|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oral frailty and neurodegeneration in Alzheimer’s disease显示文摘Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s disease.Among different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical functions.We briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease neurodegeneration.Several underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral disease.Oral microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease risk.On this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s disease.Therefore,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty. | Vittorio Dibello Madia Lozupone Daniele Manfredini Antonio Dibello Roberta Zupo Rodolfo Sardone Antonio Daniele Frank Lobbezoo Francesco Panza | 2021 | Neural Regeneration Research2021，16，11： | 10 |
| 2 | Crustal velocity structures beneath North China revealed by ambient noise tomography显示文摘We collected continuous noise waveform data from January 2007 to February 2008 recorded by 190 broadband and 10 very broadband stations of the North China Seismic Array.The study region is divided into grid with interval 0.25°×0.25°,and group velocity distribution maps between 4 s and 30 s are obtained using ambient noise tomography method.The lateral resolution is estimated to be 20-50 km for most of the study area.We construct a 3-D S wave velocity model by inverting the pure path dispersion curve at each grid using a genetic algorithm with smoothing constraint.The crustal structure observed in the model includes sedimentary basins such as North China basin,Yanqing-Huailai basin and Datong basin.A well-defined low velocity zone is observed in the Beijing-Tianjin-Tangshan region in 22-30 km depth range,which may be related to the upwelling of hot mantle material.The high velocity zone near Datong,Shuozhou and Qingshuihe within the depth range of 1-23 km reveals stable characteristics of Ordos block.The Taihangshan front fault extends to 12 km depth at least. | Lihua Fang Jianping Wu Zhifeng Ding Weilai Wang Giuliano Francesco Panza | 2010 | Earthquake Science2010，23，5： | 7 |
| 3 | Hydroxytryptamine transporter gene-linked polymorphic region(5HTTLPR)is associated with delusions in Alzheimer’s disease显示文摘Background:Serotoninergic pathways underlying delusion symptoms in Alzheimer’s disease(AD)have not been fully clarified.5-Hydroxytryptamine transporter gene-linked polymorphic region(5-HTTLPR)is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription.Methods:We investigated the association of 5-HTTLPR with delusions in a total of 257 consecutive patients clinically diagnosed as AD according to the National Institute on Aging-Alzheimer’s Association criteria.All participants underwent a comprehensive evaluation with a standardized comprehensive geriatric assessment and Neuropsychiatric Inventory.Results:Delusion symptoms were observed in 171 patients(66.54%).In respect to AD patients without delusions,AD patients with delusions showed a low prevalence of S-plus carriers(5-HTTLPR-L/S+5-HTTLPR-S/S genotypes)[p<0.001;odds ratio(OR)=0.240,95% confidence interval(CI)=0.121–0.471].Logistic regression analysis adjusted for the apolipoprotein E polymorphism showed that in AD patients with delusions the presence of an 5-HTTLPR-S allele may reduce disease duration(p=0.005;OR=0.680,95% CI=0.522–0.886)and increase aberrant motor activity(p=0.013;OR=2.257,95% CI=1.195–4.260).The present findings suggested that 5-HTTLPR might be associated with delusions in AD.S-plus carriers might be associated with protective effect against delusions in AD.Conclusions:More studies on wider samples of high selected demented patients are needed to confirm our results.However,the present findings suggested that a genetic factor related to serotonin metabolism might exert a protective role on the clinical expression of neuropsychiatric clusters in AD with important implications regarding mechanisms underlying delusions and their possible treatment across the AD and dementia spectrum. | Grazia D’Onofrio Francesco Panza Daniele Sancarlo Michele Lauriola Mariangela P.Dagostino Giulia Paroni Madia Lozupone Antonio Mangiacotti Paola Bisceglia Carolina Gravina Maria Urbano Filomena Addante Francesco Paris Leandro Cascavilla Antonio Greco Davide Seripa | 2019 | Translational Neurodegeneration2019，8，1： | 2 |
| 4 | 华北地区地震地面危害分布的定量估算显示文摘根据1500年以来的地震活动,用确定性方法对华北地区地震地面危害分布图进行了定量计算。震源和研究区域均用网格单元表示,网格点的间距取为0.2°。计算中主要的输入参量为该地区的地震目录、震源机制、地震活动水平、深部结构模型等。各个单元上模拟的理论地震图考虑到了来自不同地点的震源和传播路径的影响。计算获得了华北地区最大地面运动和设计地面加速度(DGA)的分布图。最大DGA值位于北京以东,达0.75g。该结果可对未来华北地区地震危害的分布特征研究和该地区的防震减灾工作提供依据。 | 丁志峰 F Vaccari 陈运泰 G F Panza | 2006 | 地震地质2006，28，4： | 2 |
| 5 | Interplay between SOX9, β-catenin and PPARγ activation in colorectal cancer显示文摘 | Anna Panza Valerio Pazienza Maria Ripoli Giorgia Benegiamo Annamaria Gentile Maria Rosaria Valvano Bartolomeo Augello Giuseppe Merla Clelia Prattichizzo Francesca Tavano Elena Ranieri Pierluigi di Sebastiano Manlio Vinciguerra Angelo Andriulli Gianluigi M | 2013 | BBA - Molecular Cell Research2013，，8： | 2 |
| 6 | Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer显示文摘 | Frasci G Lorusso V Panza N | 2000 | J Clin On- col2000，18，13： | 1 |
| 7 | Position of nonmuscle myosin heavy chain H A ( NMMHC- lI A) mutations predicts the natural his- tory of MYH9-related disease 显示文摘 | Pecci A Panza E Pujol-Moix N | 2008 | Hum Mutat2008，29，3： | 1 |
| 8 | Extent of coro- nary and myocardial disease and benefit from surgical re- vascularization in ischemic LV dysfunction显示文摘 | Panza J A Velazquez E J She L | 2014 | J Am Coil Cardiol2014，64，6： | 1 |
| 9 | Randomized trial comparing cisplatin,gemcitabine,and vinorelbine with either cisplatin and gemcitabine or cisplatin and vinorelbine in advanced nonsmall-cell lung cancer:interim analysis of a phase Ⅲ trial of the southern italy cooperative oncology group显示文摘 | Comella P Frasci G Panza N | 2000 | J Clin Oncol2000，18，7： | 1 |
| 10 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 11 | Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension显示文摘 | Ouyyumi AA | 1990 | N Engl J Med1990，323，1： | 1 |
| 12 | Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer显示文摘 | Frasci G Lorusso V Panza N | 2000 | J Clin Oncol2000，18，13： | 1 |
| 13 | Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression 显示文摘 | Giordano C Catalano S Panza S | 2011 | Oncogene2011，30，39： | 1 |
| 14 | Higher total cholesterol, cognitive decline, and dementia 显示文摘 | Panza F Solfrizzi V D' Introno A | 2009 | Neuro- biol Aging2009，30，4： | 1 |
| 15 | Family accommoda-tion in obsessive-compulsive disorder显示文摘 | Lebowitz ER Panza KE Su J | 2012 | Expert RevNeurother2012，12，2： | 1 |
| 16 | Position of nonmuscle myosin heavy chain IIA (NMMHC-ⅡA) mutations predicts the natural history of MYH9-related disease 显示文摘 | Peeci A Panza E Pujol-Moix N | 2008 | Hum Mutat2008，29，： | 1 |
| 17 | Randomized trial comparing cisplatin, gemcitabine and vinorelbine with either cisplatin and gemcitabine or cisplatin and vinorelbine in advanced non- small cell lung cancer: interin analysis of a phase Ⅱ trial of the Southern Italy Cooperative Oncology Group显示文摘 | Cornelia P Frasci G Panza N | 2000 | J Clin Oncol2000，18，7： | 1 |
| 18 | Real-time three-dimensionnal echocardiography: an overview 显示文摘 | Panza JA | 2001 | Int J Card Imaging2001，17，3： | 1 |
| 19 | The role of diet in cognitive decline显示文摘 | SOLFRIZZI V PANZA F CAPURSO A | 2003 | J Neural Transm2003，110，1： | 1 |
| 20 | Safety and efficacy of incobo- tulinum toxin type A (NT 201-Xeomin) fir the treatment of post- stroke lower limb spasticity: a prospective open-label study 显示文摘 | Santamato A Micello MF Panza F | 2013 | Eur J Phys Rehabil Med2013，49，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员