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| 1 | 云南省勐海县居民粪类圆线虫感染调查显示文摘采用Koga法、Bearmann法、改良加藤氏法对勐海县居民进行粪检,250人中检出粪类圆线虫感染29人,感染率11.60%。采用改良加藤厚涂片法检查254人,虫卵阳性248人,阳性率97.63%。蛔虫、钩虫、鞭虫感染率分别89.76%、70.08%和82.68%。 | 姜进勇 杜尊伟 王学忠 汪丽波 李兰花 Peter Steinmann 康钧 苏梅惠 陈然 刀宏强 | 2008 | 中国病原生物学杂志2008，3，3： | 9 |
| 2 | HIV and intestinal parasite co-infections among a Chinese population: an immunological profile显示文摘Background:Parasite infections often result in a switch of the human body’s predominant immune reaction from T-helper 1(Th1)-type to Th2-type.Hence,parasite infections are widely expected to accelerate the progression of human immunodeficiency virus(HIV)infections to acquired immunodeficiency syndrome(AIDS).In the People’s Republic of China,both parasitic diseases and AIDS are epidemic in certain rural areas,and co-infections are relatively common.However,no population-based studies have yet investigated the frequency of HIV and parasite co-infections,and its effects on immune responses.We studied(1)the immune status of an HIV-infected population,and(2)the effect of co-infection of HIV and intestinal parasites on selected parameters of the human immune system.Methods:A total of 309 HIV-infected individuals were recruited and compared to an age-matched and sex-matched control group of 315 local HIV-negative individuals.Questionnaires were administered to all participants to obtain information on sociodemographic characteristics,sanitation habits,family income,and recent clinical manifestations.Two consecutive stool samples and 10 ml samples of venous blood were also collected from each individual for the diagnosis of parasite infections and quantitative measurements of selected cytokines and CD4+T-lymphocytes,respectively.Results:During the study period,79 HIV-infected individuals were not under highly active antiretroviral therapy(HAART)and were thus included in our analysis;the prevalence of intestinal helminth infections was 6.3%and that of protozoa was 22.8%.The most common protozoan infections were Blastocystis hominis(B.hominis)(13.9%)and Cryptosporidium spp.(10.1%).The prevalence of Cryptosporidium spp.in HIV-infected individuals was significantly higher than that in HIV negative individuals(P<0.05).Compared to the non-co-infected population,no significant difference was found for any of the measured immunological indicators(P>0.05).However,the following trends were observed:IFN-γlevels were lower,but the IL-4 level was higher,in the population co-infected with HIV and helminths.In the population co-infected with HIV and B.hominis,the IL-2 level was higher.The population co-infected with HIV and Cryptosporidium spp.had markedly lower CD4+T-lymphocyte counts.Conclusion:According to the immunologic profile, co-infection with helminths is disadvantageous to HIV-infected individuals. It was associated with a shift in the Th1/Th2 balance in the same direction as that caused by the virus itself, which might indicate an acceleration of the progress from an HIV infection to AIDS. Co-infection with Cryptosporidium spp. was not associated with a significant change in immune factors but co-infection with Cryptosporidium spp. was associated with a reduced level of CD4 + T-lymphocytes, confirming the opportunistic nature of such infections. Co-infection with B. hominis, on the other hand, was associated with an antagonistic shift in the immunological profile compared to an HIV infection. | Li-Guang Tian Tian-Ping Wang Shan Lv Feng-Feng Wang Jian Guo Xiao-Mei Yin Yu-Chun Cai Mary Kathryn Dickey Peter Steinmann Jia-Xu Chen | 2013 | Infectious Diseases of Poverty2013，2，1： | 8 |
| 3 | 病原学和血清学检验方法在大山区血吸虫病流行区的应用显示文摘目的了解血吸虫病病原学及血清学检测方法在大山区流行区应用的效果,为制定防治对策提供科学依据。方法采用随机抽样法在大山区血吸虫病未控制县抽取流行程度轻、中、重的1个自然村,每村抽取35户作为调查对象。采用孵化法及Kato-Katz法进行病原学检查,同时采用检测抗体的ELISA和DDIA法对受试者进行血清学检查。结果总感染率为8.26%(29/351),孵化法三送三检与Kato-Katz法三送十二检2种病原学检查方法差异无统计学意义(χ2=1.831,P>0.05),孵化法一送一检与Kato-Katz法一送四检差异也无统计学意义(χ2=0.313,P>0.05)。不同流行程度村的查病结果Kato-Katz法差异无统计学意义(χ2=2.188,P>0.05),孵化法差异有统计学意义(χ2=7.203,P<0.05),DDIA和ELISA法在不同流行程度村的查病结果间差异均有统计学意义(χ2=22.36、36.282,P均<0.01)。ELISA、DDIA2种血清学筛检方法的敏感性、特异性和约登指数分别为65.52%、59.35%、0.25和44.83%、69.79%、0.15。ELISA法优于DDIA法(χ2=19.253,P<0.01)。ELISA结果与粪检有关联,但一致性较差(χ2=5.772,P<0.05,Kappa=0.076762),DDIA结果与粪检无关联(χ2=2.019,P>0.05)。结论防治实际工作中采用收集一次粪便孵化或制作三张Kato-Katz片,分别有62.07%、72.41%的感染者漏检,必将严重低估病情现状。检测血吸虫抗体的ELISA和DDIA2种血清学筛查方法将漏检34.48%、55.17%感染者,成为血吸虫病病情反弹的原因之一。 | 陈绍荣 陈凤 周晓农 李宏军 Peter Jacob Steinmann 杨忠 李远林 | 2007 | 寄生虫病与感染性疾病2007，5，1： | 7 |
| 4 | 不同检测方法对粪类圆线虫钩虫检出率的比较显示文摘目的用不同方法检查粪便中的粪类圆线虫和钩虫,掌握检测粪类圆线虫的方法。方法在云南省勐海县选择土源性线虫感染率相对高的自然村1个,以户为单位随机抽样,采用改良加藤法(Kato-Katz法)、Koga法和Baerm ann法3种粪便检查方法对粪样进行检查,每人送检粪样3次。结果粪类圆线虫阳性率Kato-Katz法为0,Koga法为11.72%,Baerm ann法为12.55%。钩虫阳性率Kato-Katz法为64.44%,Koga法为57.74%,Baerm ann法为4.60%。结论Baer-m ann法仅适用于粪类圆线虫检测,Koga法可用作钩虫和粪类圆线虫检测,而Kato-Katz法仅适用于钩虫检测。 | 杜尊伟 姜进勇 Peter Steinmann 王剑 周卉 吕山 王学忠 刀天有 刀宏祥 朱建平 张老三 陈绍秋 倪坎 陈然 苏梅惠 李鸿兵 车英 周晓农 | 2009 | 中国血吸虫病防治杂志2009，21，1： | 5 |
| 5 | 云南省洱源县人体重要寄生虫病调查显示文摘目的了解云南省洱源县人体重要寄生虫感染的现状和特点,为制定防治对策提供科学依据。方法采用随机抽样法在全县抽取35个自然村为调查点,每个调查点随机抽取35户居民作为调查对象。对土源性线虫、绦虫和血吸虫感染等采用病原学检查,旋毛虫病、猪囊尾蚴病和血吸虫病采用血清学检查。结果寄生虫总感染率为23.34%(772/3308),其中坝区与山区人群感染率分别为19.55%(333/1703)和27.35%(439/1605),两者差异有统计学意义(P<0.01)。共查出7种寄生虫,感染率分别为蛔虫15.75%、钩虫0.33%、鞭虫1.87%、绦虫(包括链状带绦虫和微小膜壳绦虫)3.72%、蛲虫0.18%、血吸虫1.51%。混合感染人数占总感染人数的8.94%(69/772)。旋毛虫病、猪囊尾蚴病和血吸虫病的血清阳性率分别为57.30%(2103/3670)、18.20%(668/3670)、21.16%(958/3662)。本次调查结果寄生虫总感染率低于2004年全省调查的28.86%,而高于全国的19.56%。结论洱源县山区人群的人体重要寄生虫感染率明显高于坝区。感染虫种以蛔虫为主,其次为绦虫。绦虫病、猪囊尾蚴病、旋毛虫病和血吸虫病为今后该县寄生虫病防治工作的重点。 | 陈绍荣 杨忠 李远林 Peter Jacob Steinmann 李宏军 陈凤 李兰花 马俊华 贾铁武 王尚位 许静 方文 杨慧 段玉春 刘榆华 周晓农 | 2007 | 中国血吸虫病防治杂志2007，19，1： | 4 |
| 6 | Biomechanical Comparison of Unipedicular Versus Bipedicular Kyphoplasty显示文摘 | John Steinmann Craig T. Tingey Gina Cruz Qian Dai | 2005 | Spine2005，，2： | 4 |
| 7 | Comprehensive lifestyle intervention vs soy protein-based meal regimen in non-alcoholic steatohepatitis显示文摘BACKGROUND Non-alcoholic steatohepatitis(NASH) has become one of the leading causes of liver disease in the western world. In obese patients weight reduction is recommended. Up to now there are no specific guidelines for weight loss in order to reduce hepatic fat content.AIM To investigate the effects of a 24-wk guided lifestyle intervention program compared to a meal replacement regimen based on soy protein.METHODS Twenty-six subjects with NASH participated in a randomized single-center study. They were randomly assigned to either meal replacement group(MR-G)with soy-yogurt-honey preparation or to guided lifestyle change group(LC-G)with endurance activity and nutrition counselling. Serum alanine transaminase(ALT), aspartate transaminase(AST), lipid parameters, and adipokines were measured. Liver fat content and lipid composition were determined by magnetic resonance imaging and magnetic resonance spectroscopy. Body fat mass and lean body mass were assessed using Bod Pod? device. Pre-and post-intervention monitoring of parameters was performed. Statistical analyses were conducted with SPSS software, results were expressed as median(interquartile range).RESULTS Twenty-two subjects(MR-G, n = 11 and LC-G, n = 11) completed the study(9 women, 13 men; age 52.1(15.0) years, body mass index(BMI) 32.3(3.3) kg/m^2).In both groups a significant weight loss was achieved(MR-G:-6.4(3.6) kg, P <0.01; LC-G:-9.1(10.4) kg, P < 0.01). BMI dropped in both groups(MR-G:-2.3(1.5)kg/m^2, P = 0.003; LC-G:-3.0(3.4) kg/m^2, P = 0.006). Internal fat and hepatic lipid content were markedly reduced in both groups in comparable amount. There was a strong correlation between reduction in liver fat and decrease in ALT.Likewise, both groups showed an improvement in glycemic control and lipid profile. Changes in adipokines, particularly in adiponectin and leptin were closely related to intrahepatic lipid changes.CONCLUSION Comprehensive lifestyle intervention and meal replacement regimen have comparable effects on body and liver fat, as well as decrease in markers of hepatic inflammation among NASH patients. | Peter Deibert Adhara Lazaro Denise Schaffner Aloys Berg Daniel Koenig Wolfgang Kreisel Manfred W Baumstark Daniel Steinmann Martin Buechert Thomas Lange | 2019 | World Journal of Gastroenterology2019，25，9： | 3 |
| 8 | Buffer storage for direct steam generation显示文摘 | Wolf-Dieter Steinmann Markus Eck | 2005 | Solar Energy2005，，10： | 2 |
| 9 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 2 |
| 10 | Buffer storage for direct steam generation显示文摘 | Wolf-Dieter Steinmann Markus Eck | 2005 | Solar Energy2005，，10： | 2 |
| 11 | Chinese herbal medicines for treatment of hand, foot and mouth disease: A systematic review of randomized clinical trials显示文摘 | Huijuan Cao Zhaolan Liu Peter Steinmann Yujie Mu Hui Luo Jianping Liu | 2011 | European Journal of Integrative Medicine2011，，1： | 2 |
| 12 | The genetic variation of Angiostrongylus cantonensis in the People’s Republic of China显示文摘Background:The People’s Republic of China(P.R.China)is the presumptive home range of the rat lungworm Angiostrongylus cantonensis,a major aetiological agent of human eosinophilic meningitis.We present a study of the genetic variation of A.cantonensis in P.R.China.Our aim was to deepen the current knowledge pertaining to its origin and global spread from a molecular perspective.Methods:Adult A.cantonensis were collected in the frame of a national survey and identified based on morphological criteria.Polymerase chain reaction(PCR)was employed to amplify the target DNA sequences(cytochrome c oxidase subunit I(cox1),nicotinamide adenine dinucleotide dehydrogenase subunit 1(nad1)and internal transcribed spacer(ITS)).The PCR product of cox1 was directly submitted to sequencing,while clone sequencing was used for nad1 and ITS.The identity of the samples was verified by comparing the sequences to those of accepted A.cantonensis specimens.The specific composition of substitutions in each gene was analysed,and the genotypes were compared based on the complete cox1,nad1 and ITS genes.Results:We characterised the complete mitochondrial genes cox1 and nad1 of 130 specimens and obtained 357 nuclear sequences containing two complete ITS(ITS1 and ITS2)and 5.8S rRNA of the same samples.All specimens were genetically confirmed as A.cantonensis.Two major groups(i.e.I and II)were identified according to the phylogeny of cox1 sequences.Group I could be further categorised into six distinct clades.Almost half of the specimens(47.7%)belong to the clade Ia and 22.3%to the group II.The former was widely distributed across the study region.A variable number of repeat units in three microsatellites was observed,resulting in considerable length variation in ITS.Intragenomic variation of ITS sequences was found in a large proportion of the samples.Genotyping showed a striking difference between mitochondrial DNA and ITS.Conclusions:Our results demonstrate that A.cantonensis is the only rat lungworm species in P.R.China and shows high genetic diversity.Results of diversity and genotyping of A.cantonensis can be impacted by the sequencing strategy and biomarker.Although ITS may be a valuable marker for interspecific identification,it is not suitable for studying the intraspecific variation of A.cantonensis due to its high intragenomic variation and current challenges for direct sequencing. | Shan Lv Yi Zhang Peter Steinmann Jurg Utzinger Xiao-Nong Zhou | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 13 | Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy显示文摘Post-exposure prophylaxis(PEP)for leprosy is administered as one single dose of rifampicin(SDR)to the contacts of newly diagnosed leprosy patients.SDR reduces the risk of developing leprosy among contacts by around 60%in the first 2–3 years after receiving SDR.In countries where SDR is currently being implemented under routine programme conditions in defined areas,questions were raised by health authorities and professional bodies about the possible risk of inducing rifampicin resistance among the M.tuberculosis strains circulating in these areas.This issue has not been addressed in scientific literature to date.To produce an authoritative consensus statement about the risk that SDR would induce rifampicin-resistant tuberculosis,a meeting was convened with tuberculosis(TB)and leprosy experts.The experts carefully reviewed and discussed the available evidence regarding the mechanisms and risk factors for the development of(multi)drug-resistance in M.tuberculosis with a view to the special situation of the use of SDR as PEP for leprosy.They concluded that SDR given to contacts of leprosy patients,in the absence of symptoms of active TB,poses a negligible risk of generating resistance in M.tuberculosis in individuals and at the population level.Thus,the benefits of SDR prophylaxis in reducing the risk of developing leprosy in contacts of new leprosy patients far outweigh the risks of generating drug resistance in M.tuberculosis. | Liesbeth Mieras Richard Anthony Wim van Brakel Martin W.Bratschi Jacques van den Broek Emmanuelle Cambau Arielle Cavaliero Christa Kasang Geethal Perera Lee Reichman Jan Hendrik Richardus Paul Saunderson Peter Steinmann Wing Wai Yew | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 14 | Turning of aluminum metal matrix composites: influence of the reinforcement and the cutting condition on the surface layer of the workpiece显示文摘 | Jan C. Aurich Marco Zimmermann Stefan Schindler Paul Steinmann | 2016 | Advances in Manufacturing2016，4，3： | 2 |
| 15 | Direct steam generation in parabohc troughs: first results of the DISS project显示文摘 | Eck M Steinmann W D | 2002 | Journal of Solar Energy Engineering2002，124，5： | 1 |
| 16 | Adhesion Testing by the Scratch Test Method: The Influence of Intrinsic and Extrinsic Parameters on the Critical Load显示文摘 | STEINMANN P A TARDY Y HINTERMANN H E | 1987 | Thin Solid Films1987，154，12： | 1 |
| 17 | Biomechanical comparison of unipedicular versus bipedicular kyphoplasty显示文摘 | Steinmann J Tingey CT Cruz G | 2005 | Spine2005，30，2： | 1 |
| 18 | Cyclosporine A inhibits hepatitis C virus nonstruetural protein through cyelophilin A显示文摘 | Ciesek S Steinmann E Wedemeyer H | 2009 | Hepatology2009，50，5： | 1 |
| 19 | Prediction of prognosis regarding fractionation schedule and survival in patients with whole-brain radiotherapy for metastatic dis- ease显示文摘 | Meyer A Steinmann D Malaimare L | 2008 | Antieancer Res2008，28，6： | 1 |
| 20 | Hepatitis C virus hypervariable region 1modulates receptor interactions,conceals the CD81 binding site,and protects conserved neutralizing epitopes显示文摘 | Bankwitz D Steinmann E Bitzegeio J Ciesek S Friesland M Herrmann E | | 0，，： | 1 |
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