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| 1 | Animal models for the study of hepatic fibrosis显示文摘 | Peter Starkel I.A. Leclercq | 2011 | Best Practice & Research Clinical Gastroenterology2011，，2： | 4 |
| 2 | Genetic characterization and potential molecular dissemination mechanism of tet(31) gene in Aeromonas caviae from an oxytetracycline wastewater treatment system显示文摘Recently, the rarely reported tet(31) tetracycline resistance determinant was commonly found in Aeromonas salmonicida, Gallibacterium anatis, and Oblitimonas alkaliphila isolated from farming animals and related environment. However, its distribution in other bacteria and potential molecular dissemination mechanism in environment are still unknown. The purpose of this study was to investigate the potential mechanism underlying dissemination of tet(31) by analysing the tet(31)-carrying fragments in A. caviae strains isolated from an aerobic biofilm reactor treating oxytetracycline bearing wastewater. Twenty-three A. caviae strains were screened for the tet(31) gene by polymerase chain reaction(PCR). Three strains(two harbouring tet(31), one not) were subjected to whole genome sequencing using the PacBio RSII platform. Seventeen A. caviae strains carried the tet(31) gene and exhibited high resistance levels to oxytetracycline with minimum inhibitory concentrations(MICs)ranging from 256 to 512 mg/L. tet(31) was comprised of the transposon Tn6432 on the chromosome of A. caviae, and Tn6432 was also found in 15 additional tet(31)-positive A. caviae isolates by PCR. More important, Tn6432 was located on an integrative conjugative element(ICE)-like element, which could mediate the dissemination of the tet(31)-carrying transposon Tn6432 between bacteria. Comparative analysis demonstrated that Tn6432 homologs with the structure ISCR2-ΔphzF-tetR(31)-tet(31)-ΔglmM-sul2 were also carried by A. salmonicida, G. anatis, and O. alkaliphila, suggesting that this transposon can be transferred between species and even genera. This work provides the first report on the identification of the tet(31) gene in A. caviae, and will be helpful in exploring the dissemination mechanisms of tet(31) in water environment. | Yanhong Shi Zhe Tian Sébastien Olivier Leclercq Hong Zhang Min Yang Yu Zhang | 2019 | Journal of Environmental Sciences2019，31，2： | 4 |
| 3 | Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay显示文摘 | Cazeau S Leclercq C Lavergne T | | 0，，： | 3 |
| 4 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 5 | Sequential therapies for proliferative lupus nephritis显示文摘 | Contreras G Pardo V Leclercq B | | 0，，： | 2 |
| 6 | Adipose tissues as endocrine target organs显示文摘 | Nicolas Lanthier Isabelle A. Leclercq | 2014 | Best Practice & Research Clinical Gastroenterology2014，，4： | 2 |
| 7 | Human B cell growth and differentiation in the spleen of immunodeficient mice显示文摘 | Verhoye L Leclercq G | 2001 | J Immunol2001，166，5： | 1 |
| 8 | Comparison of Fecal Coliform Agar and Violet Red Bile Lactose Agar for Fecal Coliform Enumeration in Foods显示文摘 | Leclercq A Wanegue C Baylac P | 2002 | Applied and Environmental Microbiology2002，68，4： | 1 |
| 9 | Nonhydrolytic Sol-Gel process:aluminum titanate gels显示文摘 | ANDRIANAINARIVELO M CORRIU R J P LECLERCQ D | 1997 | Chem Mater1997，9，5： | 1 |
| 10 | Assessment of longitu- dinal and radial ventricular dyssynehrony in isehemic and no- nischemic chronic systolic heart failure: a two-dimensional e- chocardiographic speckle-tracking strain study 显示文摘 | Donal E Toumoux F Leclercq C | 2008 | J Am Soc Echocardiogr2008，21，1： | 1 |
| 11 | Is vitamin KI supplementation necessary in long-term parenteral nutrition? 显示文摘 | CHAMBRIER C LECLERCQ M SAUDIN F | 1998 | J Parenter Enteral Nutr1998，22，2： | 1 |
| 12 | CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis显示文摘 | Leclercq IA Farrell GC Field J | 2000 | J Clin Invest2000，105，8： | 1 |
| 13 | Per('utaneous injec- tion of methyl methacrylale in the vertebral body fi)r the trestment of various diseases:percutaneous vertebroplasty(abstracl)显示文摘 | Bascoulerguc Y I)uqttesnel J Leclercq R e! al | 1988 | Radi- ohJgy1988，169，： | 1 |
| 14 | Sequential therapies for proliferative lupus nephritis显示文摘 | Contreras G Pardo V Leclercq B | 2004 | N Engl J Med2004，350，10： | 1 |
| 15 | Comparison of di- ffusion tensor imaging tractography of language tracts and intraoperative subeortical stimulations 显示文摘 | Leclercq D Duffau H Delmaire C | 2010 | J Neurosurg2010，112，3： | 1 |
| 16 | One year incidence and clinical impact of bleeding outcomes in STEMI patients treated by prasugrel or clopidogrel in real life:the BLEED-MI study显示文摘 | Benoit Lattuca Florence Leclercq Sandrine Leroy | 2015 | Archives of Cardiovascular Diseases Supplements2015，7，1： | 1 |
| 17 | Nonalcoholic steatosis and steatohepatitis Ⅱ Cytochrome p450 enzymes and oxidative stress显示文摘 | Robertson G Leclercq I Farrell GC | 2001 | Physiol 6astrointest liver Physiol2001，281，： | 1 |
| 18 | Reduction in hepatic cytochrome P - 450 is correlated to the degree of liver rat content in animal models of steatosis in the absence of inflammation 显示文摘 | Leclercq I Horsmans Y Desager J P | 1998 | J Hepatol1998，28，： | 1 |
| 19 | NF-κB activation,rather than TNF,mediates hepatic inflammation in a murine dietary model of steatohepatitis显示文摘 | Pena AD Leclercq I Field J | 2005 | Gastroenterology2005，129，5： | 1 |
| 20 | Mechanisms of resistance to macrolides and lincosamides; nature of the resistance elements and their clinical implications 显示文摘 | Leclercq R | 2002 | Clin Infect Dis2002，34，4： | 1 |
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