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| 1 | 新型低密度脂蛋白胆固醇评估对全球血脂异常指南中次级靶标非高密度脂蛋白胆固醇和载脂蛋白B应用的影响显示文摘血脂异常指南通常推荐非高密度脂蛋白胆固醇(non-high-density lipoprotein-cholesterol,non-HDL-C)和载脂蛋白B(apolipoprotein B,apoB)作为主要靶点低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)的次要靶点。 | Sathiyakumar V Park J Quispe R Elshazly MB Michos ED Banach M Toth PP Whelton SP Blumenthal RS Jones SR Martin SS 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，4： | 4 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | 2013年美国心脏病学会/美国心脏协会胆固醇管理指南在美国心脏病学实践中的应用显示文摘2013年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)胆固醇管理指南建议在符合治疗标准的患者中采用中等强度至高强度他汀类药物治疗。该研究的目的在于审查2013年ACC/AHA指南在美国心脏病学实践中的应用情况。 | 刘莉 叶鹏 Pokharel Y Tang F Jones PG Nambi V Bittner VA Hira RS Nasir K Chan PS Maddox TM Oetgen WJ Heidenreich PA Borden WB Spertus JA Petersen LA Ballantyne CM Virani SS | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 4 | The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vltro显示文摘 | Jones NA Boswell-Smith V Lever R | 2005 | Pulm Pharmacol Ther2005，1，2： | 1 |
| 5 | Effects of volatileanesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampalneurons显示文摘 | JONES M V HARRISON N L | 1993 | J Neurophysiol1993，70，4： | 1 |
| 6 | Aluminum inhibition of the inositol 1,4,5-triphosphate signal transduction pathway in wheat roots:A role in aluminum toxicity?显示文摘 | JONES D L KOCHIAN L V | 1995 | Plant Cell1995，7，： | 1 |
| 7 | Human PIV-2 recombinant Sendai virus (rSeV) elicits durable immunity and combines with two additional rSeVs to protect against hPIV-1, hPIV-2, hPIV-3, and RSV 显示文摘 | Jones B Zhan X Mishin V | 2009 | Vaccine2009，27，12： | 1 |
| 8 | Small high-technology firms and interna- tional high-technology markets显示文摘 | Crick D Jones M V | 2000 | Journal of international marketing2000，8，2： | 1 |
| 9 | Calcium-stimulated autophosphorylation site of plant chimeric calcium/calmodulin dependent protein kinase显示文摘 | SATHYANARAYANAN P V SIEMS W F JONES J P POOVAISH B W | 2001 | Journal of Biological Chemistry2001，276，32： | 1 |
| 10 | Monitoring environmental quality at the landscape scale:using landscape indicators to assess biotic diversity, watershed interrity, and landscape stability显示文摘 | O'Neill R V Hunsaker C T Jones K B | 1997 | BioScience1997，47，： | 1 |
| 11 | An integrated modeling environment based on attributed graph-grammars显示文摘 | | 1993 | Decision Support Systems1993，10，： | 1 |
| 12 | Biomimetic facially amphiphilic antibacterial oligomers with conformationally still backbones显示文摘 | TANG H Z DOERKSEN R J JONES T V | 2006 | Chemistry& Biology2006，13，： | 1 |
| 13 | Effect of process variables on the holding time in an ultrahigh temperature steam injection system 显示文摘 | Edgerton E R Jones V A | 1970 | Journal of Dairy Science1970，53，10： | 1 |
| 14 | Neurofuzzy motion planners for intelligent robot显示文摘 | Tsoukalas L H Houstis E N Jones G V | 1997 | Journal of Intelligent and Robotic Systems1997，19，： | 1 |
| 15 | DNA methylation decreases in aging but not in immortal cells显示文摘 | Wilson V L Jones P A | 1988 | Science1988，220，： | 1 |
| 16 | Experimental results for Titan aerobot thermo-mechanical subsystem development显示文摘 | Hall J L Jones J A Kerzhanovich V V | | 0，，10： | 1 |
| 17 | Venous thromboem- bolism after spinal cord injury: incidence, time course, and associated risk factors in 16, 240 adults and children 显示文摘 | Jones T Ugalde V Franks P | 2005 | Arch Phys Med Rehabil2005，86，12： | 1 |
| 18 | Global standards for the education and training of the social work profession显示文摘 | SEWPAUL V JONES D | 2005 | International Journal of Social Welfare2005，14，3： | 1 |
| 19 | Identification of the sources of fecal coliforms in an urban watershed using antibiotic resistance analysis 显示文摘 | Whitlock J E Jone D T Harwood V J | 2002 | Water Research2002，36，： | 1 |
| 20 | Pharmaceutical coerystallization: Engineering a remedy for caffeine hydra- tion 显示文摘 | Trask A V Motherwell W D S Jones W | 2005 | Cryst Growth Des2005，5，： | 1 |
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