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| 1 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 2 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 3 | A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT OF MEN WITH SYMPTOMS ASSOCIATED WITH BENIGN PROSTATIC ENLARGEMENT: THE CLasP STUDY显示文摘 | JENNY L. DONOVAN TIM J. PETERS DAVID E. NEAL SARA T. BROOKES SANDEEP GUJRAL K. NINAN CHACKO MARK WRIGHT L. GAIL KENNEDY PAUL ABRAMS | 2000 | The Journal of Urology2000，，1： | 3 |
| 4 | Primary cervical cancer screening with human papillomavirus: End of study results from the ATHENA study using HPV as the first-line screening test显示文摘 | Thomas C. Wright Mark H. Stoler Catherine M. Behrens Abha Sharma Guili Zhang Teresa L. Wright | 2015 | Gynecologic Oncology2015，，2： | 2 |
| 5 | Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘 | Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity 1 1 Edited by F.E.Cohen显示文摘 | Deborah S. Wuttke Mark P. Foster David A. Case Joel M. Gottesfeld Peter E. Wright | 1997 | Journal of Molecular Biology1997，，1： | 1 |
| 7 | Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor显示文摘 | Jubao Duan Mark S Wain Wright | 2003 | Human Molecular Genetics2003，12，3： | 1 |
| 8 | Severity of overactive bladder symptoms and response to dose escalation in a randomized, double‐blind trial of solifenacin ( SUNRISE )显示文摘 | Linda Cardozo Gerard Amarenco Dmitry Pushkar Jura Mikulas Ted Drogendijk Mark Wright Gerhard Compion | 2013 | BJU Int2013，，： | 1 |
| 9 | Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: A U.S.–Canadian multicenter study显示文摘 | Norbert Br?u Rena K. Fox Peiying Xiao Kristen Marks Zeenat Naqvi Lynn E. Taylor Anita Trikha Morris Sherman Mark S. Sulkowski Douglas T. Dieterich Michael O. Rigsby Teresa L. Wright Maria D. Hernandez Mamta K. Jain Gajendra K. Khatri Richard K. Sterling M | 2007 | Journal of Hepatology2007，，4： | 1 |
| 10 | Estimating profitability of two biochar production scenarios:slow pyrolysis vs fast pyrolysis显示文摘 | Tristan R Brown Mark M Wright Robert C Brown | | 0，，： | 1 |
| 11 | Two-sided Markets, Competitive Bottlenecks and Exclusive Contracts显示文摘 | Mark Armstrong Julian Wright | 2007 | Economic Theory2007，，2： | 1 |
| 12 | A Practical Criterion for the Rapid Detection of Single‐Loop and Double‐Loop Reentry Tachycardias显示文摘 | NICK W.F. LINTON STEPHEN B. WILTON DANIEL SCHERR ASHOK J. SHAH NICOLAS DERVAL FREDERIC SACHER MATTHEW WRIGHT MéLèZE HOCINI MARK D. O’NEILL MICHEL HA?SSAGUERRE PIERRE JA?S | 2013 | J Cardiovasc Electrophysiol2013，，5： | 1 |
| 13 | The worldwide leaf economics spectrum显示文摘 | Wright Ian J Reich Peter B Westoby Mark | 2004 | Nature2004，428，6985： | 1 |
| 14 | PLANT ECOLOGICAL STRATEGIES: Some Leading Dimensions of Variation Between Species显示文摘 | Mark Westoby Daniel S. Falster Angela T. Moles Peter A. Vesk Ian J. Wright | 2002 | Annual Review of Ecology and Systematics2002，，： | 1 |
| 15 | Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection显示文摘 | Susanne Knapp Branwen J. W. Hennig Angela J. Frodsham Lyna Zhang Simon Hellier Mark Wright Rob Goldin Adrian V. S. Hill Howard C. Thomas Mark R. Thursz | 2003 | Immunogenetics2003，，6： | 1 |
| 16 | Two-sided Markets, Compet- itive Bottlenecks and Exclusive Contracts 显示文摘 | Mark Armstrong Julian Wright | 2007 | Economic The- ory2007，32，2： | 1 |
| 17 | Time of day effects on the incidence of anesthetic adverse events显示文摘 | Wright MC Phillips-Bute B Mark JB | 2006 | Qual Saf Health Care2006，15，4： | 1 |
| 18 | The L6 membrane proteins-A newfour-transmembrane superfamily显示文摘 | Mark D WRIGHT Jian N | 2000 | Protein Sci2000，9，8： | 1 |
| 19 | Cold storage of Trichogramma ostriniae reared on Sitotroga cerealella eggs显示文摘 | Sylvie A. Pitcher Michael P. Hoffmann Jeffrey Gardner Mark G. Wright Thomas P. Kuhar | 2002 | BioControl2002，，5： | 1 |
| 20 | Land-plant ecology on the basis of functional traits显示文摘 | Mark Westoby Ian J. Wright | 2006 | Trends in Ecology & Evolution2006，，5： | 1 |
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