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| 1 | Surgical treatment of anal stenosis显示文摘Anal stenosis is a rare but serious complication of anorectal surgery, most commonly seen after hemorrhoidectomy. Anal stenosis represents a technical challenge in terms of surgical management. A Medline search of studies relevant to the management of anal stenosis was undertaken. The etiology, pathophysiology and classifi cation of anal stenosis were reviewed. An overview of surgical and non-surgical therapeutic options was developed. Ninety percent of anal stenosis is caused by overzealous hemorrhoidectomy. Treatment, both medical and surgical, should be modulated based on stenosis severity. Mild stenosis can be managed conservatively with stool softeners or fiber supplements. Sphincterotomy may be quite adequate for a patient with a mild degree of narrowing. For more severe stenosis, a formal anoplasty should be performed to treat the loss of anal canal tissue. Anal stenosis may be anatomic or functional. Anal stricture is most often a preventable complication. Many techniques have been used for the treatment of anal stenosis with variable healing rates. It is extremely diffi cult to interpret the results of the various anaplastic procedures de in the literature as prospective trials have not been performed. However, almost any approach will at least improve patient symptoms. | Giuseppe Brisinda Serafino Vanella Federica Cadeddu Gaia Marniga Pasquale Mazzeo Francesco Brandara Giorgio Maria | 2009 | World Journal of Gastroenterology2009，15，16： | 22 |
| 2 | Hepatitis B virus and hepatitis C virus dual infection显示文摘Hepatitis B virus(HBV)and hepatitis C virus(HCV)share common mode of transmission and both are able to induce a chronic infection.Dual HBV/HCV chronic coinfection is a fairly frequent occurrence,especially in high endemic areas and among individuals at high risk of parenterally transmitted infections.The intracellular interplay between HBV and HCV has not yet been sufficiently clarified,also due to the lack of a proper in vitro cellular model.Longitudinal evaluation of serum HBV DNA and HCV RNA amounts has revealed that complex virological profiles may be present in coinfected patients.Dual HBV/HCV infection has been associated to a severe course of the liver disease and to a high risk of developing hepatocellular carcinoma.Despite the clinical importance,solid evidence and clear guidelines for treatment of this special population are still lacking.This review summarizes the available data on the virological and clinical features as well as the therapeutic options of the dual HBV/HCV infection,and highlights the aspects that need to be better clarified. | Gaia Caccamo Francesca Saffioti Giovanni Raimondo | 2014 | World Journal of Gastroenterology2014，20，40： | 18 |
| 3 | Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis显示文摘AIM: To investigate the effects of troglitazone (TGZ), an anti-diabetic drug which activates peroxisome proliferatoractivated receptor-γ (PPAR-γ), for liver tissue repair, and the development of ductular reaction, following common bile duct ligation (BDL) in rats.METHODS: Rats were supplemented with TGZ (0.2% w/w in the pelleted food) for 1 wk before BDL or sham operation.Animals were killed at 1, 2, or 4 wk after surgery.RESULTS: The development of liver fibrosis was reduced in rats receiving TGZ, as indicated by significant decreases of procollagen type Ⅰ gene expression and liver hydroxyproline levels. Accumulation of α-smooth-muscle actin (SMA)-expressing cells surrounding newly formed bile ducts following BDL, as well as total hepatic levels of SMA were partially inhibited by TGZ treatment, indicating the presence of a reduced number and/or activation of hepatic stellate cells (HSC) and myofibroblasts. Development of the ductular reaction was inhibited by TGZ, as indicated by histochemical evaluation and hepatic activity of γ-glutamyltransferase (GGT).CONCLUSION: Treatment with thiazolidinedione reduces ductular proliferation and fibrosis in a model of chronic cholestasis, and suggests that limiting cholangiocyte proliferation may contribute to the lower development of scarring in this system. | Fabio Marra Raffaella DeFranco Gaia Robino Erica Novo Eva Efsen Sabrina Pastacaldi Elena Zamara Alessandro Vercelli Benedetta Lottini Carlo Spirli Mario Strazzabosco Massimo Pinzani Maurizio Parola | 2005 | World Journal of Gastroenterology2005，11，32： | 9 |
| 4 | Metabolomics profile in gastrointestinal cancers:Update and future perspectives显示文摘Despite recent progress in diagnosis and therapy,gastrointestinal(GI)cancers remain one of the most important causes of death with a poor prognosis due to late diagnosis.Serum tumor markers and detection of occult blood in the stool are the current tests used in the clinic of GI cancers;however,these tests are not useful as diagnostic screening since they have low specificity and low sensitivity.Considering that one of the hallmarks of cancer is dysregulated metabolism and metabolomics is an optimal approach to illustrate the metabolic mechanisms that belong to living systems,is now clear that this-omics could open a new way to study cancer.In the last years,nuclear magnetic resonance(NMR)metabolomics has demonstrated to be an optimal approach for diseases’diagnosis nevertheless a few studies focus on the NMR capability to find new biomarkers for early diagnosis of GI cancers.For these reasons in this review,we will give an update on the status of NMR metabolomic studies for the diagnosis and development of GI cancers using biological fluids. | Giulia Nannini Gaia Meoni Amedeo Amedei Leonardo Tenori | 2020 | World Journal of Gastroenterology2020，26，20： | 5 |
| 5 | Occult HBV infection显示文摘 | Giovanni Raimondo Gaia Caccamo Roberto Filomia Teresa Pollicino | 2013 | Seminars in Immunopathology2013，，1： | 4 |
| 6 | Botulinum toxin for chronic anal fissure after biliopancreatic diversion for morbid obesity显示文摘AIM: To study the effect of botulinum toxin in patients with chronic anal fissure after biliopancreatic diversion (BPD) for severe obesity. METHODS: Fifty-nine symptomatic adults with chronic anal fissure developed after BPD were enrolled in an open label study. The outcome was evaluated clinically and by comparing the pressure of the anal sphincters before and after treatment. All data were analyzed in univariate and multivariate analysis. RESULTS: Two months after treatment, 65.4% of the patients had a healing scar. Only one patient had mild incontinence to flatus that lasted 3 wk after treatment, but this disappeared spontaneously. In the multivariate analysis of the data, two registered months after the treatment, sex (P = 0.01), baseline resting anal pressure (P = 0.02) and resting anal pressure 2 mo after treatment (P < 0.0001) were significantly related to healing rate.CONCLUSION: Botulinum toxin, despite worse results than in non-obese individuals, appears the best alternative to surgery for this group of patients with a high risk of incontinence. | Serafino Vanella Giuseppe Brisinda Gaia Marniga Anna Crocco Giuseppe Bianco Giorgio Maria | 2012 | World Journal of Gastroenterology2012，18，10： | 4 |
| 7 | Early gastric cancer:A challenge in Western countries显示文摘Early gastric cancer(EGC)is an invasive carcinoma involving only the stomach mucosa or submucosa,independently of lymph node status.EGC represents over 50%of cases in Japan and in South Korea,whereas it accounts only for approximately 20%of all newly diagnosed gastric cancers in Western countries.The main classification systems of EGC are the Vienna histopathologic classification and the Paris endoscopic classification of polypoid and non-polypoid lesions.A careful endoscopic assessment is fundamental to establish the best treatment of EGC.Generally,EGCs are curable if the lesion is completely removed by endoscopic resection or surgery.Some types of EGC can be resected endoscopically;for others the most appropriate treatment is surgical resection and D2 lymphadenectomy,especially in Western countries.The favorable oncological prognosis,the extended lymphadenectomy and the reconstruction of the intestinal continuity that excludes the duodenum make the prophylactic cholecystectomy mandatory to avoid the onset of biliary complications. | Maria Michela Chiarello Valeria Fico Gilda Pepe Giuseppe Tropeano Neill James Adams Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，7： | 3 |
| 8 | Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo显示文摘 | Song XU Kim DE VEIRMAN Holly EVANS Gaia Cecilia SANTINI: Isabelle VANDE BROEKI XavierLELEU Ann DEBECKER Ben VAN CAMP Peter CROUCHER Karin VANDERKERKEN Ivan VAN RIET | 2013 | Acta Pharmacologica Sinica2013，34，5： | 3 |
| 9 | Value of FDG PET/CT in Patients with Treated Ovarian Cancer and Raised CA125 Serum Levels显示文摘 | Azahara Palomar Cristina Nanni Paolo Castellucci Valentina Ambrosini Gian Carlo Montini Vincenzo Allegri Cinzia Pettinato Adil Al-Nahhas Angel Soriano Gaia Grassetto Domenico Rubello Stefano Fanti | 2012 | Molecular Imaging and Biology2012，，： | 2 |
| 10 | 终末期肝病患者应用G-CSF诱导骨髓源性细胞的可行性与安全性 | Gaia S. Smedile A. OmedèP. 张红凯 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 2 |
| 11 | In vitro effects of polyphenols on colorectal cancer cells显示文摘AIM:To investigate the effects of quercetin and genistein on colon cancer cell proliferation and their estrogen receptorβ(ERβ)expression.METHODS:Colon cancer cells were stably transfected with a mammalian expression vector to overexpress ERβ(HCT8-β8-expressing cells)or a control vector(HCT8-pSV2neo-expressing cells).The proliferation of these cells was examined after treatment with quercetin or genistein(5-100μmol/L),or 10 nmol/L17β-estradiol(17β-E2).Cell viability was examined by acridine orange staining following treatments for 48 or144 h.Effects of quercetin and genistein on ERβtranscriptional transactivation were examined by luciferase activity in HCT8-β8-expressing cells transiently transfected with a pEREtkLUC reporter vector.In addition,the regulation of ERβtranscription by phytoestrogens and 17β-E2 was examined by quantitative polymerase chain reaction.RESULTS:Proliferation of HCT8-β8-expressing cells was not reduced low doses(5μmol/L)of quercetin and genistein,while it was reduced at 25-50μmol/L with an effect similar to 10 nmol/L 17β-E2.Treatment with doses of phytoestrogens≥75μmol/L completely blocked cell growth and reduced overall cell counts,however no effects at any dose were observed in HCT8-pSV2neoexpressing cells.These results were supported by viability staining that revealed acridine orange-stained lysosomes with high doses or extended treatment periods.Genistein and quercetin(50μmol/L)significantly increased ER-responsive luciferase activity similar to 10nmol/L 17β-E2(P<0.05).Furthermore,genistein and quercetin(50μmol/L),as well as 10 nmol/L 17β-E2significantly increased ERβmRNA levels in HCT8-β8-expressing cells(P<0.05).In addition,treatment of HCT8-pSV2neo-expressing cells with 50μmol/L quercetin or 10 nmol/L 17β-E2 significantly increased ERβmRNA levels compared to untreated controls(P<0.05),though the absolute levels were much lower than in HCT8-β8-expressing cells.CONCLUSION:The antitumorigenic effects of the phytoestrogenic compounds quercetin and genistein on colon cancers cells occur through ERβactivity and expression. | Barbara Pampaloni Gaia Palmini Carmelo Mavilia Roberto Zonefrati Annalisa Tanini Maria Luisa Brand | 2014 | World Journal of Gastrointestinal Oncology2014，6，8： | 2 |
| 12 | Reliability of transient elastography for the detection of fibrosis in Non-Alcoholic Fatty Liver Disease and chronic viral hepatitis显示文摘 | Silvia Gaia Silvia Carenzi Angela L. Barilli Elisabetta Bugianesi Antonina Smedile Franco Brunello Alfredo Marzano Mario Rizzetto | 2010 | Journal of Hepatology2010，，： | 2 |
| 13 | HP-NAP inhibits the growth of bladder cancer in mice by activating a cytotoxic Th1 response显示文摘 | Gaia Codolo Matteo Fassan Fabio Munari Andrea Volpe Piefrancesco Bassi Massimo Rugge Francesco Pagano Mario Milco D’Elios Marina Bernard | 2012 | Cancer Immunology Immunotherapy2012，，1： | 2 |
| 14 | Therapeutic strategies in Crohn’s disease in an emergency surgical setting显示文摘Crohn’s disease(CD)remains a chronic,incurable disorder that presents unique challenges to the surgeon.Multiple factors must be considered to allow development of an appropriate treatment plan.Medical therapy often precedes or complements the surgical management.The indications for operative management of CD include acute and chronic disease complications and failed medical therapy.Elective surgery comes into play when patients are refractory to medical treatment if they have an obstructive phenotype.Toxic colitis,acute obstruction,perforation,acute abscess,or massive hemorrhage represent indications for emergency surgery.These patients are generally in critical conditions and present with intra-abdominal sepsis and a preoperative status of immunosuppression and malnutrition that exposes them to a higher risk of complications and mortality.A multidisciplinary team including surgeons,gastroenterologists,radiologists,nutritional support services,and enterostomal therapists are required for optimal patient care and decision making.Management of each emergency should be individualized based on patient age,disease type and duration,and patient goals of care.Moreover,the recurrent nature of disease mandates that we continue searching for innovative medical therapies and operative techniques that reduce the need to repeat surgical operations.In this review,we aimed to discuss the acute complications of CD and their treatment. | Maria Michela Chiarello Gilda Pepe Valeria Fico Valentina Bianchi Giuseppe Tropeano Gaia Altieri Giuseppe Brisinda | 2022 | World Journal of Gastroenterology2022，28，18： | 2 |
| 15 | MR-Guided High-Intensity Focused Ultrasound: Current Status of an Emerging Technology显示文摘 | Alessandro Napoli Michele Anzidei Federica Ciolina Eugenio Marotta Beatrice Cavallo Marincola Giulia Brachetti Luisa Mare Gaia Cartocci Fabrizio Boni Vincenzo Noce Luca Bertaccini Carlo Catalano | 2013 | CardioVascular and Interventional Radiology2013，，5： | 2 |
| 16 | 上海叙事:将城市针灸作为以社区为基础的遗产保护和发展策略显示文摘上海是一个进步与传统并存、现代化对城市肌理和本土社区不断冲击的地方。基于以上考虑,以上海虹口区提篮桥地区袖珍广场设计为例,采取城市针灸这种微干扰方式对该地区的公共空间体系进行整体性梳理,并在提升空间质量的过程中采取自下而上的社区参与模式,在落实设计时采取软硬设计相结合的方式以实现弹性空间的可能。'上海叙事'更多的是作为一种社区导向的、强调公众参与的、自下而上的规划模式探讨,而非简单的设计成果呈现,期望能对城市更新策略的探索尽绵薄之力。 | 单瑞琦 Michael Reiche Gaia Agostini | 2013 | 上海城市规划2013，，6： | 2 |
| 17 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 18 | Low-dose interleukin-2 administered pre-operatively topatients with gastric cancer activates peripheral and perit-umoral lymphocytes but does not affect prognosis显示文摘 | Giovanni Carlo Cesana Fabrizio Romano Gaia Piacentini | 2007 | Annals Surgical Oncology2007，14，4： | 1 |
| 19 | Four years of treatment with lamivudine: clinical and virological evaluations in HBe antigen-negative chronic hepatitis B 显示文摘 | Gaia S Marzano A Smedile A | 2004 | Aliment Pharmacol Ther2004，20，3： | 1 |
| 20 | The biocompatibility of dibutyryl chitin in the context of wound dressings 显示文摘 | RICCARDO A A Muzzarellia MARIO Guerrierib GAIA Goteric | 2005 | Biomaterials2005，26，： | 1 |
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