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| 1 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 2 | The Neuroprotective Agent Memantine Induces Brain-Derived Neurotrophic Factor and trkB Receptor Expression in Rat Brain显示文摘 | Markéta Marvanová Merja Lakso Jarmo Pirhonen Hiroyoki Nawa Garry Wong Eero Castrén | 2001 | Molecular and Cellular Neuroscience2001，，3： | 2 |
| 3 | Inhaled corticosteroids during and after respiratory syncytial virus-bronchiolitis may decrease subsequent asthma显示文摘 | Merja Kajosaari | 2000 | Pediatric Allergy Immunology2000，11，： | 2 |
| 4 | Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis显示文摘AIM:To investigate matrix metalloproteinases(MMPs) and their tissue inhibitors(TIMPs) in pouch mucosa of pediatric onset ulcerative colitis(UC).METHODS:In this cross-sectional study,28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years(median) after proctocolectomy.Expression of MMPs-3,-7,-8,-9,-12 and-26 and TIMPs-1,-2 and-3 in samples was examined using immunohistochemichal methods,and another biopsy was used to evaluate the grade of histological inflammation.Two investigators independently graded the immunohistochemical specimens in a semiquantitative fashion,using a scale marking staining intensity as follows:0 = less than 20 positive cells;1 = 20-50 positive cells;2 = 50-200 positive cells;3 = over 20 positive cells.Fecal calprotectin and blood inflammatory markers [serum C-reactive protein(CRP) and erythrocyte sedimentation rate] were determined during a follow-up visit to examine correlations between these markers and the expression of MMPs and TIMPs.RESULTS:Of the 28 patients with pediatric onset UC,nine had not experienced pouchitis,whereas thirteen reported a single episode,and six had recurrent pouchitis(≥ 4 episodes).At the time of the study,six patients required metronidazole.In all of the others,the most recent episode of pouchitis had occurred over one month earlier,and none were on antibiotics.Only four samples depicted no sign of inflammation,and these were all from patients who had not had pouchitis.Two samples were too small to determine the grade of inflammation,but both had suffered pouchitis,the other recurrent.No sample depicted signs of colonic metaplasia.Most pouch samples showed expression of epithelial(e) and stromal(s) MMP-3(e,n = 22;s,n = 20),MMP-7(e,n = 28;s,n = 27),MMP-12(e,n = 20;s,n =24),TIMP-2(e,n = 23;s,n = 23) and MMP-3(e,n = 23;s,n = 28) but MMP-8(e,n = 0;s,n = 1),MMP-9(e,n = 0;s,n = 9) and MMP-26(e,n = 0;s,n = 3) and TIMP-1(n = 0,both) were lacking.In samples with low grade of inflammatory activity,the epithelial MMP-3 and MMP-7 expression was increased(r =-0.614 and r =-0.472,respectively,P < 0.05 in both).MMPs and TIMPs did not correlate with the markers of inflammation,fecal calprotectin,erythrocyte sedimentation rate,or CRP,with the exception of patients with low fecal calprotectin(< 100 μg/g) in whom a higher expression of epithelial MMP-7 was found no differences in MMPor TIMP-profiles were seen in patients with a history of pouchitis compared to ones with no such episodes.Anastomosis with either straight ileoanal anastomosis or ileoanal anastomosis with J-pouch did depict differences in MMP-or TIMP-expression.CONCLUSION:The expression of MMPs pediatric UC pouch in the long-term shares characteristics with inflammatory bowel disease,but inflammation cannot be classified as a reactivation of the disease. | Laura Mkitalo Maija Piekkala Merja Ashorn Mikko Pakarinen Antti Koivusalo Riitta Karikoski Johanna Natunen Ulpu Saarialho-Kere Risto Rintala Kaija-Leena Kolho | 2012 | World Journal of Gastroenterology2012，18，30： | 2 |
| 5 | Effects of the viability of Lactobacillus rhamnosus GG on rotavirus infection in neonatal rats显示文摘AIM:To study the effects of live and dead Lactobacillus rhamnosus GG(GG) on rotavirus infection in a neonatal rat model.METHODS:At the age of 2 d,suckling Lewis rat pups were supplemented with either live or dead GG and the treatment was continued daily throughout the experi-ment.At the age of 5 and 6 d the pups received oral rotavirus(RV) SA-11 strain.The pups were sacrificed at the age of 7 or 8 d by decapitation.The gastrointestinal tract was removed and macroscopic observations were done.The consistency of feces in the colon was classified using a four-tier system.RV was detected from the plasma,small intestine,colon and feces by real-time quantitative polymerase chain reaction(PCR).RESULTS:In this neonatal rat model,RV induced a mild-to-moderate diarrhea in all except one pup of the RV-inoculated rats.RV moderately reduced body weight development from day 6 onwards.On day 7,after 2 d of RV infection,live and dead GG groups gained significantly more weight than the RV group without probiotics [36%(P = 0.001) and 28%(P = 0.031),respectively].In addition,when compared with the RV control group,both live and dead GG reduced the weight ratio of colon/animal body weight to the same level as in the healthy control group,with reductions of 22%(P = 0.002) and 28%(P < 0.001),respectively.Diarrhea increased moderately in both GG groups.However,the diarrhea incidence and severity in the GG groups were not statistically significantly different as compared with the RV control group.Moreover,observed diarrhea did not provoke weight loss or death.The RV control group had the largest amount of RV PCR-positive samples among the RV-infected groups,and the live GG group had the smallest amount.Rats receiving live GG had significantly less RV in the colon(P = 0.027) when compared with the RV control group.Live GG was also more effective over dead GG in reducing the quantity of RV from plasma(P = 0.047).CONCLUSION:Both live and dead GG have beneficial effects in RV infection.GG may increase RV clearance from the body and reduce colon swelling. | Hanna Ventola Liisa Lehtoranta Mari Madetoja Marja-Leena Simonen-Tikka Leena Maunula Merja Roivainen Riitta Korpela Reetta Holma | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 6 | Evolution of aluminosilicate structure and mullite crystallization from homogeneous nanoparticulate sol–gel precursor with organic additives显示文摘 | Jarkko Leivo Mika Lindén Jessica M. Rosenholm Merja Ritola Cilaine V. Teixeira Erkki Lev?nen Tapio A. M?ntyl? | 2008 | Journal of the European Ceramic Society2008，，9： | 1 |
| 7 | Leucocyte apheresis in the treatment of paediatric ulcerative colitis显示文摘 | Tarja Ruuska Marja-Leena L? hdeaho Yelda Sutas Merja Ashorn Juhani Gr? nlund | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
| 8 | In situ Longitudinal Tensile Tests of Pine Wood in an Environmental Scanning Electron Microscope显示文摘 | Merja Sippola Klaus Fruhmann | 2002 | Holzforschung2002，56，： | 1 |
| 9 | 'You Just Have to Make the Pain Go Away'---Children's experiences of pain man agement显示文摘 | Riitta- Liisa Kortesluoma Merja Nikkonen | 2008 | Pain Management Nursing2008，9，4： | 1 |
| 10 | A value efficiency approach to incorporating preference information in data envelopment analysis 显示文摘 | Merja Halme Tarja Joro etal | 1999 | Management Science1999，45，： | 1 |
| 11 | Cloning and characterization of cDNA clones encoding phenylalanine ammonia-lyase in barley显示文摘 | Timo K Sari P Merja U | 1997 | Plant Science1997，123，1： | 1 |
| 12 | Etiology of community-acquired pneumonia in 254 hospitalized children显示文摘 | TAINA JUVéN JUSSI MERTSOLA MATTI WARIS MAIJA LEINONEN OLLI MEURMAN MERJA ROIVAINEN JUSSI ESKOLA PEKKA SAIKKU OLLI RUUSKANEN | 2000 | The Pediatric Infectious Disease Journal2000，，： | 1 |
| 13 | Occurrence of nitri-fying bacteria and nitrification in finnish dringking water distribution systems显示文摘 | Marl T T Lipponen Merja H Suutari | 2002 | Water Research2002，36，： | 1 |
| 14 | A value efficiency approach to incorporating preference information in data envelopment analysis显示文摘 | Merja Halme Tarja Joro Pekka Korhonen Seppo Salo Jyrki Wallenius | 1999 | Management Science1999，45，： | 1 |
| 15 | Biodegradation of radiolabelled synthetic lignin (14C-DHP) and mechanical pulp in a compost environment显示文摘 | Marja Tuomela Annele Hatakka Sanni Raiskila Minna Vikman Merja It?vaara | 2001 | Applied Microbiology and Biotechnology2001，，4： | 1 |
| 16 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 17 | An overview of methods for biodegradability testing of biopolymers and packaging materials显示文摘 | Merja It?vaara Minna Vikman | 1996 | Journal of Environmental Polymer Degradation1996，，1： | 1 |
| 18 | A Simplified Risk Score for Predicting Postoperative Nausea and Vomiting: Conclusions from Cross-validations between Two Centers显示文摘 | Christian C. Apfel Esa L??r? Merja Koivuranta Clemens-A. Greim Norbert Roewer | 1999 | Anesthesiology1999，，3： | 1 |
| 19 | CSF Aβ42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment显示文摘 | Sanna-Kaisa Herukka Merja Hallikainen Hilkka Soininen Tuula Pirttil? | 2005 | Neurology2005，，7： | 1 |
| 20 | Co-circulation of coxsackieviruses A6 and A10 in hand, foot and mouth disease outbreak in Finland显示文摘 | Soile Blomqvist P?ivi Klemola Svetlana Kaijalainen Anja Paananen Marja-Leena Simonen Tytti Vuorinen Merja Roivainen | 2010 | Journal of Clinical Virology2010，，1： | 1 |
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