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| 1 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 2 | Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications显示文摘We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 Hz.To the best of our knowledge,this is the highest energy ever recorded for a diodepumped laser system. | Saumyabrata Banerjee Paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris Edwards John Collier | 2020 | High Power Laser Science and Engineering2020，8，2： | 4 |
| 3 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 4 | Simple Non-Invasive Systems Predict Long-Term Outcomes of Patients With Nonalcoholic Fatty Liver Disease显示文摘 | Paul Angulo Elisabetta Bugianesi Einar S. Bjornsson Phunchai Charatcharoenwitthaya Peter R. Mills Francisco Barrera Svanhildur Haflidadottir Christopher P. Day Jacob George | 2013 | Gastroenterology2013，，： | 2 |
| 5 | The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: An international collaborative study显示文摘 | Neeraj Bhala Paul Angulo David van der Poorten Eric Lee Jason M. Hui Giorgio Saracco Leon A. Adams Phunchai Charatcharoenwitthaya Joanne H. Topping Elisabetta Bugianesi Christopher P. Day Jacob George | 2011 | Hepatology2011，，4： | 2 |
| 6 | The Cooperative Activities of CSLD2, CSLD3, and CSLD5 Are Required for Normal Arabidopsis Development显示文摘Glycosyltransferases of the Cellulose Synthase Like D (CSLD) subfamily have been reported to be involved in tip growth and stem development in Arabidopsis. The csld2 and csld3 mutants are root hair defective and the csld5 mutant has reduced stem growth. In this study, we produced double and triple knockout mutants of CSLD2, CSLD3, and CSLD5. Unlike the single mutants and the csld2/csld3 double mutant, the csld2/csld5, csld3/csld5, and csld2/ csld3/csld5 mutants were dwarfed and showed severely reduced viability. This demonstrates that the cooperative activities of CSLD2, CSLD3, and CSLD5 are required for normal Arabidopsis development, and that they are involved in important processes besides the specialized role in tip growth. The mutant phenotypes indicate that CSLD2 and CSLD3 have overlapping functions with CSLD5 in early plant development, whereas the CSLD2 and CSLD3 proteins are non-redundant. To determine the biochemical function of CSLD proteins, we used transient expression in tobacco leaves. Microsomes containing heterologously expressed CSLD5 transferred mannose from GDP–mannose onto endogenous acceptors. The same activity was detected when CSLD2 and CSLD3 were co-expressed but not when they were expressed separately. With monosaccharides as exogenous acceptors, microsomal preparations from CSLD5-expressing plants mediated the transfer of mannose from GDP–mannose onto mannose. These results were supported by immunodetection studies that showed reduced levels of a mannan epitope in the cell walls of stem interfascicular fibers and xylem vessels of the csld2/csld3/csld5 mutant. | Lan Yin Yves Verhertbruggen Ai Oikawa Chithra Manisseri Bernhard Knierim Lina Prak Jacob Kriiger Jensen Paul Knox Manfred Auer William G.T. Willatsa and Henrik Vibe Scheller | 2011 | Molecular Plant2011，4，6： | 2 |
| 7 | Vitamin status and intake as primary determinants of homocysteinemia in an elderly population显示文摘 | Jacob S Paul FJ Peter WF | 1993 | JAM A1993，270，： | 1 |
| 8 | Cognitive Dysfunction and Depression in Adult Kidney Transplant Recipients: Baseline Findings from the FAVORIT Ancillary Cognitive Trial (FACT)显示文摘 | Aron M. Troen Tammy M. Scott Kristen E. D’Anci Denish Moorthy Beverly Dobson Gail Rogers Daniel E. Weiner Andrew S. Levey Gerard E. Dallal Paul F. Jacques Jacob Selhub Irwin H. Rosenberg | 2012 | Journal of Renal Nutrition2012，，2： | 1 |
| 9 | Fasting Plas ma Homocysteine Levels in the Insulin Resistance Syndrome:The Framingham Offspring study显示文摘 | Meigs James B Jacques Paul F Selhub Jacob | 2001 | Diabetescare2001，24，8： | 1 |
| 10 | Temporal Analysis of Early Immune Responses in Patients With Acute Hepatitis B Virus Infection显示文摘 | Claire Dunn Dimitra Peppa Pooja Khanna Gaia Nebbia Meleri Jones Nathan Brendish R. Monica Lascar David Brown Richard J. Gilson Richard J. Tedder Geoffrey M. Dusheiko Michael Jacobs Paul Klenerman Mala K. Maini | 2009 | Gastroenterology2009，，4： | 1 |
| 11 | Working Memory and Response Inhibition as One Integral Phenotype of Adult ADHD? A Behavioral and Imaging Correlational Investigation显示文摘 | Martin Schecklmann Ann-Christine Ehlis Michael M. Plichta Thomas Dresler Monika Heine Andrea Boreatti-Hümmer Marcel Romanos Christian Jacob Paul Pauli Andreas J. Fallgatter | 2013 | Journal of Attention Disorders2013，，6： | 1 |
| 12 | Rapid Prototyping and Manufacturing显示文摘 | Paul Jacobs | 1992 | Fundamentals of Stereolithograhy SME Dearborn MI1992，1992，： | 1 |
| 13 | Oxidized LDL and the metabolic syndrome显示文摘 | Paul Holvoet Dieuwke De Keyzer David R Jacobs Jr | 2008 | Future Lipidol2008，3，： | 1 |
| 14 | Prospective Study Reveals Associations Between Colorectal Cancer and Type 2 Diabetes Mellitus or Insulin Use in Men显示文摘 | Peter T. Campbell Anusila Deka Eric J. Jacobs Christina C. Newton Janet S. Hildebrand Marjorie L. McCullough Paul J. Limburg Susan M. Gapstur | 2010 | Gastroenterology2010，，4： | 1 |
| 15 | Percutaneous Coronary Intervention in the Current Era Compared With 1985–1986: The National Heart, Lung, and Blood Institute Registries显示文摘 | David O. Williams Richard Holubkov Wanlin Yeh Martial G. Bourassa Mahdi Al-Bassam Peter C. Block Paul Coady Howard Cohen Michael Cowley Gerald Dorros David Faxon David R. Holmes Alice Jacobs Sheryl F. Kelsey Spencer B. King Richard Myler James Slater Vlad | 2000 | Circulation: Journal of the American Heart Association2000，，24： | 1 |
| 16 | Effects of pioglitazone on menstrual frequency, hyperandrogenism and insulin resistance in ad- oloscents and young adults with polycystic ovary syndrome显示文摘 | Narsing Rao L Jacob J J Paul TV | 2009 | J Pe- diatr Adolesc Gynecol2009，22，2： | 1 |
| 17 | Blast-induced Liquefaction of an alluvial sand deposit显示文摘 | Charlie W A Paul J Jacobs Doehring D O | 1992 | Geotechnieal Testing Journal1992，15，1： | 1 |
| 18 | Do Magnetic Resonance Imaging and Ultrasound Add Anything to the Preoperative Workup of Parotid Gland Tumors?显示文摘 | Jacob Alexander de Ru Maarten S. van Leeuwen Peter Paul G. van Benthem Birgitta K. Velthuis Daisy M.D.S. Sie-Go Gerrit Jan Hordijk | 2007 | Journal of Oral and Maxillofacial Surgery2007，，5： | 1 |
| 19 | Provider payment methods and health worker motivation in community-based health insurance: A mixed-methods study显示文摘 | Paul Jacob Robyn Till B?rnighausen Aurélia Souares Adama Traoré Brice Bicaba Ali Sié Rainer Sauerborn | 2014 | Social Science & Medicine2014，，： | 1 |
| 20 | FEASIBILITY OF CONTRAST‐ENHANCED ULTRASOUND‐GUIDED BIOPSY OF SENTINEL LYMPH NODES IN DOGS显示文摘 | HYLTON R.GELB LYNETTA J.FREEMAN JACOB J.ROHLEDER PAUL W.SNYDER | 2010 | Veterinary Radiology & Ultrasound2010，，6： | 1 |
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