients developed hepatic encephalopathy and 4 had a variceal re-bleeding(2 after a splenectomy alone,1 each after an esophago-gastric devascularization and proximal splenorenal shunt).Patients with severe hypersplenism and those with defects in all three peripheral blood cell lineages were older,had a longer duration of symptoms,and a higher incidence of variceal bleeding and postoperative morbidity.In addition,patients with triple cell line defects had elevated portal pressure(P=0.001),portal biliopathy(P=0.02),portal gastropathy(P=0.005) and intraoperative blood loss(P=0.001).CONCLUSIONS:Hypersplenism is effectively relieved by both shunt and non-shunt operations.A proximal splenorenal shunt not only relieves hypersplenism but also effectively addresses the potential complications of underlying portal hypertension and can be safely performed with good long-term outcome.Patients with hypersplenism who have defects in all three blood cell lineages have significantly elevated portal pressures and are at increased risk of complications of variceal bleeding,portal biliopathy and gastropathy. | Rajesh Rajalingam Amit Javed Dharmanjay Sharma Puja Sakhuja Shivendra Singh Hirdaya H Nag Anil K Agarwal | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 7 |
| 9 | Delayed migration of K-wire into popliteal fossa used for tension band wiring of patellar fracture显示文摘被用于破裂固定的 K 电线和不锈钢电线的破裂不是不平常的,但是移植是稀罕的。我们报导为髌紧张乐队配线使用到腿弯部的窝的破 K 电线的移植的一个案例。破硬件通过手术被移开。我们想建议那 K 电线和电线固定使用了因为膝盖骨的破裂的治疗能移居进膝的以后的分隔空间并且引起临床的症状。在曾经,骨折统一了识别电线的硬件破裂或运动和移动的存在的内部固定以后的近临床、放射学的后续能避免如此的复杂并发症。 | Sanjay Meena Hira Lal Nag Senthil Kumar Nilesh Barwar Samarth Mittal Amit Singla | 2013 | Chinese Journal of Traumatology2013，16，3： | 7 |
| 10 | Comparative analysis of APACHE-Ⅱ and P-POSSUM scoring systems in predicting postoperative mortality in patients undergoing emergency laparotomy显示文摘BACKGROUND Laparotomy remains one of the commonest emergency surgical procedures.Early prognostic evaluation would aid in selecting the high-risk patients for an aggressive treatment.Awareness about risks could potentially contribute to the quality of perioperative care and optimum utilization of resources.Portsmouth modification of Physiological and operative severity for the enumeration of mortality and morbidity (P-POSSUM) and the acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ) have been the most widely used scoring systems for emergency laparotomies.It is always better to have a single scoring system to predict outcomes and audit healthcare organizations.AIM To compare the ability of APACHE-II and P-POSSUM to predict postoperative morbidity and mortality in patients undergoing emergency laparotomy.METHODS All patients undergoing emergency laparotomy at the Tata Main Hospital,Jamshedpur between December 2013 and November 2014 were included in the study.In this observational study,P-POSSUM and APACHE-Ⅱ scoring were done,and the outcome analysis evaluated with mortality being the primary outcome.RESULTS For P-POSSUM,at a cut off value of 63 to predict mortality using receiver operating characteristics curve analysis,the area under the curve was 0.989;and for APACHE-Ⅱ,at the cut off value of 24,the area under the curve was 0.965.CONCLUSION Because the ability of APACHE-Ⅱ to predict mortality was similar to P-POSSUM and APACHE-Ⅱ does not need scoring for intra-operative findings and histopathology reports,APACHE-Ⅱ can be used pre-operatively to assess the risk in patients undergoing emergency laparotomy.However,for audit purposes,either of the two scoring systems can be used. | Deb Sanjay Nag Ankur Dembla Pratap Rudra Mahanty Shashi Kant Abhishek Chatterjee Devi Prasad Samaddar Parul Chugh | 2019 | World Journal of Clinical Cases2019，7，16： | 5 |
| 11 | Protective Effects of Calcium Antagonists on Cadmium-induced Toxicity in Rats显示文摘Protective effects of calcium antagonists, chlorpromazine (CPZ) and nimodepine (NI-MO), on cadmium-induced toxicity were investigated. After giving CdCl2 (0. 44mg Cd/kg,ip), CPZ (5mg/kg, ip) or NIMO (8mg/kg, po) were administered every day to Sprague-Dawley (S. D. ) rats for a week. Then, urinary N- acetyl-β-D- glucosaminidase (NAG ), uri -nary cadmium and bloocl cadmium were measured. The accumulation of cadmium in the kid-ney cortex, content of renal calmodulin, hemoglobin and the ultrastructural damage of proxi-mal convoluted tubules of rats were examined three weeks after the last administration. Re-sults indicated that the calcium antagonists partly protected against toxic effects induced bycadmium in different manners. These data provide further evidence for the new hypothesisthat the cross effect of cadmium and calcium in calmodulin regulated systems may be responsi-ble for the mechanism of cadmium intoxication. ’The results suggested that the calcium antag-onists could be a new and promising approach in the therapy of heavy metaLinduced | YANG XIANFANG YANG YONG-NIAN(Institute of Applied Toxicology, Nanjing the Medical University,Nanjing 210029, China)Abbreviation are Ca, calcium CaM, calmodulin Cd, cadmium CPZ, chlorpromazine Hb, hemogobin NIMO, nimodepine NAG, N-acetyl-β-D- gluco | 1997 | Biomedical and Environmental Sciences1997，10，4： | 3 |
| 12 | Recommendations for Radioembolization of Hepatic Malignancies Using Yttrium-90 Microsphere Brachytherapy: A Consensus Panel Report from the Radioembolization Brachytherapy Oncology Consortium显示文摘 | Andrew Kennedy Subir Nag Riad Salem Ravi Murthy Alexander J. McEwan Charles Nutting Al Benson Joseph Espat Jose Ignacio Bilbao Ricky A. Sharma James P. Thomas Douglas Coldwell | 2007 | International Journal of Radiation Oncology, Biology, Physics2007，，： | 2 |
| 13 | 热处理,预应力和表面强化对微合金钢断裂韧性的影响显示文摘微合金钢在行业的各个领域中日益得到应用,而且能提供各种各样的显微组织。大量文献论述了它们显微组织和性能的关系。微合金钢具有优越的力学性能是因为有细晶粒度的显微组织和V、Ti和Nb等微合金元素的沉淀,导致改善屈服强度,也提高产品的抗拉强度和总伸长和夏比V形缺口冲击能量。热处理引起显微组织的变化,或者表面硬化或机械方式强化可能会形成残余应力状态,从而影响这些微合金钢的断裂韧性。正是在这样的背景下,目前的工作始于对轧制状态条件下没有任何热处理的低碳(0.19%)微合金钢准静态的初步实验,测定了断裂韧性(J1c)。这项研究进一步探讨了正火,喷丸加工和喷丸加工接着氰化对所研究的轧制态钢断裂韧性的影响。正火热处理、喷丸加工和喷丸加工接着氰化三种加工表明对起始断裂韧性有积极的影响。对比的结果表明,喷丸加工接着氰化使J1c增加2.7倍。因此喷丸加工接着氰化可能被视为对所研究的这类微合金钢在轧制态条件下的起始断裂韧性产生最积极的影响。虽然在线弹性断裂力学(LEFM)领域里,一般已知的起始断裂韧性是随屈服强度的增加而减少,但是所研究的微合金钢在正火时显示屈服强度和J1c同步提高。以显微组织的研究和应力深度分布为基础能解释所有这些观察到的正火,喷丸加工和氰化对起始断裂韧性的应响(弹塑性断裂力学)。 | Joydeb Nag Chaudhury | 2014 | 热处理技术与装备2014，35，1： | 2 |
| 14 | Development and validation of an HPLC-MS/MS analytical method for quantitative analysis of TCBA-TPQ,a novel anticancer makaluvamine analog,and application in a pharmacokinetic study in rats显示文摘We have recently designed and synthesized several novel iminoquinone anticancer agents that have entered preclinical development for the treatment of human cancers.Herein we developed and validated a quantitative HPLC-MS/MS analytical method for one of the lead novel anticancer makaluvamine analog,TCBA-TPQ,and conducted a pharmacokinetic study in laboratory rats.Our results indicated that the HPLC-MS/MS method was precise,accurate,and specific.Using this method,we carried out in vitro and in vivo evaluations of the pharmacological properties of TCBA-TPQ and plasma pharmacokinetics in rats.Our results provide a basis for future preclinical and clinical development of this promising anticancer marine analog. | YU Jun-Xian Sukesh Voruganti LI Dan-Dan Jiang-Jiang Qin Subhasree Nag Su Xu Sadanandan E.Velu Wei Wang Ruiwen ZHANG | 2015 | Chinese Journal of Natural Medicines2015，13，7： | 2 |
| 15 | Kinetic analysis of iron ore powder reaction with hydrogen-carbon monoxide显示文摘Iron ore powder was isothermally reduced at 1023-1373 Kwith hydrogen/carbon monoxide gas mixture(from 0vol%H_(2)/100vol%CO to 100vol%H_(2)/0vol%CO).Results indicated that the whole reduction process could be divided into two parts that proceed in series.The first part represents a double-step reduction(Fe_(2)O_(3)→Fe_(3)O_(4)→FeO),in which the kinetic condition is more feasible compared with that in the second part representing a single-step reduction(FeO→Fe).The influence of hydrogen partial pressure on the reduction rate gradually increases as the reaction proceeds.The average reduction rate of hematite ore with pure hydrogen is about three and four times higher than that with pure carbon monoxide at 1173 and 1373 K,respectively.In addition,the logarithm of the average rate is linear to the composition of the gas mixture.Hydrogen can prominently promote carbon deposition to about 30%at 1023 K.The apparent activation energy of the reduction stage increases from about 35.0 to 45.4 kJ/mol with the increase in hydrogen content from 20vol%to 100vol%.This finding reveals that the possible rate-controlling step at this stage is the combined gas diffusion and interfacial chemical reaction. | Xudong Mao Pritesh Garg Xiaojun Hu Yuan Li Samik Nag Saurabh Kundu Jianliang Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，10： | 2 |
| 16 | Fractionation of leaves and biochemical composition of the fractions显示文摘 | A Nag S Matai | 2000 | Journal of tropical agriculture and food science2000，28，2： | 1 |
| 17 | A simple method of obtaining equivalent doses for use in HDR brachytherapy显示文摘 | Nag S Gupta N | 2000 | Int J Radiat Oncol Biol Phys2000，46，2： | 1 |
| 18 | Increased caveolin - 1 expres- sion precedes decreased expression of occludin and clau - din - 5 during blood - brain barrier breakdown 显示文摘 | Nag S Venugopalan R Stewart DJ | 2007 | Acta Neuropathol2007，114，5： | 1 |
| 19 | Strengthening mechanisms in Ti–Nb–Zr–Ta and Ti–Mo–Zr–Fe orthopaedic alloys显示文摘 | Rajarshi Banerjee Soumya Nag John Stechschulte Hamish L. Fraser | 2003 | Biomaterials2003，，17： | 1 |
| 20 | Gemcitabine plus pa- clitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment显示文摘 | Albain KS Nag SM Calderillo-Ruiz G | 2008 | J Clin Oncol2008，26，24： | 1 |
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