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| 1 | Scintigraphy in laryngopharyngeal and gastroesophageal reflux disease:A definitive diagnostic test?显示文摘AIM: To investigate the utility of scintigraphic studies in predicting response to laparoscopic fundoplication(LF) for chronic laryngopharyngeal reflux symptoms.METHODS: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional p H and manometric studies. Patients mainly complained of cough, sore throat, dysphonia and globus. These patients were imaged after ingestion of 99m-technetium diethylene triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and lower oesophagus and background. Late studies of the lungs were obtained for aspiration. Patients underwent LF with post-operative review at 3 mo after surgery.RESULTS: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal in all patients. On scintigraphy, 27/34 patients demonstrated pharyngeal contamination and a rising or flat pharyngeal curve. Lung aspiration was evident in 50% of patients. There was evidence of pulmonary aspiration in 17 of 34 patients in the delayed study(50%). Pharyngeal contamination was found in 27 patients. All patients with aspiration showed pharyngeal contamination. In the 17 patients with aspiration, graphical time activity curve showed rising activity in the pharynx in 9 patients and a flat curve in 8 patients. In those 17 patients without pulmonary aspiration, 29%(5 patients) had either a rising or flat pharyngeal graph. A rising or flat curve predicted aspiration with a positive predictive value of 77% and a negative predictive valueof 100%. Over 90% of patients reported a satisfactory symptomatic response to LF with an acceptable sideeffect profile. CONCLUSION: Scintigraphic reflux studies offer a good screening tool for pharyngeal contamination and aspiration in patients with gastroesophageal reflux disease. | Gregory L Falk John Beattie Alvin Ing SE Falk Michael Magee Leticia Burton Hans Van der Wall | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 2 | Anacne grading metbod using pholographic standards显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Derma- tol1979，115，5： | 1 |
| 3 | An acne grading method using photographic standards 显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Dermatol1979，115，5： | 1 |
| 4 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells显示文摘 | Philipp Saiko Geraldine Graser Benedikt Giessrigl Marie-Thérèse Steinmann Heike Schuster Andreas Lackner Michael Grusch Georg Krupitza Walter Jaeger Venkateswarlu Somepalli Trimurtulu Golakoti Monika Fritzer-Szekeres Thomas Szekeres | 2013 | Investigational New Drugs2013，，5： | 1 |
| 5 | An overview of the extra- lipid effects of rosuvastatin 显示文摘 | Michael SK Haralampos JM Moses SE | 2008 | J Cardiovasc Pharmacol Therapeu- tics2008，13，： | 1 |
| 6 | Impairments in glucose tolerance can have a negative impact on cognitive function:a systematic research review显示文摘 | Daniel JL Clare LL Michael WM Amdd SE | | 0，，03： | 1 |
| 7 | Coronary Microembolization: From Bedside to Bench and Back to Bedside显示文摘 | Gerd Heusch Petra Kleinbongard Dirk B?se Bodo Levkau Michael Haude Rainer Schulz Raimund Erbel | 2009 | Circulation2009，，18： | 1 |
| 8 | Aromatase expression in health and disease 显示文摘 | Simpson ER Zhao Y Agarwal VR Michael MD Bulun SE | 1997 | Rec Prog Horm Res1997，52，： | 1 |
| 9 | Pressure distribution at the seating interface of custom molded Wheelchair Seats:Effect of Various Materials显示文摘 | Apatsidis DP Solomonidis SE Michaele SM | | 0，，08： | 1 |
| 10 | Two cases of non- Hodgkins lymphoma presenting as primary gynecologic malignancies显示文摘 | Jame SE Kendrik J Michael SJ | 2005 | Gynecologic Oncology2005，98，3： | 1 |
| 11 | A genetic linkage map for zebrafish: comparative analysis and localization of genes and expressed sequences 显示文摘 | Michael AG Lisa K Elizabeth SE | 1999 | Gen Res1999，9，4： | 1 |
| 12 | cDNA microarray gene expression profiling of hydroxyurea, paclitaxel, and panisidine, genotoxic compounds with differing tumorigenicity results 显示文摘 | Michael Lee Jung Kwon Se Nyun Kim | 2003 | Environmental and Molecular Mutagenesisi2003，42，2： | 1 |
| 13 | Does higher diastolic augmentation predict clinical benefit from enhanced external counterpulsation? Data from the International EECP Patient Registry (IEPR)显示文摘 | Michaels AD Kennard ED Kelsey SE | 2001 | Clin Cardiol2001，24，： | 1 |
| 14 | An acne grading method usingphotographic standards显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Dermatol1979，115，5： | 1 |
| 15 | Identification of genes regulated during mechanical load-induced cardiac hypertrophy显示文摘 | Johnatty SE Dyck JR Michael LH | 2000 | J Mol Cell Cardiol2000，32，5： | 1 |
| 16 | The Dynamic Nature of Coronary Artery Lesion Morphology Assessed by Serial Virtual Histology Intravascular Ultrasound Tissue Characterization显示文摘 | Takashi Kubo Akiko Maehara Gary S. Mintz Hiroshi Doi Kenichi Tsujita So-Yeon Choi Osamu Katoh Kenya Nasu Andreas Koenig Michael Pieper Jason H. Rogers William Wijns Dirk B?se M. Pauliina Margolis Jeffrey W. Moses Gregg W. Stone Martin B. Leon | 2010 | Journal of the American College of Cardiology2010，，15： | 1 |
| 17 | The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis显示文摘 | Yotis AS Michael G Tomlinson SE | | 0，，： | 1 |
| 18 | An acne grading method using photographic standards显示文摘 | Cook CH Centner RL Michaels SE | 1979 | Arch Dermatol1979，115，5： | 1 |
| 19 | Concentrations of polybrominated diphenyl ethers, polychlofinated dibenzo-p-dioxins and dibenzofurans, and polychlofinated biphenyls in human blood samples from Korea 显示文摘 | Byung HK Michael GI Se JL | 2005 | Science of the Total Environment2005，336，： | 1 |
| 20 | Two cases of Non-Hodgkin's lymphotna presenting as primary gynecologic malignancies显示文摘 | Jame SE Kendrik J Michael S J | 2005 | Gynecologic Ontology2005，98，3： | 1 |
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