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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | 应用无标定激光诱导击穿光谱法分析钢铁工业中氧化物材料显示文摘激光诱导击穿光谱技术是一种具有吸引力的快速定量表征材料的方法,可用于工业过程的在线监控。本文报告了该技术在多元氧化物材料分析上应用。采用激光诱导击穿光谱技术分析钢工业生产的炉渣和混合氧化物试料,然后以无标定法测定其中氧化物的浓度,结果发现,对于本研究所涉及的材料,无标定激光诱导击穿光谱方法的测定浓度值与参考值一致,大部分样品和氧化物组分的绝对误差小于2%(质量分数),大范围改变测定参数时浓度值保持稳定。研究结果表明激光诱导击穿光谱技术作为钢铁工业中新型的分析测试技术具有很大潜力。 | PEDARNIG Johannes D HEITZ Johannes PRAHER Bernhard KOLMHOFER Philipp HUBER Norbert RSSLER Roman WOLFMEIR Hermann ARENHOLZ Enno | 2012 | 冶金分析2012，32，8： | 2 |
| 3 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 4 | Elevated insulin-like growth factor 1 receptor, hepatocyte growth factor receptor and telomerase protein expression in mild ulcerative colitis显示文摘 | Ferenc Sipos Orsolya Galamb László Herszényi Béla Molnár Norbert Solymosi Tamás Zágoni Lajos Berczi Zsolt Tulassay | 2008 | Scandinavian Journal of Gastroenterology2008，，3： | 2 |
| 5 | Optimizing therapy of sei- zures in stroke patients显示文摘 | Philippe R Alexandra M Norbert N | 2006 | Neurology2006，67，： | 1 |
| 6 | Treatment of severe pulmonary hypertension:A bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and fight ventricular hypertrophy显示文摘 | TARASEVICIENE S L SCERBAVICIUS R NORBERT F V | 2005 | Peptides2005，26，8： | 1 |
| 7 | ERCP or EUS for tissue diagnosis of biliary strictures? a prospective comparative study显示文摘 | Thomas R?sch Kim Hofrichter Eckart Frimberger Alexander Meining Peter Born Norbert Weigert Hans-Dieter Allescher Meinhard Classen Marius Barbur Ulrich Schenck Martin Werner | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 8 | Biotechnological intensification of biogas production显示文摘 | Zoltán Bagi Norbert ács Balázs Bálint Lenke Horváth Krisztina Dobó Katalin R. Perei Gábor Rákhely Kornél L. Kovács | 2007 | Applied Microbiology and Biotechnology2007，，2： | 1 |
| 9 | Risk assessment of postoperative nausea and vomiting显示文摘 | Apfel CC Norbert R | 2003 | Int Anesthesiol Clin2003，41，4： | 1 |
| 10 | Comparable effec- tiveness of endovenous laser ablation and high ligation with stripping of the great saphenous vein显示文摘 | Knuth R Norbert F PaulG | 2012 | Arch Dermatol2012，148，1： | 1 |
| 11 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 12 | Management of malignant hyperthermia: diagnosis and treatment 显示文摘 | Daniel S Stephan J Norbert R | 2014 | Therapeutics and Clinical Risc Management2014，10，： | 1 |
| 13 | Impact of allogeneic haematopoietic stem cell transplantation in patients with abnl(17p) acute myeloid leukaemia显示文摘 | Brigitte Mohr Johannes Schetelig Kerstin Sch?fer‐Eckart Norbert Schmitz Mathias H?nel Wolf R?sler Norbert Frickhofen Hartmut Link Andreas Neubauer Ulrich Schuler Uwe Platzbecker Jan M. Middeke Gerhard Ehninger Martin Bornh?user Markus Schaich Friedrich St | 2013 | Br J Haematol2013，，： | 1 |
| 14 | Slower fibrosis progression in HIV/HCV-coinfected patients with successful HIV suppression using antiretroviral therapy显示文摘 | Norbert Br?u Mirella Salvatore Carlos F. Ríos-Bedoya Alberto Fernández-Carbia Fiorenzo Paronetto José F. Rodríguez-Orengo Maribel Rodríguez-Torres | 2005 | Journal of Hepatology2005，，1： | 1 |
| 15 | late clonal diseases of treated aplastic anemia显示文摘 | Gérard S Stephen R Norbert F | 2000 | Semin Hematol2000，37，： | 1 |
| 16 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 17 | Matrix Metalloproteinase-9 Expression in the Normal Mucosa–Adenoma–Dysplasia–Adenocarcinoma Sequence of the Colon显示文摘 | László Herszényi Ferenc Sipos Orsolya Galamb Norbert Solymosi István Hritz Pál Miheller Lajos Berczi Béla Molnár Zsolt Tulassay | 2008 | Pathology & Oncology Research2008，，1： | 1 |
| 18 | Sevoflurane-induced preconditioning of rat brain in vitro and the role of KATP channels显示文摘 | Franz K Ralphiel SP Norbert R | 2004 | Brain Research2004，1021，5： | 1 |
| 19 | An Activity Recognition System For Mobile Phones显示文摘 | Norbert Gy?rbíró ákos Fábián Gergely Hományi | 2009 | Mobile Networks and Applications2009，，1： | 1 |
| 20 | Different radiosensitivity of smooth muscle cells and endothelial cells in vitro as demonstrated by irradiation from a Re-188 filled balloon catheter显示文摘 | Kotzerke J Gertler R Buchmann I Baur R Hombach V Norbert Reske S | 2000 | Atherosclerosis2000，152，： | 1 |
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