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| 1 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 2 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Botulinum Toxin as Second-Line Therapy for Chronic Anal Fissure Failing 0.2 Percent Glyceryl Trinitrate显示文摘 | Ian Lindsey F.R.A.C.S. Oliver M. Jones F.R.C.S. Chris Cunningham M.D. F.R.C.S. Bruce D. George M.S. F.R.C.S. Neil J. M. Mortensen M.D. F.R.C.S | 2003 | Diseases of the Colon & Rectum2003，，3： | 2 |
| 5 | 英国私营企业的可持续供应链管理显示文摘目前,私营企业越来越关注购买和供应产品和服务时的可持续性,也即称为'可持续供应链管理',利用采购活动来减少对环境、经济和社会的负面影响。但是言辞和现实之间经常会有差距,企业经常因标榜绿色耍嘴皮子而受到指责。该研究将探讨可持续供应链在7个处于各自行业领先地位的企业的实施情况,并探究影响可持续供应链的因素及将来会有哪些变化。 | Helen Walker Neil Jones 李玉荣 | 2015 | 世界农业2015，，1： | 2 |
| 6 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 7 | Pilot study of F 18 -Fluorodeoxyglucose Positron Emission Tomography/computerised tomography in Wilms’ tumour: Correlation with conventional imaging, pathology and immunohistochemistry显示文摘 | Joanna Begent Neil J. Sebire Gill Levitt Penelope Brock Kathy Pritchard Jones Peter Ell Isky Gordon John Anderson | 2010 | European Journal of Cancer2010，，3： | 1 |
| 8 | Shear strength properties of geomembrane/ geotextile interfaces显示文摘 | RUSSELL D JONES V NEIL Dixon | 1998 | Geotextiles and Geomembranes1998，16，： | 1 |
| 9 | Apples to apples: improving the performasce of motif finders and their significance analysis in the Twilight Zone显示文摘 | Patrick Ng Niranjan Nagarajan Neil Jones Uri Keich | 2006 | Bioinformatics2006，22，14： | 1 |
| 10 | Making space for unruly water:Sustainable drainage systems and the disciplining of surfacerunoV显示文摘 | Phil Jones Neil Macdonald | 2007 | Geoforum2007，38，2： | 1 |
| 11 | The extent and limitations of local commercial property market data显示文摘 | Neil Dunse Colin Jones Allison Orr Heather Tarbet | 1998 | Journal of Property Valuation and Investment1998，，5： | 1 |
| 12 | Wegener’s granulomatosis masquerading as pancreatic carcinoma显示文摘 | Kevin M. O’Neil Dan M. Jones J. Mark Lawson | 1992 | Digestive Diseases and Sciences1992，，5： | 1 |
| 13 | Harrisl,earning def- icits in congenitally hydrocephalic rats and prevention by early shunt treatment 显示文摘 | Hazel C Jones Katia M Rivera Neil G | 1995 | Child 's Nerv Syst1995，11，： | 1 |
| 14 | The use of antiendotoxin peptides in obstructive jaundice endotoxemia显示文摘 | Claire Jones Stephen A. Badger James M. Black Neil V. McFerran Margaret Hoper Tom Diamond Rowan W. Parks Mark A. Taylor | 2012 | European Journal of Gastroenterology & Hepatology2012，，3： | 1 |
| 15 | Near-infrared (NIR) perfusion angiography in minimally invasive colorectal surgery显示文摘 | Frederic Ris Roel Hompes Chris Cunningham Ian Lindsey Richard Guy Oliver Jones Bruce George Ronan A. Cahill Neil J. Mortensen | 2014 | Surgical Endoscopy2014，，7： | 1 |
| 16 | Monitoring environmental quality at the landscape scale: using landscape indicators to assess biotic diversity,watershed interrity, and landscape stability显示文摘 | O`Neil R V Hunster C T Jones K B | 1997 | Bioscience1997，47，8： | 1 |
| 17 | Experimental study on a model azimuthing podded propulsor in ice显示文摘 | Jungyong Wang Ayhan Akinturk Neil Bose Stephen J. Jones Yun Young Song Ho Hwan Chun Moon Chan Kim | 2008 | Journal of Marine Science and Technology2008，，3： | 1 |
| 18 | Effects of Ru- mination and Initial Severity on Remissionto Cognitive Therapy for Depression显示文摘 | Neil P Jones Greg J Siegle Michael E Thase | 2008 | Cogn Ther Res2008，，32： | 1 |
| 19 | Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus 显示文摘 | Nierman WC Pain A Anderson MJ Wortman JR Kim HS Arroyo J Berriman M Abe K Archer DB Bermejo C Bennett J Bowyer P Chen D Collins M Coulsen R Davies R Dyer PS Farman M Fedorova N Fedorova N Feldblyum TV Fischer R Fosker N Fraser A Garcla JL Garcia MJ Goble A Goldman GH Gomi K Griffith- Jones S Gwilliam R Haas B Haas H Harris D Horiuchi H Huang J Humphray S Jim6nez J Keller N Khouri H Kitamoto K Kobayashi T Konzack S Kulkarni R Kumagai T Lafon A Latgo JP Li W Lord A Lu C Majoros WH May GS Miller BL Mohamoud Y Molina M Monod M Mouyna I Mulligan S Murphy L O'Neil S Paulsen I Pefialva MA Pertea M Price C Pritchard BL Quail MA Rabbinowitsch E Rawlins N Rajandream MA Reichard U Renauld H Robson GD Rodriguez de Cordoba S Rodriguez-Pefia JM Ronning CM Putter S Salzberg SL Sanchez M Sfnchez-Ferrero JC Saunders D Seeger K Squares R Squares S Takeuchi M Tekaia F Turner G Vazquez de Aldana CR Weidman J White O Woodward J Yu JH Fraser C Galagan JE Asai K Machida M Hall N Barrell B Denning DW | 2005 | Nature2005，438，7071： | 1 |
| 20 | Fraser,The spatial pattern of industrial rents and the role of distance显示文摘 | Neil Dunse Colin Jones Jim Brown William D | 2005 | Journal of Property Investment & Finance2005，23，4： | 1 |
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