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3705篇 您的检索式:作者名="Sanchez M"
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1Neurotoxicity of the pesticide rotenone on neuronal polarization: a mechanistic approach显示文摘Neurons are the most extensive and polarized cells that display a unique single long axon and multiple dendrites, which are compartments exhibiting structural and functional differences. Polarity occurs early in neuronal development and it is maintained by complex subcellular mechanisms throughout cell life. A well-defined and controlled spatio-temporal program of cellular and molecular events strictly regulates the formation of the axon and dendrites from a non-polarized cell. This event is critical for an adequate neuronal wiring and therefore for the normal functioning of the nervous system. Neuronal polarity is very sensitive to the harmful effects of different factors present in the environment. In this regard, rotenone is a crystalline, colorless and odorless isoflavone used as insecticide, piscicide and broad spectrum pesticide commonly used earlier in agriculture. In the present review we will summarize the toxicity mechanism caused by this pesticide in different neuronal cell types, focusing on a particular biological mechanism whereby rotenone could impair neuronal polarization in cultured hippocampal neurons. Recent advances suggest that the inhibition of axonogenesis produced by rotenone could be related with its effect on microtubule dynamics, the actin cytoskeleton and their regulatory pathways, particularly affecting the small RhoGTPase RhoA. Unveiling the mechanism by which rotenone produces neurotoxicity will be instrumental to understand the cellular mechanisms involved in neurodegenerative diseases influenced by this environmental pollutant, which may lead to research focused on the design of new therapeutic strategies.Mariano Bisbal Mónica Sanchez 2019Neural Regeneration Research2019,14,5:4
2Hexagonal voids and the formation of micropipes during SiC sublimation growth 显示文摘KUHR T A SANCHEZ E K SKOWRONSKI M 2001J Appl Phys2001,89,:2
3Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid 2005Lancet Oncology2005,,12:2
4Effects of organic pollution on transplanted aquatic bryophytes 显示文摘MARTINE Abaigar J NUNEZ Olivera E SANCHEZ Diaz M 1993J Bryol1993,17,4:2
5A retrospective analysis of pharmacokinetic-pharmacodynamic parameters as indicators of the clinical efficacy of ceftizoxime 显示文摘Sanchez-Navarro A Colino C I Sanchez Recio M M 2001Clin Pharmacokinet2001,40,2:2
6Clinical characteristics of children with tracheobronchial anomalies 显示文摘Sanchez I Navarro H Mendez M 2003Pediatr Pulmonol2003,35,:1
7Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘Sanchez Lopez F J Gil Garcia M D Martinez Vidal J 2004Environmental Monitoring and Assessment2004,,93:1
8Antihypertensive activity of milk fermented by Enterococcus faecalis strains isolated from raw milk显示文摘MUGUERZA B RAMOS M SANCHEZ E 2006International Dairy Journal2006,16,:1
9Tourism image,evaluation variable and after purchase behaviour:interrelationship显示文摘Bigne J E Sancbez M I Sanchez J 2001Toursim Management2001,22,:1
10The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation显示文摘Sanz L Sanchez P Lallena M J 1999EMBO J1999,18,11:1
11Inactivation of the DNA repair gene 06 - methylguanine - DNA methyl - trans- ferase by promoter hypermethylation is associated with G to A muta- tions in K - ms in colorectal tumorigenesis 显示文摘Esteller M Toyota M Sanchez - CM Hamilton 2000Cancer Res2000,60,9:1
12Hot isostatic pressing of ultrafine tungsten carbide-cobalt hardmetal 显示文摘AZCONA I ORDONEZ A SANCHEZ J M 2002Journal of Materials Science2002,37,:1
13Nitrogen and phosphorus removal from urban wastewater by the mieroalga Scenedesmus obliquus显示文摘MARTNEZ M E SANCHEZ S JIMENEZ J M 2000Bioresource Technology2000,73,3:1
14Aluminium foams as structured supports fur volatile organic compounds( VOCs )oxidation显示文摘Sanz O Echave F J Sanchez M 2008Applied Catalysis: Genera2008,340,1:1
15Enhanced production of lovastatin in a bubble column by Aspergillus terreus using a two-stage feeding strategy 显示文摘Rodriguez Porcel E M Casas Lepez J L Sanchez Perez J A 2007Journal of Chemical Technology and Biotechnology2007,82,:1
16Interception of the electron transport chain in bacteria with hydrophilic redox mediators显示文摘Lithgow A M Romero L Sanchez I C 1986J Chem Res Synop1986,,5:1
17Maturity and stability parameters of composts prepared with a wide range of organic wastes显示文摘Bernal M P Paredes C Sanchez - Monedero M A 1998Bioresource Technology1998,63,:1
18Unsaturated polyester resins: influence of the styrene concentrationon the miscibility and mechanical properties 显示文摘SANCHEZ E M S ZAVAGLIA C A C FELISBERTI M I 2000Polymer2000,41,:1
19A correlation between the pretransplantation MELD score and mortality in the first two years after liver transplantation显示文摘Onaca N N Levy M F Sanchez E Q 2003Liver Transpl2003,9,:1
20Cross-linked nanocomposite polymer electrolytes reinforced with cellulose whiskers显示文摘Samir M Alloin F Sanchez J Y 2004Macro molecules2004,37,13:1
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