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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Atomic decomposition by basis pursuit显示文摘 | CHEN S B DONOHO D L SAUNDERS M A | | 0，，01： | 2 |
| 3 | A high performance satellite data modem using real-time digital signal processing techniques显示文摘 | Allan R D Bramwell J R Saunders D A | 1988 | J IERE1988，58，3： | 2 |
| 4 | In vitro sensitivity to imatinib-induced inhibition of ABL kinase activity is predictive of molecular response in patients with de novo CML显示文摘 | White D Saunders V Lyons AB | 2005 | Blood2005，106，7： | 1 |
| 5 | Prevention of cisplatin-induced nephrotoxicosis in dogs, using hypertonic saline solution as the vehicle of administration显示文摘 | FORRESTER S D FALLIN E A SAUNDERS G K | 1993 | Am J Vet Res1993，54，12： | 1 |
| 6 | Supernumerary Spacing of Rainbows Produced by an Elliptical-cross-section Cylinder II:Experiment显示文摘 | Adler C L Phipps D Saunders K W | 2001 | Appl Opt2001，40，15： | 1 |
| 7 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 8 | Atomic decomposi- tion by basis pursuit 显示文摘 | Chen S S Donoho D L Saunders M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 9 | Modeling the ice filling process of rectangular thermal energy storage tanks with multiple ice makers显示文摘 | Gute G D S W Chandrasekharan J Saunders CK | 1995 | ASHRAE Transactions: Research1995，101，1： | 1 |
| 10 | Atomic Decomposition by Basis Pursuit 显示文摘 | Chen S Donoho D Saunders M | 1999 | SIAM Jounal on Scientific Computing1999，20，： | 1 |
| 11 | A Mantle Plume Origin for the Siberian Traps:Uplift and Extension in the East Siberian Ba- sin, Russia显示文摘 | SAUNDERS A D ENGLAND R W REICHOW M K | 2005 | Lithos2005，79，3： | 1 |
| 12 | Atomic decom-position by basis pursuit 显示文摘 | Chen S S Donoho D L and Saunders M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 13 | Atomic decomposition by basis pursuit 显示文摘 | CHEN S DONOHO D L SAUNDERS M A | 1999 | SIAM Journal on Scientific Computing1999，20，1： | 1 |
| 14 | A structural basis for differential cell signalling by PAl-1 and PAI-2 in breast cancer cells 显示文摘 | CROUCHER D R SAUNDERS D N STILLFRIED G E | 2007 | Biochem J2007，408，2： | 1 |
| 15 | Large elastic deformations of isotropic materials, part 7,Experiments on the Deformations of rubber显示文摘 | D W Saunders | 1951 | Philosophical Transactions of Royal Society1951，243，： | 1 |
| 16 | Atomic decomposition by basis pursuit显示文摘 | Chen S Donoho D Saunders M | 2001 | SIAM Review2001，43，1： | 1 |
| 17 | Atomic decomposition by basis pursuit显示文摘 | Chen Hao-bing Donoho D L and Saunders M A | 2001 | SIAM Journal on Scientific Compting2001，20，1： | 1 |
| 18 | The geochemistry of basalts from back-arc spreeding centre in the East Scotia Sea显示文摘 | Saunders A D Tarney J | 1979 | Geochim Cosmochim Acta1979，43，： | 1 |
| 19 | Modulation of neurotoxic behavior in F-344 rats by temporal disposition of benzo(a)pyrene显示文摘 | SAUNDERS C R RAMESH A SHOCKLEY D C | 2002 | Toxicol Lett2002，129，12： | 1 |
| 20 | An assessment of microbial coronal leakage in teeth root filled with gutta-percha and three different sealers显示文摘 | Chailertvanitkul P Saunders WP Mackenzie D | 1996 | Int Endod J1996，29，6： | 1 |
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