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| 1 | Evolution of systemic therapy of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) commonly occurs in hepatitis B endemic areas, especially in Asian countries. HCC is highly refractory to cytotoxic chemotherapy. This resistance is partly related to its tumor biology, pharmacokinetic properties, and both intrinsic and acquired drug resistance. There is no convincing evidence thus far that systemic chemotherapy improves overall survival in advanced HCC patients. Other systemic approaches, such as hormonal therapy and immunotherapy, have also disappointing results. Recently, encouraging results have been shown in using sorafenib in the treatment of advanced HCC patients. In this review, we concisely summarize the evolution of developments in the systemic therapy of advanced HCC. | Thomas Yau Pierre Chan Richard Epstein Ronnie T Poon | 2008 | World Journal of Gastroenterology2008，14，42： | 23 |
| 2 | Consensus Guidelines for the Management of Postoperative Nausea and Vomiting显示文摘 | Tong J. Gan Pierre Diemunsch Ashraf S. Habib Anthony Kovac Peter Kranke Tricia A. Meyer Mehernoor Watcha Frances Chung Shane Angus Christian C. Apfel Sergio D. Bergese Keith A. Candiotti Matthew TV Chan Peter J. Davis Vallire D. Hooper Sandhya Lagoo-Deena | 2014 | Anesthesia & Analgesia2014，，： | 2 |
| 3 | Long-Term Follow-up of Tibial Shaft Fractures Treated With Intramedullary Nailing显示文摘 | Kelly A Lefaivre Pierre Guy Holman Chan Piotr A Blachut | 2008 | Journal of Orthopaedic Trauma2008，，8： | 1 |
| 4 | Good practice in reviewing and publishing studies on herbal medicine, with special emphasis on traditional Chinese medicine and Chinese materia medica显示文摘 | Kelvin Chan Debbie Shaw Monique S.J. Simmonds Christine J. Leon Qihe Xu Aiping Lu Ian Sutherland Svetlana Ignatova You-Ping Zhu Rob Verpoorte Elizabeth M. Williamson Pierre Duez | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 5 | Phase II study of bevacizumab and erlotinib in the treatment of advanced hepatocellular carcinoma patients with sorafenib-refractory disease显示文摘 | Thomas Yau Hilda Wong Pierre Chan T. J. Yao R. Pang T. T. Cheung S. T. Fan Ronnie T. Poon | 2012 | Investigational New Drugs2012，，6： | 1 |
| 6 | Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa显示文摘 | Julien Bertrand Alexis Goichon Philippe Chan Saida Azhar Stéphane Lecleire Nathalie Donnadieu David Vaudry Anne-Fran?oise Cailleux Pierre Déchelotte Mo?se Co?ffier | 2014 | Amino Acids2014，，4： | 1 |
| 7 | Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis显示文摘 | Pierre Blanchard Anne Lee Sophie Marguet Julie Leclercq Wai Tong Ng Jun Ma Anthony T C Chan Pei-Yu Huang Ellen Benhamou Guopei Zhu Daniel T T Chua Yong Chen Hai-Qiang Mai Dora L W Kwong Shie Lee Cheah James Moon Yuk Tung Kwan-Hwa Chi George Fountzilas Li | 2015 | The Lancet Oncology2015，，： | 1 |
| 8 | Periprosthetic osteoly sis: characterizing the innate immune response to titanium wear-particles 显示文摘 | St Pierre CA Chan M Iwakura Y | 2010 | J Orthop Res2010，28，： | 1 |
| 9 | Periprosthetic osteolysis : characterizing the innate immune response to titanium wear-particles 显示文摘 | St Pierre CA Chan M Iwakura Y | 2010 | J Orthop Res2010，28，11： | 1 |
| 10 | Periprosthetic osteolysis : charaet - erizing the innate immune response to titanium wear - particles 显示文摘 | ST PIERRE C A CHAN M IWAKURA Y | 2010 | J Orthop Res2010，28，11： | 1 |
| 11 | Periprosthetic osteolysis: characterizing the innate immune rsponse to titanium wear-particles 显示文摘 | St Pierre CA Chan M Iwakura Y | 2010 | J Orthop Res2010，28，11： | 1 |
| 12 | A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma显示文摘 | Thomas Yau P. N. Cheng Pierre Chan William Chan Li Chen Jimmy Yuen Roberta Pang S. T. Fan Ronnie T. Poon | 2013 | Investigational New Drugs2013，，1： | 1 |
| 13 | Secondary Tricuspid Regurgitation or Dilatation: Which Should Be the Criteria for Surgical Repair?显示文摘 | Gilles D. Dreyfus Pierre J. Corbi K.M. John Chan Toufan Bahrami | 2005 | The Annals of Thoracic Surgery2005，，1： | 1 |
| 14 | The use of single‐agent sorafenib in the treatment of advanced hepatocellular carcinoma patients with underlying Child‐Pugh B liver cirrhosis显示文摘 | Joanne Chiu Yuen Fong Tang Tzy‐Jyun Yao Ashley Wong Hilda Wong Roland Leung Pierre Chan Tan To Cheung Albert C. Chan Roberta Pang Sheung‐Tat Fan Ronnie Poon Thomas Yau | 2012 | Cancer2012，，21： | 1 |
| 15 | Pharmacovigilance of herbal medicine显示文摘 | Debbie Shaw Ladds Graeme Duez Pierre Williamson Elizabeth Chan Kelvin | 2012 | Journal of Ethnopharmacology2012，，3： | 1 |
| 16 | Management of advanced hepatocellular carcinoma in era of targed therapy显示文摘 | Thomas Yau Pierre Chan Richard Epstain | 2009 | Liv er International2009，，： | 1 |
| 17 | Synthesis of biodiesel in column fixed - bed bioreactor using the fermented solid produced by Burkholderia cepacia LTEB11 显示文摘 | Thais Fabiana Chan Saluma b Pierre Vineneuveb Bruno Bareab et al | 2010 | Process Biochemistry2010，45，： | 1 |
| 18 | Staffing multi-skill call centers via search methods and a performance approximation显示文摘 | Athanassios N. Avramidis Wyean Chan Pierre L’Ecuyer | 2009 | IIE Transactions2009，，： | 1 |
| 19 | Colon cancer in a patient with underlying aplastic anemia: A clinical challenge显示文摘The association of gastrointestinal malignancy with aplastic anemia has rarely been reported in the literature. Although it is not clear whether there is any direct relationship between aplastic anemia and gastrointestinal cancers, a retrospective analysis did suggest the notion that patients with aplastic anemia might have a higher incidence of colorectal cancer. Here, we report the diagnostic and therapeutic challenges in managing a patient with aplastic anemia and advanced colorectal cancer. Early diagnosis is challenging due to overlapping symptomatology and clinical features, increased risk of diagnostic procedures, and confounding complications arising from aplastic anemia and its treatment. A high index of suspicion and multidisciplinary input are essential. | Hilda Wong Pierre Chan Thomas Yau | 2012 | World Journal of Clinical Oncology2012，3，2： | 0 |
| 20 | A Continuous Action Space Tree search for INverse desiGn (CASTING) framework for materials discovery显示文摘Material properties share an intrinsic relationship with their structural attributes,making inverse design approaches crucial for discovering new materials with desired functionalities.Reinforcement Learning(RL)approaches are emerging as powerful inverse design tools,often functioning in discrete action spaces.This constrains their application in materials design problems,which involve continuous search spaces.Here,we introduce an RL-based framework CASTING(Continuous Action Space Tree Search for inverse design),that employs a decision tree-based Monte Carlo Tree Search(MCTS)algorithm with continuous space adaptation through modified policies and sampling.Using representative examples like Silver(Ag)for metals,Carbon(C)for covalent systems,and multicomponent systems such as graphane,boron nitride,and complex correlated oxides,we showcase its accuracy,convergence speed,and scalability in materials discovery and design.Furthermore,with the inverse design of super-hard Carbon phases,we demonstrate CASTING’s utility in discovering metastable phases tailored to user-defined target properties and preferences. | Suvo Banik Troy Loefller Sukriti Manna Henry Chan Srilok Srinivasan Pierre Darancet Alexander Hexemer Subramanian K.R.S.Sankaranarayanan | 2023 | npj Computational Materials2023，，1： | 0 |
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