|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diabetes-related alterations in the enteric nervous system and its microenvironment显示文摘Gastric intestinal symptoms common among diabetic patients are often caused by intestinal motility abnormalities related to enteric neuropathy. It has recently been demonstrated that the nitrergic subpopulation of myenteric neurons are especially susceptible to the development of diabetic neuropathy. Additionally, different susceptibility of nitrergic neurons located in different intestinal segments to diabetic damage and their different levels of responsiveness to insulin treatment have been revealed. These findings indicate the importance of the neuronal microenvironment in the pathogenesis of diabetic nitrergic neuropathy. The main focus of this review therefore was to summarize recent advances related to the diabetes-related selective nitrergic neuropathy and associated motility disturbances. Special attention was given to the findings on capillary endothelium and enteric glial cells. Growing evidence indicates that capillary endothelium adjacent to the myenteric ganglia and enteric glial cells surrounding them are determinative in establishing the ganglionic microenvironment. Additionally, recent advances in the development of new strategies to improve glycemic control in type 1 and type 2 diabetes mellitus are also considered in this review. Finally, looking to the future, the recent and promising results of metagenomics for the characterization of the gut microbiome in health and disease such as diabetes are highlighted. | Mária Bagyánszki Nikolett Bódi | 2012 | World Journal of Diabetes2012，3，5： | 11 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 4 | Quality of life after burn injury:the impact of joint contracture显示文摘 | Leblebici B Adam M Bagis S | | 0，，06： | 1 |
| 5 | Detection by mulliplex real-time polymeruse chain reaction assays and isolation of Shiga tox- in-producing Escherichia coil serogroups 026, 045, Oi03, Oiii, O~2~ , and O~s in ground beef 显示文摘 | Fratamico PM Bagi LK Cray WC Jr | 2011 | Foodborne Pathogens and Dis- ease2011，8，5： | 1 |
| 6 | PPARgamma activation,by reducing oxidative stress,increases NO bioavailability in coronary arterioles of mice with type 2 diabetes显示文摘 | Bagi Z Koller A Kaley G | 2004 | Am J Physiol Heart Circ Physiol2004，286，： | 1 |
| 7 | Tear function tests and conjunctival impression cytology before and after hormone replacement therapy in postmenopausal women 显示文摘 | Pelit A Bagis T Kayaselcuk F | 2003 | Eur J Ophthalmol2003，13，4： | 1 |
| 8 | High maternal hemoglobin and ferritin values as risk factors for gestational diabetes 显示文摘 | Tarim E Kilicdag E Bagis T | 2004 | Intern J Gy- necol Obstet2004，84，3： | 1 |
| 9 | Discrete element analysis of a stonemasonry arch 显示文摘 | T6th A R Orbdn Z Bagi K | 2009 | Mechanics Research Communications2009，36，4： | 1 |
| 10 | Autoimmune thyroid disease in pregnancy and the postpartum period:relationship to spontaneous abortion显示文摘 | BAGIS T GOKCEL A SAYGILI E S | 2001 | Thyroid:Official Journal of the American Thyroid Association2001，11，11： | 1 |
| 11 | BCL-2 and P53 expression in endometrial carcinoma显示文摘 | Erkanli S Eren F Pekin S Bagis T | 2004 | Exp Clin Cancer Res2004，23，1： | 1 |
| 12 | The effect of equilibration time on survival and development rates of mouse pronuclear-stage embryos vit- rified in solid surface (SSV)and convential straws:in vitro and in viwJ evaluations 显示文摘 | Bagis H Mercan HO Cetin S | 2005 | Mol Reprod Dev2005，72，4： | 1 |
| 13 | Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2 显示文摘 | Ungvari Z Bagi Z Feher A | 2010 | Am J Physiol Heart Circ Physiol2010，299，： | 1 |
| 14 | Biotechnological intensification of biogas production显示文摘 | Zoltán Bagi Norbert ács Balázs Bálint Lenke Horváth Krisztina Dobó Katalin R. Perei Gábor Rákhely Kornél L. Kovács | 2007 | Applied Microbiology and Biotechnology2007，，2： | 1 |
| 15 | The effect of systemically adm in istered rhIGF-I/IGFBP-3 complex on contoical bone strength and structure in ovariectomized rat显示文摘 | Bagie Van DER Meule N Brommage B | 1995 | Bone1995，16，5： | 1 |
| 16 | Expansion of response surface models for the growth of escherichia coli O157:H7 to include sodium nitrite as a variable显示文摘 | Buchanan R L Bagi L K | 1994 | International jourual of food microbiology1994，27，9： | 1 |
| 17 | Study of axial bone mineral density in postmenopausal women with diffuse idiopathic skeletal hyperostosis related to type 2 diabetes mellitus显示文摘 | Sahin G Polat G Bagis S | 2002 | J Womens Health (Larchmt)2002，11，9： | 1 |
| 18 | Tear function tests and conjunctival impression cytology before and after hormone replacement therapy in postmenopausal women 显示文摘 | Pelit A Bagis T Kayaselcuk F | 2003 | Eur J Ophthalmol2003，13，： | 1 |
| 19 | Second-trimester pregnancy termi- nation with oral misoprostol in women who have had one cesarean sec- tion显示文摘 | Tarim E Kilicdag E Bagis T | 2005 | International Journal of Gynaecology & Obstetrics2005，90，1： | 1 |
| 20 | Stability of hydrolytic enzymes in water-organic solvent systems显示文摘 | Simon L.M László K Vértesi A Bagi K Szajáni B | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员