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| 1 | Preoperative serum carbohydrate antigen 19-9 levels predict early recurrence after the resection of early-stage pancreatic ductal adenocarcinoma显示文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a serious disease with a poor prognosis.Only a minority of patients undergo surgery due to the advanced stage of the disease,and patients with early-stage disease,who are expected to have a better prognosis,often experience recurrence.Thus,it is important to identify the risk factors for early recurrence and to develop an adequate treatment plan.AIM To evaluate the predictive factors associated with the early recurrence of earlystage PDAC.METHODS This study enrolled 407 patients with stage I PDAC undergoing upfront surgical resection between January 2000 and April 2016.Early recurrence was defined as a diagnosis of recurrence within 6 mo of surgery.The optimal cutoff values were determined by receiver operating characteristic(ROC)analyses.Univariate and multivariate analyses were performed to identify the risk factors for early recurrence.RESULTS Of the 407 patients,98 patients(24.1%)experienced early disease recurrence:26(26.5%)local and 72(73.5%)distant sites.In total,253(62.2%)patients received adjuvant chemotherapy.On ROC curve analysis,the optimal cutoff values for early recurrence were 70 U/mL and 2.85 cm for carbohydrate antigen 19-9(CA 19-9)levels and tumor size,respectively.Of the 181 patients with CA 19-9 level>70 U/mL,59(32.6%)had early recurrence,compared to 39(17.4%)of 226 patients with CA 19-9 level≤70 U/mL(P<0.001).Multivariate analysis revealed that CA 19-9 level>70 U/mL(P=0.006),tumor size>2.85 cm(P=0.004),poor differentiation(P=0.008),and non-adjuvant chemotherapy(P=0.025)were significant risk factors for early recurrence in early-stage PDAC.CONCLUSION Elevated CA 19-9 level(cutoff value>70 U/mL)can be a reliable predictive factor for early recurrence in early-stage PDAC.As adjuvant chemotherapy can prevent early recurrence,it should be recommended for patients susceptible to early recurrence. | Sarang Hong Ki Byung Song Dae Wook Hwang Jae Hoon Lee Woohyung Lee Eunsung Jun Jaewoo Kwon Yejong Park Seo Young Park Naru Kim Dakyum Shin Hyeyeon Kim Minkyu Sung Yunbeom Ryu Song Cheol Kim | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 2 | Variation in water-use efficiency and its relation to carbon isotope ratio in cotton显示文摘 | Y Sarange I Flash and D Yakir | 1998 | Crop Sci1998，38，： | 1 |
| 3 | Electrical conductivity of fruits and meats during ohmic heating显示文摘 | Sarang S Sastry S K Knipe L | 2008 | Journal of Food Engineering2008，87，3： | 1 |
| 4 | Immune up regulatory response of anon - caloric natural sweetener , stevioside 显示文摘 | Irum Sehar Anpurna Kaul Sarang Bani | 2008 | Chemico-Biological Interactions2008，173，1： | 1 |
| 5 | Endoscopic vein harvesting : technique, outcomes, con- cerns & controversies显示文摘 | Raja SG Sarang Z | 2013 | J Thorac Dis2013，5，6： | 1 |
| 6 | Effect of heart rate on T wave ahemans 显示文摘 | Kavesh NG Shorofsky SR Sarang SE | 1998 | J Cardiovase Eleetrophysiol1998，9，7： | 1 |
| 7 | Obstacles in provision of anti -retro- viral treatment to drug users in Central and Eastern Europe and Central A- sia:A regional overview显示文摘 | Bobrova N Sarang A Stuikyte R | 2007 | Int J Drug Policy2007，18，4： | 1 |
| 8 | DBI Global Strings 显示文摘 | SARANGE S | 2008 | J High Energy Phys2008，0807，： | 1 |
| 9 | Electrical conductivity of fruits and meats during ohmic heating显示文摘 | SARANG S SASTRY S K KNIPE L | 2008 | Journal of Food Engineering2008，87，3： | 1 |
| 10 | Conservative management of cesarean scar pregnancy with uterine arteriovenous malformation: a case report显示文摘 | Kochhar PK Sarangal M Gupta U | 2013 | J Reprod Med2013，58，12： | 1 |
| 11 | Fast and scalable pattern matching for network instrusion detection systems显示文摘 | Sarang Dharmapurikar Lockwood John | 2006 | IEEE2006，24，10： | 1 |
| 12 | Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells 显示文摘 | T6th B Garabuczi E Sarang Z | 2009 | J Immunol2009，182，4： | 1 |
| 13 | Electrical conductivity of fruits and meats during ohmic heating显示文摘 | SARANG S SASTRY S K KNIPE L | 2008 | Journal of Food Engineering2008，87，3： | 1 |
| 14 | Anaesthesia for awake craniotomy:evolution of a technique that facilitates awake neurological test显示文摘 | Dinsmore J | 2003 | Br J Anaesth2003，90，： | 1 |
| 15 | Obstacles in provision of anti - retroviral treatment to drug users in Central and Eastern Europe and Central Asia: a regional overview显示文摘 | Bobrova N Sarang A Stuikyte R | 2007 | Int J Drug Policy2007，18，： | 1 |
| 16 | Overcoming the challenges of Beidou receiver implementation显示文摘 | Mohammad Z H Stefan S Sarang T | 2014 | Sensors2014，14，22： | 1 |
| 17 | TinyLock: Affordable defense against smudge attacks on smartphone pattern lock systems显示文摘 | Taekyoung K Sarang N | 2014 | Com- puters I Security2014，，42： | 1 |
| 18 | Anaesthesia for awake craniotomyevolution of a technique that facilitates awake neurological testing显示文摘 | Sarang A Dinsmore J | 2003 | Br J Anaesth2003，90，2： | 1 |
| 19 | Anaesthesia for awake craniot- omy-evolution of a technique that facilitates awake neuro- logical testing显示文摘 | SARANG A DINSMORE J | 2003 | Br J Anaesth2003，90，2： | 1 |
| 20 | Conservative management of cesarean scar pregnancy with uterine arteriovenous malformation: a case report显示文摘 | Kochhar PK Sarangal M Gupta U | 2013 | J Reprod Med2013，58，12： | 1 |
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