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| 1 | Role of Moringa oleifera in regulation of diabetes-induced oxidative stress显示文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage. | Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha Shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair Geeta Watal | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 11 |
| 2 | Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders(Amorphous,Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications显示文摘Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair applications.Evidence indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate cements.In this study,amorphous,partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment,and characterized using techniques such as X-ray diffraction and Fourier transform infrared spectroscopy.These materials were assessed for their functionality in cementing reaction with a 3.0 mol/L,pH 7.0 ammonium phosphate solution,including setting time and pH evolution in phosphate buffered saline solution.Results indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements,while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction.X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered saline.These were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium phosphate.The crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers. | Nicole Ostrowski Vidisha Sharma Abhijit Roy Prashant N.Kumta | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 3 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 4 | Design of high-strength refractory complex solid-solution alloys显示文摘Nickel-based superalloys and near-equiatomic high-entropy alloys containing molybdenum are known for higher temperature strength and corrosion resistance.Yet,complex solid-solution alloys offer a huge design space to tune for optimal properties at slightly reduced entropy.For refractory Mo-W-Ta-Ti-Zr,we showcase KKR electronic structure methods via the coherent-potential approximation to identify alloys over five-dimensional design space with improved mechanical properties and necessary global(formation enthalpy)and local(short-range order)stability.Deformation is modeled with classical molecular dynamic simulations,validated from our first-principle data.We predict complex solid-solution alloys of improved stability with greatly enhanced modulus of elasticity(3×at 300 K)over near-equiatomic cases,as validated experimentally,and with higher moduli above 500 K over commercial alloys(2.3×at 2000 K).We also show that optimal complex solid-solution alloys are not described well by classical potentials due to critical electronic effects. | Prashant Singh Aayush Sharma A.V.Smirnov Mouhamad S.Diallo Pratik K.Ray Ganesh Balasubramanian Duane D.Johnson | 2018 | npj Computational Materials2018，，1： | 2 |
| 5 | The potential for bio-optical imaging of biomaterial-associated infection in vivo显示文摘 | Jelmer Sjollema Prashant K. Sharma Rene J.B. Dijkstra Gooitzen M. van Dam Henny C. van der Mei Anton F. Engelsman Henk J. Busscher | 2009 | Biomaterials2009，，8： | 1 |
| 6 | Control of the p53-p21CIP1 axis by E2F1,E2F2,and E2F3 is essential for G1/S progression and cellular transformation显示文摘 | Nidhi Sharma Cynthia Timmers Prashant Trikha | 2006 | Biol Chem2006，281，36： | 1 |
| 7 | Molecular typing of Mycobacterium tuberculosis isolates from a rural area of Kanpur by spotigotyping and mycobacterial interspersed repetitive units (MIRUs) typing Infection显示文摘 | Sharma P Devendra SC Prashant U | 2008 | Genetics and Evolution2008，8，： | 1 |
| 8 | Protective effect of aqueous extract of Feronia elephantum correa leaves on thioacetamide induced liver necrosis in diabetic rats显示文摘Objective:To evalueate hepatoprotective effects Feronia elephantum(F.elephantum)correa against thioacctamide(TA)induced liver necrosis in diabetic rats.Methods:Male wistar rats were made diabetic with alloxan(160 mg/kg)on day 0 of the study.They were intoxicated with hepatotoxicant(thioacetamide,300 mg/kg,ip)on day 9 of study to produce liver necrosis.Effects of 7 day daily once administration(day 2 to day 9)of EF(400 and 800 mg/kg,po)were evaluated on necorosis of liver in terms of mortality,liver volume,liver weight,serum aspartate aminotransferase(AST)and serum alanine transaminase(ALT),and histopathology of liver sections(for signs of necorosis and inflammation)on day-9 of the study.Separate groups of rats with treated only with alloxan(DA control),thioacetamide(TA control)and both(TA+DA control)were maintained.Results:FE significantly lowered the mortality rate and showed improvement in liver function parameters in TA-induced diabetic rats without change in liver weight,volume and serum glucose levels.Conclusions:FE showed promising activity against TA-induced liver necorsis in diabetic rats and so might be useful for prevention of liver complications in DM. | Prashant Sharma Subhash L Bodhankar Prasad A Thakurdesai | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，9： | 1 |
| 9 | Dermal wound healing properties of redox-active grape seed proanthocyanidins显示文摘 | Savita Khanna Mika Venojarvi Sashwati Roy Nidhi Sharma Prashant Trikha Debasis Bagchi Manashi Bagchi Chandan K Sen | 2002 | Free Radical Biology and Medicine2002，，： | 1 |
| 10 | Protective efficacy of piperine against Mycobacterium tuberculosis显示文摘 | Sandeep Sharma Nitin Pal Kalia Pankaj Suden Prashant Singh Chauhan Manoj Kumar Anshu Beulah Ram Anamika Khajuria Sarang Bani Inshad Ali Khan | 2014 | Tuberculosis2014，，： | 1 |
| 11 | Inhibition of benzopyrene-and cyclophoshamide-induced mutagenicity by Cinnamomum cassia显示文摘 | Nidhi Sharma Prashant Trikha Mohammad Athar | 2001 | Mutaion Research2001，，： | 1 |
| 12 | Prevention of pin tract infection in external stainless steel fixator frames using electric current in a goat model显示文摘 | Arnout J. van der Borden Patrick G.M. Maathuis Eefje Engels Gerhard Rakhorst Henny C. van der Mei Henk J. Busscher Prashant Kumar Sharma | 2007 | Biomaterials2007，，12： | 1 |
| 13 | Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons显示文摘 | Prashant Kumar Modi Narayana Komaravelli Neha Singh Pushkar Sharma | 2012 | Molecular Biology of the Cell2012，，18： | 1 |
| 14 | Induction with NCB-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis — A randomized, placebo-controlled, pilot study显示文摘 | Vikas Singla Venigalla Pratap Mouli Sushil Kumar Garg Tarun Rai Bikash Narayan Choudhury Prashant Verma Rachana Deb Veena Tiwari Sarika Rohatgi Rajan Dhingra Saurabh Kedia Piyush Kumar Sharma Govind Makharia Vineet Ahuja | 2014 | Journal of Crohn’s and Colitis2014，，3： | 1 |
| 15 | Accuracy of visual prediction of pathology of colorectal polyps: how accurate are we?显示文摘 | Prashant Sharma John Frye Frank Frizelle | 2014 | ANZ J Surg2014，，5： | 1 |
| 16 | Photoinduced charge transfer between CdSe quantum dots and p-phenylenediamin显示文摘 | Shai lesh N Sharma Zeena S Pillai Prashant V | | 0，，： | 1 |
| 17 | Immunization and Nutritional Profile of Cases with Atraumatic Microbial Keratitis in Preschool Age Group显示文摘 | Vishal Jhanji Prashant Naithani Ecosse Lamoureux Tushar Agarwal Namrata Sharma Rasik B. Vajpayee | 2011 | American Journal of Ophthalmology2011，，6： | 1 |
| 18 | Systematic Review and Meta-analysis of the Role of Routine Colonic Evaluation After Radiologically Confirmed Acute Diverticulitis显示文摘 | Prashant V. Sharma Timothy Eglinton Phil Hider Frank Frizelle | 2014 | Annals of Surgery2014，，2： | 1 |
| 19 | Luminescence studies and formation mechanism of symmetrically dispersed ZnO quantum dots embedded in SiO 2 matrix显示文摘 | Prashant K. Sharma Ranu K. Dutta Manvendra Kumar Prashant K. Singh Avinash C. Pandey | 2009 | Journal of Luminescence2009，，6： | 1 |
| 20 | Treatment performance of artificial floating reed beds in an experimental mesocosm to improve the water quality of river Kshipra显示文摘 | Billore S K Prashant Sharma J K | 2009 | Water Science and Technology2009，60，11： | 1 |
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