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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | Management and therapy of vasovagal syncope: A review显示文摘Vasovagal syncope is a common cause of recurrent syncope. Clinically, these episodes may present as an isolated event with an identifiable trigger, or manifest as a cluster of recurrent episodes warranting intensive evaluation. The mechanism of vasovagal syncope is incompletely understood. Diagnostic tools such as implantable loop recorders may facilitate the identification of patients with arrhythmia mimicking benign vasovagal syncope. This review focuses on the management of vasovagal syncope and discusses the non-pharmacological and pharmacological treatment options, especially the use of midodrine and selective serotonin reuptake inhibitors. The role of cardiac pacing may be meaningful for a subgroup of patients who manifest severe bradycardia or asystole but this still remains controversial. | Muhammet Ali Aydin Tushar V Salukhe Iris Wilke Stephan Willems | 2010 | World Journal of Cardiology2010，2，10： | 8 |
| 3 | Port site infection in laparoscopic surgery: A review of its management显示文摘Laparoscopic surgery(LS), also termed minimal access surgery, has brought a paradigm shift in the approach to modern surgical care. Early postoperative recovery, less pain, improved aesthesis and early return to work have led to its popularity both amongst surgeons and patients. Its application has progressed from cholecystectomies and appendectomies to various other fields including gastrointestinal surgery, urology, gynecology and oncosurgery. However, LS has its own package of complications. Port site infection(PSI), although infrequent, is one of the bothersome complications which undermine the benefits of minimal invasive surgery. Not only does it add to the morbidity of the patient but also spoils the reputation of the surgeon. Despite the advances in the field of antimicrobial agents, sterilization techniques, surgical techniques, operating room ventilation, PSIs still prevail. The emergence of rapid growing atypical mycobacteria with multidrug resistance, which are the causative organism in most of the cases, has further compounded the problem. PSIs are preventable if appropriate measures are taken preoperatively, intraoperatively and postoperatively. PSIs can often be treated non-surgically, with early identification and appropriate management. Macrolides, quinolones and aminoglycosides antibiotics do show promising activity against the atypical mycobacteria. This review article highlights the clinical burden, presentations and management of PSIs in LS as shared by various authors in the literature. We have given emphasis to atypical mycobacteria, which are emerging as a common etiological agent for PSIs in LS. Although the existing literature lacks consensus regarding PSI management, the complication can be best avoided by strictly abiding by the commandments of sterilization techniques of the laparoscopic instruments with appropriate sterilizing agent. | Prakash K Sasmal Tushar S Mishra Satyajit Rath Susanta Meher Dipti Mohapatra | 2015 | World Journal of Clinical Cases2015，3，10： | 6 |
| 4 | MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer显示文摘 | Fanyin Meng Roger Henson Hania Wehbe–Janek Kalpana Ghoshal Samson T. Jacob Tushar Patel | 2007 | Gastroenterology2007，，2： | 6 |
| 5 | Endovascular management in abdominal visceral arterial aneurysms:A pictorial essay显示文摘Visceral artery aneurysms(VAAs) include aneurysms of the splanchnic circulation and those of the renal artery.Their diagnosis is clinically important because of the associated high mortality and potential complications.Splenic,superior mesenteric,gastroduodenal,hepatic and renal arteries are some of the common arteries affected by VAAs.Though surgical resection and anastomosis still remains the treatment of choice in some of the cases,especially cases involving the proximal arteries,increasingly endovascular treatment is being used for more distal vessels.We present a pictorial review of various intra-abdominal VAAs and their endovascular management. | Manisha Jana Shivanand Gamanagatti Amar Mukund Sujoy Paul Pankaj Gupta Pramod Garg Tushar K Chattopadhyay Peush Sahni | 2011 | World Journal of Radiology2011，3，7： | 5 |
| 6 | 营养不良:实验室指标vs营养评估显示文摘营养不良是患者并发症发生率和病死率的一项独立危险因素,并造成医疗费用的增高。然而,由于对营养不良没有一个统一的定义,也没有一个标准的营养不良筛查/诊断方法,导致全世界各地的医生对营养不良在认识上十分混乱,各地的临床实践也有着各不相同的标准。作为营养不良的危险因素,炎症的作用近期已被证实。组织学上,一些血清蛋白如白蛋白和前白蛋白被广泛用于监测患者的营养状态。然而,目前的研究热点是采用恰当的营养状态体格检查(NFPE)来诊断营养不良。目前认为,实验室指标本身不太可靠,只能作为NFPE的一个补充。今后的研究中需要筛选出一些诊断营养不良的血清生物学标志物,这些标志物必须是不受炎症状态影响且具有无创及价格相对低廉的优势。然而,一个完全的NFPE在营养不良的诊断中具有无可替代的作用。 | Shishira Bharadwaj Shaiva Ginoya Parul Tandon Tushar D.Gohel John Guirguis Hiren Vallabh Andrea Jevenn Ibrahim Hanouneh | 2016 | Gastroenterology Report2016，4，4： | 5 |
| 7 | Are common factors involved in the pathogenesis of primary liver cancers? A meta-analysis of risk factors for intrahepatic cholangiocarcinoma显示文摘 | William C. Palmer Tushar Patel | 2012 | Journal of Hepatology2012，，1： | 5 |
| 8 | Visual detection of tropomyosin,a major shrimp allergenic protein using gold nanoparticles(AuNPs)-assisted colorimetric aptasensor显示文摘A gold nanoparticle-based label-free colorimetric assay was developed to detect the shrimp allergenic protein tropomyosin(TM),an important biomarker responsible for severe clinical reactivity to shellfish.In a gold nanoparticles(AuNPs)-tropomyosin-binding aptamer(TMBA)complex,the aptamer adsorbs onto the surface of AuNPs and dissociates in the presence of TM.In addition,AuNPs tend to aggregate in the presence of ionic salt,revealing a color change(i.e.,wine-red to purple/blue)with a shift in the maximum absorption peak from 520 nm.In the presence of specific binding TM,the aptamer folds into a tertiary structure where it more efficiently stabilizes AuNPs toward the salt-induced aggregation with a hypsochromic shift in the absorption spectra compared to the stabilized AuNPs by aptamer alone.Based on the aggregation and sensitive spectral transformation principle,the AuNPs-based colorimetric aptasensor was successfully applied to detect TM with a range of 10-200 nmol/L and a low detection limit of 40 nmol/L in water samples.The reliability,selectivity,and sensitivity of the aptasensor was then tested with food samples spiked with TM.The observed detection limit was as low as 70 nmol/L in shrimp,90 nmol/L in tofu,and 80 nmol/L in eggs,respectively.We anticipate the proposed AuNPs-based colorimetric aptasensor assay possesses a high potential for the easy and efficient visual colorimetric detection of TM. | Tushar Ramesh Pavase Hong Lin Maqsood Ahmed Soomro Hongwei Zheng Xiaxia Li Kexin Wang Zhenxing Li | 2021 | Marine Life Science & Technology2021，3，3： | 3 |
| 9 | Role of microRNA‐155 at early stages of hepatocarcinogenesis induced by choline‐deficient and amino acid–defined diet in C57BL/6 mice显示文摘 | Bo Wang Sarmila Majumder Gerard Nuovo Huban Kutay Stefano Volinia Tushar Patel Thomas D. Schmittgen Carlo Croce Kalpana Ghoshal Samson T. Jacob | 2009 | Hepatology2009，，4： | 3 |
| 10 | 蛤蜊壳羟基磷灰石用于脱除蚝油中铅的初步研究显示文摘[目的]研究利用蛤蜊壳制备的羟基磷灰石用于吸附去除蚝油中重金属铅的可行性。[方法]利用含有铅离子的水溶液优化羟基磷灰石的吸附条件,进而探讨羟基磷灰石对蚝油中重金属铅的脱除效果,并分析脱除工艺对蚝油品质的影响。[结果]在羟基磷灰石用量为0.17 mg/m L,蚝油样品中铅离子含量为2.33 mg/m L以下时,羟基磷灰石对蚝油中重金属铅离子的吸附率达到98%以上,而且铅离子的浓度越高,吸附率越大。通过对吸附前后蚝油主要理化性质的对比发现,吸附作用对蚝油的主要品质指标没有显著影响,而且微量元素Ca、Zn的含量有所增加。[结论]用蛤蜊壳制备的羟基磷灰石能够有效吸附蚝油中的重金属铅,这不但为蚝油中重金属铅的控制提供了新的处理技术,而且还为蛤蜊壳的资源化及深度利用提供了新的思路。 | 金科 Tushar Ramesh Pavase 李振兴 徐凤娟 | 2015 | 中国渔业质量与标准2015，5，6： | 3 |
| 11 | Bigtable显示文摘 | Fay Chang Jeffrey Dean Sanjay Ghemawat Wilson C. Hsieh Deborah A. Wallach Mike Burrows Tushar Chandra Andrew Fikes Robert E. Gruber | 2008 | ACM Transactions on Computer Systems (TOCS)2008，，2： | 3 |
| 12 | Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma显示文摘 | John Bridgewater Peter R. Galle Shahid A. Khan Josep M. Llovet Joong-Won Park Tushar Patel Timothy M. Pawlik Gregory J. Gores | 2014 | Journal of Hepatology2014，，6： | 3 |
| 13 | 2011-2015年美国初高中生的烟草使用情况显示文摘烟草使用是美国可预防性疾病和死亡的首要原因。如果维持目前的吸烟率,那么预计有560万现今小于18岁的美国人将因吸烟相关的疾病而过早死亡。大部分烟草使用和成瘾始于青少年期和青年期。 | Tushar Singh RenéA.Arrazola Catherine G.Corey Corinne G.Husten Linda J.Neff David M.Homa Brian A.King 汪源(译) 金克峙(审校) 蔡颖(审校) | 2017 | 上海预防医学2017，29，9： | 3 |
| 14 | Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States显示文摘 | Tushar Patel | 2001 | Hepatology2001，，： | 2 |
| 15 | Double-vessel verylate stent thrombosis following Resolute Onyx zotarolimus eluting stents implantation in an octogenarian显示文摘Compared with bare-metal stents (BMS),drug-eluting stems (DES)have shown better clinical outcomes for pa- tients undergoing percutaneous coronary intervention (PCI) by inhibition of neo-intirnal hyperplasia.[1]However,early- generation DES produced late thrombotic events,more than l-year,by delaying arterial healing of stented vessels,[2-5] New-generation DES have been developed'with thinner stent struts,more biocompatible polymer coatings for drug release,and a variety of antiproliferative agents with similar or superior anti-restenotic efficacy.[6]This development has led to a significant improvement in the efficacy and safety of new-generation DES,and consistently lower rates of very late stent thrombosis (VLST).[7,8]In fact,use of new-ge- neration DES is the standard treatment in contemporary PCI practice.[9] | George Kassimis Tushar Raina | 2018 | Journal of Geriatric Cardiology2018，15，10： | 2 |
| 16 | 孟加拉国饮用水砷污染控制策略与方向显示文摘孟加拉国是'一带一路'重要节点国家,经济社会快速发展,正从'最不发达国家'进入到'发展中国家'行列。同时,孟加拉国是全世界砷污染最严重的国家之一,其地下水砷污染形成过程与环境地球化学机制、人群砷暴露途径与风险水平、砷中毒机制与控制原理等在全球范围内具有重要研究价值。此外,孟加拉国政府和国际社会为控制饮用水砷污染开展了大量工作,已取得很好的成效。以饮用水砷污染及其健康风险控制为目标,制定科学、合理、有效的砷污染控制策略,对于孟加拉国在全国范围内从根本解决饮用水安全问题具有重要意义。 | 刘锐平 MOHON SHADHU KHAN Tushar MD RAHMAN Saifur 曲久辉 | 2020 | 环境工程学报2020，14，8： | 2 |
| 17 | 细菌产生的纤维素酶(综述)(续2)显示文摘本期主要介绍纤维素酶在细菌体系中的作用方式、细菌共培养以及纤维素酶基因在异源宿主中的克隆与表达。 | 严鸿林 唐彩琰 Sangrila Sadhu1 Tushar Kanti Maiti | 2018 | 国外畜牧学(猪与禽)2018，38，12： | 2 |
| 18 | Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines显示文摘 | Fanyin Meng Roger Henson Molly Lang Hania Wehbe Shail Maheshwari Joshua T. Mendell Jinmai Jiang Thomas D. Schmittgen Tushar Patel | 2006 | Gastroenterology2006，，7： | 2 |
| 19 | Local infiltration analgesia following total hip replacement: a review of current literature显示文摘在全部的新潮的代替以后控制手术后的疼痛是重要的,争吵关于不同政体留下。由考察 18 研究,我们试图发现在全部的新潮的代替以后的本地渗入痛觉缺失是否在手术后的疼痛,一些医院停留和 opioid 消费上有任何效果。我们断定本地渗入痛觉缺失是为减少的手术后的疼痛的一个有效方法。 | Tushar Gupta Nidhi Garg Mayank Gupta | 2014 | Chinese Journal of Traumatology2014，17，5： | 2 |
| 20 | Multiple bilateral lower limb fractures in a 2-year-old child: previously unreported injury with a unique mechanism显示文摘Fall from height is a common cause of unintentional injuries in children and accounts for 6% of all trauma-related childhood deaths, usually from head injury. We report a case of a 2-year-old child with multiple fractures of the bilateral lower limbs due to this reason. A child fell from a height of around 15 feet after toppling from a balcony. He developed multiple fractures involving the right femoral shaft, right distal femoral epiphysis (Salter Harris type 2), right distal metaphysis of the tibia and fibula, and undisplaced Salter Harris type 2 epiphyseal injury of the left distal tibia. There were no head, abdominal or spinal injuries. The patient was taken into emergency operation theatre after initial management which consisted of intravenous fluids, blood transfusion, and splintage of both lower limbs. Fracture of the femoral shaft was treated by closed reduction and fixation using two titanium elastic nails. Distal femoral physeal injury required open reduction and fixation with K wires. Distal tibia fractures were closely reduced and managed nonoperatively in both the lower limbs. All the fractures united in four weeks. At the last follow-up, the child had no disability and was able to perform daily activities comfortably. We also proposed the unique mechanism of injury in this report. | Basant Repswal Anuj Jain Sunil Gupta Aditya Aggarwal Tushar Kohli Devendra Pathrot | 2014 | Chinese Journal of Traumatology2014，17，5： | 2 |
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