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| 1 | Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles显示文摘Objective:To prepare curcumin-piperine(Cu-Pi) nanoparticles by various methods and to study the effect of various manufacturing parameters on Cu-Pi nanoparticles and to identify a suitable method for the preparation of Cu-Pi nanoparticles to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer.Methods:Cu-Pi nanoparticles were prepared by thin film hydration method,solid dispersion method,emulsion polymerization method and Fessi method.Optimization was carried out to study the effect of various manufacturing parameter on the Cu-Pi nanoparticles.Results:Out of four methods,Fessi method produced a minimum average particle size of 85.43 nm with a polydispersity index of 0.183 and zeta potential of 29.7 mV.Change of organic solvent(acetone or ethanol) did not have any significant effect on Cu-Pi nanoparticles.However,increase in sonication time,stirring speed,viscosity,use of 1:10:10 ratio of drag/polymer/surfactant,and use of anionic surfactant or combination of anionic surfactant with cationic polymer or combination of non-ionic surfactant with cationic polymer had a significant effect on Cu-Pi nanoparticles.Conclusions:Cu-Pi nanoparticles coated with PEC containing copolymer produced by Fessi method had a minimum average particle size,excellent polydispersity index and optimal zeta potential which fall within the acceptable limits of the study.This dual nanoparticulate drug delivery system appears to be promising to overcome oral bioavailability and cancer cell targeting limitations in the treatment of cancer. | C Moorthi Kiran Krishnan R Manavalan K Kathiresan | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 2 | Larvicidal activity of green synthesized silver nanoparticles using bark aqueous extract of Ficus racemosa against Culex quinquefasciatus and Culex gelidus显示文摘Objective:To investigate the larvicidal activity of synthesized silver nanoparticles(Ag NPs) utilizing aqueous bark extract of Ficus racemosa(F.racemosa) was tested against fourth instar larvae of filariasis vector,Culex quinquefasciatus(Cx.quinquefasciatus) and japanese encephalitis vectors,Culex gelidus(Cx.gelidus).Methods:The synthesized Ag NPs was characterized by UV-vis spectrum,X-ray diffraction(XRD),Scanning electron microscopy(SEM) and Fourier transform infrared(FTIR).The larvicidal activities were assessed for 24 h against the larvae of Cx.quinquefasciatus and Cx.gelidus with varying concentrations of aqueous bark extract off.racemosa and synthesized Ag NPs.LC50 and r2 values were calculated.Results:The maximum efficacy was observed in crude aqueous extract of F.racemosa against the larvae of Cx.quinquefasciatus and Cx.gelidus(LC50=67.72 and 63.70 mg/L;r2=0.995 and 0.985) and the synthesized Ag NPs(LC50=12.00 and 11.21 mg/L;r2=0.997 and 0.990).respectively.Synthesized Ag NPs showed the XRD peaks at 2θvalues of 27.61,29.60,35.48,43.48 and 79.68 were identified as (210),(121),(220),(200) and(311) reflections,respectively.The FTIR spectra of Ag NPs exhibited prominent peaks at 3 425,2 878,1 627 and 1 382 in the region 500-3 000 cm-1.The peaks correspond to the presence of a stretching vibration of(NH) C=O group.SEM analysis showed shape in cylindrical,uniform and rod with the average size of 250.60 nm.Conclusions:The biosynthesis of silver nanoparticles using bark aqueous extract of F.racemosa and its larvicidal activity against the larvae of disease spreading vectors.The maximum larvicidal efficacy was observed in the synthesized Ag NPs. | Kanayairam Velayutham Abdul Abdul Rahuman Govindasamy Rajakumar Selvaraj Mohana Roopan Gandhi Elango Chinnaperumal Kamaraj Sampath Marimuthu Thirunavukkarasu Santhoshkumar Moorthy Iyappan Chinnadurai Siva | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，2： | 2 |
| 3 | Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa显示文摘Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(C.gigantea)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(H.bispinosa).Methods:The lyophilized C.gigantea flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 h.Synthesized TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of H.bispinosa were exposed to filter paper impregnated method.Results:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 nm.The functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for C-O.SEM micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in shape.The maximum efficacy was observed in the aqueous flower extract of C.gigantea and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against H.bispinosa(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).respectively.Conclusions:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of H.bispinosa.This study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity. | Sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu Santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai Siva Loganathan Karthik Kokati Venkata Bhaskara Rao | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，9： | 2 |
| 4 | THE NCEP CLIMATE FORECAST SYSTEM REANALYSIS显示文摘 | Saha Suranjana Moorthi Shrinivas Pan Hua-Lu Wu Xingren Wang Jiande Nadiga Sudhir Tripp Patrick Kistler Robert Woollen John Behringer David Liu Haixia Stokes Diane Grumbine Robert Gayno George Wang Jun Hou Yu-Tai Chuang Hui-ya Juang Hann- | 2010 | Bulletin of the American Meteorological Society2010，，8： | 2 |
| 5 | Rxcitatoey effects and electroencephalographic correlation of etomidate thiopental,Methohexital and propofol显示文摘 | Reddy RV Moorthy SS Dierdorf SF | 1993 | Anesth Analg1993，77，： | 1 |
| 6 | Managing a distribution channel under asymmetric information with performation with performance requirements显示文摘 | Desiraju R Moorthy S | 1997 | Management Science1997，43，12： | 1 |
| 7 | Cobahous oxide infiltrated yttrium iron garnet thin films as high - coercivity media for data storage 显示文摘 | RASTOGI A C MOORTHY V N Sandip Dhara | 2001 | Appl PhysLett2001，78，12： | 1 |
| 8 | Managing channel profits:Comment显示文摘 | Moorthy K S | 1987 | Marketing Science1987，6，4： | 1 |
| 9 | No-reference image quality assessment in the spatial domain 显示文摘 | Mittal A Moorthy A K Bovik A C | 2012 | IEEE Transactions on Image Processing2012，21，12： | 1 |
| 10 | No-reference image quality assessment in the spatial domain 显示文摘 | MITTAL A MOORTHY A K BOVIK A C | 2012 | IEEE Transactions on Image Processing2012，21，12： | 1 |
| 11 | Branding in developing markets显示文摘 | Keller K L Moorthi Y L R | 2003 | Business Horizons2003，46，3： | 1 |
| 12 | A vacuum packaged surface micromachined resonant accelerometer显示文摘 | Ashwin A Seshia Moorthi Palaniapan Trey A Roessig | 2002 | Journal of Microelectromechanical Systems2002，11，6： | 1 |
| 13 | Retrieving crown leaf area index from an individual tree using ground-based lidar data显示文摘 | Moorthy I Miller J R | 2008 | Canadian Journal of Remote Sensing2008，34，3： | 1 |
| 14 | Human Leukocyte response to an endurance race显示文摘 | Moorthy AV | 1978 | Eur J Appl Physiol1978，10，5： | 1 |
| 15 | Strategic decentralization in channels显示文摘 | Moorthy K S | 1988 | Marketing Science1988，7，4： | 1 |
| 16 | Visual importance pooling for image quality assessment显示文摘 | MOORTHY A K BOVIK A C | 2009 | IEEE Journal of Selected Topics in Signal Processing2009，3，2： | 1 |
| 17 | Idiopathic polypoidal choroidal vasculopathy of the macula显示文摘 | Moorthy RS Lyon AT Rabb MF | | 0，，： | 1 |
| 18 | TURP syndrome-current concepts' in the pathophysiology and management 显示文摘 | Moorthy HK Philip S | 2001 | Indian J Urol2001，17，2： | 1 |
| 19 | No-reference image quality assessment in the spatial domain显示文摘 | MITTAL A MOORTHY A K BOVIK A C | 2012 | IEEE Transactions on Image Processing2012，21，12： | 1 |
| 20 | Development of glioblastoma mutiforme following traumatic cerebral contusion: case report and review of literature显示文摘 | Moorthy RK Rajshekhar V | 2004 | Surg Neurol2004，61，2： | 1 |
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